EKS-SAH-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	517.0	1.0E-155	38	320	283

Status

Unreviewed

Ensembl Protein

ENSSHAP00000016822

UniProt Accession

G3WN17;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL4

Gene Synonyms/Alias

CDKL4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000014310	ENSSHAP00000016822	ENSSHAT00000016964

Organism

Sarcophilus harrisii

Functional Description

Protein Length

380

Protein Sequence
(FASTA)

MMEEKEDLAV TNKEEVKVQH NPPTRTTLVH NSNIMEKYEK LGKIGEGSYG VVFKCRNKSS 60

GQVVAIKKFV ESEDDPIVKK IALREIRLLK QLKHANLVNL IEVFRRKRKM HLVFEYCDHT 120

LLNELERNPN GVADRMLKSV LWQTLQALSF CHKHNCIHRD VKPENILITK QGMIKICDFG 180

FARLLSPGDA YTDYVATRWY RAPELLVGDT QYGPTVDVWA VGCVFAELLT GRPLWPGKSD 240

VDQLYLIIKT LGKLIPRHQS IFKSNQFFHG INLPEPENME TLEEKFPQTP PVALNFMKSC 300

LKMNPDDRLN CAQLLESPYF ESFRESQVKR KSRNEGKNRR RSQVPTQNQL LPLIPGRHNT 360

PTPDGRRQVL QLKFDHLPNI 380

Nucleotide Sequence
(FASTA)

ATGATGGAAG AGAAAGAGGA CCTTGCAGTG ACCAACAAAG AGGAGGTAAA GGTGCAGCAT 60

AATCCACCAA CACGTACTAC TTTAGTTCAT AATTCAAATA TAATGGAAAA ATATGAAAAA 120

CTTGGTAAAA TTGGAGAAGG ATCTTATGGT GTTGTATTCA AGTGCAGAAA TAAAAGCTCC 180

GGACAAGTTG TGGCCATTAA AAAATTTGTG GAATCTGAGG ATGATCCCAT TGTTAAGAAA 240

ATAGCATTAA GAGAAATACG TTTATTGAAG CAACTAAAGC ATGCTAACCT TGTGAACCTC 300

ATTGAAGTGT TCCGAAGAAA GCGGAAAATG CACTTGGTTT TTGAATACTG TGATCATACA 360

CTTTTGAATG AGCTGGAGAG AAATCCAAAT GGAGTTGCTG ACCGTATGCT CAAAAGTGTT 420

TTGTGGCAAA CACTCCAAGC TCTCAGTTTC TGCCATAAAC ATAATTGTAT TCACAGGGAT 480

GTAAAACCTG AAAACATTCT GATAACAAAA CAAGGGATGA TCAAGATCTG TGACTTTGGA 540

TTTGCTCGAC TTCTGAGTCC AGGAGATGCC TATACAGATT ATGTTGCTAC AAGGTGGTAC 600

AGAGCTCCAG AACTTCTGGT AGGAGATACG CAATATGGTC CTACAGTAGA TGTGTGGGCT 660

GTTGGCTGTG TTTTTGCTGA ATTGCTGACT GGCCGGCCCC TCTGGCCTGG AAAATCGGAT 720

GTGGACCAAC TCTATCTGAT CATCAAAACT CTGGGAAAAC TAATTCCAAG GCACCAGTCC 780

ATCTTTAAAA GCAACCAGTT TTTCCATGGC ATAAATCTAC CGGAACCAGA AAATATGGAA 840

ACACTTGAGG AAAAATTTCC TCAAACTCCT CCAGTGGCTT TGAACTTCAT GAAGAGTTGC 900

TTGAAGATGA ATCCAGATGA TAGACTAAAT TGTGCACAGC TCTTAGAGAG CCCTTATTTT 960

GAATCTTTTC GAGAAAGTCA AGTTAAAAGA AAATCACGTA ATGAAGGAAA GAACAGAAGA 1020

CGATCACAAG TACCTACCCA GAATCAGCTG TTGCCTCTCA TACCGGGAAG ACACAACACC 1080

CCCACACCTG ATGGAAGAAG ACAGGTCCTC CAATTAAAAT TTGATCATCT TCCAAACATT 1140

TAA 1143

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yeklgk+GeGsyGvv+kcrnk++gq+vaikkf+esedd+ vkkialrei+llkqlkh nl

Q: 38    YEKLGKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDPIVKKIALREIRLLKQLKHANL  97

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfrrk+k++lvfey+d+t+l+eler+pnGv ++++k++l+q+l+a++fchk+n+i

Q: 98    VNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADRMLKSVLWQTLQALSFCHKHNCI  157

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k+g++k+cdfGfarll+ pgd+ytdyvatrwyrapellvgdt+yG++v

Q: 158   HRDVKPENILITKQGMIKICDFGFARLLS-PGDAYTDYVATRWYRAPELLVGDTQYGPTV  216

         ****************************9.******************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwa+Gc++aelltG+pl+pgksdvdqly+i+ktlG+liprhq+if++n++f+G++lpe+

Q: 217   DVWAVGCVFAELLTGRPLWPGKSDVDQLYLIIKTLGKLIPRHQSIFKSNQFFHGINLPEP  276

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         e++e+le+k+p+  +v+l+++k+clk++p++rl c++ll+++yf

Q: 277   ENMETLEEKFPQTPPVALNFMKSCLKMNPDDRLNCAQLLESPYF  320

         ******************************************98

Domain Sequence
(FASTA)

YEKLGKIGEG SYGVVFKCRN KSSGQVVAIK KFVESEDDPI VKKIALREIR LLKQLKHANL 60

VNLIEVFRRK RKMHLVFEYC DHTLLNELER NPNGVADRML KSVLWQTLQA LSFCHKHNCI 120

HRDVKPENIL ITKQGMIKIC DFGFARLLSP GDAYTDYVAT RWYRAPELLV GDTQYGPTVD 180

VWAVGCVFAE LLTGRPLWPG KSDVDQLYLI IKTLGKLIPR HQSIFKSNQF FHGINLPEPE 240

NMETLEEKFP QTPPVALNFM KSCLKMNPDD RLNCAQLLES PYF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013