EKS-SAH-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	342.1	2.7E-102	874	1147	274

Status

Unreviewed

Ensembl Protein

ENSSHAP00000016889

UniProt Accession

G3WN84;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000014365	ENSSHAP00000016889	ENSSHAT00000017031

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1153

Protein Sequence
(FASTA)

MQYLNFKEDC NAMAFCAKMR SYKKNEVNLD VLEPGVEVAF YLPDRKPLHL LNGEYTVEDL 60

CIRAAQECSI SPLCHNLFAL YDEKAKLWYA PNHCIKIEEK TSLRLHYRMR FYFTNWHGTN 120

ENEQSVWRHS PKKQKNGYER RRVLDATPLL DANSLEYLFA QGQYDLVKCL APVRDPKTDQ 180

EVHEIENECL GMAVLAISHY AMMNNIQLPD LPKDVSYKRY IPETLNKTIR QRNLLTRLRI 240

NNVFKDFLKE FNNKTICDSS VTPHDLKVKY LSTLETLTKH YGAEIFETSL LLISSENEMN 300

KLNSKDCGNV ISYEVMVTGN LGIQWRQKPN VVPVEKEKNK LKRKKQDNRH RKEEEKNKAR 360

EEWNSFSYFP EITHVVIKES MVSINKQDNK KMELSLSSHE EALSFVSLVD GYFRLTADAH 420

HYLCTDVAPP LIVHNIENGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480

CFEKSEQMLT SQKQYKNFQI EVKKGKYSLH GSDRVFPSLK GLMDHLKKQI LKTDNISFVL 540

KKCCQPKPRE ISNLLVATKK AQECQPVYTM SQLSFHRILK EDIIQGEHMG RGTRTQIYSG 600

TLDYKDDEGS SDEKKMKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV 660

ENIMVEEYME FGPLDLFMHR KSELLTTPWK FKVAKQLASA LSYLEDKDLV HGNVCAKNVL 720

LAREGLDGEC SPFIKLSDPS IPITVLSRQE CVERIPWIAP ECVDDSKNLS VAADKWSFGT 780

TLWEICYNGE IPLKDKTLAE KERFYEGRVM PVTPSCKELA DLMTQCMNYD PSQRPFFRAI 840

MRDINRLEEQ NPDILSEKQP TTEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT 900

GEQVAVKSLK PESGGNQIAD LKKEIEILKN LYHENIVKYK GICTEDGGNR IKLIMEFLPS 960

GSLKEYLPRN KNKINLKQQL KYAVQICKGM DYLGSCQYVH RDLAARNVLV ENEHRVKIGD 1020

FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLVQCKFYIA SDVWSFGVTL HELLTYCDSE 1080

SSPMAMFLKM IGPTQGQMTV TRLVRALKEG KRLQCPPNCP EEVYQLMKKC WEYQPNNRTS 1140

FQNLIRGFEA LIK 1153

Nucleotide Sequence
(FASTA)

ATGCAGTATC TAAATTTCAA GGAAGACTGC AATGCGATGG CGTTCTGTGC AAAAATGAGG 60

AGCTACAAAA AGAACGAGGT GAACCTGGAT GTGCTGGAGC CCGGCGTGGA GGTGGCCTTC 120

TACCTGCCCG ACAGGAAGCC CCTCCACTTG CTCAACGGCG AGTACACGGT GGAAGATCTG 180

TGCATCAGAG CCGCCCAGGA GTGCTCCATC TCCCCTCTGT GCCACAACCT GTTCGCCCTG 240

TACGATGAGA AGGCCAAGCT CTGGTACGCC CCAAATCACT GCATCAAGAT CGAAGAGAAA 300

ACCTCACTGC GGCTGCACTA TCGCATGAGG TTCTATTTCA CCAACTGGCA TGGGACCAAT 360

GAGAACGAGC AGTCGGTGTG GAGACACTCC CCAAAGAAGC AGAAAAATGG TTATGAAAGA 420

AGGCGGGTCC TGGATGCTAC CCCCCTCCTG GATGCCAACT CACTGGAGTA TCTGTTTGCT 480

CAGGGACAAT ATGACTTGGT GAAATGCTTG GCTCCTGTAC GAGACCCGAA GACCGACCAG 540

GAAGTGCACG AGATCGAAAA TGAATGTCTG GGGATGGCAG TGCTGGCCAT ATCCCATTAT 600

GCCATGATGA ATAACATCCA GCTTCCGGAT CTGCCCAAGG ATGTCAGTTA CAAGCGATAT 660

ATTCCAGAAA CACTGAACAA GACCATCAGA CAAAGGAATC TCTTAACCAG ATTGCGAATC 720

AATAACGTTT TCAAGGATTT CCTTAAGGAA TTTAACAACA AGACCATCTG TGACAGCAGC 780

GTGACTCCCC ATGACCTGAA GGTGAAATAC CTGTCCACCT TGGAGACGCT GACCAAACAT 840

TACGGAGCTG AAATTTTCGA GACTTCACTC TTGTTGATTT CGTCTGAAAA TGAAATGAAT 900

AAATTAAACT CAAAGGACTG TGGGAACGTC ATAAGTTATG AAGTGATGGT GACTGGGAAT 960

CTCGGAATAC AATGGAGGCA AAAACCAAAT GTGGTTCCTG TTGAGAAAGA GAAAAATAAG 1020

CTGAAGAGGA AGAAACAGGA CAACAGACAC AGGAAAGAAG AGGAGAAAAA CAAAGCCCGA 1080

GAGGAATGGA ACAGCTTCTC TTACTTCCCC GAAATCACCC ATGTCGTCAT CAAGGAATCC 1140

ATGGTCAGCA TTAACAAGCA GGACAACAAA AAGATGGAGT TAAGCCTGTC CTCCCACGAG 1200

GAAGCCTTGT CTTTCGTGTC TCTGGTGGAC GGGTATTTCC GGCTCACGGC GGACGCCCAT 1260

CATTACCTCT GCACGGATGT CGCCCCTCCA CTGATTGTGC ACAACATCGA GAATGGCTGT 1320

CATGGTCCAA TCTGCACTGA GTATGCAATC AACAAACTGA GGCAAGAAGG AAGCGAGGAA 1380

GGCATGTATG TTCTGCGCTG GAGCTGCACA GACTTTGACA ACATCCTCAT GACCGTGACC 1440

TGCTTCGAGA AATCGGAGCA GATGCTCACG AGCCAGAAAC AGTACAAGAA CTTCCAGATT 1500

GAGGTGAAGA AGGGCAAATA CTCCCTGCAC GGCTCCGACC GTGTGTTCCC CTCTCTCAAA 1560

GGCCTCATGG ACCATCTCAA AAAGCAGATC CTGAAAACGG ACAACATCAG CTTCGTCCTA 1620

AAGAAATGCT GCCAGCCCAA ACCGAGAGAA ATCTCTAACC TGCTGGTGGC CACCAAGAAG 1680

GCCCAGGAGT GCCAGCCAGT CTACACCATG AGCCAGCTGA GTTTCCATCG GATTCTCAAG 1740

GAAGACATCA TCCAGGGAGA GCACATGGGA CGAGGCACTC GCACCCAGAT CTACTCGGGG 1800

ACCCTGGATT ACAAGGACGA TGAAGGCAGC TCTGATGAGA AAAAAATGAA AGTCATCCTC 1860

AAGGTCTTGG ACCCCAGTCA CAGGGACATT TCTCTGGCTT TCTTCGAGGC AGCCAGCATG 1920

ATGAGGCAGG TGTCCCACAA GCACATCGTG TACCTCTACG GCGTCTGCGT CCGTGACGTG 1980

GAAAATATCA TGGTGGAGGA GTACATGGAG TTCGGGCCCC TGGACCTCTT CATGCATCGG 2040

AAAAGCGAGC TGCTCACCAC GCCCTGGAAG TTTAAGGTGG CCAAACAGCT GGCCAGCGCA 2100

CTGAGTTACT TGGAGGACAA AGATTTAGTC CACGGCAACG TGTGTGCCAA GAACGTGCTG 2160

TTGGCCAGAG AGGGCCTGGA CGGGGAGTGT AGCCCCTTCA TCAAGCTCAG CGATCCCAGC 2220

ATCCCCATCA CCGTGCTCTC CCGCCAGGAA TGTGTGGAAC GGATTCCATG GATTGCCCCA 2280

GAGTGTGTGG ATGACTCCAA GAACCTGAGC GTGGCCGCTG ATAAATGGAG TTTCGGCACA 2340

ACCCTCTGGG AGATCTGCTA CAATGGAGAG ATCCCCCTGA AAGATAAGAC TCTAGCAGAG 2400

AAAGAAAGAT TTTATGAAGG TCGAGTTATG CCGGTCACGC CTTCATGCAA GGAGCTGGCC 2460

GACCTGATGA CTCAGTGCAT GAACTACGAC CCTAGTCAGA GACCCTTCTT CCGAGCCATC 2520

ATGAGAGACA TCAACAGGCT AGAAGAACAG AACCCAGATA TCCTTTCAGA GAAACAGCCA 2580

ACAACTGAGG TAGATCCCAC TCATTTTGAA AAACGGTTCT TGAAGAGGAT CCGGGACTTA 2640

GGAGAGGGTC ACTTCGGGAA AGTTGAACTG TGCAGGTACG ACCCGGAAGG GGACAACACA 2700

GGGGAACAGG TCGCAGTGAA GTCCCTGAAG CCAGAGAGTG GGGGCAACCA GATCGCCGAC 2760

CTGAAGAAGG AGATCGAAAT CTTGAAGAAC CTCTATCACG AAAACATTGT GAAATACAAG 2820

GGGATCTGTA CAGAGGATGG AGGAAATAGG ATTAAGCTCA TCATGGAGTT CCTGCCTTCT 2880

GGGAGCCTTA AGGAATATCT TCCCAGGAAT AAGAACAAAA TCAACCTCAA ACAGCAGCTG 2940

AAGTACGCAG TTCAGATCTG TAAGGGGATG GACTATCTGG GATCCTGTCA GTATGTCCAC 3000

CGAGATCTTG CAGCAAGAAA TGTCCTTGTT GAGAATGAGC ACCGGGTGAA GATTGGAGAT 3060

TTTGGCTTAA CGAAAGCCAT TGAAACAGAC AAGGAGTACT ACACGGTGAA AGATGATCGA 3120

GACAGTCCCG TCTTCTGGTA TGCCCCAGAA TGTTTAGTTC AATGCAAATT TTATATCGCC 3180

TCTGACGTCT GGTCATTCGG GGTCACGTTA CATGAACTGC TCACCTACTG CGATTCAGAA 3240

TCCAGTCCCA TGGCGATGTT CTTGAAGATG ATCGGCCCAA CTCAAGGCCA GATGACCGTC 3300

ACCCGGCTTG TGAGAGCATT AAAGGAAGGG AAACGTTTGC AGTGCCCACC CAATTGCCCA 3360

GAAGAGGTTT ACCAGCTAAT GAAGAAATGC TGGGAGTATC AGCCAAACAA TCGGACATCT 3420

TTTCAGAACC TCATCCGGGG ATTTGAAGCA CTTATAAAAT AA 3462

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 874   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNQIADLKKEIEILKNLYH  933

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+++k++++l+++l++a q++k+m+YL

Q: 934   ENIVKYKGICTEDGGNriKLIMEFLPSGSLKEYLPRNKNKINLKQQLKYAVQICKGMDYL  993

         ****************999*****************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++ ++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 994   GSCQYVHRDLAARNVLVENEHR------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1047

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl ++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r+++

Q: 1048  APECLVQCK-FYIASDVWSFGVTLHELLTyCDSESSPmamfLKMIGPTqgqmtvtRLVRA  1106

         *********.***************************9999999999999**********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264

         l+e++rl +p+ cp+e+++lm++c++y+p++r+sF+++++

Q: 1107  LKEGKRLQCPPnCPEEVYQLMKKCWEYQPNNRTSFQNLIRG  1147

         *************************************9985

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNQIADLKK EIEILKNLYH 60

ENIVKYKGIC TEDGGNRIKL IMEFLPSGSL KEYLPRNKNK INLKQQLKYA VQICKGMDYL 120

GSCQYVHRDL AARNVLVENE HRVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLV 180

QCKFYIASDV WSFGVTLHEL LTYCDSESSP MAMFLKMIGP TQGQMTVTRL VRALKEGKRL 240

QCPPNCPEEV YQLMKKCWEY QPNNRTSFQN LIRG 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013