EKS-SAH-00216

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00216

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	336.2	1.5E-100	168	419	252

Status

Unreviewed

Ensembl Protein

ENSSHAP00000016930

UniProt Accession

G3WNC5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000014400	ENSSHAP00000016930	ENSSHAT00000017072

Organism

Sarcophilus harrisii

Functional Description

Protein Length

448

Protein Sequence
(FASTA)

MLWLALGPSH AMENQVLVIR IKIPDGGAVD WTVHSGPQLL FRDVLDVIGQ VLPDATTTAF 60

EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGKRNIHGL 120

KVNTRAGPSH HSSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV 180

YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240

TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 300

DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 360

KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM KKQPKERPAP EDLMGHPFIM 420

QYNDGNAEVV SMWVCRMLEE RRTQQGPQ 448

Nucleotide Sequence
(FASTA)

ATGCTGTGGC TGGCCCTTGG CCCTTCCCAT GCCATGGAGA ACCAGGTGCT GGTGATTCGA 60

ATCAAGATCC CAGACGGCGG AGCTGTGGAC TGGACAGTGC ACTCTGGGCC TCAGTTGCTT 120

TTCCGGGATG TGCTGGATGT GATAGGCCAG GTTTTGCCCG ATGCAACAAC TACAGCATTT 180

GAATATGAAG ATGAGGATGG TGATCGCATT ACTGTGAGAA GTGATGAAGA AATGAAGGCC 240

ATGCTGTCAT ATTATTATTC CACAGTAATG GAACAGCAAG TAAATGGACA GTTAATAGAG 300

CCTCTGCAGA TATTTCCAAG AGCCTGCAAG CCTCCTGGGA AACGGAACAT ACATGGCCTG 360

AAGGTGAATA CACGGGCCGG GCCCTCTCAT CATAGCAGCC CAGCAGTTTC AGATTCACTT 420

CCAAGCAATA GCTTAAAGAA GTCTTCTGCT GAATTGAAAA AAATTTTAGC CAATGGCCAG 480

ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTCGGTC ATGGCAATGG AGGCACAGTC 540

TACAAAGCAT ATCATGTCCC AAGTGGAAAA ATATTAGCTG TAAAGGTGAT ATTGCTAGAT 600

ATTACACTGG AACTTCAAAA ACAAATTATG TCTGAATTGG AAATTCTTTA TAAGTGTGAT 660

TCATCATATA TTATAGGATT TTATGGTGCA TTTTTTGTAG AAAACAGGAT TTCAATATGT 720

ACAGAATTCA TGGATGGGGG ATCTTTGGAT GTGTATAGGA AAATTCCAGA GCATGTCCTG 780

GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTAACTTACC TGTGGAGTTT AAAGATATTA 840

CATAGAGATG TGAAGCCTTC CAATATGTTG GTGAACACAA GAGGACAGGT CAAGCTGTGT 900

GATTTTGGAG TTAGCACTCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 960

GCTTATATGG CGCCTGAAAG AATTTCAGGG GAGCAATATG GAATCCATTC GGATGTTTGG 1020

AGCTTAGGAA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGATTCAG 1080

AAAAACCAGG GATCTTTAAT GCCTCTCCAG CTACTGCAGT GCATTGTTGA TGAGGATTCG 1140

CCAGTCCTTC CGGTTGGAGA GTTCTCCGAA CCATTTGTAC ACTTCATCAC TCAGTGTATG 1200

AAGAAACAGC CAAAAGAAAG GCCGGCACCT GAGGATTTGA TGGGCCACCC ATTTATCATG 1260

CAGTACAATG ATGGGAATGC TGAAGTGGTC TCCATGTGGG TGTGCAGGAT GCTGGAGGAG 1320

AGACGGACCC AGCAGGGGCC CCAGTGA 1347

Domain Profile

S: 3     kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk  62

           ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++

Q: 168   YRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG  226

         5679************************************************.*******

S: 63    fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl  122

         fyGaf+ e+++sic+e+mdg+sld v++k       ipe+vlg+iavavvk+l+yl+ +l

Q: 227   FYGAFFVENRISICTEFMDGGSLD-VYRK-------IPEHVLGRIAVAVVKGLTYLW-SL  277

         ************************.6876.......9********************.78

S: 123   kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk  182

         ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++

Q: 278   KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH  336

         *****************************************************.******

S: 183   sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv  236

         sdvWslG++++ela gr+py++ ++      +l+ll++iv+e++p+lp  efse f++f+

Q: 337   SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPVLPVGEFSEPFVHFI  396

         ***********************9999*********************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++C+kk++keRp  ++l+ h+fi

Q: 397   TQCMKKQPKERPAPEDLMGHPFI  419

         **********************7

Domain Sequence
(FASTA)

YRDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60

YGAFFVENRI SICTEFMDGG SLDVYRKIPE HVLGRIAVAV VKGLTYLWSL KILHRDVKPS 120

NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180

ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPVLPVGE FSEPFVHFIT QCMKKQPKER 240

PAPEDLMGHP FI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013