EKS-SAH-00228

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00228

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	361.5	2.2E-108	20	271	252

Status

Unreviewed

Ensembl Protein

ENSSHAP00000016989

UniProt Accession

G3WNI4;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000014444	ENSSHAP00000016989	ENSSHAT00000017131

Organism

Sarcophilus harrisii

Functional Description

Protein Length

920

Protein Sequence
(FASTA)

MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120

RKFWQILSAV DYCHSRKIVH RDLKAENLLL DNNMNIKIAD FGFGNFFKSG EPLATWCGSP 180

PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240

SEECEHLIRR MLVLDPSKRL TIAQIKEHKW MLVEVPVQRP VLYPQEQENE PSLGEYNEQV 300

LRLMHSLGID QQKTMESLQN KSYNHFAAIY YLLVERLKSH RSSFPVEQRV DARQRRPSTV 360

AEQTVAKAQT VGPPMTIRSQ NMRLLRSPIL PQTSNVDAFS FPNSGCQAEA AFMEEERVDT 420

PKVNGCLLDP VPPIMMRKGC QSLPSNMMET SIDEGIETEG ESEEDPSHAF DAFQSTRCGQ 480

RRHTLAEVTN QLVMMPGTGK VFSVNDHPSL GSVDSEYDMG SIQRDLNFLE DNPSLKDIML 540

ANQPAHRLTP PFISIRPANP AMQVLSSQKR EAHNRSPVSF REGRRASDTS LTQGLVAFRQ 600

HLQNLARTKG ILELNKVQLL YEQMGSEAEP SLASAGPQLQ DLVNSASQEE ATQPQENTSV 660

FSNSVHPQLS RRQSLETQYL QHRLQKPSLL SKAQNTCQLY CKDPPRSLEQ QLQEHRLHQK 720

RLFLQKQSQL QAYFNQMQIA ENSYPRPNQQ LPLPHQEQLS SPPPQPPQPP QFSLAQSLSP 780

VLEPSSEQMQ YDPFLSQYRK LQLQPLPSSQ VPNSPPPLSS PLQQQPPQPP AAPPPLAFSY 840

QTRELSGAAP PEPDYPTPCQ YSMDPAQQSN VAPPDSPRSS GPREPPSSYD PLALSELPGL 900

FDCEMMEAVD PQPSGYVLVN 920

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGATGGCCC GAGGCACTTG CAGCGCGGGC CGGTTCGGGT GGGGTTTTAC 60

GACATCGAGG GCACGCTGGG CAAGGGCAAC TTCGCCGTGG TGAAGCTGGG GCGCCACCGC 120

ATCACCAAGA CCGAGGTGGC AATAAAAATC ATAGATAAAT CTCAGCTGGA TGCAGTGAAT 180

CTAGAGAAAA TCTACAGAGA AGTACAAATA ATGAAAATGT TAGATCACCC TCACATAATA 240

AAACTCTACC AGGTGATGGA GACCAAAAGT ATGTTGTACC TTGTCACTGA ATATGCCAAA 300

AATGGAGAGA TTTTTGATTA CCTTGCAAAT CATGGCCGAT TGAATGAGTC TGAGGCAAGG 360

CGAAAATTTT GGCAAATTCT TTCTGCAGTA GATTATTGTC ATAGTCGGAA GATTGTGCAC 420

CGTGACCTCA AGGCTGAAAA TCTGCTGCTA GATAACAACA TGAACATCAA AATAGCAGAT 480

TTTGGCTTTG GAAATTTCTT TAAGAGTGGT GAACCACTGG CTACGTGGTG TGGCAGCCCT 540

CCTTATGCAG CCCCAGAAGT CTTTGAAGGA CAACAGTATG AAGGACCACA ACTGGACATT 600

TGGAGTATGG GAGTAGTTCT TTATGTTCTT GTCTGTGGAG CTCTGCCTTT TGATGGACCA 660

ACTCTCCCTA TCCTGAGGCA AAGAGTTCTG GAAGGAAGAT TCCGGATTCC ATATTTCATG 720

TCAGAAGAGT GTGAGCATCT CATCCGAAGG ATGTTGGTCT TAGATCCATC TAAGAGACTG 780

ACAATAGCCC AAATAAAAGA ACACAAGTGG ATGCTGGTGG AAGTTCCTGT ACAGAGACCT 840

GTTCTTTATC CACAAGAGCA GGAAAATGAG CCATCTCTTG GGGAGTATAA TGAGCAGGTC 900

CTGCGGCTAA TGCATAGTCT TGGAATAGAT CAACAGAAAA CCATGGAGTC TTTGCAGAAC 960

AAGAGTTATA ACCACTTTGC TGCTATCTAT TACTTATTGG TGGAAAGGCT GAAATCTCAC 1020

CGCAGCAGCT TCCCCGTGGA GCAGAGAGTT GATGCCCGCC AGCGTCGGCC CAGCACTGTC 1080

GCTGAACAAA CAGTTGCCAA GGCACAAACT GTTGGTCCCC CAATGACCAT ACGTTCACAG 1140

AACATGAGAC TGTTGAGGTC CCCCATCCTT CCTCAAACAT CAAACGTGGA CGCCTTTTCA 1200

TTTCCAAATT CTGGATGCCA GGCCGAGGCA GCATTTATGG AGGAAGAACG AGTTGATACA 1260

CCAAAGGTGA ATGGTTGTCT GCTGGACCCA GTGCCCCCCA TAATGATGAG AAAAGGATGC 1320

CAATCTCTGC CAAGTAATAT GATGGAGACG TCTATCGATG AAGGAATAGA GACAGAAGGG 1380

GAGTCGGAGG AAGATCCCAG CCATGCATTT GATGCTTTCC AATCAACACG CTGTGGGCAG 1440

CGACGTCACA CACTGGCAGA AGTGACCAAT CAGCTAGTCA TGATGCCCGG AACAGGAAAA 1500

GTCTTTTCTG TGAATGACCA CCCTTCCTTG GGCAGTGTGG ATTCTGAGTA TGACATGGGA 1560

TCCATTCAGA GGGATCTGAA CTTTCTAGAG GACAATCCAT CCCTGAAGGA CATCATGTTG 1620

GCCAATCAGC CGGCTCATCG CCTGACCCCT CCTTTCATAA GCATACGGCC AGCCAATCCA 1680

GCCATGCAGG TGCTGAGCTC TCAGAAACGA GAGGCCCACA ACAGGTCCCC AGTGAGCTTC 1740

AGAGAAGGCC GGAGGGCATC AGATACCTCT CTCACACAAG GGCTTGTAGC GTTTAGACAG 1800

CACCTTCAGA ACCTGGCTCG AACCAAAGGA ATTCTTGAAC TGAACAAAGT CCAGTTGCTT 1860

TATGAACAGA TGGGGTCAGA GGCAGAACCT AGTTTAGCAT CAGCAGGTCC TCAGCTCCAA 1920

GACCTTGTTA ACAGTGCCTC ACAGGAGGAA GCCACTCAGC CACAGGAAAA CACCTCTGTT 1980

TTTTCTAACA GTGTGCATCC ACAACTGTCT AGACGGCAAA GCCTAGAGAC GCAATACCTG 2040

CAGCATAGAC TCCAGAAACC TAGTCTCCTG TCCAAAGCAC AGAATACCTG CCAACTTTAC 2100

TGTAAGGATC CTCCCCGAAG CTTGGAGCAG CAGCTGCAGG AGCACAGGCT CCATCAGAAG 2160

CGCCTCTTCC TCCAGAAGCA GTCCCAGCTG CAGGCATACT TTAACCAGAT GCAAATAGCA 2220

GAGAATTCCT ACCCCAGGCC AAACCAGCAG CTGCCGCTTC CCCATCAGGA GCAGCTCTCC 2280

AGTCCTCCGC CTCAGCCGCC CCAGCCTCCC CAGTTCAGCT TGGCCCAGTC GTTGAGTCCA 2340

GTCCTGGAGC CTTCCTCCGA GCAGATGCAA TATGACCCCT TCCTCAGCCA GTACCGTAAA 2400

CTGCAGCTAC AGCCCTTGCC CTCCTCCCAG GTTCCCAACT CCCCCCCTCC ACTGTCCTCC 2460

CCACTGCAGC AGCAGCCACC ACAGCCGCCA GCAGCACCTC CCCCCTTAGC ATTCTCTTAT 2520

CAGACTCGTG AGCTGTCAGG TGCTGCCCCC CCTGAGCCAG ACTATCCAAC CCCCTGTCAG 2580

TATTCCATGG ACCCAGCTCA GCAAAGCAAT GTAGCGCCTC CGGACTCTCC CAGGAGCTCT 2640

GGGCCAAGGG AGCCCCCCTC CAGCTACGAC CCGTTAGCAC TCTCTGAGCT GCCTGGACTC 2700

TTTGATTGTG AAATGATGGA GGCTGTGGAC CCCCAGCCCA GTGGCTATGT CCTCGTGAAT 2760

TAG 2763

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g+f+ Vkl +h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  79

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e+ear+ f q++sav+Y+hs++iv

Q: 80    IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHSRKIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+fk+g+ l t+cGsppYaaPe+++g++Yegp++D

Q: 140   HRDLKAENLLLDNNMNIKIADFGFGNFFKSGEPLATWCGSPPYAAPEVFEGQQYEGPQLD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+e+e+L+r++Lv dp+kR

Q: 200   IWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEECEHLIRRMLVLDPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

         +ti +i++h+w+

Q: 260   LTIAQIKEHKWM  271

         ***********8

Domain Sequence
(FASTA)

YDIEGTLGKG NFAVVKLGRH RITKTEVAIK IIDKSQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK SMLYLVTEYA KNGEIFDYLA NHGRLNESEA RRKFWQILSA VDYCHSRKIV 120

HRDLKAENLL LDNNMNIKIA DFGFGNFFKS GEPLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEECEHLIR RMLVLDPSKR 240

LTIAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013