EPS-SAH-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAH-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	287.3	1.5E-85	23	289	267

Status

Unreviewed

Ensembl Protein

ENSSHAP00000017052

UniProt Accession

G3WNP7;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000014493	ENSSHAP00000017052	ENSSHAT00000017194

Organism

Sarcophilus harrisii

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL EGWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT NNQDFKGSEG PPSVENVKNG IRTGFLQIDE HMRIISEKKH 120

GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VYEIERSEKD DQFIILACDG 240

IWDVMGNEEL CDFVRSRLEV TDDLERVCNE VVDTCLYKGS RDNMSVILIC FPSAPKVSPE 300

AVKKETELDK YLESRVEEII KKQGEGVPDL VHVMRTLATE NIPNLPPGGE LASKRSLIEA 360

VYNRLNPFRN DDTDSTSADD MW 382

Nucleotide Sequence
(FASTA)

ATGGGGGCAT TTTTAGACAA GCCAAAGATG GAAAAGCATA ATGCCCAAGG ACAAGGTAAT 60

GGGCTACGTT ATGGGCTAAG CAGTATGCAA GGTTGGCGAG TTGAAATGGA AGATGCACAT 120

ACAGCTGTGA TTGGTTTGCC TAGTGGACTT GAAGGATGGT CATTCTTTGC TGTGTATGAT 180

GGGCATGCTG GTTCCCAGGT TGCCAAATAC TGCTGTGAGC ATTTGTTAGA TCATATCACA 240

AATAACCAAG ATTTTAAAGG ATCTGAAGGA CCACCTTCTG TGGAAAATGT CAAGAATGGA 300

ATAAGAACAG GTTTTCTGCA GATTGATGAA CATATGAGAA TAATATCAGA GAAGAAACAT 360

GGTGCAGACC GAAGTGGGTC AACGGCAGTG GGTGTCCTGA TTTCTCCCCA ACATACATAT 420

TTCATCAACT GTGGAGACTC AAGAGGTTTA CTTTGTAGGA ACAGGAAAGT TCATTTCTTC 480

ACACAAGATC ACAAACCAAG TAATCCTTTG GAAAAAGAAC GTATTCAGAA TGCAGGTGGT 540

TCTGTAATGA TTCAGCGTGT GAATGGCTCT CTTGCTGTAT CTAGGGCACT TGGAGACTTT 600

GATTACAAAT GTGTCCATGG TAAAGGTCCT ACAGAGCAGC TTGTCTCTCC AGAGCCAGAA 660

GTCTATGAAA TTGAAAGATC AGAAAAAGAT GATCAGTTTA TCATCCTCGC ATGTGATGGT 720

ATCTGGGATG TTATGGGAAA TGAAGAGCTC TGTGATTTTG TAAGATCCAG ACTTGAAGTC 780

ACTGATGACC TTGAGAGAGT ATGCAACGAA GTAGTGGATA CCTGTTTATA TAAGGGAAGT 840

CGAGACAACA TGAGTGTGAT ATTGATCTGT TTTCCAAGTG CACCAAAAGT ATCACCAGAG 900

GCAGTGAAGA AAGAGACAGA ATTGGACAAG TACCTGGAAA GCAGAGTAGA AGAAATCATA 960

AAGAAGCAGG GCGAAGGCGT ACCAGACTTA GTCCATGTGA TGCGCACATT AGCAACTGAG 1020

AACATCCCAA ACCTCCCACC AGGGGGTGAA CTGGCAAGCA AGCGGAGTTT AATTGAAGCC 1080

GTTTACAATA GACTGAATCC TTTCAGAAAT GATGACACTG ACTCTACATC AGCTGATGAT 1140

ATGTGGTAA 1149

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++   p+  + ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTAVIGL---PSGLEGWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************984444...444445***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         +++ +    ++ ++ ++vk+ ++++Fl++de++++++ek++  d+sGstav +li++++

Q: 80    TNNQDfkgsEGPPSVENVKNGIRTGFLQIDEHMRIISEKKHGADRSGSTAVGVLISPQHT  139

         ***998888888899*********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev++++++++d+ f+iLa+DG+wdv+ nee++++vr+

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVYEIERSEKDDqFIILACDGIWDVMGNEELCDFVRS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++ +++++v+++l +gs+dn+s+i++

Q: 257   RLEVTDDLERVCNEVVDTCLYKGSRDNMSVILI  289

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPSGLEG WSFFAVYDGH AGSQVAKYCC EHLLDHITNN 60

QDFKGSEGPP SVENVKNGIR TGFLQIDEHM RIISEKKHGA DRSGSTAVGV LISPQHTYFI 120

NCGDSRGLLC RNRKVHFFTQ DHKPSNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVY EIERSEKDDQ FIILACDGIW DVMGNEELCD FVRSRLEVTD 240

DLERVCNEVV DTCLYKGSRD NMSVILI 267

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013