EKS-SAH-00461

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00461

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	372.4	1.3E-111	20	289	270

Status

Unreviewed

Ensembl Protein

ENSSHAP00000017074

UniProt Accession

G3WNR9;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK2

Gene Synonyms/Alias

RIPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000014513	ENSSHAP00000017074	ENSSHAT00000017216

Organism

Sarcophilus harrisii

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

MNGDSLAISS SLPTIPYQKL ADLRFLSRGA SGTVSSARHS DWRVQVAVKH LHFQTPPQES 60

EISDILREAK ILHKARFSYI LPILGICYEP EFLGIVTEYM NNGSLNELLH RKNDYPDIAW 120

ALRFRILHEI ALGVNYLHNM NPPLLHHDLK TQNILLDNEF HVKIADFGLS KWRQMSLSQS 180

RNSVSTPEGG TIIYMPPENY DLSQKSRASI KHDIYSFAII MWEVLSRKQP FEEVINPLQI 240

MYSVSKGNRP DTDTESLPLD IPHRTRMINL IEAGWAQNPD ERPSFLKCLI ELEPVMRTFE 300

DISILEAVLE LKKTKLQNNS SIISLCSKKT MEYPLNIPVN HGPQEESCGT QVTVRSDPEI 360

ARSLSTTQDN VFSSVQNQEL STLPHSVANN SWVGSISSIQ RAKLYNQQTT YSSAVIQPLR 420

AEGNSDLLSE SQGNDIAQQW IQSKREDIVN QMTEACLNQC LDALLSKDLL MKEDYELIYT 480

KPTRTSKVRQ MLDTSDIQGE EFAKIIIQKL KDNKQLGLQP YPEISVVSRG TSLNLYQNKS 540

F 541

Nucleotide Sequence
(FASTA)

ATGAACGGAG ACAGCCTAGC CATCTCTAGC TCATTACCCA CCATCCCTTA TCAAAAGCTC 60

GCCGACCTGC GGTTCCTGAG CAGGGGGGCA TCAGGCACCG TATCCTCGGC ACGCCACTCT 120

GACTGGCGCG TTCAGGTGGC AGTGAAGCAC CTGCATTTCC AGACCCCGCC GCAGGAAAGT 180

GAAATAAGTG ATATCTTAAG AGAAGCCAAG ATTTTACACA AAGCAAGATT TAGTTATATC 240

CTTCCAATTT TGGGAATTTG CTATGAGCCC GAGTTCTTGG GAATAGTCAC TGAATACATG 300

AACAATGGAT CACTCAATGA GCTCCTGCAC AGGAAAAATG ACTATCCTGA CATTGCTTGG 360

GCTTTGAGAT TCCGAATTCT GCATGAAATT GCATTGGGAG TAAATTATCT TCACAATATG 420

AACCCACCAC TACTGCATCA TGACTTGAAG ACTCAAAACA TCTTATTGGA TAATGAATTT 480

CATGTTAAGA TTGCAGATTT TGGTTTATCA AAATGGCGGC AGATGTCTTT ATCTCAATCA 540

AGGAATAGTG TATCTACCCC AGAGGGTGGA ACCATCATCT ACATGCCACC TGAAAATTAT 600

GACCTCAGCC AGAAGTCACG GGCTAGCATC AAACATGATA TATACAGCTT TGCTATTATC 660

ATGTGGGAAG TGTTGTCCAG AAAGCAGCCC TTTGAAGAAG TTATCAATCC CTTGCAGATA 720

ATGTATAGTG TATCAAAGGG AAATCGACCT GATACTGACA CAGAAAGTTT ACCACTTGAT 780

ATTCCACATC GAACTCGGAT GATTAACCTA ATTGAAGCTG GATGGGCACA AAATCCAGAT 840

GAAAGACCAT CTTTTTTAAA ATGTCTGATA GAACTTGAAC CAGTTATGAG AACCTTTGAA 900

GACATTAGCA TTCTTGAAGC TGTCCTTGAG CTGAAGAAAA CGAAGTTACA GAATAATTCG 960

AGTATCATTT CTTTATGTTC CAAGAAGACA ATGGAGTACC CTCTCAACAT ACCTGTAAAT 1020

CATGGTCCAC AGGAGGAATC ATGTGGAACT CAGGTGACTG TAAGGAGTGA TCCTGAAATA 1080

GCAAGGTCTC TATCAACCAC TCAAGACAAT GTCTTTTCTT CTGTACAAAA TCAAGAGTTG 1140

TCAACACTGC CTCATTCAGT AGCAAATAAC AGCTGGGTTG GTAGCATTTC TTCAATCCAA 1200

AGGGCTAAAT TGTACAACCA GCAGACAACT TATTCTTCAG CAGTAATACA GCCGCTCAGA 1260

GCTGAAGGAA ATTCAGATCT CCTGTCAGAG AGTCAGGGAA ATGATATTGC CCAGCAGTGG 1320

ATCCAAAGCA AAAGGGAAGA CATTGTGAAC CAGATGACCG AAGCTTGTCT CAACCAGTGC 1380

CTGGATGCCC TTCTGTCAAA GGATTTGCTT ATGAAGGAAG ACTATGAACT TATTTACACC 1440

AAACCTACAA GGACCTCAAA AGTGAGACAA ATGTTAGATA CCTCCGACAT CCAAGGAGAA 1500

GAGTTTGCCA AAATTATAAT ACAGAAATTG AAAGATAACA AACAATTGGG TCTTCAGCCA 1560

TACCCAGAAA TATCTGTGGT TTCTAGGGGA ACATCTTTAA ATTTATACCA AAATAAAAGC 1620

TTTTAA 1626

Domain Profile

S: 1     leelelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsy  60

         l++l+++++G++g+v++arh +wrv+vavk+l+++t+ ++se +++l+eak+++k+rfsy

Q: 20    LADLRFLSRGASGTVSSARHSDWRVQVAVKHLHFQTPPQESEISDILREAKILHKARFSY  79

         67899*******************************************************

S: 61    vlkllGvikeeeklglvmeymenGsLeklLkseielp...wplkfRilkevvlgmnyLhs  117

         +l++lG++ e+e+lg+v+eym+nGsL++lL+++ ++p   w l+fRil+e++lg+nyLh+

Q: 80    ILPILGICYEPEFLGIVTEYMNNGSLNELLHRKNDYPdiaWALRFRILHEIALGVNYLHN  139

         ************************************9999********************

S: 118   lkPpllhkDLkpeniLlDnelhvkiaDfGlskf.meessqskevsssaegGtlaYlaPel  176

         ++Ppllh+DLk++niLlDne+hvkiaDfGlsk+  ++ sqs+++ s++egGt++Y++Pe+

Q: 140   MNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWrQMSLSQSRNSVSTPEGGTIIYMPPEN  199

         *********************************88999**********************

S: 177   leevnk.kaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseel  235

         +  ++k +as k+D+Ysfai++W+vl++k+p+ee++n lqi+++v+kgnRP+++   e+l

Q: 200   YDLSQKsRASIKHDIYSFAIIMWEVLSRKQPFEEVINPLQIMYSVSKGNRPDTDT--ESL  257

         *9998889********************************************998..9**

S: 236   Prevpq...lieLmkrcWeadpeeRPsFleie  264

         P ++p+   +i+L++ +W+++p+eRPsFl++

Q: 258   PLDIPHrtrMINLIEAGWAQNPDERPSFLKCL  289

         *****9999********************986

Domain Sequence
(FASTA)

LADLRFLSRG ASGTVSSARH SDWRVQVAVK HLHFQTPPQE SEISDILREA KILHKARFSY 60

ILPILGICYE PEFLGIVTEY MNNGSLNELL HRKNDYPDIA WALRFRILHE IALGVNYLHN 120

MNPPLLHHDL KTQNILLDNE FHVKIADFGL SKWRQMSLSQ SRNSVSTPEG GTIIYMPPEN 180

YDLSQKSRAS IKHDIYSFAI IMWEVLSRKQ PFEEVINPLQ IMYSVSKGNR PDTDTESLPL 240

DIPHRTRMIN LIEAGWAQNP DERPSFLKCL 270

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0042981	; P:regulation of apoptotic process

KEGG

InterPros

IPR001315	; CARD.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00619	; CARD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00114

; CARD; 1.

Prosites

PS50209	; CARD; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013