EKS-SAH-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph401.89.9E-121604816213
StatusUnreviewed
Ensembl ProteinENSSHAP00000017171
UniProt AccessionG3WP16;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000014595ENSSHAP00000017171ENSSHAT00000017314
OrganismSarcophilus harrisii
Functional Description
Protein Length928
Protein Sequence
(FASTA)
VNLLDTSTIH GDWGWLTYPA HGWDSINEVD EFFSPIHTYQ VCNVMSPNQN NWLRTSWVPR 60
DGARRVYAEI KFTLRDCNSM PGVPGTCKET FNLYYLESDR DLGASTQESQ FVKIDTIAAD 120
ESFTGADLGV RRLKLNTEVR GVGPLSKRGF YLAFQDIGAC IAILSLRVYY KKCPAMVRNL 180
AAFSEAVTGA DSSSLVEVRG ECVGHSEERD TPKMYCSAEG EWLVPIGKCV CSAGYEELQD 240
ACVACELGTY KSAPGDQLCA RCPSHSHAAT TAAQTCHCDL SYYRAALDPP SAACTRPPSA 300
PVNLISSVNG TSVTLEWDPP LDKGGRSDIT YNAVCRRCSW DPSQCDACGS GTRFVPQQMN 360
LVQTALTVAN LLAHMNYTFW IEAVNGVSDL SLEPRRAASV NITTNQAAPS QVVAIRQERA 420
GQTSVTLLWQ EPAQPNGIIL EYEIKYYEKD KEMQSYSTLK ATTTRATVSG LKPGTHYVFQ 480
VRARTSAGCG RFSPAMEVET GKPRLRYDTR TIVWICLTLI TGLLILLLLL ICKKRHCGYS 540
KAFQDSDEEK MHYQNGQAPP PVFLPLHHPP GKIPEPQFYS DPHTYEEPGR ARRSFSREIE 600
ASRIHIEKII GSGESGEVCY GRLQMPGQRE VPVAIKALKA GSSERQRRDF LSEASIMGQF 660
DHPNIIRLEG VVTRGRLAMI VTEYMENGSL DSFLRTHDGQ FSIVQLVGML RGVGAGMRYL 720
SDLGYVHRDL AARNVLVNSQ LVCKVSDFGL SRVLEDDPDA AYTTTGGKIP IRWTAPEAIA 780
FRKFSSASDV WSFGVVMWEV LAYGERPYWN MTNRDVSVPP GQGPWAGRWG PRGKLWAQPG 840
SDPLPPRTGS WKAPAVPWAA LPPLLTRPSS TLRCPAPAFA RSCFDLRGGG GGVTVGDWLD 900
SIRMGRYREH FAAGGYSSLG MVLRMNVQ 928
Nucleotide Sequence
(FASTA)
GTGAATTTGC TGGATACATC AACCATCCAC GGGGACTGGG GCTGGCTCAC GTACCCGGCA 60
CATGGGTGGG ACTCCATCAA CGAGGTGGAC GAGTTCTTTA GCCCCATCCA CACGTACCAG 120
GTGTGCAACG TCATGAGCCC CAACCAGAAC AACTGGCTGC GCACGAGCTG GGTGCCGCGG 180
GACGGAGCCC GCCGGGTGTA CGCCGAGATC AAGTTCACCC TGCGGGACTG CAACAGCATG 240
CCGGGGGTGC CGGGCACCTG CAAGGAGACC TTCAATCTCT ACTACCTGGA GTCCGACCGG 300
GACCTGGGCG CCAGCACGCA GGAGAGCCAG TTCGTGAAGA TCGACACCAT CGCCGCGGAC 360
GAGAGCTTCA CCGGGGCGGA TCTGGGCGTC CGGCGCCTGA AGCTCAACAC GGAGGTGCGG 420
GGCGTGGGGC CGCTGAGCAA GCGCGGCTTC TACCTGGCCT TCCAGGACAT CGGCGCCTGC 480
ATCGCCATCC TCTCCCTGCG AGTCTACTAC AAGAAGTGCC CGGCCATGGT GCGCAACCTG 540
GCCGCCTTCT CGGAGGCGGT GACGGGGGCC GACTCCTCCT CCCTGGTGGA GGTTCGCGGC 600
GAGTGCGTGG GGCACTCCGA GGAGCGGGAC ACCCCCAAGA TGTACTGCAG CGCCGAGGGG 660
GAGTGGCTGG TGCCCATCGG CAAGTGCGTC TGCAGCGCCG GCTACGAGGA GCTCCAGGAC 720
GCCTGCGTGG CCTGTGAGCT GGGGACTTAC AAGTCAGCTC CGGGTGACCA GCTGTGCGCC 780
AGGTGCCCCT CACACAGCCA CGCGGCCACC ACTGCAGCCC AGACCTGCCA CTGTGACCTC 840
AGCTATTACC GGGCAGCCCT TGACCCACCA TCCGCGGCCT GCACTCGGCC TCCCTCTGCC 900
CCCGTGAACC TGATCTCCAG TGTGAACGGG ACCTCGGTGA CCCTGGAGTG GGACCCTCCC 960
CTGGACAAGG GAGGTCGCAG TGACATCACT TACAACGCCG TCTGCCGCCG CTGCTCCTGG 1020
GACCCGAGCC AATGTGATGC CTGCGGCAGC GGCACCCGGT TTGTGCCCCA GCAGATGAAC 1080
CTGGTGCAGA CGGCCCTGAC GGTCGCCAAT CTGCTTGCCC ACATGAATTA TACCTTCTGG 1140
ATCGAGGCTG TCAATGGCGT GTCCGACCTC AGTCTAGAGC CCCGACGAGC CGCCTCCGTC 1200
AACATCACCA CGAACCAGGC AGCCCCGTCC CAAGTGGTGG CGATCCGCCA GGAGCGAGCT 1260
GGGCAGACCA GTGTCACGCT GCTGTGGCAA GAACCGGCCC AGCCCAACGG GATCATCCTG 1320
GAGTACGAAA TCAAATACTA CGAGAAGGAC AAGGAGATGC AGAGTTACTC CACCCTGAAG 1380
GCCACAACCA CGAGGGCAAC TGTGTCTGGG CTGAAGCCTG GCACCCACTA CGTGTTCCAG 1440
GTGCGAGCCC GCACGTCCGC AGGCTGTGGC CGCTTTAGCC CGGCCATGGA AGTGGAGACT 1500
GGAAAACCAA GGCTCCGCTA TGACACCAGG ACCATTGTCT GGATCTGCTT GACTCTCATC 1560
ACAGGTCTGC TCATCCTTCT GCTGCTGCTC ATCTGCAAGA AGAGGCACTG TGGCTACAGC 1620
AAGGCCTTCC AGGACTCTGA TGAGGAGAAG ATGCACTATC AGAATGGGCA GGCTCCTCCC 1680
CCGGTCTTCC TTCCCCTGCA CCATCCCCCC GGGAAGATCC CCGAACCCCA GTTCTACTCA 1740
GACCCTCACA CCTATGAAGA GCCTGGGCGA GCCCGGCGCA GCTTCAGTCG CGAGATCGAA 1800
GCCTCCAGGA TCCATATTGA GAAGATCATT GGTTCTGGTG AGTCCGGGGA GGTGTGCTAC 1860
GGACGCCTGC AGATGCCAGG GCAGCGAGAG GTGCCAGTGG CCATCAAGGC CCTGAAAGCA 1920
GGGTCCTCAG AGCGCCAGCG GCGGGACTTC CTCAGCGAGG CGTCCATCAT GGGACAGTTT 1980
GACCACCCCA ACATCATCCG CCTTGAGGGC GTTGTCACCC GAGGCCGCTT GGCAATGATT 2040
GTGACTGAAT ACATGGAGAA CGGCTCCCTG GATTCTTTCT TGAGGACCCA TGACGGGCAG 2100
TTCAGCATCG TGCAGCTGGT CGGCATGCTG CGAGGGGTGG GCGCTGGGAT GCGCTACCTC 2160
TCTGACCTAG GCTATGTCCA TCGAGATCTG GCTGCCCGCA ATGTCCTGGT CAACAGCCAG 2220
CTGGTATGCA AGGTGTCCGA CTTTGGCCTC TCTCGTGTCC TGGAGGACGA CCCTGATGCA 2280
GCCTACACCA CCACGGGTGG GAAGATCCCC ATCCGCTGGA CGGCCCCCGA AGCCATCGCT 2340
TTCCGAAAGT TCTCTTCGGC CAGTGACGTG TGGAGTTTTG GGGTGGTGAT GTGGGAGGTG 2400
CTGGCCTACG GGGAGCGGCC CTACTGGAAT ATGACCAACC GTGATGTGAG TGTCCCTCCC 2460
GGGCAGGGAC CCTGGGCGGG AAGGTGGGGG CCCAGGGGAA AGCTTTGGGC CCAGCCAGGG 2520
TCAGACCCCC TCCCCCCCAG AACTGGGTCT TGGAAGGCGC CGGCCGTGCC CTGGGCAGCG 2580
CTGCCCCCGT TGCTCACCAG ACCTTCCTCT ACCCTCAGGT GCCCAGCCCC GGCCTTCGCC 2640
CGGAGCTGCT TTGACCTTCG GGGCGGAGGC GGCGGCGTCA CTGTCGGGGA CTGGCTGGAC 2700
TCCATCAGGA TGGGCCGGTA CCGGGAGCAT TTCGCAGCAG GCGGCTACTC GTCCCTGGGC 2760
ATGGTCCTGC GCATGAACGT CCAGTGA 2787
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iek+iG+Ge Gevc Grl++pg+re++vaik+lkags+e+qrrdflseasi+Gqfdhp
Q: 604   IHIEKIIGSGESGEVCYGRLQMPGQREVPVAIKALKAGSSERQRRDFLSEASIMGQFDHP  663
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+++  mivteymeng+ldsflr++dgqf+++qlvgmlrG+++gm+ylsd+
Q: 664   NIIRLEGVVTRGRLAMIVTEYMENGSLDSFLRTHDGQFSIVQLVGMLRGVGAGMRYLSDL  723
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarn+lvns+lvckvsdfGlsrvledd++aaytt+ggkipirwtapeaia+rk
Q: 724   GYVHRDLAARNVLVNSQLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRK  783
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdv  213
         f+sasdvws+G+v+wevl+yGerpyw+m+n+dv
Q: 784   FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDV  816
         ********************************9
Domain Sequence
(FASTA)
IHIEKIIGSG ESGEVCYGRL QMPGQREVPV AIKALKAGSS ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT RGRLAMIVTE YMENGSLDSF LRTHDGQFSI VQLVGMLRGV GAGMRYLSDL 120
GYVHRDLAAR NVLVNSQLVC KVSDFGLSRV LEDDPDAAYT TTGGKIPIRW TAPEAIAFRK 180
FSSASDVWSF GVVMWEVLAY GERPYWNMTN RDV 213
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-ANC-00008
EKS-BOT-00009
EKS-CAE-00001
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORC-00010
EKS-OTG-00011
EKS-PAT-00013
EKS-PES-00012
EKS-POA-00007
EKS-RAN-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013