EKS-SAH-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	339.8	1.4E-101	854	1125	272

Status

Unreviewed

Ensembl Protein

ENSSHAP00000017539

UniProt Accession

G3WQ34;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000014900	ENSSHAP00000017539	ENSSHAT00000017684

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1137

Protein Sequence
(FASTA)

TGMACLTMTE MEESATSSTH QNGDIPGNDD TLKQIEPILQ VYLYHSLGKT EGDYLQFPVG 60

EYIAEEICIA ACKACGITPV YHNMFALMSE TERIWYPPNH VFHVDEATRY NVLYRIRFYF 120

PHWYCNGGNR TYRYGISRGA EAPLLDDFVM SYLFAQWRDD FVHGWIKVPV THETQEECLG 180

MAVLDIMRIA KEKDQTPLAV YNSTSYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF 240

SQCKATARIL KLKYLINLET LQSAFYSEQF EVKEPGRGPS GEEIFATIII TGNGGIQWSR 300

GKHKDSETLT EQDLQMYCDF PDIIDVSIKQ ANQEGSNENR VVTIHKQDSK NLEIEFCSLR 360

EALSFVSLID GYYRLTADAH HYLCKEVAPP TVLENIQSNC HGPISMDFAI SKLKKAGNQT 420

GLYVLRCSPK DFNTYFLTFA VEIKLKKREN ITDYKHCLIT KNENGEFNLS GTKKNFTNLK 480

DLLNCYQMET VRSDNIIFQF TKCCPPKPKD KSNLLVFRSN GISDVPTSPT LQRHNNVNQM 540

VFHKIRNEDL IFNESLGQGT FTKIFKGVRR EIGDYGQLHE TEVLLKVLDK AHRNYSESFF 600

EAASMMSQLS YKHLVLNYGV CVCGEENILV QEFVKFGSLD TYLKKNKNSI NILWKLEVAK 660

QLAWAMHFLE EKSLTHGNVC TKNILLIREE DRKTGNPPFI KLSDPGISIT VLPKDILQER 720

IPWVPPECID SPKNLSLAAD KWSFGTTLWE ICSGGDKPLN ALDSQRKLQF YEDRHQLPAP 780

KWTELANLIN NCMDYEPDFR PSFRAIIRDL NSLFTPDYEL LTENDMLPNT RFGALGFSGA 840

FEDRDPTQFE ERHLKFLQQL GKGNFGSVEM CRYDPLQDNT GEVVAVKKLQ HSTEEHLRDF 900

EREIEILKSL QHDNIVKYKG VCYSAGRRNL RLIMEYLPYG SLRDYLQKHK ERLDHKKLLQ 960

YTSQICKGME YLGTKRYIHR DLATRNILVE NENRVKIGDF GLTKVLPQDK EYYKVKEPGE 1020

SPIFWYAPES LTESKFSVAS DVWSFGVVLY ELFTYIEKSK SPPAEFMRMI GNDKQGQMIV 1080

FHLIELLKNN GRLPRPDGCP DEIYSIMTEC WNNNVSLRPA FRDLALRVDQ IRDDMGG 1137

Nucleotide Sequence
(FASTA)

ACTGGAATGG CTTGCCTCAC CATGACAGAA ATGGAGGAAT CTGCCACATC TTCTACCCAC 60

CAAAATGGAG ATATTCCTGG GAACGATGAT ACTTTGAAGC AGATTGAGCC AATTCTTCAG 120

GTCTATCTTT ACCACTCTCT TGGGAAGACT GAAGGAGATT ATTTACAGTT TCCAGTTGGA 180

GAATATATTG CTGAGGAAAT TTGTATTGCT GCTTGTAAAG CTTGTGGTAT CACCCCTGTC 240

TATCATAATA TGTTTGCTTT AATGAGTGAA ACTGAGAGGA TCTGGTATCC TCCCAACCAT 300

GTCTTCCATG TGGATGAGGC AACCAGATAC AATGTACTCT ACCGAATAAG GTTTTACTTT 360

CCTCATTGGT ATTGTAATGG AGGAAATAGA ACATATCGGT ATGGAATATC TCGAGGTGCA 420

GAGGCCCCTC TTCTTGATGA CTTTGTCATG TCTTACCTTT TTGCTCAGTG GCGGGATGAT 480

TTTGTTCATG GATGGATCAA AGTACCTGTG ACTCATGAAA CACAAGAAGA ATGTCTTGGG 540

ATGGCTGTCT TAGATATAAT GAGAATAGCT AAAGAAAAGG ATCAGACCCC ACTGGCAGTC 600

TATAACTCTA CCAGCTACAA GACCTTCTTA CCAAAATGTG TTCGAGCAAA GATCCAAGAT 660

TATCATATTT TGACACGAAA GCGAATAAGG TACAGATTCC GCAGATTTAT TCAGCAGTTC 720

AGCCAATGCA AAGCTACTGC CAGAATCTTG AAACTTAAAT ATCTTATAAA TCTGGAAACT 780

CTTCAGTCTG CCTTCTACTC AGAGCAATTT GAAGTAAAAG AACCTGGCAG AGGTCCTTCA 840

GGTGAGGAGA TTTTTGCAAC CATTATAATA ACTGGAAACG GTGGAATTCA ATGGTCACGA 900

GGGAAACATA AAGACAGTGA GACCCTGACA GAACAGGATT TACAGATGTA CTGTGACTTT 960

CCTGATATTA TTGATGTCAG CATTAAGCAA GCAAATCAAG AAGGTTCAAA TGAGAACAGA 1020

GTGGTGACTA TCCATAAGCA GGATAGCAAA AATTTGGAAA TTGAATTTTG CTCATTGAGA 1080

GAAGCGCTAT CTTTTGTATC ATTAATTGAT GGATACTATA GATTAACTGC TGATGCACAT 1140

CATTACCTTT GTAAAGAAGT AGCTCCTCCA ACAGTCCTTG AAAATATTCA AAGCAACTGT 1200

CATGGCCCAA TTTCGATGGA TTTTGCCATA AGTAAACTGA AGAAAGCAGG TAACCAGACT 1260

GGACTCTATG TCCTTCGATG TAGCCCCAAG GACTTTAATA CATATTTTCT CACTTTTGCC 1320

GTTGAGATTA AACTCAAAAA GCGGGAAAAT ATCACTGATT ATAAGCACTG TTTGATTACA 1380

AAAAATGAGA ATGGAGAGTT CAACCTCAGT GGGACTAAAA AGAACTTCAC TAATCTTAAG 1440

GACCTCTTGA ATTGCTATCA GATGGAAACT GTCCGCTCAG ATAACATCAT TTTCCAGTTT 1500

ACCAAGTGTT GCCCCCCAAA GCCCAAAGAT AAATCAAATC TTCTAGTCTT CAGGAGTAAT 1560

GGCATTTCTG ATGTTCCCAC ATCACCAACA TTGCAGAGGC ATAATAATGT GAACCAAATG 1620

GTGTTTCATA AAATCAGAAA TGAAGATTTA ATATTTAATG AAAGCCTTGG GCAAGGCACT 1680

TTTACCAAGA TTTTTAAAGG TGTAAGAAGA GAAATAGGAG ACTATGGCCA GCTCCATGAA 1740

ACAGAAGTCC TATTAAAAGT TCTGGATAAA GCACATAGAA ATTATTCAGA GTCTTTTTTT 1800

GAAGCAGCAA GCATGATGAG CCAGCTTTCT TACAAGCATC TGGTATTAAA TTATGGAGTC 1860

TGTGTTTGTG GAGAAGAGAA TATTCTAGTT CAAGAATTTG TGAAATTTGG ATCATTGGAC 1920

ACATACCTTA AAAAGAACAA AAATTCTATA AACATATTAT GGAAGCTTGA AGTGGCTAAA 1980

CAGTTGGCAT GGGCTATGCA TTTTCTTGAA GAAAAAAGCC TCACTCATGG TAATGTGTGT 2040

ACTAAGAACA TTTTGCTAAT CAGAGAAGAG GACAGAAAGA CAGGAAATCC TCCTTTCATC 2100

AAGCTCAGTG ATCCTGGCAT TAGTATTACA GTTTTGCCAA AAGACATTCT TCAAGAGAGG 2160

ATACCATGGG TCCCACCTGA ATGTATTGAC AGTCCTAAAA ATCTAAGTTT GGCAGCAGAC 2220

AAGTGGAGTT TTGGTACCAC TTTGTGGGAA ATCTGCAGTG GAGGAGACAA ACCTCTTAAT 2280

GCATTAGATT CTCAAAGAAA ACTTCAGTTC TATGAAGATA GACACCAGCT CCCTGCACCA 2340

AAGTGGACAG AATTAGCAAA TCTTATAAAT AATTGTATGG ACTATGAGCC AGACTTCAGA 2400

CCTTCTTTCC GGGCCATCAT ACGAGACCTT AACAGCTTAT TCACTCCAGA CTATGAACTA 2460

CTAACAGAAA ATGACATGTT GCCAAATACG AGATTTGGTG CCCTAGGATT TTCTGGTGCT 2520

TTTGAAGACA GAGATCCCAC ACAGTTTGAA GAAAGACATC TTAAATTCCT ACAGCAACTT 2580

GGCAAGGGTA ATTTTGGGAG TGTGGAGATG TGCCGATATG ACCCTCTACA AGACAACACT 2640

GGTGAAGTGG TGGCTGTGAA AAAGTTACAG CACAGTACTG AGGAGCACCT GAGAGACTTT 2700

GAAAGAGAAA TTGAAATTCT TAAGTCTTTA CAACATGACA ACATTGTCAA ATACAAGGGA 2760

GTGTGCTACA GTGCTGGCCG TCGTAACTTG AGGTTAATTA TGGAATATTT ACCTTATGGA 2820

AGTTTACGTG ACTATCTCCA GAAACATAAG GAAAGACTGG ATCATAAGAA ACTTTTACAG 2880

TACACATCTC AAATCTGCAA GGGAATGGAG TATCTTGGTA CAAAAAGATA TATCCATAGG 2940

GATCTGGCCA CAAGAAATAT TTTAGTGGAA AATGAGAATA GAGTTAAAAT TGGAGATTTT 3000

GGATTAACAA AAGTCCTGCC ACAAGACAAA GAATACTACA AAGTGAAAGA ACCTGGTGAA 3060

AGTCCCATAT TCTGGTATGC TCCAGAATCA CTCACAGAAA GCAAGTTTTC TGTAGCCTCA 3120

GATGTGTGGA GTTTTGGAGT GGTTCTGTAT GAACTTTTCA CATATATTGA GAAAAGCAAA 3180

AGCCCACCAG CGGAATTTAT GCGTATGATT GGTAATGACA AACAAGGGCA GATGATTGTA 3240

TTCCATCTAA TAGAACTTTT AAAGAATAAT GGAAGGTTGC CAAGACCAGA TGGATGTCCT 3300

GATGAGATTT ATTCTATCAT GACTGAGTGT TGGAACAATA ATGTAAGCTT ACGCCCTGCC 3360

TTCAGGGATC TTGCTCTTCG AGTGGATCAA ATAAGAGATG ACATGGGTGG ATGA 3414

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 854   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  913

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke+l++++ll++++q++k+meYL+

Q: 914   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERLDHKKLLQYTSQICKGMEYLG  973

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 974   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1027

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1028  PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  1086

         ********.*******************************999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l+++ rlp+p+ cp+e++ +mt+c++++ s rp+Fr+++

Q: 1087  LKNNGRLPRPDgCPDEIYSIMTECWNNNVSLRPAFRDLA  1125

         ************************************995

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERL DHKKLLQYTS QICKGMEYLG 120

TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PRPDGCPDEI YSIMTECWNN NVSLRPAFRD LA 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013