EKS-SAH-00164

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00164

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	442.9	4.5E-133	227	495	269

Status

Unreviewed

Ensembl Protein

ENSSHAP00000017724

UniProt Accession

G3WQL9;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000015052	ENSSHAP00000017724	ENSSHAT00000017870

Organism

Sarcophilus harrisii

Functional Description

Protein Length

569

Protein Sequence
(FASTA)

MCLFFLRDIM ITHFEPSISF EGLCNEVRDM CSFDNEQLFT MKWIDEEGDP CTVSSQLELE 60

EAFRLYELNK DSELLIHVFP CVPERPGMPC PGEDKSIYRR GARRWRKLYC ANGHTFQAKR 120

FNRRAHCAIC TDRIWGLGRQ GYKCINCKLL VHKKCHKLVT IECGRHSLPP EPMMPMDQTS 180

VHSDHVETVI PYNPSSHESL DHVGEEKEAM STRDSGKASS SLGLLDFDLL RVIGRGSYAK 240

VLLVRLKKTE RIYAMKVVKK ELVNDDEDID WVQTEKHVFE QASNHPFLVG LHSCFQTESR 300

LFFVIEYVNG GDLMFHMQRQ RKLPEEHARF YSAEISLALN YLHERGIIYR DLKLDNVLLD 360

SEGHIKLTDY GMCKEGLRPG DTTSTFCGTP NYIAPEILRG EDYGFSVDWW ALGVLMFEMM 420

AGRSPFDIVG SSDNPDQNTE DYLFQVILEK QIRIPRSLSV KAASVLKSFL NKDPKERLGC 480

HPQTGFADIQ GHPFFRNVDW DMMEQKQVVP PFKPNISGEF GLDNFDSQFT NEPVQLTPDD 540

DDIVKKIDQS EFEGFEYINP LLMSAEECV 569

Nucleotide Sequence
(FASTA)

ATGTGTCTTT TTTTCCTCAG GGACATCATG ATAACACACT TCGAACCATC TATTTCCTTT 60

GAAGGACTTT GCAATGAGGT TCGCGACATG TGTTCCTTTG ATAACGAACA GCTCTTCACA 120

ATGAAATGGA TAGATGAGGA AGGAGACCCG TGCACAGTTT CATCTCAGCT GGAGTTGGAG 180

GAAGCCTTTC GGCTCTATGA ACTCAACAAA GATTCGGAGC TCCTAATTCA CGTATTTCCA 240

TGTGTACCGG AAAGACCTGG AATGCCATGT CCTGGAGAAG ATAAGTCCAT CTATCGCCGA 300

GGCGCCCGCC GCTGGAGGAA GCTCTACTGT GCCAATGGCC ACACTTTCCA AGCCAAACGG 360

TTCAACAGGC GAGCCCACTG TGCAATTTGC ACCGACCGAA TCTGGGGCCT TGGGCGCCAG 420

GGCTACAAGT GCATCAACTG CAAGCTGCTC GTTCACAAGA AGTGCCACAA GCTCGTTACC 480

ATTGAATGTG GACGGCATTC TCTGCCCCCG GAACCAATGA TGCCCATGGA CCAAACCTCT 540

GTGCATTCAG ATCACGTGGA GACAGTGATT CCATATAACC CTTCAAGTCA TGAAAGTTTG 600

GACCATGTTG GTGAAGAAAA GGAGGCGATG AGTACTAGGG ACAGCGGCAA AGCTTCGTCC 660

AGTCTGGGTC TCCTGGATTT CGATTTGCTC CGTGTGATAG GGAGGGGGAG CTATGCCAAG 720

GTGCTGTTGG TACGACTTAA AAAAACTGAG CGCATTTATG CCATGAAAGT TGTGAAGAAG 780

GAGCTGGTCA ATGATGATGA GGATATCGAT TGGGTGCAGA CAGAGAAGCA CGTCTTTGAG 840

CAGGCCTCCA ACCACCCCTT CCTTGTGGGC CTGCACTCTT GCTTCCAGAC AGAAAGCAGG 900

TTGTTCTTTG TGATAGAGTA CGTGAATGGA GGAGATCTCA TGTTTCATAT GCAGCGACAG 960

AGGAAACTCC CAGAAGAACA TGCTAGATTT TATTCTGCAG AAATAAGTCT AGCATTAAAT 1020

TACCTTCATG AACGAGGGAT AATCTATCGA GACCTGAAGT TGGACAATGT GTTGCTGGAT 1080

TCTGAAGGAC ACATTAAGCT CACTGATTAC GGCATGTGCA AGGAAGGATT AAGGCCAGGA 1140

GACACAACCA GTACTTTCTG TGGTACTCCA AATTACATTG CTCCTGAAAT CTTACGAGGA 1200

GAAGATTATG GCTTCAGTGT GGACTGGTGG GCGCTCGGCG TGCTGATGTT TGAGATGATG 1260

GCGGGAAGGT CTCCCTTTGA TATTGTTGGG AGCTCTGATA ACCCTGATCA GAACACAGAG 1320

GATTATCTCT TTCAAGTTAT TTTGGAGAAG CAGATTCGAA TACCCCGCTC CCTGTCAGTC 1380

AAAGCCGCCA GTGTCCTGAA GAGTTTTCTT AATAAAGACC CGAAGGAACG TTTAGGCTGC 1440

CACCCGCAGA CAGGCTTTGC TGACATTCAG GGCCATCCGT TCTTCCGAAA CGTTGACTGG 1500

GATATGATGG AGCAGAAGCA GGTGGTGCCT CCCTTCAAGC CAAACATCTC GGGGGAGTTT 1560

GGTCTGGATA ACTTCGACTC TCAGTTCACT AACGAGCCTG TGCAGCTCAC TCCCGATGAT 1620

GATGACATCG TGAAGAAGAT TGACCAGTCT GAATTTGAGG GCTTCGAGTA TATCAATCCC 1680

CTTCTAATGT CTGCAGAAGA GTGTGTCTGA 1710

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkkt+++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 227   FDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  286

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 287   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  346

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 347   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  406

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 407   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  466

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         k++l+kdp++rlG++ ++g +di+ h+ff

Q: 467   KSFLNKDPKERLGCHpQTGFADIQGHPFF  495

         **************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVRL KKTERIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240

KSFLNKDPKE RLGCHPQTGF ADIQGHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013