EKS-SAH-00280

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00280

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	486.6	1.7E-146	721	978	258

Status

Unreviewed

Ensembl Protein

ENSSHAP00000017757

UniProt Accession

G3WQQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB2

Gene Synonyms/Alias

ERBB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000015078	ENSSHAP00000017757	ENSSHAT00000017903

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1255

Protein Sequence
(FASTA)

MDLPGCCCWG LLLVLLPPAV WGTQVCTGTD MKLQYPASIE NHLDTLSHLY QGCQVVQGNL 60

ELTYLPADAN LSFLQDIQEV QGYVLIAHSL VRSFPLQRLR IIRGTQLFED KYALVVLDNG 120

IPLGTAPPTA EGPPGLRELQ LRSLTEILKG GVLIQKNPQL CHQDTVLWAD IFHKNNRLGT 180

TSIDTNHSRT CNPCSSSCKS GQCWGEGHDN CQNLTRTICA SGCARCKGPL PTDCCHEQCA 240

AGCTGPKHSD CLACLHFNHS GICEQHCPPL VIYNSDTFES MPNPDGRYTF GSSCVKSCPY 300

NYLATDVGST SCTLVCPLHS QEVTAEDGTH RCEKCSKACP KVCYGLGMGH LRSVRAVNST 360

NIQDFAGCKK IFGSLAFFPE TFSGDLATNT SPLMPEDLKV FENLEEITGY LYISAWPDSL 420

PDLSIFQNLR VIRGRVLHNG VYSLTLEHLG IGWLGLRSLR ELGSGLALIH HNAHLCFVHT 480

VPWNQLFRNP RQALLYSANR PAQECESKGL TCYSLCAQGH CWGPGPTQCL NCSQFLRGQE 540

CVEECRVLQG YPREYVKERR CFPCHEECQP QNGTETCFGS EADKCVACVH FKDPPSCVAR 600

CPSGVKPDLS FIPIWKYPDD EGICQTCPTN CTHSCTVLDE KGCPAEQKPS PVTSIIAGVV 660

GVLLALIIGL IIGILIKRRK QKERKHTMRR LLQETELVEP LTPSGALPNQ AQMRILKETE 720

LRKVKVLGSG AFGTVYKGIW IPDGESVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 780

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VRENRGRLCS QDLLNWCVQI AKGMNYLEEV 840

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILCRRF 900

THQSDVWSYG VTVWELMTFG AKPYEGIPAR EIPDLLEKGD RLPQPPVCTI DVYMIMVKCW 960

MIDSECRPRF RELVTEFSRM ARDPQRFVVI QNEDSGPASP LDSTFYRSLL EEDDMSDLVD 1020

AEEYLVPQQG FFCPDPPLAP GPGGTAHRRH RSSSTRSGGE LPGGLEGAEE DPPQSSAEPW 1080

EATGSDVFDG DPGGSPKGLK GLPPRDLSPL QRYSEDPTGP LTPEMDGYIV PPVCGPLPEY 1140

VNQPEVHLPP SSPREGTLTP PHPSNSTLER PKLPPPGKNG VVKDTFTFGA AVENPEYLAP 1200

HGGGPLHLPP TFSSPAFDNL YYWDQDPPDR GAAPNGFAGT PTAENPEYLG LDMPV 1255

Nucleotide Sequence
(FASTA)

ATGGACCTGC CCGGCTGCTG CTGTTGGGGG CTCCTTCTGG TCCTCCTGCC CCCAGCAGTC 60

TGGGGAACCC AAGTGTGCAC AGGCACAGAC ATGAAGCTGC AGTATCCTGC CAGTATCGAG 120

AATCACCTTG ACACACTGAG CCACCTGTAC CAAGGATGCC AGGTTGTACA GGGCAATCTG 180

GAGCTCACTT ACCTGCCTGC TGATGCCAAC CTCTCCTTCC TCCAGGACAT CCAGGAAGTG 240

CAGGGATATG TGCTGATTGC TCACAGCCTG GTGAGGAGTT TCCCACTGCA GAGGCTAAGA 300

ATCATTCGAG GAACGCAGCT CTTTGAAGAC AAATATGCCC TAGTCGTTCT GGACAACGGG 360

ATTCCCCTTG GGACCGCTCC TCCTACAGCG GAGGGGCCCC CTGGCCTTCG GGAACTGCAA 420

CTTCGAAGCC TCACAGAGAT TCTGAAAGGC GGGGTTCTGA TCCAGAAGAA TCCTCAGCTA 480

TGTCACCAAG ACACAGTGTT GTGGGCTGAC ATCTTCCATA AGAACAACCG CTTGGGTACC 540

ACCTCCATCG ACACAAACCA CAGCCGAACT TGCAACCCTT GCTCTTCATC ATGTAAATCC 600

GGACAGTGTT GGGGAGAAGG ACACGACAAC TGTCAGAACT TGACCCGCAC AATTTGTGCC 660

AGTGGCTGTG CTCGCTGCAA GGGGCCCCTC CCCACAGACT GCTGCCACGA GCAGTGTGCT 720

GCTGGCTGCA CTGGCCCCAA GCATTCTGAC TGCCTGGCCT GCCTCCACTT CAACCACAGT 780

GGCATCTGTG AGCAGCACTG CCCACCGCTG GTGATCTACA ATTCAGACAC CTTTGAGTCA 840

ATGCCTAATC CTGATGGGCG CTACACCTTT GGGTCCAGTT GTGTGAAATC ATGTCCCTAT 900

AATTACCTAG CCACAGATGT GGGCTCTACA TCCTGTACCC TCGTGTGTCC CCTACACAGT 960

CAAGAGGTGA CCGCTGAGGA CGGAACCCAT CGGTGTGAGA AGTGCAGCAA AGCCTGCCCC 1020

AAAGTGTGTT ATGGGCTGGG CATGGGCCAC TTGAGATCAG TGAGAGCGGT CAACAGCACT 1080

AATATCCAGG ATTTTGCGGG CTGCAAGAAG ATCTTTGGAA GTCTGGCCTT CTTCCCCGAG 1140

ACCTTCTCTG GGGACTTGGC TACCAATACT TCTCCATTAA TGCCCGAAGA CCTCAAGGTC 1200

TTTGAGAACC TGGAGGAGAT TACAGGCTAT CTGTACATCT CGGCCTGGCC CGACAGCCTC 1260

CCTGATCTCA GCATCTTTCA GAACCTCAGG GTGATCAGGG GAAGGGTGTT GCACAATGGT 1320

GTCTACTCCC TGACGCTGGA GCATCTGGGT ATTGGCTGGC TGGGGCTGCG GTCACTGAGA 1380

GAGCTGGGCA GTGGGCTGGC ACTCATCCAT CACAATGCCC ACCTATGCTT TGTCCACACG 1440

GTACCTTGGA ACCAACTCTT CCGCAACCCC CGCCAGGCCC TGCTCTACAG CGCCAACCGA 1500

CCTGCCCAGG AGTGTGAAAG CAAGGGGCTC ACGTGCTACT CCCTGTGTGC CCAGGGGCAC 1560

TGCTGGGGCC CTGGGCCTAC CCAGTGTCTC AACTGCAGCC AGTTTCTCCG AGGGCAGGAG 1620

TGTGTGGAGG AGTGCCGGGT CCTGCAGGGG TACCCCCGGG AGTATGTAAA GGAGAGACGC 1680

TGTTTCCCGT GCCATGAGGA GTGCCAGCCC CAGAATGGCA CAGAAACCTG CTTTGGATCG 1740

GAGGCTGACA AATGTGTAGC CTGTGTCCAC TTCAAGGACC CCCCTTCCTG CGTGGCCCGA 1800

TGCCCCAGTG GGGTGAAGCC CGACCTCTCC TTCATACCCA TCTGGAAGTA TCCAGATGAT 1860

GAGGGCATTT GCCAGACCTG CCCCACCAAC TGTACCCACT CCTGTACTGT ATTGGATGAA 1920

AAAGGCTGTC CTGCTGAGCA GAAACCCAGC CCCGTGACCT CCATCATTGC TGGGGTGGTT 1980

GGGGTGCTTC TAGCCCTCAT CATAGGCCTG ATCATTGGCA TCTTGATTAA GCGTCGGAAA 2040

CAGAAGGAAC GGAAGCACAC CATGAGGAGG CTGCTTCAGG AGACAGAGCT GGTGGAGCCC 2100

TTGACGCCCA GCGGAGCGCT GCCCAACCAA GCGCAGATGC GAATCCTAAA AGAGACAGAG 2160

CTGAGGAAAG TGAAGGTTCT TGGCTCTGGG GCCTTCGGCA CAGTCTACAA GGGTATTTGG 2220

ATCCCTGATG GTGAAAGTGT GAAAATCCCC GTGGCTATCA AGGTGTTGAG GGAAAACACA 2280

TCCCCCAAAG CCAACAAGGA GATCTTGGAT GAAGCATACG TGATGGCAGG GGTCGGCTCG 2340

CCGTATGTGT CTCGCCTTCT GGGCATCTGC CTGACATCCA CAGTGCAGCT AGTGACCCAG 2400

CTGATGCCCT ATGGCTGCCT CCTGGACCAC GTTCGGGAAA ATCGAGGGCG GCTCTGCTCC 2460

CAGGACCTCC TCAACTGGTG TGTGCAGATT GCCAAGGGGA TGAACTACCT GGAGGAGGTT 2520

CGGCTAGTGC ACAGAGACCT GGCTGCCAGA AATGTGCTGG TCAAGAGTCC CAACCACGTC 2580

AAGATCACAG ACTTCGGACT GGCCAGGCTC TTGGACATCG ATGAGACAGA GTACCACGCA 2640

GATGGGGGCA AGGTCCCCAT CAAGTGGATG GCCCTGGAGT CCATTCTCTG CCGGAGATTC 2700

ACCCATCAGA GCGATGTGTG GAGCTACGGG GTGACAGTGT GGGAACTGAT GACCTTTGGG 2760

GCCAAACCAT ATGAGGGGAT TCCAGCTCGA GAGATTCCGG ACCTGCTGGA GAAGGGGGAC 2820

CGGCTGCCTC AGCCCCCTGT CTGCACCATC GATGTCTACA TGATCATGGT TAAATGTTGG 2880

ATGATTGACT CTGAGTGTCG GCCTCGGTTC CGGGAACTGG TTACTGAATT TTCACGAATG 2940

GCCCGAGACC CTCAGCGCTT TGTGGTCATT CAGAATGAGG ATTCTGGCCC AGCCAGCCCC 3000

CTGGACAGCA CTTTCTACCG CTCACTGTTG GAGGAAGACG ACATGAGTGA CTTAGTGGAT 3060

GCAGAAGAAT ACCTGGTGCC CCAGCAAGGC TTCTTCTGCC CTGACCCTCC CTTGGCTCCA 3120

GGGCCTGGAG GCACTGCCCA TCGAAGGCAC AGAAGTTCTT CTACGAGGAG TGGTGGGGAG 3180

CTTCCAGGAG GACTGGAAGG TGCTGAAGAG GACCCTCCAC AATCTTCAGC AGAACCTTGG 3240

GAAGCAACTG GTTCTGATGT GTTTGATGGG GACCCTGGAG GGAGCCCTAA GGGACTAAAG 3300

GGACTCCCCC CTAGAGACCT CAGCCCCCTG CAGCGCTACA GTGAGGATCC GACAGGACCA 3360

CTGACCCCTG AGATGGATGG CTATATTGTC CCACCCGTCT GTGGCCCCCT GCCTGAATAC 3420

GTGAACCAGC CAGAGGTGCA CCTACCACCC TCTTCTCCCC GGGAGGGGAC CCTGACTCCC 3480

CCTCACCCAT CCAACTCCAC CTTGGAACGT CCCAAGTTGC CTCCTCCAGG GAAGAATGGA 3540

GTGGTCAAAG ACACATTTAC CTTTGGCGCA GCTGTGGAGA ACCCCGAGTA CTTGGCCCCC 3600

CATGGTGGGG GTCCCCTTCA TCTTCCTCCA ACTTTCTCCA GCCCAGCCTT TGACAACCTC 3660

TACTACTGGG ACCAGGATCC CCCTGATCGA GGAGCTGCCC CTAATGGCTT TGCAGGGACC 3720

CCCACAGCCG AGAACCCTGA GTACTTGGGT TTGGATATGC CTGTGTGA 3768

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+kvlGsGafGtvykGiwip+ge+vkipvaikvl+e+t++kanke+ldea+v+a + +

Q: 721   LRKVKVLGSGAFGTVYKGIWIPDGESVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  780

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+qlvtql+p+Gclld+vre++++l sq+llnwcvqiakGm+ylee

Q: 781   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLCSQDLLNWCVQIAKGMNYLEEV  840

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil r++

Q: 841   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILCRRF  900

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGakpy+gipa+eipdllekG+rl+qpp+ctidvym++vkcw

Q: 901   THQSDVWSYGVTVWELMTFGAKPYEGIPAREIPDLLEKGDRLPQPPVCTIDVYMIMVKCW  960

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mid+e+rp+f+el++efs

Q: 961   MIDSECRPRFRELVTEFS  978

         ****************96

Domain Sequence
(FASTA)

LRKVKVLGSG AFGTVYKGIW IPDGESVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60

PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VRENRGRLCS QDLLNWCVQI AKGMNYLEEV 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILCRRF 180

THQSDVWSYG VTVWELMTFG AKPYEGIPAR EIPDLLEKGD RLPQPPVCTI DVYMIMVKCW 240

MIDSECRPRF RELVTEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR021157	; Cyt_c1_TM_anchor_C.
IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013