EKS-SAH-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	469.0	2.9E-141	195	440	246

Status

Unreviewed

Ensembl Protein

ENSSHAP00000018390

UniProt Accession

G3WSI5;

Protein Name

Protein Synonyms/Alias

Gene Name

CSK

Gene Synonyms/Alias

CSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000015608	ENSSHAP00000018390	ENSSHAT00000018542

Organism

Sarcophilus harrisii

Functional Description

Protein Length

450

Protein Sequence
(FASTA)

MSAIQAVWPS GTECIAKYNF HGTAEQDLPF SKGDVLTIVA VTKDPNWYKA KNKVGREGII 60

PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

SCEGKVEHYR IIYSASKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ 180

DEFSRSGWAL NMKDLKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240

TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300

AMEYLEANNF VHRDLAARNV LVSEDNIAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360

KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPAAVYEVMR 420

NCWHLDAANR PTFLQLREQL EHIKAHELHL 450

Nucleotide Sequence
(FASTA)

ATGTCGGCAA TCCAGGCCGT CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 60

CACGGCACAG CCGAGCAAGA CCTGCCCTTC AGCAAAGGGG ATGTGCTCAC CATAGTTGCT 120

GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TCGGCCGGGA AGGCATCATC 180

CCAGCCAACT ATGTGCAGAA ACGGGAAGGA GTGAAAGCCG GCACCAAGCT GAGCCTCATG 240

CCGTGGTTCC ATGGAAAGAT CACTCGGGAG CAGGCAGAGA GGCTGCTCTA CCCCCCAGAG 300

ACAGGCCTGT TCCTGGTCCG AGAGAGCACC AACTACCCGG GGGACTACAC ACTGTGCGTG 360

AGCTGCGAGG GCAAGGTGGA ACACTACCGA ATCATCTATT CTGCCAGCAA ACTCAGCATC 420

GATGAGGAGG TCTACTTTGA GAATCTCATG CAGCTGGTAG AGCACTACAC CACCGATGCC 480

GATGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGGACTGT CGCAGCCCAA 540

GATGAGTTCT CCCGAAGTGG CTGGGCTCTC AACATGAAAG ACCTCAAGCT GCTTCAAACC 600

ATTGGCAAGG GCGAGTTTGG GGATGTGATG CTCGGGGACT ACCGGGGGAA CAAAGTCGCC 660

GTTAAGTGCA TTAAGAACGA CGCCACCGCT CAGGCCTTCC TGGCAGAAGC TTCAGTCATG 720

ACGCAACTCC GGCATAGCAA CCTTGTGCAG CTACTCGGGG TGATCGTGGA GGAGAAGGGG 780

GGCCTTTATA TCGTTACGGA GTACATGGCC AAGGGCAGCC TCGTGGACTA TTTGCGATCA 840

AGGGGCAGGT CGGTGCTGGG TGGAGATTGC CTCCTCAAAT TCTCCCTGGA CGTGTGTGAA 900

GCTATGGAGT ACCTGGAGGC CAACAACTTT GTGCACCGGG ACCTGGCGGC CAGGAACGTG 960

CTGGTGTCCG AAGACAACAT CGCCAAGGTC AGCGACTTCG GCCTCACCAA GGAGGCCTCC 1020

AGCACCCAGG ACACCGGGAA GCTGCCCGTC AAATGGACGG CCCCTGAGGC CCTGAGAGAA 1080

AAGAAATTCT CCACCAAGTC TGATGTGTGG AGTTTTGGGA TACTCCTCTG GGAAATCTAC 1140

TCCTTCGGCC GAGTGCCTTA TCCGAGAATC CCTCTGAAGG ACGTGGTCCC AAGAGTGGAG 1200

AAGGGCTACA AAATGGACGC TCCGGATGGC TGCCCAGCCG CCGTCTATGA AGTGATGAGG 1260

AACTGCTGGC ACCTGGATGC CGCCAACCGG CCCACCTTCC TGCAGCTTAG GGAACAGCTA 1320

GAGCATATCA AAGCCCACGA GCTGCACCTG TGA 1353

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv

Q: 195   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd

Q: 255   IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEANNFVHRD  314

         *****99*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvsed++akvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi

Q: 315   LAARNVLVSEDNIAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  374

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcp++vye+m+++w+l+aa+rp+f

Q: 375   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPAAVYEVMRNCWHLDAANRPTFL  434

         ************************************************************

S: 240   klkekl  245

         +l+e+l

Q: 435   QLREQL  440

         ***997

Domain Sequence
(FASTA)

LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60

IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEANNFVHRD 120

LAARNVLVSE DNIAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180

LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPAA VYEVMRNCWH LDAANRPTFL 240

QLREQL 246

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013