EKS-SAH-00102
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00102
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec466.22.4E-140363613251
StatusUnreviewed
Ensembl ProteinENSSHAP00000018411
UniProt AccessionG3WSK6;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000015627ENSSHAP00000018411ENSSHAT00000018564
OrganismSarcophilus harrisii
Functional Description
Protein Length620
Protein Sequence
(FASTA)
MNNCILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKANLAY FEDRHGKKRT LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET KNNNSLVPKY 120
HPNFWMDGRW RCCAQTEKLA SGCAEYDPTK NASKKPLPPT PEDNRRSLRE PEEALVIALY 180
DYNTNDPQEL TLQSNEEYYL LDNSEIHWWR VQDKNGHEGY VPSSYLVEKS PNNLETYEWY 240
NKSISRDKAE KLLLDEGKEG AFMVRDSRTP KTYTLSVFTK AILSENNPCI KHYHIKETND 300
HPKRYYVAEK FVFDSIPNLI NYHQHNGGGL VTRLRYPVCS WRKKAPITAG LRYGKWVIHP 360
SELTFVQEIG SGQFGLVHLG YWLRKHKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420
LYGVCLEQAP ICLVFEFMEH GCLSDYLRNQ RGLFSAESLL GMCQDVCEGM AYLEEACVIH 480
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540
VWSFGVLMWE VFSEGKIPYE NSSNTKVVED ISTGYRLYKP RLCSPLIYQI MNDCWKEKPE 600
DRPSFASLLC QLAEIAESAL 620
Nucleotide Sequence
(FASTA)
ATGAATAACT GTATCCTTCT GGAAGAACAA CTGATCAAAA AATCCCAACA AAAGAGAAGG 60
ACTTCCCCCT CCAACTTCAA AGTGCGCTTC TTTGTTTTAA CTAAAGCCAA CTTGGCATAT 120
TTTGAAGACC GCCATGGGAA AAAGAGAACT TTGAAGGGTT CCATTGAACT TTCAAGAATC 180
AAATGCGTGG AGATTGTGAA GAGCGACATC AGCATCCCTT GCCACTATAA ATACCCCTTC 240
CAAGTGGTAC ATGATAATTA TCTCCTATAT GTATTTGCTC CTGATCGAGA GAGCCGACAG 300
AGATGGGTGT TGGCCCTTAA GGAAGAAACC AAGAATAACA ACAGTTTAGT GCCTAAGTAC 360
CATCCCAATT TCTGGATGGA TGGGAGGTGG AGATGCTGTG CCCAGACTGA AAAGCTTGCA 420
TCTGGCTGTG CTGAGTATGA TCCAACCAAG AATGCTTCAA AGAAGCCTCT TCCTCCCACT 480
CCTGAAGACA ACCGACGGTC ATTAAGAGAA CCTGAAGAAG CCCTAGTCAT TGCCTTGTAT 540
GACTACAACA CAAATGATCC CCAAGAACTC ACCTTACAAA GTAATGAAGA GTATTACCTC 600
CTTGACAATT CAGAAATCCA TTGGTGGAGA GTGCAAGATA AGAACGGGCA TGAAGGTTAC 660
GTGCCAAGCA GTTACCTGGT AGAGAAATCT CCAAATAACC TGGAAACATA TGAGTGGTAC 720
AACAAAAGCA TCAGTCGGGA CAAAGCAGAA AAACTCCTTT TAGATGAGGG CAAAGAAGGA 780
GCCTTCATGG TGAGAGACTC TAGGACGCCA AAAACATACA CTCTTTCAGT TTTCACGAAA 840
GCAATCTTAA GTGAGAACAA TCCATGTATC AAGCACTATC ACATCAAAGA GACCAATGAC 900
CATCCCAAAA GATATTACGT GGCAGAAAAA TTTGTATTTG ATTCCATCCC CAACCTGATC 960
AACTATCACC AGCACAATGG AGGAGGTCTT GTTACACGTT TAAGGTACCC TGTTTGTTCC 1020
TGGAGAAAAA AGGCCCCTAT CACAGCTGGC TTGAGATATG GCAAGTGGGT GATCCATCCC 1080
TCAGAACTCA CTTTTGTGCA GGAAATTGGC AGTGGGCAGT TTGGTCTGGT GCATCTCGGC 1140
TACTGGCTAA GGAAGCACAA GGTTGCCATC AAGACCATTC AGGAAGGAGC CATGTCAGAA 1200
GAGGATTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTCT CTCATCCTAA ACTGGTGCAA 1260
CTCTATGGAG TCTGTCTGGA GCAGGCCCCT ATTTGCCTGG TGTTTGAGTT CATGGAGCAT 1320
GGCTGCCTGT CTGATTATCT TCGGAACCAG CGGGGGCTCT TTTCTGCTGA GAGTCTCCTA 1380
GGCATGTGCC AGGATGTGTG TGAGGGGATG GCTTACTTGG AGGAAGCTTG TGTCATTCAC 1440
AGAGACCTGG CCGCCAGGAA CTGTTTGGTG GGAGAAAACC AGGTCATCAA AGTGTCAGAC 1500
TTTGGCATGA CAAGGTTTGT TCTCGACGAC CAGTATACAA GCTCGACAGG CACCAAGTTC 1560
CCTGTGAAGT GGGCATCTCC AGAGGTTTTC TCTTTCAGTC GTTATAGCAG CAAATCTGAT 1620
GTGTGGTCAT TCGGAGTCCT CATGTGGGAA GTCTTCAGTG AGGGCAAAAT CCCTTATGAA 1680
AACAGTAGCA ACACCAAGGT GGTGGAGGAC ATCAGCACTG GATACCGGTT GTATAAACCA 1740
AGGCTATGTT CCCCTCTCAT CTACCAGATT ATGAATGATT GTTGGAAAGA GAAACCAGAA 1800
GACAGACCAT CTTTTGCTAG CCTGCTGTGT CAGCTGGCTG AAATCGCTGA ATCTGCACTT 1860
TAA 1863
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w  k++vaik+i+egamseedfieea+vmmklshpklvqly
Q: 363   LTFVQEIGSGQFGLVHLGYWLRKHKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  422
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e ll mc+dvcegm+yle++++ihrd
Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRNQRGLFSAESLLGMCQDVCEGMAYLEEACVIHRD  482
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye+ sn++vve++s+g+rly+p+l+s  +y++m+ cwkekpe+r
Q: 543   SFGVLMWEVFSEGKIPYENSSNTKVVEDISTGYRLYKPRLCSPLIYQIMNDCWKEKPEDR  602
         ************************************************************
S: 241   ptfkellsale  251
         p+f++ll +l+
Q: 603   PSFASLLCQLA  613
         *******9986
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LRKHKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRNQRG LFSAESLLGM CQDVCEGMAY LEEACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENS SNTKVVEDIS TGYRLYKPRL CSPLIYQIMN DCWKEKPEDR 240
PSFASLLCQL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013