EKS-SAH-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TTK	468.3	8.1E-141	507	774	268

Status

Unreviewed

Ensembl Protein

ENSSHAP00000018447

UniProt Accession

G3WSP2;

Protein Name

Protein Synonyms/Alias

Gene Name

TTK

Gene Synonyms/Alias

TTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000015661	ENSSHAP00000018447	ENSSHAT00000018600

Organism

Sarcophilus harrisii

Functional Description

Protein Length

843

Protein Sequence
(FASTA)

MKNEDLTDEL NFNKVSADTS DNSGTVNRIM MTANTPENWL SFLLKIEKKS VPQDDGFLNK 60

LIGRYSQAIE ALPPDKYGQN ESFARIQVRF AELKAIQEPD DARDCFQMAK ANCKRFAFVH 120

ISFAQFELSQ GNFKKSKQLL QKALECGAVP QEMLENAMRN LNLQKKQLLS EEEKNNYLAI 180

PILNTQESFQ NPLGNLQNRN INSDSRRLSN VSRFLYGENI PPQDTEISSR NPLKQLNKSK 240

PSCPFGRVPV NLINSPGGPV EKDGPAGQSS DDRQSPGSEY QDLNVPKLEA SEGDSYELKN 300

IKILENIYFM NFQLSTDKDS ELTPDSTVTL RNKTESCLPT KKEENRMHYE EPKVPENNQI 360

HRLSNFSSSS NRKSESLNQN PVATSNHWQI PEANRNAIPE QKRSSSEQPG LTISKQSSPI 420

TVPKRIDNKF VCNTPSSNSR STLNDYMSCF RTPVVKNDFP SGHQFSTPYS QPSYLQQQHT 480

PVTPFQSLQI SGSFSSNEYI SVKGRIYSIL KQIGSGGSSK VFQVLSEKKQ IYAIKYVNLE 540

EADPQTIESY RNEIAFLSKL QQHSDKIIRL YDYEITGHHI YMVMECGNID LNSWLKKKKA 600

INPWERKSYW KNMLEAVHTI HQHGGIVHSD LKPANFLIVD GMLKLIDFGI ANQIQPDMTS 660

IVKDSQVGTV NYMPPEAIKD MSSSRENGKS RSKISPKSDV WSLGCILYCM TYGKTPFQHI 720

INQITKLHAI IDPNHEIKFP EIAEKDLQDV LRCCLIRDPK QRISVPELLV HPYVQIQTQS 780

QPASQVAKGT TEEMKHVLGQ LVVLNSPNSI LKAARTLYEQ YSSGESHDSS SFSKSYDQKW 840

KKK 843

Nucleotide Sequence
(FASTA)

ATGAAGAATG AAGATCTTAC TGATGAATTG AATTTTAATA AAGTCTCTGC AGATACTTCT 60

GACAATTCAG GAACTGTTAA CCGAATTATG ATGACAGCGA ACACTCCAGA GAATTGGTTA 120

AGCTTTTTGC TCAAAATAGA AAAAAAAAGT GTTCCTCAAG ATGATGGATT TCTAAATAAA 180

TTGATTGGCC GTTATAGTCA AGCAATTGAA GCGCTTCCTC CAGACAAATA TGGTCAAAAT 240

GAAAGTTTTG CTCGAATTCA AGTGAGATTT GCTGAACTGA AAGCTATTCA AGAACCAGAT 300

GATGCACGTG ACTGTTTTCA AATGGCCAAG GCTAATTGCA AGAGATTTGC TTTTGTGCAT 360

ATATCTTTTG CACAGTTTGA ACTATCTCAA GGCAACTTTA AAAAAAGTAA GCAGCTTCTC 420

CAGAAAGCTC TAGAATGTGG TGCAGTCCCA CAAGAAATGT TAGAAAATGC CATGCGGAAT 480

TTGAATCTGC AGAAAAAACA GTTGCTTTCA GAGGAGGAAA AAAACAACTA TTTAGCAATT 540

CCCATTTTAA ATACCCAGGA ATCATTCCAA AACCCACTTG GAAATTTACA GAATAGAAAT 600

ATTAATTCTG ATTCCAGAAG GCTATCTAAT GTGTCCAGAT TTTTATATGG GGAGAACATA 660

CCTCCTCAGG ATACAGAAAT AAGTAGTAGA AATCCCTTGA AGCAGTTAAA TAAATCTAAA 720

CCGTCATGCC CATTTGGAAG GGTTCCAGTT AACCTTATAA ATAGCCCCGG TGGACCTGTG 780

GAGAAAGATG GTCCAGCTGG ACAGAGTTCG GATGACAGAC AAAGCCCTGG ATCAGAGTAT 840

CAAGATCTCA ATGTGCCAAA ACTGGAAGCA AGTGAAGGTG ATTCCTATGA ATTAAAAAAT 900

ATAAAGATAC TTGAAAATAT CTACTTTATG AATTTTCAGT TATCCACTGA TAAGGATTCA 960

GAGCTTACTC CTGATTCAAC AGTGACACTA AGGAATAAAA CAGAATCTTG TCTTCCAACC 1020

AAAAAAGAAG AAAACAGAAT GCATTATGAA GAACCAAAAG TACCAGAAAA TAATCAGATC 1080

CATCGACTGT CTAATTTCAG TAGTAGTAGT AACAGAAAAT CAGAATCTTT AAACCAAAAT 1140

CCCGTTGCAA CTTCTAATCA TTGGCAGATT CCAGAGGCAA ACCGAAATGC CATACCAGAG 1200

CAAAAACGTT CCAGTTCTGA ACAACCTGGC CTAACTATTT CAAAACAGTC ATCACCAATA 1260

ACAGTTCCTA AAAGAATTGA TAACAAATTT GTGTGTAATA CACCCAGCAG CAACAGCAGA 1320

AGCACACTAA ATGACTACAT GTCCTGTTTT AGAACTCCAG TTGTGAAGAA TGACTTTCCA 1380

TCTGGGCATC AATTTTCTAC TCCTTACAGC CAGCCTTCCT ACTTACAGCA GCAACACACA 1440

CCAGTTACTC CGTTTCAAAG CTTACAGATT TCAGGATCAT TTTCTTCAAA TGAATACATT 1500

TCGGTTAAGG GAAGAATTTA TTCCATATTA AAGCAAATAG GAAGTGGAGG TTCAAGTAAG 1560

GTATTTCAAG TATTGAGTGA AAAGAAGCAG ATATATGCTA TAAAGTATGT GAATTTGGAA 1620

GAAGCAGACC CGCAGACTAT TGAGAGCTAT CGGAATGAAA TTGCTTTTTT AAGTAAACTG 1680

CAACAGCACA GTGATAAGAT CATTCGACTT TATGATTATG AAATCACTGG CCACCATATC 1740

TATATGGTGA TGGAATGTGG GAATATTGAT CTTAACAGTT GGCTTAAAAA GAAAAAAGCA 1800

ATCAATCCAT GGGAACGGAA AAGTTATTGG AAAAATATGT TGGAAGCAGT TCATACAATC 1860

CACCAACATG GAGGCATTGT TCACAGTGAT CTGAAACCTG CTAACTTTCT GATAGTTGAT 1920

GGAATGCTAA AGCTAATTGA TTTTGGAATT GCAAACCAAA TACAGCCAGA TATGACAAGC 1980

ATTGTTAAAG ATTCTCAGGT TGGTACAGTT AATTATATGC CACCAGAAGC CATCAAAGAC 2040

ATGTCGTCTT CAAGAGAGAA TGGGAAATCC AGATCAAAGA TAAGCCCAAA AAGTGATGTC 2100

TGGTCCTTAG GATGCATCTT ATACTGCATG ACTTATGGGA AGACTCCTTT TCAGCATATA 2160

ATAAATCAGA TCACTAAGTT ACATGCTATC ATTGATCCTA ATCATGAAAT AAAATTTCCT 2220

GAAATTGCAG AAAAAGACCT ACAAGATGTG CTACGGTGCT GCTTAATAAG GGACCCTAAG 2280

CAGAGAATAT CTGTTCCTGA ACTCTTGGTA CATCCATATG TTCAGATTCA AACTCAGTCA 2340

CAACCAGCTA GTCAAGTGGC TAAAGGAACC ACAGAAGAAA TGAAACATGT TCTTGGCCAA 2400

CTTGTTGTCC TGAATTCTCC CAACTCCATT TTGAAAGCTG CCAGAACTTT ATATGAACAG 2460

TACAGCAGTG GTGAAAGTCA TGATTCATCT TCATTTTCCA AATCATATGA CCAAAAATGG 2520

AAAAAGAAAT GA 2532

Domain Profile

S: 1     yeilkklGsGGsskvfkvksekkrvyalkvvdleaaddqtidgykneielleklqdqs.k  59

         y+ilk++GsGGsskvf+v+sekk++ya+k+v+le+ad+qti++y+nei++l klq++s k

Q: 507   YSILKQIGSGGSSKVFQVLSEKKQIYAIKYVNLEEADPQTIESYRNEIAFLSKLQQHSdK  566

         99********************************************************9*

S: 60    virlydyeledsllylvmecGdidlnkilkkkksiepdyelvsyykemleavkvihqh.G  118

         +irlydye++ +++y+vmecG+idln++lkkkk+i+p +e++sy+k+mleav++ihqh G

Q: 567   IIRLYDYEITGHHIYMVMECGNIDLNSWLKKKKAINP-WERKSYWKNMLEAVHTIHQHgG  625

         *************************************.********************55

S: 119   ivhsdlkPanfllvdGilklidfGianavaedttsivkesqvGtvnylaPealkdmsssq  178

         ivhsdlkPanfl+vdG+lklidfGian++++d tsivk+sqvGtvny++Pea+kdmsss

Q: 626   IVHSDLKPANFLIVDGMLKLIDFGIANQIQPDMTSIVKDSQVGTVNYMPPEAIKDMSSS-  684

         ***********************************************************.

S: 179   ssereaekskikvsrksdvwslGcilylllygktPfgsirnqvskllaiinPdveiefPe  238

            re++ks++k+s+ksdvwslGcily ++ygktPf++i+nq++kl+aii+P++ei+fPe

Q: 685   ---RENGKSRSKISPKSDVWSLGCILYCMTYGKTPFQHIINQITKLHAIIDPNHEIKFPE  741

         ...*********************************************************

S: 239   itsniekslvellkaclkrnPkkrisvdellsspfv  274

         i+   ek+l+++l++cl r+Pk+risv+ell +p+v

Q: 742   IA---EKDLQDVLRCCLIRDPKQRISVPELLVHPYV  774

         **...*****************************96

Domain Sequence
(FASTA)

YSILKQIGSG GSSKVFQVLS EKKQIYAIKY VNLEEADPQT IESYRNEIAF LSKLQQHSDK 60

IIRLYDYEIT GHHIYMVMEC GNIDLNSWLK KKKAINPWER KSYWKNMLEA VHTIHQHGGI 120

VHSDLKPANF LIVDGMLKLI DFGIANQIQP DMTSIVKDSQ VGTVNYMPPE AIKDMSSSRE 180

NGKSRSKISP KSDVWSLGCI LYCMTYGKTP FQHIINQITK LHAIIDPNHE IKFPEIAEKD 240

LQDVLRCCLI RDPKQRISVP ELLVHPYV 268

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR011990	; TPR-like_helical.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013