EKS-SAH-00115
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00115
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met480.61.3E-14410761336261
StatusUnreviewed
Ensembl ProteinENSSHAP00000018708
UniProt AccessionG3WTF3;
Protein Name
Protein Synonyms/Alias
Gene NameMET
Gene Synonyms/Alias MET;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000015881ENSSHAP00000018708ENSSHAT00000018863
OrganismSarcophilus harrisii
Functional Description
Protein Length1379
Protein Sequence
(FASTA)
MKPPAVLVPG ITMLLLALVP NCKAECKEAL VKSEMDVNRK YPLPNFIAET PIQNIVFHNH 60
HIFLGAINKI YVLNEDLHNV SEYKTGPVLE HPDCSPCQDC SHKANLSGSV WKDNVNKALL 120
IDTYYDDQLI SCGSVNRGTC QRHVFQPNNA ADIQSQVYCI YSPQMDEESL QCPDCVVSTL 180
GTKVLLTEKD RFINFFVGNT INSSYADHSS HSISVRRLKE TQDGFKFLTD QSYIDVLPEF 240
QDSYPIKYIH AFESSDFIYF LTVQRETLES QTFHTRIIRF CSIDSGLHSY MEMPLECILT 300
EKRRKRSPRE EVFNVLQAAY VSKPGAHLAR QIGVGPNDDI IFGVFAQSKP DSSEPIKRSA 360
VCAFPIKFVN DFFNRIVNKN NVRCLQHFYG NNHKHCFNRT FLRNSSGCEA RDDEYRTEFT 420
TGLQRIDLFT GQFKQVLLTS ISTFIKEDLT IANLGTSDGR FMQVVVSRGQ STPHVNFQLD 480
SHPVSPEVIV EHPLNADGFT LVITGKKITK IPLNGLGCDH FKSCSQCLSA PPFVQCTWCH 540
NQCVKSKECV TELGNQDICL PTIYEILPTS APLEGGTTLT VCGWDFGLRK NNKFDFRKTK 600
VFIGNESCIL NTSESTTNKL KCTVGPAVNL HFNVSIIISN GRETTKFNSF SYVDPVITNI 660
SPSYGPKAGG TVLTLIGKYL NSGNSRRISI GGKPCILKSV SHSLLECYTP AQTIPSEYPI 720
KMKIDLANRE AYSFTYKEDP IVHKIHPTKS FLSGGSTITG FGKNLNSASV PKMVINVPEV 780
GRNFTVACKH RSNSEIICCS TPSLQQLNLQ PPLETKALFI FDGIHSTYFD LIYVHNPVFK 840
PFEKPVMISM GNENVLEIKG NDIDPEAVKG EVLKVGNKSC ENIRLNSETV LCTVPSDLLK 900
LNSELNIEWK QAVSSTVLGK VIVQPDQNFT GLIVGVVLIS LLLLFLLGLF LWLKKRKQIK 960
DLGSDLVRYD ARVHTPHLDR LVSARSVSPT TEMVSNESVD YRATFPEDQF PHSSQNGSCR 1020
QAHYPLTDLS PILTSADSDI SSPLLQNHVH IDISALNPDL VQAVQHVVIG PNSLIVHFNE 1080
IIGRGHFGCV YHGTLLDNDG KKIHCAVKSL NRITDIGEVS QFLTEGIIMK DFSHPNVLSL 1140
LGICLRSEGS PLVVLPYMKH GDLRNFIRNE THNPTVKDLI GFGLQVAKGM KYLASKKFVH 1200
RDLAARNCML DEKFTVKVAD FGLARDMYDK EYYSVHNKTG AKLPVKWMAL ESLQTQKFTT 1260
KSDVWSFGVL LWELMTRGAP PYPDVNTFDI TVYLLQGRRL LQPEYCPDPL YEVMLKCWHP 1320
KAEMRPSFSE LVSKISVIFS TFIGEHYVHV NATYVNVKCV APYPSLLSSQ DNVDREVDT 1379
Nucleotide Sequence
(FASTA)
ATGAAGCCCC CTGCTGTGCT TGTACCTGGG ATTACAATGT TACTGCTTGC CTTGGTGCCG 60
AATTGCAAAG CAGAGTGTAA GGAAGCCCTA GTCAAGTCTG AAATGGATGT TAATAGGAAG 120
TATCCACTTC CCAACTTCAT TGCAGAAACC CCGATCCAAA ACATCGTTTT TCACAATCAC 180
CACATCTTTC TGGGTGCAAT CAACAAGATT TATGTCTTAA ATGAAGATCT TCATAATGTT 240
TCTGAGTATA AGACGGGACC TGTGCTGGAA CACCCTGATT GTTCTCCGTG TCAGGATTGC 300
AGTCACAAAG CCAACTTATC AGGTAGTGTT TGGAAGGATA ATGTCAATAA AGCCTTGCTT 360
ATTGATACCT ACTATGATGA CCAGCTCATT AGTTGTGGCA GTGTCAATCG AGGGACCTGC 420
CAGCGCCATG TGTTTCAGCC CAATAATGCT GCTGATATAC AGTCACAAGT TTATTGCATA 480
TATTCCCCAC AGATGGATGA GGAGTCCCTC CAATGTCCTG ACTGTGTGGT AAGCACTTTA 540
GGGACCAAAG TTCTACTGAC AGAAAAAGAC CGATTTATAA ACTTCTTTGT AGGCAATACC 600
ATAAATTCTT CTTACGCTGA TCATTCCTCG CATTCAATAT CTGTTAGGAG GCTAAAGGAA 660
ACACAAGATG GTTTTAAATT TTTGACTGAT CAATCCTATA TTGATGTTCT ACCTGAATTC 720
CAAGATTCTT ACCCTATTAA ATATATACAT GCCTTTGAAA GCAGTGACTT CATTTATTTT 780
CTGACTGTAC AAAGAGAAAC TCTCGAATCT CAGACTTTTC ACACACGAAT AATCAGGTTC 840
TGTTCCATTG ACTCTGGATT GCATTCATAC ATGGAAATGC CTCTTGAATG TATTCTTACT 900
GAGAAGAGGA GAAAGAGGTC GCCAAGGGAA GAAGTATTTA ATGTTCTACA AGCTGCATAT 960
GTGAGTAAGC CTGGTGCACA TCTAGCTAGG CAAATAGGCG TTGGACCCAA TGATGACATT 1020
ATCTTTGGAG TATTTGCACA AAGTAAACCA GACTCTTCAG AACCAATCAA GAGATCAGCA 1080
GTCTGCGCAT TCCCAATCAA ATTTGTCAAT GATTTCTTCA ACAGAATTGT GAACAAAAAT 1140
AATGTGAGAT GTCTTCAGCA CTTTTATGGG AACAATCACA AGCACTGCTT TAATAGGACA 1200
TTTTTAAGAA ACTCATCAGG TTGTGAAGCA AGAGATGATG AATATAGGAC AGAATTTACT 1260
ACAGGCTTGC AACGTATCGA TTTATTCACT GGACAATTCA AGCAAGTTCT TTTAACATCA 1320
ATATCTACTT TTATCAAGGA AGACCTAACC ATTGCAAACC TTGGAACATC AGATGGTCGA 1380
TTTATGCAGG TTGTGGTTTC TCGGGGACAA TCAACCCCTC ATGTGAATTT TCAATTGGAT 1440
TCCCATCCCG TTTCCCCAGA AGTGATTGTT GAGCATCCAC TAAATGCAGA TGGCTTCACA 1500
CTAGTTATTA CTGGGAAAAA GATAACTAAG ATCCCATTGA ATGGCCTAGG TTGTGACCAT 1560
TTTAAGTCCT GCAGCCAATG TCTCTCAGCT CCTCCTTTTG TGCAATGTAC CTGGTGTCAT 1620
AATCAATGTG TGAAATCTAA AGAATGTGTC ACTGAACTAG GGAACCAAGA TATTTGTCTG 1680
CCTACTATTT ATGAGATTCT CCCAACTAGT GCACCCCTAG AGGGAGGCAC AACACTGACT 1740
GTGTGTGGCT GGGATTTTGG ATTAAGAAAA AATAATAAAT TTGATTTTAG AAAAACCAAA 1800
GTTTTCATTG GAAATGAGAG TTGCATATTG AATACAAGTG AGAGCACTAC AAATAAGTTG 1860
AAATGTACTG TTGGTCCTGC TGTGAACCTG CATTTCAATG TATCCATCAT TATTTCAAAT 1920
GGTCGAGAAA CAACAAAATT TAATTCCTTC TCTTATGTGG ATCCTGTAAT AACAAATATT 1980
TCTCCAAGCT ATGGTCCCAA GGCTGGTGGT ACAGTACTTA CTTTAATTGG GAAATATCTA 2040
AACAGTGGAA ATTCTAGACG TATTTCAATC GGTGGAAAGC CATGTATTTT AAAAAGTGTG 2100
TCTCATAGCC TTCTAGAATG TTATACTCCT GCACAAACCA TTCCAAGTGA GTACCCCATT 2160
AAAATGAAAA TTGACTTAGC CAATCGAGAA GCCTACAGTT TTACATACAA AGAGGACCCT 2220
ATTGTTCATA AAATCCATCC AACCAAATCT TTTCTTAGTG GAGGAAGCAC AATAACAGGT 2280
TTTGGAAAAA ACCTGAATTC TGCTAGCGTG CCCAAGATGG TAATAAATGT CCCTGAAGTA 2340
GGAAGGAACT TCACAGTGGC ATGTAAGCAT CGATCTAATT CAGAGATAAT CTGTTGTTCG 2400
ACTCCTTCCT TACAACAGCT AAATCTGCAA CCCCCCCTGG AAACAAAAGC TCTTTTCATA 2460
TTTGATGGTA TCCATTCCAC TTACTTTGAT CTCATTTATG TCCATAATCC TGTATTTAAG 2520
CCTTTTGAAA AGCCAGTGAT GATCTCAATG GGCAATGAAA ATGTACTAGA AATTAAGGGA 2580
AATGATATTG ACCCTGAGGC AGTAAAAGGT GAAGTGTTAA AAGTGGGAAA TAAAAGCTGT 2640
GAGAATATCC GCTTGAACTC TGAAACAGTC TTATGTACAG TCCCCAGTGA CCTGCTGAAA 2700
CTGAACAGTG AGCTAAATAT AGAGTGGAAG CAAGCAGTTT CTTCTACTGT CCTTGGAAAA 2760
GTGATAGTAC AACCAGATCA AAATTTCACA GGACTCATTG TTGGAGTGGT CTTGATATCA 2820
TTGTTGCTCT TGTTTTTACT GGGCCTTTTT CTGTGGCTGA AAAAGAGGAA GCAGATTAAA 2880
GATCTGGGCA GTGACTTAGT TCGCTATGAT GCAAGAGTAC ACACTCCTCA CTTGGACAGG 2940
CTTGTAAGTG CCCGAAGTGT GAGCCCTACC ACAGAAATGG TTTCAAATGA ATCTGTAGAC 3000
TACAGAGCAA CTTTTCCAGA AGATCAGTTT CCACATTCTT CTCAGAATGG ATCCTGCAGA 3060
CAAGCTCATT ATCCTCTGAC AGATTTGTCC CCCATCCTAA CCAGTGCAGA TTCAGATATA 3120
TCCAGTCCGC TGCTTCAGAA TCATGTCCAC ATTGATATCA GCGCCTTAAA TCCAGACCTG 3180
GTCCAAGCTG TTCAACATGT GGTTATTGGG CCAAACAGCC TGATTGTGCA TTTCAATGAA 3240
ATCATAGGAA GAGGGCATTT TGGATGTGTG TATCATGGGA CCTTATTGGA TAATGATGGC 3300
AAGAAGATTC ATTGTGCTGT GAAGTCCTTG AATAGAATTA CTGACATAGG AGAGGTTTCC 3360
CAATTTCTGA CTGAAGGGAT CATCATGAAA GATTTTAGTC ATCCCAATGT CCTCTCACTT 3420
TTGGGAATCT GCCTTCGTAG TGAAGGGTCC CCATTGGTGG TCCTGCCATA TATGAAACAT 3480
GGAGATCTTC GAAACTTCAT AAGAAATGAG ACTCATAACC CAACAGTGAA AGATCTTATT 3540
GGCTTTGGTC TTCAAGTAGC GAAAGGCATG AAATACCTTG CAAGCAAAAA GTTTGTCCAC 3600
AGAGACTTGG CTGCAAGAAA TTGTATGCTG GATGAAAAAT TCACTGTCAA GGTTGCTGAT 3660
TTTGGGCTTG CCAGAGATAT GTATGATAAA GAATATTACA GTGTACACAA TAAAACAGGA 3720
GCAAAACTGC CAGTGAAGTG GATGGCTTTA GAAAGCTTGC AAACTCAGAA GTTTACTACA 3780
AAGTCAGATG TGTGGTCTTT TGGAGTGCTT CTCTGGGAAC TAATGACTAG AGGAGCACCT 3840
CCTTATCCTG ATGTTAATAC CTTTGATATA ACAGTTTATT TATTGCAAGG TCGAAGGCTT 3900
TTGCAACCTG AATACTGCCC AGATCCACTG TATGAAGTTA TGCTAAAATG CTGGCACCCA 3960
AAAGCTGAAA TGCGTCCCTC TTTCTCTGAA CTGGTCTCAA AGATATCAGT CATATTCTCT 4020
ACATTTATTG GAGAGCATTA TGTTCACGTG AATGCAACCT ACGTCAATGT AAAATGTGTT 4080
GCTCCTTACC CTTCCCTTTT GTCATCCCAA GACAACGTTG ACAGGGAGGT GGACACCTGA 4140
Domain Profile
S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60
         v+++e+iG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp
Q: 1076  VHFNEIIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1135
         799*********************************************************
S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120
         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas
Q: 1136  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1195
         ************************************************************
S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180
         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt
Q: 1196  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1255
         ************************************************************
S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240
         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm
Q: 1256  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1314
         **.*********************************************************
S: 241   lkcwkakpaerpqfsdlvsiis  262
         lkcw++k+++rp+fs+lvs+is
Q: 1315  LKCWHPKAEMRPSFSELVSKIS  1336
         *******************997
Domain Sequence
(FASTA)
VHFNEIIGRG HFGCVYHGTL LDNDGKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60
NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120
KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180
QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240
KCWHPKAEMR PSFSELVSKI S 261
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00115
EKS-ANC-00111
EKS-BOT-00123
EKS-CAE-00100
EKS-CAJ-00125
EKS-CAF-00126
EKS-CAP-00120
EKS-CII-00062
EKS-CIS-00142
EKS-DAR-00379
EKS-EQC-00119
EKS-FEC-00114
EKS-GAG-00103
EKS-GAA-00142
EKS-GOG-00122
EKS-HOS-00125
EKS-ICT-00115
EKS-LAC-00128
EKS-LOA-00118
EKS-MAM-00119
EKS-MEG-00093
EKS-MOD-00120
EKS-MUM-00124
EKS-MUP-00126
EKS-MYL-00133
EKS-NOL-00115
EKS-OCP-00079
EKS-ORN-00150
EKS-ORA-00101
EKS-ORC-00115
EKS-ORL-00139
EKS-OTG-00126
EKS-PAT-00111
EKS-PES-00105
EKS-PEM-00067
EKS-POA-00116
EKS-RAN-00120
EKS-SUS-00109
EKS-TAG-00152
EKS-TAR-00154
EKS-TEN-00142
EKS-VIP-00058
EKS-XET-00102
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275; P:multicellular organismal development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016244; Tyr_kinase_HGF/MSP_rcpt.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01403; Sema; 1.
PF01833; TIG; 3.
SMARTs
SM00429; IPT; 4.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013