EKS-SAH-00361

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00361

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	336.0	2.1E-100	861	1124	264

Status

Unreviewed

Ensembl Protein

ENSSHAP00000018765

UniProt Accession

G3WTL0;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000015928	ENSSHAP00000018765	ENSSHAT00000018920

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1128

Protein Sequence
(FASTA)

FPLPQLSFLS TGSSQLVLLE NNKLLKKTER HFTSTPSPMP GLIEPTSRSN GFQSPNKLQQ 60

IQSKVSVNHS IRTPDGYNSI WSRNMCSFQK DHWHSLGEDL REHVEREGNL KHRKVEDGTQ 120

LEDSHFEKDQ LCVSIENEDI FKEDNISKDK EIALHDGGIR HIEEKNTQNT TSRNQHGSLR 180

SRNHEQEQGV TYAIQTSQEI NPLVMTQDQS EGSRNEFPTL KNAPGHTDET SEQNHISKLV 240

FTTIPIVITP DPLAKLSESH MSRETSTKIA SETTGTEMSE MVPLVCITFP GNECPREPSI 300

AKQDLSKRKS ILHSNNNTFH RFAHQENDKR RMKTYRKKLD SKTKMNSKIP QSPTISIEGS 360

IKPTVQKASM KRQVFPTLGL DESRPRQSTK LQKRGQHTGE KPLNFHALKP QRQGFPCICK 420

NSEPKKPTAP VSVPPAKSNF NFLDLKYSDM FKEINSTDKG PGIYEMFGTP VYCYVREAGR 480

EENKFYRETN SAPPGRCLSN KCCSINERNG NGRVRISQKK GHIKPPKTSL GIKQKHKNLT 540

SKEKIPKSTA SIIENMQNDD VISEPDCHMK SSGNTSPSCK DGAQPLNSIQ SPEDLTAHQN 600

QNEPTSTSDL SSMEKDSVEQ SVSHSPSQIL ATSLRDLHEL EEKHQTKSVA SVNIWLRPSQ 660

ENAIESVLQK RLNMETLENL KVSQTLSETP RDDRVSNNLQ TPSAISFLEK SKSISSQVPL 720

NQNWTYSMED NTLANKSVTY QNSEKSLSVT SSVSMDSLES ENNEQVTDEL LGCLAAELLA 780

LEEKDSKSWQ MVTNDTNSEA QNPTISGRVN AFQDLDKETP RFKMQKYSNN FWLSDDEKPF 840

FSLNEKPFSE NSLKHEEPIL WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSDQVA 900

NEREYQKLQE EVDLLKVLKH VNIVAYLGTC LEKNLVSIFM EFVPGGSISS IISRFGPLPE 960

MVISKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII KLIDFGCARR LAYVSLTGTH 1020

SEMLKSMHGT PYWMAPEVIN ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG 1080

THRGLMPSLP GHFSENAADF VRVCLTRDQH DRPSALQLLE HTFLQRSH 1128

Nucleotide Sequence
(FASTA)

TTTCCCTTAC CACAACTATC ATTCTTATCT ACTGGATCAA GTCAACTTGT TCTTCTAGAA 60

AATAACAAGC TTCTTAAAAA GACAGAAAGA CATTTTACAA GCACCCCAAG TCCTATGCCT 120

GGTCTCATAG AACCCACGAG TCGGTCTAAT GGTTTTCAGT CACCCAATAA GTTGCAACAA 180

ATCCAGTCTA AAGTCTCTGT GAACCATAGC ATCAGAACAC CTGATGGTTA CAATTCTATT 240

TGGTCTAGGA ATATGTGCTC TTTTCAGAAG GATCATTGGC ATTCATTAGG TGAGGACTTG 300

AGAGAGCATG TGGAAAGGGA AGGAAATCTC AAACATAGGA AAGTTGAAGA TGGTACCCAA 360

CTTGAAGACT CTCACTTTGA AAAAGATCAG TTGTGTGTGT CCATTGAGAA TGAGGACATT 420

TTTAAAGAAG ACAACATCTC CAAAGACAAA GAGATTGCTC TCCATGATGG AGGAATAAGA 480

CATATTGAAG AGAAAAATAC TCAAAACACA ACATCAAGAA ATCAACATGG TTCCTTAAGG 540

AGTAGGAACC ATGAACAAGA ACAAGGAGTG ACATATGCCA TTCAAACTAG CCAAGAAATT 600

AATCCTTTAG TAATGACACA AGACCAGAGT GAAGGTTCTA GAAATGAGTT TCCCACTTTG 660

AAGAATGCAC CAGGACATAC AGATGAGACA AGTGAGCAAA ATCATATTTC AAAACTTGTT 720

TTTACAACCA TTCCCATTGT TATTACTCCT GACCCTTTAG CAAAACTATC CGAAAGCCAC 780

ATGAGCAGAG AGACATCTAC AAAAATAGCA TCAGAAACAA CAGGAACAGA AATGAGTGAA 840

ATGGTCCCTC TGGTCTGCAT TACTTTTCCT GGAAATGAAT GTCCCAGGGA GCCATCCATA 900

GCCAAACAGG ATCTCTCAAA GAGAAAGAGT ATTCTTCATA GCAATAACAA CACCTTTCAT 960

AGATTTGCTC ACCAAGAAAA TGATAAGCGT AGGATGAAAA CCTATAGGAA GAAATTGGAT 1020

TCAAAGACAA AGATGAATAG CAAGATACCT CAGAGTCCTA CAATTTCTAT TGAAGGTTCC 1080

ATCAAACCTA CTGTTCAGAA AGCAAGTATG AAAAGGCAAG TGTTTCCCAC TTTAGGGCTT 1140

GATGAGTCCA GGCCCAGGCA ATCAACCAAG CTTCAGAAGA GAGGACAACA CACAGGGGAG 1200

AAACCATTAA ACTTCCATGC TTTGAAACCC CAAAGACAAG GATTTCCTTG TATCTGCAAA 1260

AATTCGGAAC CAAAAAAACC TACTGCTCCT GTTTCTGTTC CTCCAGCAAA ATCAAACTTT 1320

AATTTTTTGG ACCTGAAATA TAGTGATATG TTTAAGGAAA TCAATTCAAC TGACAAAGGA 1380

CCAGGAATTT ATGAAATGTT TGGGACTCCT GTATATTGTT ATGTCAGAGA AGCTGGGCGT 1440

GAGGAAAACA AATTCTATAG GGAAACAAAT TCTGCTCCAC CTGGAAGATG TCTTTCAAAT 1500

AAGTGTTGTT CCATAAATGA AAGAAATGGC AATGGCAGAG TAAGGATTTC CCAGAAAAAG 1560

GGACATATAA AACCCCCAAA GACTTCTCTT GGCATTAAAC AAAAGCACAA AAATTTAACT 1620

TCAAAAGAAA AAATTCCTAA GTCTACAGCA AGTATCATAG AAAATATGCA AAATGATGAT 1680

GTAATTTCAG AACCTGATTG CCATATGAAA TCTTCAGGAA ATACTTCTCC CTCTTGTAAA 1740

GATGGAGCTC AACCCCTTAA TTCCATTCAG TCTCCAGAGG ACCTTACTGC ACACCAAAAC 1800

CAGAATGAAC CCACTTCTAC CTCAGATTTG TCTAGTATGG AAAAAGATTC TGTGGAACAA 1860

TCCGTAAGTC ATTCCCCCAG TCAAATACTT GCCACAAGTC TCAGAGATCT ACATGAACTT 1920

GAAGAGAAAC ATCAAACCAA ATCTGTAGCT TCAGTGAATA TCTGGCTAAG GCCAAGTCAG 1980

GAGAATGCCA TTGAGTCTGT ACTACAAAAA AGATTAAATA TGGAGACTCT TGAAAATCTC 2040

AAAGTCAGTC AGACTCTTTC TGAAACCCCA AGAGATGACA GAGTTTCCAA TAATCTTCAA 2100

ACACCGAGTG CTATCTCTTT CCTGGAGAAA TCAAAAAGTA TATCTTCTCA GGTACCTCTA 2160

AACCAAAACT GGACATATTC AATGGAAGAT AATACTTTAG CAAATAAGTC AGTTACATAT 2220

CAGAATTCTG AAAAATCTTT AAGTGTTACA AGCTCGGTTT CTATGGACTC TCTGGAATCT 2280

GAAAATAACG AACAAGTGAC AGATGAATTA CTGGGTTGTT TAGCTGCAGA ACTATTAGCT 2340

CTTGAGGAAA AAGACAGTAA ATCCTGGCAA ATGGTGACAA ATGACACAAA TTCTGAAGCA 2400

CAAAATCCAA CCATCAGTGG AAGAGTAAAT GCCTTCCAAG ACCTTGACAA AGAGACACCA 2460

AGATTCAAAA TGCAGAAGTA TAGTAATAAT TTCTGGCTCT CTGACGATGA AAAGCCTTTC 2520

TTCAGTTTGA ATGAAAAGCC ATTTTCTGAA AACAGTTTAA AGCATGAAGA GCCTATTCTA 2580

TGGACCAAAG GTGAAATCCT TGGGAAGGGC GCATATGGCA CGGTATACTG TGGTCTCACA 2640

AGTCAGGGCC AACTCATAGC TGTGAAACAA GTAGCTTTGG ATACCTCTGA TCAAGTAGCT 2700

AATGAGAGAG AATATCAGAA ACTGCAAGAA GAAGTGGACT TGCTTAAGGT ACTGAAACAT 2760

GTCAACATTG TGGCTTACTT GGGAACATGC TTAGAAAAGA ACCTTGTAAG TATTTTCATG 2820

GAGTTTGTTC CTGGTGGCTC TATTTCTAGT ATTATAAGCC GTTTTGGACC CCTGCCTGAG 2880

ATGGTGATTT CCAAATACAC CAAACAAATT CTCCAAGGAG TAGCCTATTT GCATGAGAAC 2940

TGTGTGGTAC ACAGAGATAT CAAAGGGAAT AATGTTATGC TCATGCCGAC TGGAATAATA 3000

AAACTGATTG ACTTTGGATG TGCCAGGCGT TTGGCCTATG TAAGCTTGAC AGGCACTCAT 3060

AGTGAAATGC TTAAGTCTAT GCATGGAACA CCATATTGGA TGGCACCTGA AGTCATCAAT 3120

GAATCTGGCT ATGGAAGGAA GTCAGACATC TGGAGTATTG GCTGCACTGT ATTTGAGATG 3180

GCTACTGGGA AACCACCTTT GGCTTCTATG GACAGGATGG CAGCAATGTT TTACATTGGC 3240

ACTCATAGAG GGCTAATGCC TTCTTTACCA GGCCACTTTT CAGAAAATGC AGCAGACTTT 3300

GTACGTGTTT GTTTAACCAG GGACCAACAT GATCGACCAT CTGCTCTGCA GCTCCTGGAG 3360

CACACTTTCC TTCAGAGGAG TCACTGA 3387

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekk.sekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ ++ ++++e+++l+eE++llk lk

Q: 861   WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTSDQvANEREYQKLQEEVDLLKVLK  919

         89*****************8.89***********8766514556****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ e++ ++if+E+v+gGs+ss+++++g+l e+vi+kytkqil+g+ayLHe

Q: 920   HVNIVAYLGTCLEKNLVSIFMEFVPGGSISSIISRFGPLPEMVISKYTKQILQGVAYLHE  979

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG+++rla ++ + ++   l+s++Gt+++maPEvi

Q: 980   NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAYVSLTGTHsemLKSMHGTPYWMAPEVI  1039

         *********************************9998887767789**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +g+++  +P++p ++se+

Q: 1040  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGTHRgLMPSLPGHFSEN  1096

         988..****************************.9**********9989***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LL+h+fl

Q: 1097  AADFVRVCLTRDQHDRPSALQLLEHTFL  1124

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSDQVA NEREYQKLQE EVDLLKVLKH 60

VNIVAYLGTC LEKNLVSIFM EFVPGGSISS IISRFGPLPE MVISKYTKQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCARR LAYVSLTGTH SEMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG THRGLMPSLP GHFSENAADF 240

VRVCLTRDQH DRPSALQLLE HTFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013