EKS-SAH-00050
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00050
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF405.41.3E-121411670260
StatusUnreviewed
Ensembl ProteinENSSHAP00000018862
UniProt AccessionG3WTV7;
Protein Name
Protein Synonyms/Alias
Gene NameBRAF
Gene Synonyms/Alias BRAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000016011ENSSHAP00000018862ENSSHAT00000019018
OrganismSarcophilus harrisii
Functional Description
Protein Length716
Protein Sequence
(FASTA)
VWNIKQMIKL TQEHIEALLD KFGGEHNPPS IYLEAYEEYT SKLDALQQRE QQLLESMGNG 60
TDFSVSSSAS TDTVTSSSSS SLSVAPSSLA VFQNPTDMSR SNPKSPQKPI VRVFLPNKQR 120
TVVPARCGVT VRDSLKKALM MRGLIPECCA VYRRQDGEKK PIGWDTDISW LTGEELHVEV 180
LENVPLTTHN FVRKTFFTLA FCDFCRKLLF QGFRCQTCGY KFHQRCSTEV PLMCVNYDQL 240
DLLFVSKFFE HHPIPQEEAS LGETTLTSGS SPSAPPSDSI GPPLLTPSPS KSIPIPQPFR 300
PADEDHRNQF GQRDRSSSAP NVHINTIEPV NIDDLIRDQG LRGDGGSTTG LSATPPASLP 360
GSLTNVKALQ KSPGPQRERK SSSSSEDRNR MKTLGRRDSS DDWEIPDGQI TVGQRIGSGS 420
FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRG GRKTRHVNIL LFMGYSTKPQ 480
LAIVTQWCEG SSLYHHLHII ETKFEMIKLI DIARQTAQGM DYLHAKSIIH RDLKSNNIFL 540
HEDLTVKIGD FGLATVKSRW SGSHQFEQLS GSILWMAPEV IRMQDKNPYS FQSDVYAFGI 600
VLYELMTGQL PYSNINNRDQ IIFMVGRGYL SPDLSKVRSN CPKAMKRLMA ECLKKKRDER 660
PLFPQILASI ELLARSLPKI HRSASEPSLN RAGFQTEDFS LYACASPKTP IQAGGY 716
Nucleotide Sequence
(FASTA)
GTATGGAATA TCAAGCAAAT GATAAAATTG ACACAGGAAC ACATAGAAGC CCTATTGGAC 60
AAATTTGGAG GAGAACATAA CCCACCATCA ATCTATCTCG AGGCCTATGA AGAATACACC 120
AGCAAGCTAG ATGCACTTCA ACAACGGGAA CAACAATTAT TAGAGTCCAT GGGGAATGGA 180
ACTGATTTTT CTGTTTCTAG CTCAGCTTCA ACAGACACAG TTACATCTTC TTCCTCTTCT 240
AGCCTGTCAG TGGCACCTTC ATCTCTTGCA GTTTTTCAGA ATCCCACAGA CATGTCAAGA 300
AGCAATCCCA AGTCACCACA AAAACCAATT GTTAGAGTCT TCCTGCCCAA CAAACAGAGG 360
ACTGTGGTAC CAGCAAGATG TGGAGTAACT GTCCGAGATA GTCTAAAGAA GGCATTGATG 420
ATGAGAGGCT TGATCCCAGA ATGCTGTGCA GTGTACAGAA GACAGGATGG AGAGAAGAAG 480
CCTATTGGCT GGGACACTGA TATTTCCTGG CTTACTGGAG AAGAACTGCA TGTAGAAGTT 540
TTGGAGAATG TTCCCCTAAC AACACACAAT TTTGTACGGA AGACATTTTT CACTTTAGCA 600
TTCTGTGACT TTTGTCGAAA GCTGCTTTTC CAAGGTTTCC GCTGTCAGAC ATGTGGTTAT 660
AAATTTCACC AACGCTGTAG TACAGAGGTG CCACTGATGT GTGTTAATTA TGACCAACTT 720
GATTTGCTGT TTGTCTCCAA GTTCTTTGAA CATCACCCAA TACCGCAGGA GGAGGCCTCC 780
TTAGGAGAGA CCACCCTTAC GTCGGGATCA TCCCCTTCAG CACCCCCCTC AGATTCCATT 840
GGGCCCCCAC TTCTTACTCC ATCGCCTTCA AAATCCATTC CAATCCCACA GCCCTTTCGA 900
CCAGCAGATG AGGATCATCG GAACCAGTTT GGGCAACGTG ACAGGTCCTC ATCAGCTCCC 960
AATGTGCATA TAAACACAAT AGAGCCTGTC AATATTGATG ACTTGATTAG AGACCAAGGG 1020
TTACGGGGTG ATGGAGGATC TACTACAGGG TTGTCTGCCA CTCCTCCTGC TTCCTTGCCT 1080
GGATCTCTAA CTAATGTGAA AGCATTACAA AAATCTCCAG GACCTCAGCG TGAAAGAAAA 1140
TCTTCATCAT CTTCTGAAGA CAGGAATAGA ATGAAAACCC TTGGTCGACG AGACTCAAGT 1200
GATGATTGGG AAATTCCAGA TGGGCAGATT ACAGTTGGAC AAAGGATAGG ATCTGGATCA 1260
TTTGGAACAG TCTATAAGGG GAAATGGCAT GGTGATGTAG CTGTGAAAAT GTTGAATGTG 1320
ACAGCACCCA CACCTCAGCA GTTACAGGCC TTCAAAAATG AAGTAGGAGT GCTCAGGGGG 1380
GGCAGGAAAA CACGACATGT GAATATCCTA CTCTTTATGG GCTATTCAAC AAAACCACAG 1440
TTGGCCATTG TTACACAGTG GTGTGAAGGC TCCAGTTTAT ATCACCATCT ACATATCATT 1500
GAGACCAAAT TTGAGATGAT CAAGCTAATA GATATTGCAC GGCAAACAGC ACAAGGCATG 1560
GATTATTTAC ATGCCAAGTC CATCATCCAT AGAGACCTCA AGAGTAATAA TATATTTCTT 1620
CATGAAGACC TCACAGTAAA AATAGGAGAT TTTGGTCTGG CTACAGTAAA GTCACGATGG 1680
AGTGGTTCCC ATCAGTTTGA ACAGTTATCT GGATCCATCT TGTGGATGGC ACCAGAGGTC 1740
ATTAGAATGC AAGATAAAAA CCCATATAGT TTTCAATCAG ATGTATATGC ATTTGGGATT 1800
GTTCTGTATG AGTTGATGAC AGGACAGTTA CCTTACTCAA ACATCAACAA CAGGGACCAG 1860
ATAATTTTTA TGGTGGGGCG AGGATACTTG TCGCCAGATC TTAGTAAGGT GCGGAGTAAT 1920
TGTCCAAAAG CCATGAAGAG GTTAATGGCA GAGTGCCTGA AGAAGAAGAG AGATGAGAGG 1980
CCACTTTTTC CCCAGATTCT TGCCTCCATT GAACTTCTGG CCCGCTCATT GCCAAAAATT 2040
CACCGCAGTG CATCTGAACC CTCATTGAAT CGGGCTGGCT TCCAAACGGA GGATTTTAGT 2100
CTGTATGCTT GTGCTTCTCC AAAAACACCC ATCCAGGCAG GGGGATAT 2148
Domain Profile
S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaay...kktRheniv  58
         +++++iGsG+fGtvy+gkwhGdvavk+lnv++++++ql+aFk+ev ++   +ktRh+ni+
Q: 411   TVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLrggRKTRHVNIL  470
         7899*******************************************944459*******
S: 59    LFmGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilh  118
         LFmGy +kp+laivt++c+gssLy++lh  etk+++ klidiarq+aqgmdYLhak+i+h
Q: 471   LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIH  530
         ************************************************************
S: 119   kDlksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidl  178
         +Dlks+ni+l+e+l+v+i+DFgl++vk+++sg  ++q+e+ +g+il++apevir+     
Q: 531   RDLKSNNIFLHEDLTVKIGDFGLATVKSRWSG--SHQFEQLSGSILWMAPEVIRM-----  583
         ********************************..*********************.....
S: 179   eqdelpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklp  236
          qd++p+s++sDvyafGivlyel++++lpy++ +++dqi+f+vgrG l+pdlskv+s++p
Q: 584   -QDKNPYSFQSDVYAFGIVLYELMTGQLPYSNiNNRDQIIFMVGRGyLSPDLSKVRSNCP  642
         .***********************************************************
S: 237   kelkellleClkfekeeRPlftqilkkl  264
         k++k+l++eClk++++eRPlf+qil+++
Q: 643   KAMKRLMAECLKKKRDERPLFPQILASI  670
         ************************9875
Domain Sequence
(FASTA)
TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRG GRKTRHVNIL 60
LFMGYSTKPQ LAIVTQWCEG SSLYHHLHII ETKFEMIKLI DIARQTAQGM DYLHAKSIIH 120
RDLKSNNIFL HEDLTVKIGD FGLATVKSRW SGSHQFEQLS GSILWMAPEV IRMQDKNPYS 180
FQSDVYAFGI VLYELMTGQL PYSNINNRDQ IIFMVGRGYL SPDLSKVRSN CPKAMKRLMA 240
ECLKKKRDER PLFPQILASI 260
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00046
EKS-ANC-00043
EKS-BOT-00051
EKS-CAJ-00051
EKS-CAF-00052
EKS-CAP-00053
EKS-CII-00019
EKS-DAR-00064
EKS-EQC-00048
EKS-FEC-00048
EKS-GAG-00041
EKS-GAA-00067
EKS-GOG-00049
EKS-HOS-00052
EKS-ICT-00047
EKS-LAC-00057
EKS-LOA-00051
EKS-MEG-00042
EKS-MOD-00052
EKS-MUM-00052
EKS-MUP-00052
EKS-MYL-00057
EKS-NOL-00048
EKS-ORA-00043
EKS-ORC-00046
EKS-ORL-00064
EKS-OTG-00053
EKS-PAT-00046
EKS-PES-00045
EKS-PEM-00028
EKS-POA-00047
EKS-RAN-00051
EKS-SUS-00042
EKS-TAG-00045
EKS-TAR-00070
EKS-TEN-00073
EKS-VIP-00024
EKS-XET-00051
EKS-XIM-00072
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013