EKS-SAH-00149

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00149

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	368.1	3.1E-110	91	352	262

Status

Unreviewed

Ensembl Protein

ENSSHAP00000018933

UniProt Accession

G3WU29;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB1

Gene Synonyms/Alias

RPS6KB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000016073	ENSSHAP00000018934	ENSSHAT00000019090
ENSSHAG00000016073	ENSSHAP00000018933	ENSSHAT00000019089

Organism

Sarcophilus harrisii

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

MRRRRRRDGF YPAPDFRDGE AEAMAGGFDI DLDQPEDAGS EDELEEGGQL SESMDHGGVG 60

PYEIGMEHCE KFEISETSVN KGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF 120

AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL 180

FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC 240

KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK 300

TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL 360

LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE 420

SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASAATTQT PVDYPMETSG 480

IEQMDVTIFD SAHYGKASQT LKCKMIGVKK ARLLLFLLLV K 521

Nucleotide Sequence
(FASTA)

ATGAGGCGGC GGCGGCGGCG GGACGGATTT TACCCAGCGC CAGACTTCAG AGACGGGGAA 60

GCTGAGGCCA TGGCAGGAGG TTTTGACATC GACCTGGACC AGCCGGAAGA CGCAGGCTCT 120

GAGGATGAGC TGGAGGAAGG GGGTCAATTA AGTGAAAGCA TGGACCATGG GGGAGTTGGA 180

CCATATGAAA TTGGCATGGA ACATTGTGAA AAATTTGAAA TCTCAGAAAC TAGTGTGAAC 240

AAAGGGCCAG AAAAAATAAG ACCAGAATGT TTTGAGCTAC TTCGAGTACT TGGTAAAGGA 300

GGCTATGGAA AGGTTTTCCA AGTACGAAAA GTAACAGGAG CAAATACTGG GAAAATATTT 360

GCCATGAAGG TGCTTAAAAA GGCTATGATA GTAAGAAATG CAAAAGATAC AGCTCATACA 420

AAAGCAGAAC GAAATATCCT CGAAGAAGTA AAGCACCCCT TCATTGTGGA CTTAATTTAT 480

GCCTTTCAGA CTGGTGGAAA ACTCTACCTC ATCCTGGAGT ATCTCAGTGG AGGAGAATTA 540

TTTATGCAGT TAGAAAGAGA GGGAATATTT ATGGAAGATA CAGCTTGCTT TTACTTGGCA 600

GAAATCTCCA TGGCTTTGGG GCATTTACAT CAAAAAGGGA TCATCTACAG AGACCTGAAG 660

CCGGAAAATA TCATGCTTAA TCACCAAGGT CATGTGAAAT TGACGGACTT TGGACTATGC 720

AAAGAATCCA TTCATGATGG AACAGTCACA CACACGTTCT GTGGAACAAT AGAATACATG 780

GCTCCTGAAA TCTTGATGAG AAGTGGTCAT AATCGTGCCG TGGACTGGTG GAGTTTGGGG 840

GCATTAATGT ATGACATGCT GACTGGAGCA CCTCCATTTA CTGGGGAGAA CAGAAAAAAG 900

ACGATTGACA AAATCCTAAA ATGTAAACTT AATTTGCCTC CCTACCTCAC ACAAGAAGCC 960

AGAGATCTGC TTAAAAAGCT GCTAAAAAGA AATGCTGCTT CACGTCTTGG AGCTGGTCCT 1020

GGCGATGCTG GAGAAGTTCA GGCTCATCCT TTCTTCAGAC ACATTAACTG GGAAGAACTT 1080

CTGGCTCGGA AGGTGGAGCC CCCTTTTAAA CCTCTTTTGC AATCTGAAGA GGATGTGAGC 1140

CAGTTTGATT CAAAGTTTAC ACGTCAGACA CCTGTTGACA GCCCAGATGA CTCAACTCTC 1200

AGTGAAAGTG CCAACCAGGT CTTTCTGGGT TTTACATATG TGGCTCCATC TGTACTTGAA 1260

AGTGTGAAAG AAAAATTTTC ATTTGAACCA AAAATCCGAT CACCTCGAAG ATTCATTGGT 1320

AGCCCTCGGA CACCTGTCAG CCCAGTCAAA TTTTCTCCTG GGGATTTCTG GGGAAGAGGT 1380

GCTTCAGCCA GTGCAGCAAC TACTCAGACA CCTGTGGATT ATCCCATGGA GACGAGTGGA 1440

ATTGAACAAA TGGATGTGAC GATTTTTGAT TCAGCTCATT ATGGAAAAGC ATCCCAAACT 1500

TTAAAATGCA AAATGATTGG TGTGAAGAAA GCCAGACTAC TTCTGTTTCT TCTTTTGGTG 1560

AAATAA 1566

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++ +tgk++a+Kvlkka +v+  k++++tk+er+iLeev

Q: 91    FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  150

         89***********************************9999999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH

Q: 151   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  210

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 211   QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  269

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k

Q: 270   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLK  325

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLk++ a+Rlga   +a e+++h+f+

Q: 326   KLLKRNAASRLGAgpgDAGEVQAHPFF  352

         *************9*9*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60

KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120

QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR 240

NAASRLGAGP GDAGEVQAHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013