EKS-SAH-00015

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00015

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	510.5	8.9E-154	987	1254	268

Status

Unreviewed

Ensembl Protein

ENSSHAP00000019299

UniProt Accession

G3WV44;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSRR

Gene Synonyms/Alias

INSRR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000016391	ENSSHAP00000019299	ENSSHAT00000019455

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1308

Protein Sequence
(FASTA)

MTAPSSWLWG SCLLMNFLPL GFGLDTPEVC PSLDIRTEVS ELRRLENCTV VEGYLQILLI 60

FTATGEDFQG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGTRLF FSYALVIFEM 120

PHLRDVGLPG LGAILRGAVR VEKNQELCHL STVDWSLLQP TTDANHIVGN KLGEECADVC 180

PGMLGTEEPC IRTTVNGRMD YRCWTSGHCQ RVCPCARGLA CTPRGECCHP ECLGGCSRPS 240

DAQACVACRH FHFGGTCHSA CPQGTYQYEA WRCVTAEYCA SLRALPDLPG RGSDFVIHQG 300

SCLAQCPPGY THNDSSIFCH KCEGLCPKEC KVGTKTIDSL QAAQELIGCT HLKGSLILNL 360

RQGYNLETEL QRSLGLVETI TGFLKIKHSF ALISLGFFRN LKLIRGDFMV DGNYTLYVLD 420

NQNLQQLGEW AEAGLSIPVG KIYFAFNPRL CLEHIYQLEE VTGTRGRQNK AEINPRTNGD 480

RAACKTRPLR FVSNVTESDR ILLRWERYEP LEARDLLSFI VYYKESPFQN ATEHMGPDAC 540

GAPNWNLLDV ELPLSRTQEP GVTLAPLKPW TQYAVFVRAI TLSMAEDSPH QGAQSPIIYL 600

RTLPAAPTVP LDVMSTSNSS SHLLVRWKPP TQRNGNLTYY LVLWQRLAED ADLYLNDYCQ 660

RGLRLPSSST DARFDQEERE PLAEAEPGCC PCRSPSPEQP QQPALEAHEA SFQKKFENFL 720

HNAITLPRSP WKVTSINKNP QRDAGRYRRA AKAPGGGGNG SDFGIQDKVP RERAVLSGLR 780

HFTEYRIDIH ACNHAAHTVG CSAATFVFAR TMPHREADSI PGKVAWKPAS KSSVLLHWPE 840

PPDPNGLILK YEIKYRRLGE EATVLCVSRL RYAKFGGVHL ALLPPGNYTA RVRATSLAGN 900

GSWTDGLPFY IPGPEEEESG GLHVLLTVTP VGLLLLVVLA ALGFFYSRKR NSDGYPNGTL 960

YASVNPEYFS TSDMYVPDEW EVPREQISVM RELGQGSFGM VYEGLAQGLE EGEAPTPVAL 1020

KTVNELASLR ERIEFLKEAS VMKAFKCHHV VRLLGVVSQG QPVLVIMELM TRGDLKSHLR 1080

SLRPEAENNP GLPRPELGDM IQMAGEIADG MAYLTANKFV HRDLAARNCM VSQDFTVKIG 1140

DFGMTRDVYE TDYYRKGGKG LLPVRWMAPE SLKDGIFSTH SDVWSFGVVL WEIVTLAEQP 1200

YQGLSNEQVL RFVMDNGVLE EPEGCPPQLQ ELMSRCWQQN PRQRPTFLQI LDSIKDELRP 1260

SFRLLSFYYS PESRGGRGSL APPDTDPDPH LSPEAPPDYS PPNGSLGH 1308

Nucleotide Sequence
(FASTA)

ATGACAGCAC CCAGCTCTTG GCTCTGGGGA TCTTGCCTGC TGATGAACTT CCTCCCTTTG 60

GGATTTGGCC TGGATACTCC AGAGGTCTGC CCCAGCCTGG ACATCCGCAC AGAGGTGTCG 120

GAACTCCGGC GACTGGAAAA CTGTACCGTG GTGGAAGGCT ACCTACAGAT CCTGCTCATA 180

TTCACAGCAA CTGGGGAGGA TTTCCAGGGA CTCAGCTTCC CCCGCCTCAC CCAGGTCACC 240

GACTACCTTC TCCTCTTCCG GGTCTATGGG CTGGAGAGTC TTCGGGACCT TTTCCCCAAC 300

CTGGCAGTCA TTCGAGGCAC CCGCCTTTTC TTCAGCTATG CCCTGGTCAT CTTTGAGATG 360

CCCCATTTGA GGGATGTGGG GCTTCCAGGC CTGGGTGCCA TCCTTCGAGG GGCTGTGCGT 420

GTAGAGAAAA ACCAAGAGCT GTGCCATCTG TCTACTGTTG ACTGGAGCCT GCTGCAGCCA 480

ACAACCGATG CCAACCACAT TGTGGGCAAC AAGCTAGGAG AGGAATGTGC CGATGTGTGC 540

CCTGGAATGC TGGGCACTGA GGAACCCTGC ATCAGAACCA CCGTCAATGG GCGCATGGAC 600

TACCGCTGCT GGACCTCGGG GCACTGCCAG AGAGTGTGCC CGTGTGCCAG GGGCCTGGCT 660

TGCACCCCAC GGGGTGAGTG CTGCCATCCC GAGTGTCTGG GAGGATGCAG CCGGCCCAGC 720

GACGCCCAGG CCTGCGTGGC CTGCCGGCAC TTCCATTTTG GAGGCACTTG CCACTCAGCC 780

TGTCCCCAGG GCACCTACCA GTATGAGGCT TGGCGCTGTG TGACAGCCGA GTACTGCGCC 840

AGCCTCAGGG CATTGCCCGA CCTGCCTGGC AGAGGCTCTG ACTTTGTCAT CCACCAGGGC 900

AGCTGCTTGG CCCAGTGCCC TCCAGGCTAC ACCCACAACG ACAGCAGCAT CTTCTGCCAT 960

AAGTGTGAGG GGCTGTGCCC CAAGGAGTGT AAGGTGGGCA CCAAGACCAT AGACTCTCTC 1020

CAGGCAGCCC AGGAGCTCAT AGGCTGCACC CATTTGAAGG GCAGCCTGAT CCTTAACCTG 1080

CGCCAAGGCT ATAACTTAGA GACAGAACTA CAGCGAAGTC TGGGCCTGGT GGAAACCATT 1140

ACTGGCTTCC TCAAAATCAA ACACTCCTTT GCCCTCATCT CCCTGGGATT CTTCAGGAAC 1200

CTCAAACTCA TCCGGGGAGA CTTCATGGTG GATGGGAACT ACACGCTCTA TGTGTTGGAC 1260

AATCAGAACC TACAGCAGCT GGGGGAGTGG GCAGAGGCCG GGCTGTCCAT CCCCGTGGGG 1320

AAGATTTATT TTGCCTTCAA TCCACGTCTC TGCCTGGAAC ACATCTACCA GCTCGAGGAG 1380

GTGACGGGAA CGCGGGGCCG GCAGAACAAG GCTGAGATCA ATCCTCGCAC CAATGGAGAC 1440

CGAGCGGCCT GCAAGACCCG GCCTCTCCGG TTTGTCTCCA ATGTGACAGA ATCAGATCGG 1500

ATCCTCCTTC GCTGGGAGCG CTATGAGCCC CTAGAAGCTC GAGACCTCCT GAGTTTCATC 1560

GTTTACTACA AGGAATCTCC ATTCCAGAAT GCCACAGAGC ACATGGGCCC AGATGCTTGT 1620

GGAGCCCCGA ACTGGAACCT GCTGGACGTG GAACTGCCCC TGAGCAGAAC CCAGGAGCCA 1680

GGAGTGACCC TCGCCCCCCT CAAGCCCTGG ACCCAGTATG CCGTCTTCGT GCGGGCTATC 1740

ACCCTGAGCA TGGCAGAGGA CAGCCCCCAT CAGGGGGCCC AGAGCCCTAT CATCTACCTG 1800

CGAACCCTGC CTGCAGCCCC CACAGTGCCC CTGGACGTCA TGTCCACGTC CAACTCTTCC 1860

TCGCACCTGC TGGTGCGCTG GAAGCCGCCC ACGCAGCGGA ACGGGAATCT CACGTACTAC 1920

CTGGTGCTGT GGCAGCGGCT GGCGGAGGAC GCGGATCTGT ACCTCAATGA TTACTGCCAG 1980

CGGGGCCTGC GGCTACCCAG CAGCAGCACG GACGCCCGCT TCGACCAGGA GGAAAGGGAA 2040

CCCCTTGCCG AGGCTGAGCC CGGCTGCTGC CCCTGCCGGA GTCCGTCCCC GGAGCAGCCC 2100

CAGCAGCCTG CCCTCGAAGC GCACGAGGCC TCCTTCCAGA AGAAGTTTGA GAACTTTCTG 2160

CACAATGCTA TCACCCTTCC CAGATCCCCC TGGAAGGTGA CTTCGATCAA CAAGAACCCC 2220

CAGAGGGACG CAGGCCGCTA CCGGAGGGCT GCAAAGGCCC CCGGGGGAGG GGGGAATGGC 2280

TCGGACTTCG GGATCCAAGA CAAGGTACCT CGCGAGCGGG CAGTGCTGAG CGGCCTGCGC 2340

CATTTCACCG AGTACCGCAT CGACATCCAC GCCTGCAATC ACGCCGCGCA CACGGTGGGC 2400

TGCAGCGCGG CCACCTTCGT CTTTGCCCGG ACCATGCCCC ATCGTGAGGC AGACAGCATT 2460

CCGGGGAAGG TGGCCTGGAA GCCAGCCAGT AAAAGCAGCG TCCTCTTGCA CTGGCCTGAG 2520

CCCCCAGACC CTAATGGGCT CATTCTCAAG TATGAAATCA AGTACAGGCG CCTAGGTGAG 2580

GAGGCCACAG TGCTGTGTGT ATCCCGCCTC CGCTATGCCA AGTTTGGGGG AGTCCACCTG 2640

GCCCTCCTGC CCCCCGGCAA CTACACAGCC CGAGTCCGAG CCACCTCCCT GGCCGGAAAT 2700

GGCTCCTGGA CAGATGGCCT GCCGTTCTAT ATCCCTGGTC CTGAGGAAGA GGAGTCAGGG 2760

GGGTTACATG TTCTCCTCAC GGTCACCCCT GTGGGGCTCC TATTGCTCGT GGTCCTGGCT 2820

GCCCTTGGCT TCTTCTACAG TAGGAAGAGG AATAGTGATG GTTACCCCAA TGGGACTCTC 2880

TATGCTTCTG TCAACCCTGA ATACTTCAGC ACTTCCGACA TGTATGTTCC AGATGAATGG 2940

GAAGTGCCTC GAGAGCAGAT TTCTGTGATG CGAGAACTGG GCCAGGGCTC CTTCGGGATG 3000

GTGTATGAGG GGTTGGCACA GGGGCTTGAG GAGGGGGAGG CCCCCACCCC AGTGGCCCTC 3060

AAGACCGTGA ATGAGCTGGC CAGTCTTCGA GAGCGCATCG AATTCCTCAA GGAGGCTTCC 3120

GTCATGAAAG CCTTCAAATG TCACCATGTG GTGCGGCTCC TGGGCGTGGT GTCCCAAGGA 3180

CAACCAGTTC TAGTCATTAT GGAGCTCATG ACCCGAGGGG ACCTCAAAAG CCATCTCCGG 3240

TCCCTGAGGC CTGAGGCAGA GAACAACCCA GGACTCCCTA GACCAGAACT GGGTGACATG 3300

ATCCAGATGG CAGGTGAGAT CGCTGATGGC ATGGCCTACC TCACTGCCAA CAAGTTTGTG 3360

CACCGAGACC TGGCTGCCCG AAACTGCATG GTGTCTCAAG ACTTCACAGT CAAGATTGGG 3420

GACTTTGGGA TGACTCGGGA TGTGTATGAG ACAGATTATT ACCGAAAGGG AGGAAAGGGG 3480

CTGCTCCCTG TCCGTTGGAT GGCTCCTGAA TCCTTAAAAG ATGGAATCTT CAGCACTCAC 3540

TCGGATGTCT GGTCGTTTGG TGTAGTGCTG TGGGAGATTG TGACCCTGGC AGAACAGCCT 3600

TACCAGGGTC TTTCCAATGA GCAGGTGCTC AGGTTTGTCA TGGACAATGG CGTCCTGGAG 3660

GAGCCCGAGG GCTGCCCTCC CCAGCTACAG GAACTAATGA GTCGCTGCTG GCAACAGAAC 3720

CCCCGCCAGC GCCCAACCTT CCTGCAGATC CTGGACAGCA TCAAGGATGA GCTGCGCCCA 3780

TCCTTTCGGC TCCTCTCCTT CTACTACAGC CCCGAAAGCC GAGGGGGCAG GGGCTCCTTG 3840

GCACCTCCTG ACACAGACCC TGATCCCCAC CTGTCCCCTG AGGCCCCCCC AGACTACAGC 3900

CCTCCTAATG GCAGCCTAGG ACACTGA 3927

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+a+++++ge+ t+va+ktvne as rerieflkeasvmk+fk

Q: 987   ISVMRELGQGSFGMVYEGLAQGLEEGEAPTPVALKTVNELASLRERIEFLKEASVMKAFK  1046

         6789********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++p l+++iqma+e

Q: 1047  CHHVVRLLGVVSQGQPVLVIMELMTRGDLKSHLRSLRPEAENNPGLPRPELGDMIQMAGE  1106

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw

Q: 1107  IADGMAYLTANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1166

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdG+f+++sdvwsfGvvlweivtlaeqpyqGlsneqvl+fv+d+gvle+pe cp

Q: 1167  MAPESLKDGIFSTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLRFVMDNGVLEEPEGCP  1226

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

          +l+elm++cwq np++rp+fl+i++++

Q: 1227  PQLQELMSRCWQQNPRQRPTFLQILDSI  1254

         ************************9976

Domain Sequence
(FASTA)

ISVMRELGQG SFGMVYEGLA QGLEEGEAPT PVALKTVNEL ASLRERIEFL KEASVMKAFK 60

CHHVVRLLGV VSQGQPVLVI MELMTRGDLK SHLRSLRPEA ENNPGLPRPE LGDMIQMAGE 120

IADGMAYLTA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180

MAPESLKDGI FSTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLRFVMDN GVLEEPEGCP 240

PQLQELMSRC WQQNPRQRPT FLQILDSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013