EKS-SAH-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	458.3	1.1E-137	173	464	292

Status

Unreviewed

Ensembl Protein

ENSSHAP00000019670

UniProt Accession

G3WW65;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000016699	ENSSHAP00000019670	ENSSHAT00000019827

Organism

Sarcophilus harrisii

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

LQCYCHLCIK ENYTCVTDGI CFVAVTQNAD KVIYNSMCIP EVDLIPRDRP FVCAPSLRDG 60

FLMSPFCCSK DHCNKIEFPT GTPMKPSNLG PVELAAVIAG PVCLVCISLM LMIYICHNRT 120

VIHHRVPNEE DPSLDRPFIS EGTTLKDLIY DMTTSGSGSG LPLLVQRTIA RTIVLQESIG 180

KGRFGEVWRG KWRGEEVAVK IFSSREERSW FREAEIYQTV MLRHENILGF IAADNKDNGT 240

WTQLWLVSDY HEHGSLFDYL NRYTVTVEGM IKLALSTASG LAHLHMEIVG TQGKPAIAHR 300

DLKSKNILVK KNGTCCIADL GLAVRHDSAT DTIDIAPNHR VGTKSRYMAP EVLDDSINMK 360

HFESFKRADI YAMGLVFWEI ARRCSIGDKL GIHEDYQLPY YDLVPSDPSV DEMRKVVCEQ 420

KLRPNIPNRW QSCEALRVMA KIMRECWYAN GAARLTALRI KKTLSQLSQQ EGIKM 475

Nucleotide Sequence
(FASTA)

TTGCAGTGTT ACTGCCACCT CTGCATTAAA GAAAACTACA CATGTGTGAC AGATGGAATT 60

TGCTTTGTTG CTGTAACACA GAATGCAGAC AAAGTTATAT ACAATAGCAT GTGTATACCA 120

GAAGTTGATT TAATTCCCCG AGATAGGCCA TTTGTATGTG CTCCTTCTTT AAGAGATGGG 180

TTTTTGATGT CACCTTTCTG TTGTTCCAAA GACCACTGCA ATAAAATAGA ATTCCCAACA 240

GGTACCCCTA TGAAACCATC TAATCTTGGT CCTGTGGAAT TGGCAGCTGT TATTGCTGGA 300

CCTGTTTGCC TTGTCTGTAT CTCATTGATG TTAATGATCT ACATTTGCCA CAATCGTACT 360

GTCATACATC ATCGTGTTCC AAATGAAGAA GATCCCTCAT TAGATCGCCC TTTTATTTCA 420

GAGGGTACAA CATTAAAGGA CCTAATTTAT GACATGACAA CATCAGGATC TGGGTCAGGA 480

TTACCATTAC TTGTTCAAAG AACTATTGCA AGAACTATTG TATTGCAAGA AAGCATAGGG 540

AAAGGTCGAT TTGGAGAAGT CTGGAGAGGA AAATGGAGAG GAGAAGAAGT GGCAGTAAAA 600

ATATTTTCTT CAAGAGAAGA ACGTTCATGG TTCCGTGAAG CAGAAATTTA TCAAACTGTA 660

ATGTTACGCC ATGAAAACAT TCTGGGATTT ATAGCAGCTG ACAATAAAGA CAATGGTACA 720

TGGACTCAGC TTTGGTTGGT TTCAGATTAT CATGAGCATG GGTCCCTTTT TGATTATTTA 780

AATAGATACA CAGTCACTGT GGAAGGAATG ATAAAATTAG CTTTATCCAC TGCTAGTGGA 840

CTTGCACATC TTCACATGGA GATTGTTGGC ACTCAAGGCA AACCAGCAAT TGCCCATAGA 900

GATCTGAAAT CAAAGAATAT TTTAGTCAAG AAGAATGGAA CGTGCTGTAT TGCAGACTTA 960

GGACTTGCAG TAAGACATGA TTCAGCCACA GATACAATTG ATATAGCTCC AAACCACAGA 1020

GTGGGAACAA AAAGTAGATA CATGGCTCCT GAAGTTCTTG ATGATTCCAT AAATATGAAG 1080

CATTTTGAAT CATTCAAGCG TGCTGACATC TATGCAATGG GATTAGTTTT CTGGGAAATA 1140

GCTCGGAGAT GTTCAATTGG TGACAAACTA GGAATACATG AAGACTACCA ACTGCCTTAT 1200

TATGATCTCG TACCTTCTGA CCCATCAGTA GATGAAATGC GGAAAGTTGT TTGTGAACAG 1260

AAGTTACGAC CAAATATTCC AAATCGGTGG CAGAGCTGTG AAGCCTTGAG AGTTATGGCC 1320

AAAATTATGC GAGAATGTTG GTATGCCAAT GGAGCAGCTA GGCTTACAGC TTTACGTATT 1380

AAGAAAACAT TATCACAACT CAGTCAACAG GAGGGCATAA AAATGTAA 1428

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 173   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  232

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 233   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  292

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk.RYmaP  179

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtk RYmaP

Q: 293   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKsRYMAP  350

         *..**************************************************87*****

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvgsdPsl  237

         Evl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+   + +++e+y+lp+++ v+sdPs+

Q: 351   EVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIgdKLGIHEDYQLPYYDLVPSDPSV  410

         ***********************************977788*******************

S: 238   eemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +em++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 411   DEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  464

         ****************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKSRYMAPEV 180

LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGDKLGI HEDYQLPYYD LVPSDPSVDE 240

MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TL 292

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013