EKS-SAH-00159

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00159

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	490.4	1.1E-147	453	711	259

Status

Unreviewed

Ensembl Protein

ENSSHAP00000019781

UniProt Accession

G3WWH6;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000016791	ENSSHAP00000019781	ENSSHAT00000019938

Organism

Sarcophilus harrisii

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKQ SKIPDGHAGK FSGTTDSLRS KVIELERELK KKDEELQQKE YHLRDLQEKL 60

SKQTIALAEI TEELQNKCIQ LNKLQDVVNI QGGNSLLFSP CKVSLQINRR SSGLVSLHSR 120

RGAKEGVSAE PTTKTFAEFS FEKARVRKDS STSDKKLITD ALNKNQFLKR LDPQQIKDMV 180

ECMYGRNYPQ GSYIIKQGEP GNHIFVLAEG RVEVFQGNKL LSSIPMWTTF GELAILYNCT 240

RTASVKAVSN VKTWALDREV FQNIMRRTAQ ARDEQYRQFL RSVCLLKNLP EDKLTKIIDC 300

LEVEYYDKGD YIIREGEEGS TFFILAKGMV KVTQSTEGND KPQVIKTLQK GDYFGEKALI 360

SSDDVRSANI IAEENDVACL VIDRETFSQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSGWRQTKPL SLEMIQLKEK VAKFSSSSPF QNLEIVTTLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHIYS EKKILEEMCS PFIVKFYRTF KDRKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGMDQMMTYN 660

LILKGIEKID FPKKVTRRPE DLIRRLCRQN PTERLGNLKN GINDIKRHRW LNGFNWEGLK 720

ARSLPSPLKR ELNGPIDHSY FDNYPPEKGI PPDEMSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GCTCTGTGAA ACCCAAACAG TCCAAGATTC CAGATGGCCA TGCGGGGAAG 60

TTTTCCGGCA CAACTGATTC CCTTAGGAGC AAAGTGATAG AACTGGAAAG GGAACTAAAG 120

AAGAAGGATG AAGAGCTGCA GCAGAAGGAA TATCATCTGA GAGACCTGCA AGAAAAGCTC 180

TCAAAGCAGA CTATTGCTCT TGCTGAGATC ACTGAAGAAC TCCAAAACAA GTGCATCCAG 240

CTGAATAAGC TACAAGATGT GGTTAACATT CAGGGAGGAA ACTCACTTCT ATTTTCTCCA 300

TGCAAAGTGT CTCTGCAGAT TAACCGGAGG AGCTCTGGCT TGGTCTCTCT CCACAGCAGG 360

AGAGGTGCCA AGGAAGGGGT ATCTGCTGAA CCAACCACCA AGACCTTTGC AGAATTTTCA 420

TTTGAGAAAG CAAGAGTCAG GAAGGACTCA AGCACCAGTG ACAAGAAGCT CATCACAGAT 480

GCCCTGAATA AAAATCAGTT TTTGAAGAGA TTGGATCCTC AGCAGATCAA AGATATGGTG 540

GAATGTATGT ATGGAAGAAA CTATCCACAA GGCAGTTATA TTATTAAGCA AGGAGAACCT 600

GGAAATCATA TTTTTGTCTT GGCAGAGGGA AGAGTAGAGG TATTCCAAGG GAACAAGCTT 660

CTATCATCAA TCCCTATGTG GACAACATTT GGCGAACTAG CCATTTTATA CAACTGCACA 720

AGGACTGCCT CAGTAAAAGC TGTCTCCAAT GTGAAGACGT GGGCACTAGA TAGAGAAGTA 780

TTCCAGAATA TTATGAGAAG AACAGCCCAA GCTCGAGATG AACAGTATAG ACAGTTCCTT 840

AGGAGTGTGT GTTTGTTGAA GAATTTACCT GAAGATAAAC TAACCAAGAT CATTGACTGC 900

TTAGAAGTGG AATATTATGA CAAAGGAGAT TACATCATCA GAGAGGGGGA GGAAGGAAGC 960

ACCTTTTTCA TTTTAGCCAA AGGAATGGTG AAAGTCACTC AGAGTACTGA AGGCAATGAT 1020

AAACCTCAAG TTATTAAAAC ACTACAAAAA GGTGATTATT TTGGAGAAAA GGCTCTCATC 1080

AGCAGTGATG ACGTTAGATC GGCTAACATC ATCGCAGAAG AAAATGATGT GGCATGCTTG 1140

GTTATTGATC GAGAAACATT CAGTCAAACA GTTGGGACCT TTGAAGAACT CCAAAAGTAC 1200

CTTGAGGGAT ATGTGGCAAA TCTGAATCGT GATGATGAAA AAAGACATGC CAAGAGATCC 1260

ATGTCTGGCT GGAGGCAGAC CAAACCTCTG TCTCTAGAGA TGATTCAGCT AAAGGAGAAG 1320

GTGGCCAAAT TTTCTTCCTC GTCCCCATTC CAGAACCTTG AAATTGTCAC CACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAACTTGTT AAAGTGAAAA ATGAAAATGT GGCATTTGCT 1440

ATGAAGTGTA TAAGGAAGAA ACATATTGTT GATACTAAGC AACAGGAGCA TATTTATTCA 1500

GAAAAGAAAA TCCTGGAAGA GATGTGTTCT CCATTTATTG TAAAATTTTA TCGTACTTTC 1560

AAGGACAGAA AGTATGTCTA TATGCTTTTG GAGGCCTGTT TAGGTGGGGA ACTGTGGAGT 1620

ATTCTAAGAG ACAGGGGCAG CTTTGATGAA CCCACTTCTA AGTTCTGTGT TGCCTGTGTG 1680

ACAGAAGCAT TTGATTATTT GCATCGCCTG GGTATTATCT ACAGGGATTT AAAGCCAGAG 1740

AATTTAATTC TAGATGCTGA GGGATACCTT AAACTGGTGG ATTTTGGATT TGCAAAGAAG 1800

ATTGGATCTG GACAGAAAAC GTGGACCTTC TGCGGGACCC CGGAATATGT GGCTCCCGAA 1860

GTCATTCTCA ACAAAGGGCA CGACTTCAGT GTGGATTTTT GGTCTTTAGG AATCCTAGTC 1920

TATGAACTGC TGACCGGCAA CCCTCCATTT TCTGGCATGG ACCAAATGAT GACTTATAAT 1980

TTGATTCTCA AGGGAATTGA GAAAATAGAT TTTCCCAAGA AGGTGACACG ACGCCCTGAA 2040

GATTTGATTC GCCGACTTTG CAGGCAAAAT CCTACCGAAA GACTGGGAAA CCTGAAGAAT 2100

GGAATCAATG ATATCAAGAG GCACAGGTGG CTGAATGGTT TTAACTGGGA GGGACTGAAG 2160

GCAAGAAGCT TGCCATCACC TTTAAAAAGA GAGCTCAATG GACCCATAGA TCACAGCTAC 2220

TTTGACAACT ATCCCCCTGA GAAGGGTATA CCCCCAGACG AAATGTCAGG TTGGGATAAG 2280

GACTTCTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++++tlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqeh++sek+ilee++s+

Q: 453   LEIVTTLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHIYSEKKILEEMCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivk+yrtfkd kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKFYRTFKDRKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++p+k+t+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGMDQMMTYNLILKGIEKIDFPKKVTRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dik+h+w+

Q: 692   TERLGNLKNGINDIKRHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIVTTLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHIYSEK KILEEMCSPF 60

IVKFYRTFKD RKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG MDQMMTYNLI LKGIEKIDFP KKVTRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKRHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013