EKS-SAH-00375
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00375
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR535.66.6E-161585910326
StatusUnreviewed
Ensembl ProteinENSSHAP00000019960
UniProt AccessionG3WX05;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000016935ENSSHAP00000019959ENSSHAT00000020116
ENSSHAG00000016935ENSSHAP00000019960ENSSHAT00000020117
OrganismSarcophilus harrisii
Functional Description
Protein Length963
Protein Sequence
(FASTA)
REVLSLAVRT ASFSSQAVPM IEPKGPELVV EQGLNVTLHC VGNTTVDWVS DVNCNTTNCI 60
QQSMGNINTL TIINTTISHT GTYKCLEKGT GNMDGDNSAA SLHLYVKDPE HLWSVPINKV 120
IVFEGSDVLL PCRITDPTAV SSASLERNYN KLVKANVTFD PWKGFTIHKV QFIHRDIYIC 180
KTVVEGKKRL SSKIKLTVEK VLPGPPKLWL EPSEQVRIQG ESAQIVCTAT NIDTRFDIVL 240
KHQQKENISL GQYNYKFIEN YQTTINYTIR DVSPEDSGTY ICKASNHVGS SISFSVLKVV 300
EQGYMNLSSE QSLQQAVVVG ENLDLKVNIE TYPKLLSWNW TYDGPFPDSH HRLQTSLSGK 360
TYRFNTILTL SRLKESEAGY YTFHAENSDA KASLRFEVVL YYPPEVQVHQ ASLNISNALS 420
CIAFGYPAPE ITWYHCLDNK ESCNQDRVLL WHDTNTSVLS QEPFKKVTVE SIFHIQTLME 480
NTTYMCMASN KVGNKSSIFW PILRAPEPVV RSDKDSLFIP VVIACVTIVI LLFFLLLLLL 540
YKYKQKPKYQ VHWKIIEACE GNNYIFIDPT QLPYNEKWEF PRNNLQFGKT LGAGAFGKVV 600
EATAFGLGKE DAVLKVAVKM LKSTAHTDEK EALISELKIM SHLGQHENIV NLLGACTHGG 660
PVLVITEYCH YGDLLNFLRR KTEDMLVPTL SSEPDGGPGY RNIHLEKKYI HGSSTFSSQG 720
LDTYVEMRPV SSSGSFSEQG KLDQEDGRPL ELCDLLRFSS QVAQGMAFLA SKNCIHRDVA 780
ARNVLVTSSR VAKIGDFGLA RDIMNDTNYV VKGNARLPVK WMAPESIFDC VYTVQSDVWS 840
YGILLWEIFS LGLSPYPGIL VNSKFYKLVK EGYQMAQPNF SPPNIYSIMQ ACWDLEPTRR 900
PTFQQICSLL QEEMDSTSKK QDYANVPSSG SSEEEDSVTE PLDCCDQVDS SQPLLQANNY 960
QFC 963
Nucleotide Sequence
(FASTA)
AGAGAAGTAC TGTCTCTAGC AGTCCGTACT GCTTCTTTTT CAAGTCAGGC AGTTCCTATG 60
ATTGAGCCCA AAGGTCCAGA ACTGGTGGTG GAACAAGGAT TAAATGTAAC ACTTCATTGT 120
GTGGGCAATA CCACTGTGGA CTGGGTCAGC GATGTGAACT GCAACACTAC TAACTGTATT 180
CAGCAATCCA TGGGCAACAT CAACACCCTT ACTATCATCA ACACTACAAT TAGTCATACG 240
GGCACCTACA AATGTTTGGA GAAAGGGACA GGAAACATGG ATGGAGATAA CTCTGCTGCC 300
TCCCTGCATC TCTATGTAAA AGATCCGGAA CATCTTTGGA GTGTCCCCAT CAATAAGGTC 360
ATTGTGTTTG AGGGCAGTGA TGTGCTACTG CCCTGTCGGA TCACAGATCC CACAGCAGTG 420
TCTTCAGCAT CCCTGGAGAG AAACTACAAT AAACTTGTCA AGGCCAATGT CACTTTTGAC 480
CCTTGGAAGG GCTTCACCAT CCACAAGGTG CAGTTCATCC ACAGGGACAT TTACATCTGT 540
AAGACTGTGG TTGAAGGGAA GAAAAGATTA TCTTCAAAGA TCAAGCTGAC TGTGGAAAAA 600
GTCCTCCCAG GGCCTCCAAA GTTGTGGCTA GAACCTTCTG AGCAGGTTCG GATACAAGGG 660
GAATCTGCCC AGATTGTCTG CACAGCCACC AATATAGACA CAAGATTTGA TATTGTCCTC 720
AAACACCAGC AGAAGGAGAA TATTTCCCTG GGACAATACA ACTATAAGTT TATTGAGAAC 780
TATCAAACTA CCATCAACTA TACCATCAGA GATGTCAGCC CAGAAGATAG TGGTACCTAT 840
ATCTGTAAGG CTTCCAACCA TGTGGGCTCC AGCATTTCTT TTTCAGTTCT AAAGGTGGTA 900
GAGCAGGGGT ACATGAATCT GTCTTCTGAG CAAAGTCTCC AGCAAGCTGT GGTTGTTGGG 960
GAGAATTTGG ACTTGAAGGT CAATATTGAG ACTTATCCTA AACTGCTTTC CTGGAATTGG 1020
ACTTATGATG GCCCCTTTCC CGACTCCCAC CACAGACTTC AGACCTCCCT ATCAGGGAAA 1080
ACCTACAGGT TCAACACAAT CCTCACTCTG TCTCGGCTGA AAGAATCAGA AGCTGGGTAC 1140
TACACCTTCC ATGCTGAGAA CTCGGATGCT AAGGCTTCTC TCCGCTTTGA GGTCGTCCTA 1200
TACTATCCTC CAGAAGTACA AGTCCATCAG GCATCTCTCA ATATCTCTAA TGCCCTTAGC 1260
TGCATTGCTT TTGGATATCC AGCTCCTGAG ATTACATGGT ACCACTGTTT AGACAATAAA 1320
GAAAGCTGCA ACCAGGACAG AGTGTTGCTG TGGCATGATA CCAATACCTC AGTCTTGAGC 1380
CAGGAGCCCT TCAAAAAAGT GACAGTTGAG AGTATCTTCC ATATCCAAAC CCTGATGGAA 1440
AACACCACCT ACATGTGCAT GGCCAGCAAC AAAGTTGGGA ACAAGTCATC CATCTTCTGG 1500
CCCATCCTGA GAGCTCCAGA ACCTGTTGTC CGGTCTGACA AAGATAGCCT CTTTATCCCT 1560
GTCGTCATTG CCTGCGTCAC CATCGTTATC CTACTTTTTT TTCTGCTCCT CCTGCTCCTG 1620
TATAAATACA AACAGAAACC CAAGTACCAA GTGCACTGGA AGATCATTGA GGCCTGCGAA 1680
GGGAACAACT ACATCTTCAT TGATCCTACA CAGCTGCCCT ATAATGAGAA ATGGGAGTTC 1740
CCCCGAAATA ACCTGCAGTT TGGTAAGACA CTTGGAGCTG GAGCCTTTGG AAAAGTGGTG 1800
GAAGCCACAG CCTTTGGATT GGGGAAGGAA GATGCTGTGC TCAAGGTGGC TGTGAAGATG 1860
CTGAAGTCCA CTGCTCACAC GGATGAGAAG GAGGCCCTCA TATCAGAACT CAAGATCATG 1920
AGCCACCTAG GGCAGCACGA GAACATTGTC AACTTGCTGG GAGCCTGCAC CCACGGAGGC 1980
CCAGTGCTGG TCATCACAGA GTATTGTCAC TACGGTGACC TGCTCAACTT TCTACGCCGT 2040
AAGACAGAAG ACATGTTGGT GCCAACCCTA AGTTCTGAGC CCGATGGAGG CCCAGGGTAC 2100
AGGAATATCC ATCTGGAGAA GAAGTATATC CATGGCAGTA GTACCTTCTC TAGCCAGGGC 2160
CTGGACACCT ACGTGGAGAT GAGACCCGTT TCCTCCTCCG GCTCCTTCTC TGAGCAGGGT 2220
AAGCTAGACC AGGAAGATGG GCGGCCTCTA GAGCTCTGTG ACCTGCTGCG CTTCTCCAGC 2280
CAAGTGGCTC AGGGAATGGC TTTCCTTGCT TCCAAGAACT GTATTCACCG GGATGTAGCT 2340
GCCAGAAACG TGTTGGTGAC CAGTAGTCGT GTAGCCAAGA TTGGGGACTT TGGGCTGGCA 2400
AGGGACATCA TGAATGACAC TAACTATGTG GTCAAAGGCA ATGCACGATT GCCTGTGAAG 2460
TGGATGGCCC CAGAAAGTAT CTTTGACTGC GTCTACACGG TGCAGAGTGA TGTCTGGTCC 2520
TATGGGATTT TGCTCTGGGA AATATTCTCA CTGGGTTTGA GCCCTTACCC TGGCATCCTG 2580
GTGAACAGCA AATTTTATAA GTTGGTGAAG GAGGGATATC AGATGGCCCA GCCCAACTTC 2640
TCTCCCCCAA ACATATACAG CATTATGCAG GCATGCTGGG ACCTGGAGCC CACTCGAAGG 2700
CCCACCTTTC AGCAGATCTG CTCCCTTCTT CAAGAGGAGA TGGATAGTAC TAGTAAAAAA 2760
CAGGACTATG CCAATGTGCC CAGTAGTGGC AGCAGTGAGG AAGAAGACAG TGTCACTGAG 2820
CCCCTGGACT GCTGTGACCA AGTGGACAGC AGCCAACCCC TACTACAAGC CAACAACTAT 2880
CAGTTCTGTT AA 2892
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekeal+selki+shlG
Q: 585   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHTDEKEALISELKIMSHLG  644
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyc yGdlln+lrrk e +l   l+   e++    +++
Q: 645   QHENIVNLLGACTHGGPVLVITEYCHYGDLLNFLRRKTEDMLVPTLSS--EPDGGPGYRN  702
         ******************************************888777..7778888888
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k+++ +s++ss++ ++yv++++    vsss   +++++            +l++e
Q: 703   IhLEKKYIHGSSTFSSQGLDTYVEMRP----VSSS--GSFSEQ-----------GKLDQE  745
         8789***********************....4333..333333...........357899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel dll fs+qva+Gm+flasknc+hrd+aarnvl+t+ +v+ki+dfGlardim+
Q: 746   DGRPLELCDLLRFSSQVAQGMAFLASKNCIHRDVAARNVLVTSSRVAKIGDFGLARDIMN  805
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         d+nyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 806   DTNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLSPYPGILVNSKF  865
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+keGy+maqp++++ +iy+imq+cw+ ep++rp+f+q+++ll
Q: 866   YKLVKEGYQMAQPNFSPPNIYSIMQACWDLEPTRRPTFQQICSLL  910
         ******************************************996
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHTDEKEALI SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCHYGDL LNFLRRKTED MLVPTLSSEP DGGPGYRNIH 120
LEKKYIHGSS TFSSQGLDTY VEMRPVSSSG SFSEQGKLDQ EDGRPLELCD LLRFSSQVAQ 180
GMAFLASKNC IHRDVAARNV LVTSSRVAKI GDFGLARDIM NDTNYVVKGN ARLPVKWMAP 240
ESIFDCVYTV QSDVWSYGIL LWEIFSLGLS PYPGILVNSK FYKLVKEGYQ MAQPNFSPPN 300
IYSIMQACWD LEPTRRPTFQ QICSLL 326
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013