EKS-SAH-00371
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00371
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR580.11.9E-174587942356
StatusUnreviewed
Ensembl ProteinENSSHAP00000020111
UniProt AccessionG3WXF6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000017061ENSSHAP00000020111ENSSHAT00000020271
ENSSHAG00000017061ENSSHAP00000020112ENSSHAT00000020272
OrganismSarcophilus harrisii
Functional Description
Protein Length1092
Protein Sequence
(FASTA)
MLPVLSAWLW LVLLLEVEAL KITPHGSEFV LNISSTFVLT CTGDSPVVWE KTPQQTPPPV 60
LEAQDGTFSS ILTITNVTGL DTGEYICSYN GSQGLEFGGQ KRVYIFVPDS SVGFLPVDPE 120
ELFIFFTGDS ETTIPCRVTD PKLVVTLHEK KVDISLPVAY DHQRGFTGPF EDKTYICKTI 180
IDEREVDSDA YYVYRIQVSS INVSVNAVQT VVRKGENITV LCIVKGNEVV NFDWTYPRME 240
SKRLVEPVTD FLSGLEYDIR SILHIPSAEL GDSGTYVCNV SESYNGHRDM KGVNVTVVDK 300
GFVRFLGELD ELEFAELHKS RTLQMFIEAY PAPTIVWLKD NQTLGSGTAS EISISTRNLS 360
ETRYVSELTL VRVKVNEGGY YTLRAFHDDA ADSFSFQLQI NVPAKVMDLS ESHPSSGEQL 420
LTCRSQGMPQ PILNWFSCSD FKRCPRDVLP TPLGNSSKEE TQLETNVTYW EQEKLFEVVS 480
ILRLQRVDQP LSVICDVYNL LGRDSKEVTI VPHSLPFKVV VISAILALVV LTIISMIILV 540
ILWQKKPRYE IRWKVIESVS SDGHEYIYVD PMQLPYDSSW ELPRERLVLG RTLGSGAFGQ 600
VVEATAHGLS HSQATMKVAV KMLKSTARSS EKQALMSELK IMSHLGPHLN IVNLLGACTK 660
GGPIYIITEY CRYGDLVDYL HRTKHTFLQH CPEKGGSYQC SEVLNPPDHQ LHRQTSLSGE 720
SDGGYMDMRK DDCVDYVPML GMKGEIMYVD IESSNYSSPY DSFAPSVPER SYRATLINDS 780
PILSYMDLVG FSYQVANGME FLASKNCVHR DLAARNVLIC EGKLVKICDF GLARDIMRDS 840
NYISKGSTFL PLKWMAPESI FNSLYTTLSD VWSFGILLWE IFTLGGTPYP ELPMNEQFYN 900
AIKRGYRMAK PTHASEEIYE IMQKCWEEKF EIRPSFSQLV ILMEGLLGEG YKKKYQQVDE 960
EFLRSDHPAI LRTRAQLPTF GGPRGPLDTS SVLYTAVQQN EGDNDYIIPL PDPKPEGPEA 1020
APLESSHSLA SSTLNEVNTS STISCDSPLE LQEELEPEPE EPELEPKPEP QLEPEPEPSP 1080
GPGQQEVEDS FL 1092
Nucleotide Sequence
(FASTA)
ATGCTTCCTG TTCTCTCAGC TTGGCTGTGG CTGGTGTTAT TGCTTGAGGT GGAGGCACTG 60
AAGATAACCC CCCATGGCTC AGAGTTTGTT CTGAACATCT CCAGCACCTT TGTCCTGACT 120
TGCACAGGGG ATTCCCCAGT GGTCTGGGAA AAGACTCCCC AGCAGACCCC ACCACCTGTT 180
CTTGAGGCCC AAGATGGCAC CTTCTCCAGC ATCTTGACCA TCACCAACGT CACTGGTCTT 240
GACACAGGAG AGTACATATG TTCCTACAAT GGCTCCCAAG GCTTAGAGTT TGGTGGGCAG 300
AAGCGGGTCT ACATCTTTGT GCCAGATTCC TCTGTGGGTT TCCTCCCTGT GGATCCTGAA 360
GAGCTGTTCA TCTTCTTCAC GGGAGACAGT GAGACCACAA TCCCGTGTCG AGTGACTGAC 420
CCCAAACTGG TGGTAACGTT GCATGAGAAG AAGGTGGACA TATCCCTGCC TGTTGCCTAT 480
GACCACCAGC GTGGATTCAC CGGCCCCTTT GAGGACAAGA CCTACATCTG CAAAACCATC 540
ATTGATGAGA GGGAGGTAGA CTCTGACGCT TATTATGTCT ACCGCATCCA AGTCTCATCC 600
ATCAATGTCT CTGTGAATGC AGTTCAGACT GTGGTGCGGA AGGGTGAGAA CATCACTGTG 660
CTCTGCATTG TGAAGGGTAA TGAAGTGGTG AACTTTGACT GGACTTACCC TCGAATGGAG 720
AGTAAGCGGC TGGTGGAGCC AGTGACAGAT TTCCTTTCGG GGTTAGAGTA TGACATCCGC 780
TCCATCCTGC ATATCCCCAG TGCCGAGCTG GGAGATTCTG GTACCTATGT CTGCAATGTC 840
TCAGAGAGTT ACAATGGCCA CAGGGACATG AAAGGAGTCA ACGTCACAGT GGTGGACAAA 900
GGGTTTGTGA GATTTCTGGG GGAGTTGGAT GAGCTGGAGT TTGCTGAACT GCACAAAAGT 960
CGAACCCTAC AGATGTTCAT CGAAGCGTAC CCTGCACCCA CCATTGTGTG GCTCAAGGAC 1020
AACCAGACTT TGGGCTCTGG AACTGCCAGT GAGATCTCTA TCTCCACCAG GAATTTGTCT 1080
GAGACGAGGT ATGTGTCAGA GCTGACCTTA GTACGAGTAA AGGTGAATGA AGGGGGTTAT 1140
TATACCCTCA GAGCCTTCCA TGATGATGCT GCTGACTCGT TCTCCTTCCA GTTGCAGATC 1200
AACGTTCCCG CTAAGGTGAT GGATCTGAGT GAGAGCCACC CCAGCAGTGG GGAGCAACTC 1260
CTCACTTGCC GAAGTCAGGG GATGCCACAG CCAATCCTCA ACTGGTTCAG TTGCAGTGAT 1320
TTTAAGAGGT GTCCCCGCGA TGTTCTGCCT ACCCCACTGG GGAACAGCTC CAAGGAGGAA 1380
ACTCAGTTGG AAACCAATGT GACCTACTGG GAGCAAGAGA AATTGTTTGA GGTAGTCAGC 1440
ATCCTGCGCT TGCAACGTGT GGACCAGCCC CTCTCTGTCA TCTGTGACGT GTACAACCTC 1500
CTGGGGAGAG ACAGCAAGGA AGTCACCATT GTTCCACATT CCCTGCCCTT CAAGGTGGTT 1560
GTGATTTCAG CCATCCTGGC CTTAGTGGTC CTCACAATCA TCTCCATGAT CATCCTTGTA 1620
ATTCTGTGGC AGAAGAAACC CCGCTATGAG ATCCGCTGGA AGGTGATTGA ATCTGTGAGC 1680
TCGGATGGTC ATGAATACAT CTACGTGGAT CCCATGCAAT TGCCCTATGA CTCCAGCTGG 1740
GAACTGCCCC GAGAGCGGCT TGTGCTTGGT CGTACACTTG GTTCTGGAGC CTTTGGGCAA 1800
GTAGTGGAGG CCACAGCCCA TGGACTAAGC CACTCCCAGG CCACAATGAA GGTGGCTGTC 1860
AAGATGCTAA AATCCACCGC CCGGAGCAGT GAGAAGCAGG CCCTTATGTC TGAATTGAAG 1920
ATCATGAGCC ACCTGGGGCC CCACCTGAAC ATTGTCAACC TGCTGGGGGC GTGCACTAAA 1980
GGAGGCCCCA TCTACATCAT CACAGAATAC TGCCGTTATG GAGATCTCGT AGACTATCTA 2040
CATCGAACCA AGCACACGTT CTTGCAGCAT TGTCCTGAGA AAGGAGGGTC TTACCAGTGC 2100
TCAGAGGTCC TGAACCCTCC TGACCATCAG CTGCACAGAC AAACATCGCT ATCGGGGGAG 2160
AGTGACGGAG GCTACATGGA CATGAGGAAG GATGACTGTG TGGACTATGT CCCAATGCTG 2220
GGCATGAAGG GAGAGATCAT GTATGTGGAT ATTGAATCCT CCAACTACAG CTCGCCCTAT 2280
GATAGCTTTG CACCCTCTGT TCCAGAGAGA TCCTACAGAG CCACCCTGAT CAACGATTCC 2340
CCTATCCTCA GTTACATGGA CCTTGTGGGC TTCAGTTACC AGGTGGCCAA TGGCATGGAG 2400
TTCCTGGCTT CCAAGAATTG TGTCCATCGA GACCTGGCAG CCAGGAACGT GCTCATCTGT 2460
GAGGGTAAAC TTGTCAAGAT CTGTGACTTT GGCCTGGCCC GGGACATCAT GCGTGACTCC 2520
AACTACATCT CCAAAGGCAG TACTTTCCTG CCCTTGAAGT GGATGGCTCC AGAAAGCATC 2580
TTCAACAGCC TGTACACCAC CCTGAGTGAT GTGTGGTCCT TCGGCATCCT CCTCTGGGAG 2640
ATCTTCACCC TGGGTGGCAC CCCTTATCCA GAGTTGCCCA TGAATGAGCA GTTCTACAAT 2700
GCCATCAAGC GTGGCTACCG CATGGCCAAA CCCACTCATG CCTCTGAAGA GATCTATGAA 2760
ATCATGCAGA AGTGTTGGGA GGAGAAATTC GAAATTCGAC CCTCCTTCTC TCAATTGGTC 2820
ATTCTGATGG AGGGCCTTCT GGGGGAGGGC TACAAGAAGA AGTACCAGCA AGTTGATGAA 2880
GAATTTTTGA GAAGCGACCA CCCGGCCATT CTGCGCACCC GAGCCCAGCT CCCTACATTT 2940
GGTGGCCCGA GGGGCCCCCT TGACACCAGC TCTGTTCTCT ACACGGCCGT GCAGCAGAAT 3000
GAAGGGGACA ATGACTACAT CATCCCCCTG CCAGACCCTA AGCCTGAAGG ACCCGAGGCA 3060
GCCCCACTGG AGAGTTCCCA CAGTCTCGCC AGCTCTACCC TGAATGAAGT CAACACATCA 3120
TCCACCATCT CTTGTGATAG TCCCCTGGAG CTTCAAGAAG AACTAGAGCC CGAGCCAGAG 3180
GAGCCAGAGC TGGAGCCGAA GCCAGAGCCA CAGCTGGAGC CAGAGCCAGA GCCCAGCCCG 3240
GGCCCGGGGC AGCAGGAGGT GGAGGATAGC TTCCTGTAG 3279
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 587   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  646
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactkgGpiy+iteyc+yGdl++yl+r +++fl++  ek    + +   + 
Q: 647   PHLNIVNLLGACTKGGPIYIITEYCRYGDLVDYLHRTKHTFLQHCPEKGGSYQCSEVLN-  705
         ******************************************99999977666655555.
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
          + d++l++++sls es++ y+d++kd                + d++ss++++++++  
Q: 706   -PPDHQLHRQTSLSGESDGGYMDMRKDdcvdyvpmlgmkgeimYVDIESSNYSSPYDSFA  764
         .89*********************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          s+ er+++a+l+++ s  l+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk
Q: 765   PSVPERSYRATLIND-SPILSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  823
         *************98.9*******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+
Q: 824   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  883
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         lG+tpyp+l+++++fy++ik+Gyrma+p++a+eeiyeimqkcwe+++e rpsf+qlv l
Q: 884   LGGTPYPELPMNEQFYNAIKRGYRMAKPTHASEEIYEIMQKCWEEKFEIRPSFSQLVIL  942
         ********************************************************987
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNIVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRTKHT FLQHCPEKGG SYQCSEVLNP 120
PDHQLHRQTS LSGESDGGYM DMRKDDCVDY VPMLGMKGEI MYVDIESSNY SSPYDSFAPS 180
VPERSYRATL INDSPILSYM DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK 240
ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 300
TPYPELPMNE QFYNAIKRGY RMAKPTHASE EIYEIMQKCW EEKFEIRPSF SQLVIL 356
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013