EKS-SAH-00260

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00260

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	449.9	3.9E-135	174	463	290

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020127

UniProt Accession

G3WXH2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017075	ENSSHAP00000020127	ENSSHAT00000020287

Organism

Sarcophilus harrisii

Functional Description

Protein Length

474

Protein Sequence
(FASTA)

SGLKCVCLLC EYSNFTCQTE GACWASVMLT NGREEVIKSC VSLPELNAQV FCHSSNNITK 60

TECCFTDFCN NITLHLPTAA VSPKLQKLGP VELTIIITIP VCLLSIAAML TICTCQGRQC 120

TYKKKKRQNV EEPLNECNLV NSGKTLKDLI YDMTTSGSGS GLPLLVQRTI ARTIVLQEIV 180

GKGRFGEVWH GRWCGEDVAV KIFSSRDERS WFREAEIYQT VMLRHENILG FIAADNKVLD 240

NGTWTQLWLV SEYHEQGSLY DYLNRNTVTL DGMIRLALSV ASGLAHLHME IVGTQGKPAI 300

AHRDLKSKNI LVKKCEACAI ADLGLAVKHD SVLNTIDIPQ NPRVGTKRYM APEVLDDTMN 360

MNIFESFKRA DIYSLGLVYW EIARRCSVGG ITEEYQLPFY DMVPSDPSVE DMRKVVCEQK 420

YRPNIPNQWQ SCEALRVMGR IMRECWYANG AARLTALRIK KTISQLCVKE DSKI 474

Nucleotide Sequence
(FASTA)

TCAGGACTGA AGTGTGTGTG TCTGTTGTGT GAATATTCAA ACTTTACCTG TCAAACTGAA 60

GGAGCATGTT GGGCCTCAGT CATGCTTACA AATGGAAGAG AAGAGGTGAT CAAATCCTGT 120

GTCTCCCTAC CTGAGCTCAA TGCTCAAGTC TTCTGTCACA GTTCGAATAA TATTACAAAG 180

ACTGAATGCT GCTTCACAGA TTTTTGCAAC AATATTACCC TACACCTCCC AACAGCTGCA 240

GTATCTCCAA AACTGCAAAA ACTAGGACCA GTGGAGCTAA CCATAATTAT CACCATACCA 300

GTGTGCCTTT TGTCTATAGC TGCAATGTTG ACTATATGTA CCTGTCAAGG ACGTCAATGC 360

ACTTATAAAA AGAAAAAGAG GCAAAATGTG GAAGAACCAC TAAATGAATG CAACTTAGTA 420

AATTCTGGGA AAACTCTTAA AGATCTTATT TATGATATGA CTACATCTGG GTCTGGATCG 480

GGTTTACCTC TATTGGTTCA GAGAACAATT GCAAGGACAA TTGTACTTCA GGAAATAGTA 540

GGAAAAGGTA GATTTGGTGA AGTATGGCAT GGCAGGTGGT GTGGGGAAGA TGTGGCTGTG 600

AAAATATTTT CCTCAAGAGA TGAAAGGTCT TGGTTTCGTG AGGCAGAAAT CTACCAAACA 660

GTTATGCTGC GACATGAAAA CATCCTTGGC TTCATTGCTG CTGATAATAA AGTTTTAGAT 720

AATGGAACTT GGACTCAGTT GTGGCTTGTC TCTGAATACC ATGAGCAAGG TTCTTTATAT 780

GACTATTTAA ATAGAAACAC AGTGACATTG GATGGTATGA TACGATTGGC ACTTTCAGTA 840

GCGAGTGGTC TGGCCCATCT ACATATGGAG ATAGTTGGGA CACAAGGCAA ACCTGCAATT 900

GCTCATCGAG ATCTAAAATC AAAGAATATT TTAGTGAAAA AATGTGAAGC CTGTGCCATT 960

GCAGACTTAG GACTGGCTGT GAAGCATGAT TCAGTATTGA ACACAATTGA CATCCCTCAG 1020

AACCCCAGAG TGGGAACAAA GAGGTATATG GCTCCTGAGG TGCTTGATGA TACAATGAAT 1080

ATGAATATTT TTGAATCCTT CAAACGTGCT GACATATATT CTCTTGGTCT GGTATATTGG 1140

GAAATAGCAC GGAGATGTTC AGTTGGAGGA ATCACTGAAG AGTACCAATT GCCTTTTTAT 1200

GACATGGTGC CTTCAGATCC CTCAGTAGAA GACATGAGAA AAGTTGTTTG TGAACAGAAA 1260

TATAGACCAA ATATACCAAA TCAGTGGCAA AGTTGTGAGG CACTCCGAGT AATGGGTAGA 1320

ATAATGAGGG AGTGTTGGTA TGCAAATGGG GCAGCTCGCT TGACAGCTCT GCGTATTAAG 1380

AAGACCATTT CCCAACTTTG TGTAAAAGAA GACTCCAAAA TATAA 1425

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 174   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  233

         5789********************************************************

S: 61    adk..keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivg  118

         ad+   +++++t+l+lv+eyhe+gsL+dyL+r+t++++ ++rlals+asGlahLH+eivg

Q: 234   ADNkvLDNGTWTQLWLVSEYHEQGSLYDYLNRNTVTLDGMIRLALSVASGLAHLHMEIVG  293

         **977799****************************************************

S: 119   tkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYma  178

         t+g  KpaiaHRDlkskNilvkk ++c+iaDlGLa+k+++  +++d+ +n +vGtkRYma

Q: 294   TQG--KPAIAHRDLKSKNILVKKCEACAIADLGLAVKHDSVLNTIDIPQNPRVGTKRYMA  351

         ***..*******************************************************

S: 179   PEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsle  238

         PEvl++++n++ fe+fkraD+YslgLv+WE+a+Rc+  ++++eey+lpf+++v+sdPs+e

Q: 352   PEVLDDTMNMNIFESFKRADIYSLGLVYWEIARRCSV-GGITEEYQLPFYDMVPSDPSVE  410

         ************************************9.**********************

S: 239   emkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +m++vv+e+k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 411   DMRKVVCEQKYRPNIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  463

         **************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKVLDNGT WTQLWLVSEY HEQGSLYDYL NRNTVTLDGM IRLALSVASG LAHLHMEIVG 120

TQGKPAIAHR DLKSKNILVK KCEACAIADL GLAVKHDSVL NTIDIPQNPR VGTKRYMAPE 180

VLDDTMNMNI FESFKRADIY SLGLVYWEIA RRCSVGGITE EYQLPFYDMV PSDPSVEDMR 240

KVVCEQKYRP NIPNQWQSCE ALRVMGRIMR ECWYANGAAR LTALRIKKTI 290

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013