EKS-SAH-00288

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00288

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	511.1	6.9E-154	449	718	270

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020271

UniProt Accession

G3WXW6;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

LTK

Gene Synonyms/Alias

LTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017193	ENSSHAP00000020271	ENSSHAT00000020431

Organism

Sarcophilus harrisii

Functional Description

Protein Length

835

Protein Sequence
(FASTA)

SPTPTPVILG IFSAGAILCS SSSESPVPSL TPPPLPPPVL SLERTGVVSQ SGTQEPAASH 60

GLSGLDGQWQ FSTCGASGRR GPTQAQCDGA YAGGNVAVTV GAEGSLRGVQ LWKVPAPARY 120

LISAYGAAGG KGAKNHNSRA HGVFVSSIFT LHQGELLYIL VGQQGGDACP GGSPESQDVC 180

LGASTAAEEE EKAAGTPASL GRRRWAGGGG GGGGASYGLL GWAPTGGLGG GGGPCTAGGG 240

GGGYREDPAL GSTWQISVCL SLPPYLPHSP GGDTSETDDL WTDGEDGVSF VHPSSELYLH 300

PLQVTENHGE VDIRLHLNCS HCPLKECHWK AELRAAVCLC PDGTALVGDN VTCTELPSPL 360

SPLVLTMVVV VVMASTLSLL LVCGGLVAHQ QKWWGLWGTR LPGAEFSLSK LRISAIRTAP 420

NPNYCQVGLC PRLPLPLPPG LLEVPRGNIT LLRALGHGAF GEVYEGLVLG IADGPNPLQV 480

AIKTLPELCS QQDEMDFLME ALIISKFSHQ NIVRCVGLSL RAPPRLILLE LMAGGDMKSF 540

LRHSRPHLGQ PSPLTMRDLL HLARDVAQGC HYLEENHFIH RDIAARNCLL TCGGPGRVAK 600

IGDFGMARDI YRASYYRKGG RAMLPVKWMP PEAFLEGIFT SKTDSWSFGV LLWEIFSLGY 660

MPYPGRTNQE VLDFIIGGGR MDPPRSCPGP VYRIMTQCWQ HQPDHRPNFA SILERLHYCS 720

QDPDVLNTPL PVDLGPAPEE EGASVLGNGL SHPLLATGRV NAPQPQELRV DNLETWGVSS 780

SGPKPSKAKG LQLLDKRQSL WNPTYGSWAS PGFEGEDSGI EENSTSSPSP SPTFL 835

Nucleotide Sequence
(FASTA)

AGCCCGACTC CCACCCCTGT TATTCTCGGC ATTTTTTCTG CAGGTGCCAT TCTCTGCTCC 60

TCGAGCTCCG AGTCTCCGGT GCCTTCCCTC ACACCCCCGC CTCTGCCGCC TCCCGTCCTC 120

AGTCTCGAGA GGACCGGTGT CGTCTCCCAG AGTGGCACTC AGGAGCCCGC AGCTTCCCAT 180

GGCCTTTCCG GACTAGATGG TCAGTGGCAG TTTTCCACCT GCGGAGCTAG CGGCAGGCGC 240

GGCCCCACGC AGGCGCAGTG CGACGGGGCG TACGCGGGAG GCAACGTGGC GGTGACCGTG 300

GGAGCTGAGG GCTCCCTGCG GGGAGTGCAG CTCTGGAAGG TGCCGGCTCC CGCCCGTTAT 360

CTGATCTCTG CTTACGGGGC CGCCGGAGGC AAAGGAGCCA AGAATCACAA CTCTCGGGCC 420

CACGGGGTCT TCGTCTCGTC TATCTTTACC TTGCACCAAG GGGAGCTGCT CTACATCCTG 480

GTGGGGCAGC AGGGAGGGGA TGCCTGTCCC GGAGGGAGCC CGGAGAGCCA AGACGTTTGC 540

CTCGGGGCGT CTACAGCAGC GGAGGAAGAA GAGAAGGCGG CTGGAACCCC AGCATCCCTG 600

GGTCGCAGGC GCTGGGCTGG AGGGGGCGGG GGCGGGGGGG GCGCCTCCTA CGGCCTTCTC 660

GGCTGGGCGC CGACTGGCGG CTTGGGGGGC GGGGGCGGAC CCTGCACCGC GGGAGGCGGC 720

GGCGGCGGCT ACCGGGAGGA TCCTGCTCTG GGATCTACCT GGCAAATATC TGTCTGTCTG 780

TCTCTCCCTC CCTACCTCCC TCATTCCCCA GGGGGTGATA CTTCAGAGAC AGATGATCTC 840

TGGACAGATG GAGAGGATGG TGTTTCCTTT GTACATCCCA GCAGTGAGCT CTACCTGCAC 900

CCTTTGCAAG TCACGGAGAA CCACGGCGAG GTGGACATCC GGCTGCACCT CAACTGCAGT 960

CACTGTCCCT TGAAAGAATG CCACTGGAAG GCTGAGCTGC GGGCGGCTGT GTGCCTGTGC 1020

CCTGACGGCA CCGCCTTGGT CGGGGATAAC GTTACTTGCA CAGAACTGCC CTCCCCCCTG 1080

AGCCCTCTGG TTCTGACCAT GGTAGTGGTG GTGGTGATGG CTTCCACCCT GAGCCTGCTC 1140

TTGGTCTGTG GAGGTCTGGT AGCACACCAG CAGAAGTGGT GGGGCTTGTG GGGGACAAGA 1200

CTGCCCGGAG CCGAGTTCTC TCTCAGCAAA CTTCGAATCT CAGCTATCAG AACCGCCCCC 1260

AACCCCAACT ACTGCCAGGT CGGGCTTTGT CCACGCCTGC CCTTGCCCCT CCCTCCAGGG 1320

CTTCTCGAGG TTCCCAGAGG CAATATCACT CTGCTCAGAG CACTGGGACA CGGTGCCTTT 1380

GGTGAGGTCT ACGAGGGGTT GGTGCTGGGC ATTGCTGATG GCCCCAATCC ACTTCAGGTG 1440

GCTATCAAGA CCCTCCCTGA ACTCTGCTCC CAACAGGATG AGATGGATTT CCTGATGGAA 1500

GCACTTATCA TCAGTAAGTT CAGCCACCAG AACATTGTGC GGTGTGTGGG GCTTAGCCTC 1560

CGGGCCCCCC CTCGGCTCAT CCTGCTGGAG CTGATGGCCG GTGGGGATAT GAAGAGCTTC 1620

CTGAGACACA GCCGGCCGCA CCTGGGCCAG CCTTCCCCGC TGACCATGCG AGATCTGCTC 1680

CACCTTGCCC GGGATGTGGC CCAGGGCTGC CATTACCTGG AAGAAAACCA CTTCATCCAC 1740

AGGGACATTG CAGCCCGGAA CTGCCTCCTG ACCTGCGGTG GACCTGGCCG AGTGGCTAAG 1800

ATTGGCGACT TTGGGATGGC TCGGGACATC TACCGAGCAA GTTATTATCG AAAGGGAGGC 1860

CGGGCTATGC TACCTGTCAA GTGGATGCCC CCTGAGGCTT TCCTGGAGGG CATTTTCACC 1920

TCTAAGACTG ACTCCTGGTC TTTTGGGGTC CTGTTATGGG AGATCTTTTC CCTGGGCTAC 1980

ATGCCTTACC CGGGTCGCAC CAACCAGGAG GTGCTGGACT TTATCATTGG AGGAGGCAGG 2040

ATGGACCCGC CTCGGAGCTG CCCTGGCCCA GTGTACCGCA TCATGACCCA GTGCTGGCAA 2100

CATCAGCCTG ACCACCGGCC CAACTTTGCT AGTATCCTGG AACGGCTCCA CTATTGTTCC 2160

CAGGACCCAG ACGTGCTGAA CACACCTCTA CCAGTTGACC TAGGGCCAGC CCCAGAGGAA 2220

GAGGGGGCTT CTGTGCTGGG GAATGGTCTC TCACACCCCC TGCTAGCTAC AGGCCGGGTG 2280

AACGCTCCCC AGCCTCAGGA GCTGCGGGTT GACAACCTTG AGACTTGGGG AGTGAGTTCC 2340

TCTGGCCCCA AGCCCTCCAA GGCCAAGGGG CTCCAGCTGC TGGACAAGAG GCAGAGTCTG 2400

TGGAATCCCA CCTATGGGTC CTGGGCCTCC CCCGGTTTTG AGGGTGAAGA CTCGGGCATT 2460

GAAGAGAACA GCACTTCCTC CCCCAGCCCT TCCCCCACTT TTCTT 2505

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+ralG+GafGevyeglv g+ + + +l+va+ktlpe +s+qde+dfl+ealiiskf+

Q: 449   ITLLRALGHGAFGEVYEGLVLGIADGPNPLQVAIKTLPELCSQQDEMDFLMEALIISKFS  508

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr++G+sl++ prlillel+aGGd+ksflr+srp+  q+s+l+m+dll++a+dva+

Q: 509   HQNIVRCVGLSLRAPPRLILLELMAGGDMKSFLRHSRPHLGQPSPLTMRDLLHLARDVAQ  568

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll++ Gp+rvaki+dfGmardiyra+yyrkggra+lpvkw

Q: 569   GCHYLEENHFIHRDIAARNCLLTCGGPGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKW  628

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeafleGiftsktd+wsfGvllwe+fslG++pypg++nqevl++++ Ggr+d+p+ +p

Q: 629   MPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFIIGGGRMDPPRSCP  688

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+p++rp+f+silerl++

Q: 689   GPVYRIMTQCWQHQPDHRPNFASILERLHY  718

         ***************************975

Domain Sequence
(FASTA)

ITLLRALGHG AFGEVYEGLV LGIADGPNPL QVAIKTLPEL CSQQDEMDFL MEALIISKFS 60

HQNIVRCVGL SLRAPPRLIL LELMAGGDMK SFLRHSRPHL GQPSPLTMRD LLHLARDVAQ 120

GCHYLEENHF IHRDIAARNC LLTCGGPGRV AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180

MPPEAFLEGI FTSKTDSWSF GVLLWEIFSL GYMPYPGRTN QEVLDFIIGG GRMDPPRSCP 240

GPVYRIMTQC WQHQPDHRPN FASILERLHY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR026984	; LTK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013