EKS-SAH-00380
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00380
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk555.91.4E-167538809272
StatusUnreviewed
Ensembl ProteinENSSHAP00000020337
UniProt AccessionG3WY32;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK3
Gene Synonyms/Alias NTRK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000017249ENSSHAP00000020337ENSSHAT00000020498
OrganismSarcophilus harrisii
Functional Description
Protein Length825
Protein Sequence
(FASTA)
MDVSLCPTKC SFWRIFLLGS FWLDYLGSVL ACPANCVCSK TEINCKNPDD GNLFPLLEGQ 60
DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRNIQP 120
RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 180
KLNSQNLFCI STDGSRIPLQ RMNITQCDLP EISVSHINLT VREGENAVIT CNGSGSPLPD 240
VDWTVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 300
VYYPPRVMSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIRV EYYQEGEVSE 360
GCLLFNKPTH YNNGNYTLIA KNQLGTANQT IKGHFLKEPF PESTDNFVSI YEVSPTPPIT 420
VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 480
LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 540
KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 600
VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 660
SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RVGGHTMLPI 720
RWMPPESIMY RKFTTESDVW SFGVILWEIF TYGKQPWFQL SNTEVIECIT QGRVLERPRV 780
CPKEVYDIML GCWQREPQQR LNIKEIYKIL HALGKATPIY LDILG 825
Nucleotide Sequence
(FASTA)
ATGGATGTCT CTCTTTGCCC TACCAAGTGC AGTTTCTGGA GGATTTTTTT GCTGGGAAGC 60
TTCTGGCTGG ACTATCTGGG TTCGGTGCTG GCTTGCCCTG CGAACTGTGT CTGCAGTAAG 120
ACAGAGATCA ATTGCAAGAA TCCCGATGAT GGGAATCTTT TCCCCCTCTT GGAAGGGCAG 180
GATTCAGGGA ACAGTAATGG CAACGCCAGC ATCAATATCA CGGACATCTC AAGGAATATC 240
ACTTCCATAC ACATAGAGAA CTGGCGGAGC TTGCATACAC TCAATGCAGT GGACATGGAG 300
CTCTATACTG GACTTCAAAA GCTGACTATC AAGAACTCAG GACTTCGGAA CATCCAGCCT 360
AGGGCATTTG CCAAGAATCC TCACTTACGT TACATAAATC TTTCCAGCAA TCGGCTCACC 420
ACCCTGTCAT GGCAGCTCTT CCAGACGTTG AGTCTCCGTG AATTGAGATT AGAACAAAAT 480
TTCTTCAACT GTAGCTGTGA CATCCGCTGG ATGCAGCTGT GGCAAGAGCA GGGTGAGGCC 540
AAACTGAACA GTCAGAATCT CTTCTGCATC AGCACAGATG GCTCTCGAAT TCCCCTGCAA 600
CGTATGAACA TCACCCAGTG TGATCTACCC GAGATCAGTG TAAGCCACAT CAACCTGACT 660
GTACGAGAAG GTGAGAATGC TGTCATCACC TGTAACGGCT CTGGCTCCCC TCTGCCTGAT 720
GTGGACTGGA CTGTCACAGG GCTGCAGTCC ATCAATACCC ACCAGACAAA CCTTAACTGG 780
ACCAATGTTC ACGCCATCAA CCTGACCCTG GTTAATGTCA CCAGTGAAGA CAATGGCTTT 840
ACCTTGACCT GCATTGCTGA AAATGTGGTG GGCATGAGTA ATGCTAGTGT GGCACTCACC 900
GTTTACTATC CTCCACGTGT GATGAGCCTA GAAGAACCTG AACTACGGCT GGAGCATTGC 960
ATCGAATTTG TGGTCCGGGG GAACCCACCC CCAACCTTGC ACTGGCTGCA CAATGGGCAG 1020
CCACTAAGGG AATCTAAGAT CATTCGGGTG GAGTACTACC AGGAGGGTGA GGTCTCTGAA 1080
GGCTGCCTCC TCTTCAATAA ACCCACTCAT TATAACAATG GCAACTACAC CCTTATTGCC 1140
AAAAACCAAC TGGGCACAGC CAATCAGACC ATCAAGGGTC ACTTCCTCAA GGAACCCTTT 1200
CCAGAGAGTA CGGATAACTT TGTCTCAATA TATGAAGTGA GCCCCACACC TCCTATCACC 1260
GTGACCCACA AACCAGAGGA GGACACTTTT GGGGTGTCCA TAGCTGTTGG ACTTGCAGCT 1320
TTTGCCTGCG TCCTTTTGGT GGTTCTCTTT ATCATGATCA ACAAGTATGG CCGACGGTCC 1380
AAGTTTGGAA TGAAAGGTCC TGTGGCCGTA ATCAGTGGTG AGGAGGATTC AGCCAGCCCA 1440
CTCCACCACA TAAACCATGG TATCACCACA CCCTCGTCGC TGGACGCCGG GCCGGACACA 1500
GTGGTGATTG GTATGACGCG AATCCCTGTC ATTGAGAACC CTCAATATTT CCGACAGGGA 1560
CACAACTGCC ACAAGCCAGA CACATACGTC CAGCACATCA AGAGGAGAGA CATTGTGTTG 1620
AAGAGGGAGC TGGGTGAAGG AGCTTTTGGG AAGGTATTTT TGGCAGAGTG CTACAACCTC 1680
AGTCCAACCA AGGACAAGAT GCTGGTGGCA GTGAAGGCTT TGAAAGACCC TACCCTTGCT 1740
GCACGTAAGG ATTTCCAGCG AGAAGCAGAA CTGCTCACCA ACCTACAGCA TGAGCACATT 1800
GTCAAGTTCT ATGGTGTGTG TGGAGATGGT GATCCTCTTA TCATGGTCTT TGAGTATATG 1860
AAGCATGGAG ACCTCAACAA ATTCCTCAGG GCTCATGGAC CTGATGCTAT GATTCTGGTG 1920
GATGGGCAAC CTCGCCAGGC CAAAGGAGAA CTGGGCTTGT CCCAGATGCT ACACATTGCC 1980
AGCCAGATTG CCTCTGGCAT GGTATACCTT GCCTCACAGC ATTTTGTCCA CCGGGATCTG 2040
GCCACCAGGA ATTGTTTAGT TGGAGCCAAT CTGTTGGTGA AGATCGGAGA CTTTGGAATG 2100
TCAAGAGATG TCTACAGCAC TGATTACTAC AGGGTGGGAG GTCATACTAT GCTACCAATT 2160
CGCTGGATGC CCCCAGAGAG CATCATGTAC AGGAAGTTTA CTACAGAGAG TGATGTCTGG 2220
AGCTTTGGGG TGATCCTCTG GGAGATCTTC ACTTATGGCA AACAGCCTTG GTTTCAACTC 2280
TCGAATACAG AGGTCATTGA ATGCATTACC CAAGGTCGTG TCTTGGAGAG GCCCCGGGTT 2340
TGCCCCAAGG AGGTCTATGA CATCATGTTG GGATGTTGGC AGAGGGAACC CCAACAGAGG 2400
CTCAATATCA AGGAAATCTA CAAAATTCTT CATGCTCTGG GGAAGGCCAC CCCAATTTAC 2460
CTGGACATCC TTGGCTAG 2478
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlkrelgegafgkvflaecynl+p+kdk+lvavkalkd++ aarkdf+reaelltnlqh
Q: 538   IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQH  597
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep...kgelglsqll  117
         ehivk+yGvc +gdpl++vfeymkhGdlnkflrahgpda++lv+g+p   kgelglsq+l
Q: 598   EHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPrqaKGELGLSQML  657
         ***********************************************9999*********
S: 118   aiakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtm  177
         +ia+qia+G+vylasqhfvhrdlatrnclvg++llvkigdfgmsrdvystdyyrvgg+tm
Q: 658   HIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTM  717
         ************************************************************
S: 178   lpirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvler  237
         lpirw+ppesi+yrkfttesdvws+Gv+lwei+tyGkqp++qlsnteviecitqGrvler
Q: 718   LPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLER  777
         ************************************************************
S: 238   pracpkevydlmlgcwqrepqkrlnikeiyal  269
         pr+cpkevyd+mlgcwqrepq+rlnikeiy++
Q: 778   PRVCPKEVYDIMLGCWQREPQQRLNIKEIYKI  809
         *****************************985
Domain Sequence
(FASTA)
IVLKRELGEG AFGKVFLAEC YNLSPTKDKM LVAVKALKDP TLAARKDFQR EAELLTNLQH 60
EHIVKFYGVC GDGDPLIMVF EYMKHGDLNK FLRAHGPDAM ILVDGQPRQA KGELGLSQML 120
HIASQIASGM VYLASQHFVH RDLATRNCLV GANLLVKIGD FGMSRDVYST DYYRVGGHTM 180
LPIRWMPPES IMYRKFTTES DVWSFGVILW EIFTYGKQPW FQLSNTEVIE CITQGRVLER 240
PRVCPKEVYD IMLGCWQREP QQRLNIKEIY KI 272
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00381
EKS-ANC-00398
EKS-BOT-00410
EKS-CAJ-00415
EKS-CAF-00412
EKS-CAP-00438
EKS-DAR-00796
EKS-EQC-00403
EKS-FEC-00393
EKS-GAG-00347
EKS-GAA-00497
EKS-GOG-00402
EKS-HOS-00417
EKS-ICT-00390
EKS-LAC-00425
EKS-LOA-00419
EKS-MAM-00409
EKS-MEG-00340
EKS-MIM-00063
EKS-MOD-00388
EKS-MUM-00443
EKS-MUP-00405
EKS-MYL-00406
EKS-NOL-00374
EKS-ORN-00522
EKS-ORA-00358
EKS-ORC-00385
EKS-ORL-00477
EKS-OTG-00413
EKS-PAT-00388
EKS-PES-00363
EKS-PEM-00224
EKS-POA-00403
EKS-PTV-00117
EKS-RAN-00425
EKS-SUS-00363
EKS-TAG-00481
EKS-TAR-00517
EKS-TEN-00518
EKS-TUT-00124
EKS-XIM-00513
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005030; F:neurotrophin receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000483; Cys-rich_flank_reg_C.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR001611; Leu-rich_rpt.
IPR000372; LRR-contain_N.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020446; Tyr_kin_neurotrophic_rcpt_3.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07679; I-set; 2.
PF01462; LRRNT; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00013; LRRNT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS51450; LRR; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01942; NTKRECEPTOR3.
PR00109; TYRKINASE.
Created Date20-Feb-2013