EKS-SAH-00365

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00365

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	537.8	4.9E-162	481	746	266

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020382

UniProt Accession

G3WY77;

Protein Name

Protein Synonyms/Alias

Gene Name

TYRO3

Gene Synonyms/Alias

TYRO3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017287	ENSSHAP00000020381	ENSSHAT00000020542
ENSSHAG00000017287	ENSSHAP00000020382	ENSSHAT00000020543

Organism

Sarcophilus harrisii

Functional Description

Protein Length

841

Protein Sequence
(FASTA)

ILLPLLSGLK LIGSPLKLTV SQGQPVKLNC SVEGLEDPEI QWVKDGTLVQ SVDQVYIPIS 60

EQRWISFLSL KSVDRSDAGR YWCQVEDGGE TEPVWLTVEG VPYFTVEPED LTVLPNAPFQ 120

LSCEAVGPPE PVTIIWWRGG TKVGGPALSP SILNVTGVTQ STVFSCEAHN LKGLASSRLA 180

TVYLQALPAA PSNVTVTRLS SNNASVAWIP DSDGRALLHS CTVQVTEAPG GWEVLAVVVP 240

VPPFSCLLRG LEPATNYSLR VRCTNALGPS PYADWVPFQT HGLAPSSTPQ NLHAIRTDYG 300

LILEWEEVIP ESSSEGPLGP YRISWIQENG TQGELTVLGT RVNLTGWDPL KDLTARVCVS 360

NEVGCGPWSQ PLLVSYRDHA GQQGPPHSRT SWVPVVLGVL TALVTAAALA LILLRKRRKE 420

TRFGQAFDSV MARGEPAVHF RAARSFNREG PERIEATLDS LGISDELKDK LEDVLIPEQK 480

FTLGRMLGKG EFGSVREAQL KQEDGSFEKV AVKMLKADII NSSDIEEFLR EAACMKEFNH 540

PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 600

DIASGMEYLS SQNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 660

WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIS GNRLKQPPEC 720

LEEVYELMYQ CWCSDPKQRP SFLTLRMELE EILGRMSVLS ASRDPLYINI ERAEEQAEGG 780

DQLGGDQAVG EGDRNNNGAG PVGGIPSDYR YILSPGGPAE QSGEDLQLEG ACGEAQRQML 840

L 841

Nucleotide Sequence
(FASTA)

ATTCTGCTTC CCCTTCTCTC AGGCCTGAAG CTCATTGGGT CCCCTCTGAA GCTGACAGTA 60

TCTCAAGGGC AGCCAGTGAA GTTGAACTGC AGTGTGGAGG GATTAGAGGA TCCTGAGATC 120

CAGTGGGTCA AAGATGGAAC TTTGGTGCAG AGTGTGGACC AAGTTTACAT TCCTATCAGT 180

GAGCAGCGCT GGATCAGCTT TCTCAGCTTG AAGTCAGTAG ATCGATCGGA TGCTGGGCGG 240

TACTGGTGCC AGGTGGAAGA TGGGGGCGAA ACTGAGCCAG TGTGGCTGAC CGTAGAAGGT 300

GTGCCGTATT TCACTGTGGA GCCAGAGGAT CTCACGGTGC TCCCTAATGC TCCTTTCCAA 360

CTGTCTTGTG AAGCAGTGGG CCCCCCCGAA CCTGTGACCA TCATCTGGTG GAGGGGGGGC 420

ACAAAGGTGG GAGGACCAGC TCTCTCTCCC TCCATTTTGA ATGTGACAGG GGTGACCCAG 480

AGTACTGTGT TCTCCTGTGA AGCCCATAAC CTGAAAGGCC TGGCATCTTC CCGCCTAGCC 540

ACAGTGTATC TTCAAGCTCT TCCAGCAGCA CCTTCTAATG TAACAGTGAC CCGACTATCT 600

AGCAACAATG CCAGTGTGGC CTGGATTCCT GACTCTGATG GCCGAGCTCT GCTCCACTCC 660

TGCACAGTCC AGGTAACGGA GGCTCCAGGA GGTTGGGAGG TCCTGGCGGT GGTAGTTCCG 720

GTGCCACCAT TCAGTTGTTT GCTTCGGGGC TTAGAACCTG CCACCAACTA CAGCTTAAGA 780

GTTCGATGCA CCAATGCCTT GGGACCTTCT CCATATGCAG ACTGGGTACC CTTCCAGACC 840

CACGGCTTGG CCCCATCTAG TACCCCTCAG AACCTCCATG CCATTCGAAC AGACTATGGT 900

CTGATCTTGG AGTGGGAAGA AGTTATTCCT GAGAGTTCTA GTGAGGGCCC CCTGGGGCCT 960

TATAGAATAT CCTGGATTCA AGAAAATGGG ACTCAGGGTG AGCTGACTGT TCTAGGAACT 1020

AGAGTCAACC TGACTGGCTG GGACCCCTTG AAGGACTTGA CAGCCAGAGT GTGTGTCTCC 1080

AATGAAGTTG GCTGTGGTCC TTGGAGCCAG CCTCTGCTTG TCTCCTATCG GGACCATGCT 1140

GGCCAGCAGG GCCCCCCTCA CAGCCGCACA TCTTGGGTGC CTGTAGTCTT GGGCGTTCTG 1200

ACAGCACTTG TGACAGCTGC TGCCCTGGCC TTAATCCTGT TACGTAAAAG AAGGAAGGAA 1260

ACACGGTTTG GGCAAGCCTT TGACAGCGTC ATGGCCCGTG GGGAGCCTGC TGTTCATTTC 1320

CGTGCTGCCA GATCCTTTAA TAGGGAAGGT CCAGAACGAA TTGAGGCCAC ATTGGACAGC 1380

CTGGGTATCA GTGATGAACT GAAAGACAAA CTGGAGGATG TGCTGATCCC CGAGCAGAAG 1440

TTCACCTTGG GCCGGATGTT GGGCAAAGGG GAGTTTGGGT CAGTGAGGGA AGCCCAGCTG 1500

AAGCAGGAGG ATGGCTCCTT TGAAAAGGTG GCAGTGAAAA TGCTCAAAGC GGACATCATC 1560

AACTCCAGTG ACATTGAAGA GTTCCTTCGA GAAGCTGCTT GCATGAAAGA ATTTAACCAC 1620

CCACATGTGG CCAAGCTTGT TGGGGTGAGC CTTCGGAGCC GTGCCAAGGG TCGCTTGCCT 1680

ATCCCCATGG TGATCCTGCC CTTCATGAAG CATGGGGACC TACATGCTTT TCTGCTTGCC 1740

TCCCGAATAG GAGAAAATCC TTTTAACCTG CCTTTGCAGA CACTGATCCG ATTCATGGTG 1800

GACATTGCCA GTGGCATGGA GTACCTGAGC TCCCAGAACT TCATCCACAG GGACCTGGCT 1860

GCTCGGAATT GCATGCTAGC TGAGGACATG ACTGTGTGTG TGGCTGACTT TGGCCTATCT 1920

CGGAAAATAT ACAGTGGTGA TTATTACCGG CAGGGCTGTG CTTCGAAATT GCCTGTCAAA 1980

TGGCTAGCCC TAGAAAGCTT GGCTGATAAC CTGTACACAG TGCATAGTGA TGTGTGGGCA 2040

TTTGGTGTGA CCATGTGGGA AATAATGACT CGGGGACAAA CACCTTATGC CGGTATTGAA 2100

AATGCTGAGA TTTACAACTA CCTCATCAGT GGGAACCGTC TGAAGCAGCC ACCAGAATGT 2160

CTTGAGGAAG TCTATGAGCT CATGTACCAG TGCTGGTGCT CGGACCCCAA GCAGCGTCCT 2220

AGTTTCCTGA CCCTCCGGAT GGAGCTAGAA GAGATCCTGG GCCGAATGTC TGTTCTCTCC 2280

GCCAGTCGAG ACCCTCTTTA CATCAATATT GAGAGGGCTG AGGAGCAAGC AGAAGGGGGT 2340

GACCAGCTGG GTGGGGACCA GGCTGTTGGG GAGGGGGACA GGAACAATAA TGGTGCAGGA 2400

CCGGTAGGGG GTATTCCCAG TGACTATCGC TATATCCTTA GCCCTGGAGG GCCAGCTGAG 2460

CAGTCTGGGG AGGACCTGCA GTTGGAGGGG GCCTGTGGGG AGGCCCAGAG GCAGATGCTC 2520

CTCTAG 2526

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         ++lg++lg+gefgsv+e+qlkqedgs+ kvavk+lk+dii +s+ieefl+eaacmkef+h

Q: 481   FTLGRMLGKGEFGSVREAQLKQEDGSFEKVAVKMLKADIINSSDIEEFLREAACMKEFNH  540

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv

Q: 541   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMV  600

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         diasgmeylss+nfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk

Q: 601   DIASGMEYLSSQNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  660

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl+ gnrlkqp++c

Q: 661   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGNRLKQPPEC  720

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         l+e+y+lmy+cw  dpk+rpsf +lr

Q: 721   LEEVYELMYQCWCSDPKQRPSFLTLR  746

         **********************9988

Domain Sequence
(FASTA)

FTLGRMLGKG EFGSVREAQL KQEDGSFEKV AVKMLKADII NSSDIEEFLR EAACMKEFNH 60

PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 120

DIASGMEYLS SQNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180

WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIS GNRLKQPPEC 240

LEEVYELMYQ CWCSDPKQRP SFLTLR 266

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013