EKS-SAH-00446

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00446

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK2	582.6	9.4E-176	13	271	259

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020493

UniProt Accession

G3WYI8;

Protein Name

Protein Synonyms/Alias

Gene Name

CAMK2A

Gene Synonyms/Alias

CAMK2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017375	ENSSHAP00000020493	ENSSHAT00000020656

Organism

Sarcophilus harrisii

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

MATITCTRFT EEYQLFEELG KGAFSIVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 60

ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 120

EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 180

SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 240

TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 300

GAILTTMLAT RNFSGGKSGG NKKNDGVKKR KSSSSVQLME SSESTNTTIE DEDTKVRKQE 360

IIKVTEQLIE AISNGDFESY TKMCDPGMTA FEPEALGNLV EGLDFHRFYF ENLWSRNSKP 420

VHTTILNPHI HLMGDESACI AYIRITQYVD ANGIPRTAQS EETRIWHRRD GKWQIVHFHR 480

SGAPSVLP 488

Nucleotide Sequence
(FASTA)

ATGGCCACGA TTACCTGCAC CCGCTTCACT GAAGAGTATC AGCTCTTTGA GGAACTGGGC 60

AAGGGTGCCT TTTCCATCGT TAGAAGGTGT GTGAAAGTGT TAGCTGGTCA AGAGTATGCT 120

GCCAAGATTA TCAACACGAA GAAACTCTCA GCCCGAGATC ATCAGAAGCT GGAGCGAGAG 180

GCCCGCATCT GCCGCCTGCT GAAGCATCCA AACATTGTCC GACTCCATGA CAGCATATCG 240

GAGGAAGGGC ATCACTACCT GATATTTGAC CTGGTCACGG GTGGGGAGCT GTTTGAGGAC 300

ATTGTGGCTC GAGAGTACTA CAGTGAAGCT GACGCCAGTC ACTGCATCCA GCAAATCCTA 360

GAGGCTGTCC TTCATTGCCA CCAGATGGGT GTGGTGCATC GGGACTTGAA GCCGGAGAAC 420

CTGCTCCTTG CATCAAAGCT GAAGGGGGCT GCCGTGAAGC TGGCTGACTT TGGCCTGGCC 480

ATCGAGGTGG AAGGGGAGCA GCAGGCGTGG TTTGGCTTTG CAGGGACACC AGGGTACCTC 540

TCTCCTGAAG TTCTCCGAAA AGACCCATAT GGGAAGCCTG TGGATCTTTG GGCATGTGGT 600

GTCATCCTAT ACATCTTGTT GGTAGGATAT CCTCCTTTCT GGGATGAGGA CCAACACCGA 660

CTATACCAGC AGATCAAGGC TGGAGCCTAT GATTTCCCAT CCCCGGAATG GGACACGGTT 720

ACCCCAGAAG CGAAGGACCT GATTAATAAA ATGCTCACCA TCAACCCCTC CAAGCGCATC 780

ACAGCTGCTG AAGCCCTCAA GCACCCCTGG ATCTCTCACC GATCTACAGT GGCCTCCTGC 840

ATGCACAGAC AGGAGACTGT GGACTGCTTG AAGAAATTCA ATGCAAGGAG GAAACTGAAG 900

GGAGCTATCC TTACCACCAT GCTGGCCACC AGGAACTTCT CTGGAGGAAA GAGCGGGGGC 960

AACAAGAAGA ACGATGGTGT GAAGAAAAGA AAGTCCAGTT CCAGTGTTCA GTTAATGGAA 1020

TCCTCTGAGA GTACCAATAC CACCATTGAA GATGAAGACA CCAAAGTGAG AAAGCAAGAA 1080

ATCATTAAGG TGACAGAGCA GCTGATCGAA GCAATAAGCA ATGGGGATTT TGAGTCCTAC 1140

ACGAAGATGT GTGACCCTGG GATGACAGCC TTTGAACCTG AGGCTCTGGG AAACCTGGTT 1200

GAAGGCCTGG ACTTCCACCG ATTCTACTTT GAAAACCTGT GGTCCAGGAA CAGCAAGCCT 1260

GTCCACACCA CTATCCTGAA CCCCCACATC CACTTGATGG GTGATGAATC AGCCTGCATT 1320

GCTTACATCC GCATCACACA ATATGTGGAC GCCAATGGTA TCCCTCGCAC TGCCCAGTCT 1380

GAGGAGACCC GCATCTGGCA CCGCCGGGAT GGCAAATGGC AGATCGTCCA CTTCCACAGA 1440

TCTGGAGCAC CTTCAGTTCT ACCA 1464

Domain Profile

S: 1     yqlfeelgkgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpni  60

         yqlfeelgkgafs+vrrcvkv +gqeyaakiintkklsardhqklerearicrllkhpni

Q: 13    YQLFEELGKGAFSIVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI  72

         9***********************************************************

S: 61    vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvv  120

         vrlhdsiseeg+hyl+fdlvtggelfedivareyyseadashciqqile+vlh+hq+gvv

Q: 73    VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV  132

         ************************************************************

S: 121   hrdlkpenlllaskakgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk  180

         hrdlkpenlllask+kgaavkladfglaiev+g+qqawfgfagtpgylspevlrkdpygk

Q: 133   HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK  192

         ************************************************************

S: 181   pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml  240

         pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml

Q: 193   PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML  252

         ************************************************************

S: 241   tinpakritadealkhpwi  259

         tinp+krita+ealkhpwi

Q: 253   TINPSKRITAAEALKHPWI  271

         ******************8

Domain Sequence
(FASTA)

YQLFEELGKG AFSIVRRCVK VLAGQEYAAK IINTKKLSAR DHQKLEREAR ICRLLKHPNI 60

VRLHDSISEE GHHYLIFDLV TGGELFEDIV AREYYSEADA SHCIQQILEA VLHCHQMGVV 120

HRDLKPENLL LASKLKGAAV KLADFGLAIE VEGEQQAWFG FAGTPGYLSP EVLRKDPYGK 180

PVDLWACGVI LYILLVGYPP FWDEDQHRLY QQIKAGAYDF PSPEWDTVTP EAKDLINKML 240

TINPSKRITA AEALKHPWI 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543	; Ca/CaM-dep_prot_kinase-assoc.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08332	; CaMKII_AD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013