EKS-SAH-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	333.1	1.3E-99	34	292	259

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020494

UniProt Accession

G3WYI9;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK

Gene Synonyms/Alias

SLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017376	ENSSHAP00000020495	ENSSHAT00000020658
ENSSHAG00000017376	ENSSHAP00000020494	ENSSHAT00000020657

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1239

Protein Sequence
(FASTA)

MSFFNFRKIF KLGSDKKKKQ YEHVKRDLNP EDFWEIIGEL GDGAFGKVFK AQNKETNVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTES QIQVVCKQTL EALNYLHENK IIHRDLKAGN ILFTLEGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAQ IEPPHHELNP 240

MRVLLKIAKS EPPTLAQPSK WSSNFKDFLK KCLEKNVDAR WNTSQLLQHP FVTVTSNKPI 300

RELIAEAKAE VTEEVEDGKD DDDDEETENS LPIPANKRAS SDLSIASSEE DKLSQNACVL 360

ESVSEKTEHS TIGDKPESNV INEKTVADKP EKIVERNIDY IADDHLENIV ELQNGTGLIK 420

ANKAEEKELK VEEILEVEDR VSEGNAVIER KDNDQLTTSE IGADLKPEEE KNQKKQQLSK 480

NEIKTNEKDS ADHIAELVSE ETGEKEENIR EANIQGSESE VRLKTEVQDK IEETEVIKGE 540

VGDTGTVETG EVEDLGCNSA GNNAKEAQIN DKNEVIELSE KLKQIKPDPE VSGIKETQEQ 600

RIVETNITDH MSVEGICVMN RSEEHLISTS GDIVLIGDKP VTSEIEEIKE TSSTEEILVQ 660

NTIHTGEKSV GSKTQDSHQP LLDIEQTEFP SEIPVKIEPQ VIITSQPSET QPIIPSININ 720

SQETEEKGET GTSSQAETSV HLEPENQKEN DTDSGTGSTA DNSSIDLNLS ITSFLSKNKD 780

TGSISLQETR RHKKTLKKTR KFVVDGVEVS VTTSKIVTDS DSKTEELRFL RRQELRELRF 840

LQKEEQRAQQ QLNNKLQQQR EQIFRRFEQE MMSKKRQYDQ EIENLEKQQK QTIERLEQEH 900

TNRLRDEAKR IKGEQEKELS KFQNMLKNRK KEVINEVEKA PKELRKELMK RRKEELAQTQ 960

HAQEQEFVQK QQQELDGSLK KIIQQQKAEL ANIERECLNN KQQLMRAREA AIWELEERHL 1020

QEKHQLLKQQ LKDQYFMQRH QLLKRHEKET EQMQRYNQRL IEELKNRQTQ ERARLPKIQR 1080

SEAKTRMAMF KKSLRINSTG TPDQDRDKIK QFAAQEEKRQ KNERMAQHQK HENQMRDLQL 1140

QCEANVRELH QLQNEKCHLL VEHETQKLKE LDEEHGQELK EWREKLRPRK KTLEEEFARK 1200

LQEQEVFFKM TGESECLNPS TQSRISKFYP IPSLHSTGS 1239

Nucleotide Sequence
(FASTA)

ATGTCCTTTT TTAATTTCCG CAAAATCTTC AAATTGGGCA GCGACAAGAA GAAGAAGCAG 60

TACGAGCATG TGAAGAGAGA CCTGAACCCC GAGGATTTTT GGGAAATTAT AGGTGAATTG 120

GGGGACGGAG CCTTTGGGAA AGTGTTCAAG GCCCAGAATA AAGAGACAAA TGTGTTAGCT 180

GCTGCAAAAG TGATTGACAC TAAATCTGAA GAAGAACTTG AAGATTATAT GGTTGAGATT 240

GATATTTTAG CATCATGTGA TCATCCAAAT ATAGTCAAGC TGCTAGATGC ATTCTATTAT 300

GAAAATAATC TTTGGATCCT CATTGAATTT TGTGCAGGTG GTGCAGTAGA TGCTGTGATG 360

CTTGAGCTTG AGAGACCATT AACAGAATCC CAGATACAAG TAGTTTGCAA GCAGACTTTA 420

GAGGCATTGA ACTATTTGCA TGAAAATAAA ATTATCCATA GAGATTTAAA AGCAGGCAAC 480

ATTCTTTTTA CATTGGAAGG AGACATTAAA TTGGCGGATT TTGGTGTATC GGCTAAAAAT 540

ACAAGGACTA TACAAAGAAG AGATTCTTTT ATTGGCACAC CATATTGGAT GGCTCCGGAA 600

GTGGTTATGT GTGAAACATC TAAAGATAGA CCCTATGATT ATAAAGCTGA TGTTTGGTCC 660

TTGGGCATCA CTTTGATAGA AATGGCTCAG ATAGAACCTC CTCATCATGA GCTAAATCCA 720

ATGCGTGTAC TGTTGAAAAT TGCAAAGTCT GAACCACCTA CACTGGCACA ACCATCAAAA 780

TGGTCTTCAA ACTTTAAGGA CTTCCTAAAG AAATGTTTGG AAAAGAATGT GGATGCCAGG 840

TGGAATACTT CCCAGCTTCT CCAGCATCCT TTTGTTACTG TGACTTCCAA CAAACCCATC 900

CGAGAACTGA TTGCAGAGGC AAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAT 960

GATGATGATG ATGAAGAAAC AGAGAATTCT CTGCCTATAC CTGCTAATAA GCGTGCCTCA 1020

TCTGACCTCA GTATTGCCAG TTCAGAAGAA GATAAACTTT CACAGAATGC TTGTGTTCTG 1080

GAATCTGTAT CAGAAAAAAC TGAGCATAGC ACTATTGGAG ACAAACCTGA AAGTAATGTT 1140

ATTAATGAAA AAACTGTTGC TGACAAGCCT GAAAAAATTG TTGAGAGAAA TATTGACTAC 1200

ATTGCTGATG ATCATCTTGA AAATATTGTT GAGCTCCAGA ATGGGACAGG ATTAATTAAG 1260

GCAAATAAGG CAGAAGAGAA AGAACTCAAG GTAGAAGAGA TATTGGAAGT AGAAGATCGT 1320

GTGAGTGAAG GAAATGCAGT GATAGAAAGA AAAGACAATG ATCAACTTAC AACCTCAGAA 1380

ATTGGTGCTG ATCTGAAACC TGAGGAGGAA AAGAATCAGA AAAAGCAGCA GTTATCTAAA 1440

AATGAGATTA AAACAAATGA AAAAGACTCT GCTGATCACA TAGCAGAATT GGTTTCTGAA 1500

GAGACTGGAG AAAAAGAAGA AAATATAAGA GAGGCAAACA TTCAGGGAAG TGAAAGTGAA 1560

GTTAGGCTTA AAACCGAAGT ACAAGATAAA ATAGAGGAAA CTGAAGTCAT TAAAGGTGAG 1620

GTGGGTGACA CAGGCACAGT AGAAACAGGT GAAGTAGAAG ATCTAGGCTG CAACTCAGCT 1680

GGAAACAATG CCAAGGAAGC TCAGATTAAT GACAAAAATG AAGTGATTGA ATTAAGTGAA 1740

AAACTAAAAC AAATTAAACC TGATCCTGAG GTTAGTGGTA TTAAGGAAAC TCAGGAACAA 1800

AGGATAGTTG AAACAAATAT TACAGATCAT ATGTCTGTAG AAGGTATATG TGTTATGAAC 1860

AGAAGTGAGG AACACTTAAT TAGTACTTCA GGGGACATAG TGCTTATTGG TGATAAACCA 1920

GTAACAAGTG AAATTGAAGA AATTAAAGAA ACAAGTAGCA CTGAAGAAAT ATTGGTCCAA 1980

AACACAATTC ATACTGGTGA AAAGTCAGTA GGAAGTAAAA CTCAGGATTC TCATCAGCCT 2040

CTGCTAGACA TTGAACAAAC AGAATTTCCA AGTGAAATAC CAGTTAAAAT TGAACCTCAA 2100

GTTATCATAA CTTCACAACC CAGTGAAACT CAACCAATTA TACCCAGTAT TAATATTAAC 2160

TCTCAAGAGA CAGAAGAGAA AGGGGAAACA GGTACATCAT CCCAAGCTGA AACCTCAGTA 2220

CATTTAGAAC CTGAGAATCA AAAGGAAAAT GACACTGATT CAGGCACTGG CTCCACAGCT 2280

GATAATAGCA GCATTGATTT GAATTTGTCC ATCACTAGTT TCCTAAGCAA AAACAAAGAC 2340

ACTGGATCAA TATCTTTACA AGAAACAAGA AGACATAAGA AAACATTGAA GAAAACAAGA 2400

AAATTTGTTG TTGATGGTGT AGAAGTGAGT GTGACAACTT CAAAAATAGT TACAGATAGT 2460

GATTCAAAAA CTGAAGAATT GAGGTTTCTT CGACGTCAGG AGCTTCGAGA ATTAAGATTT 2520

CTGCAGAAAG AGGAACAAAG AGCTCAGCAG CAGCTCAACA ACAAATTGCA GCAACAGCGG 2580

GAACAAATTT TCAGACGTTT TGAACAAGAA ATGATGAGTA AAAAGCGACA GTATGACCAA 2640

GAGATTGAAA ATCTAGAAAA ACAACAGAAA CAAACAATAG AACGCCTAGA ACAAGAACAT 2700

ACAAATCGCT TACGAGATGA GGCCAAACGA ATCAAAGGAG AACAAGAGAA GGAACTGTCC 2760

AAATTTCAGA ATATGTTGAA AAACCGAAAA AAAGAGGTTA TAAATGAAGT GGAGAAAGCA 2820

CCCAAAGAGC TGAGAAAAGA GCTCATGAAA CGCAGGAAAG AGGAGCTTGC ACAAACCCAG 2880

CATGCTCAGG AACAAGAATT TGTTCAGAAG CAACAACAGG AATTAGATGG ATCATTGAAA 2940

AAGATCATCC AACAGCAGAA GGCAGAATTA GCTAACATTG AGCGAGAATG TCTAAATAAT 3000

AAACAGCAGC TCATGAGAGC ACGCGAAGCT GCTATTTGGG AACTTGAGGA ACGACATTTA 3060

CAAGAAAAAC ATCAACTGCT TAAACAACAA CTCAAGGATC AGTATTTCAT GCAAAGGCAT 3120

CAACTACTTA AGCGCCATGA AAAGGAAACT GAACAAATGC AGAGATATAA TCAACGGCTT 3180

ATTGAAGAAT TAAAAAACAG ACAGACTCAA GAAAGAGCAA GACTACCTAA GATCCAGCGT 3240

AGTGAAGCCA AGACTCGGAT GGCCATGTTT AAGAAGAGTT TGAGAATCAA TTCAACAGGC 3300

ACTCCAGACC AGGACCGTGA CAAAATTAAA CAGTTTGCTG CTCAAGAAGA AAAGAGACAA 3360

AAAAACGAAA GGATGGCTCA GCATCAAAAG CATGAAAATC AGATGCGGGA CCTTCAGTTG 3420

CAGTGTGAAG CTAATGTCCG AGAACTACAT CAACTACAGA ATGAAAAATG TCATCTATTG 3480

GTTGAACATG AGACTCAGAA ACTAAAGGAA TTAGATGAAG AGCATGGTCA AGAACTAAAG 3540

GAGTGGAGAG AAAAATTGAG ACCCAGGAAA AAGACACTGG AGGAAGAATT TGCAAGGAAG 3600

CTTCAAGAAC AAGAAGTATT CTTTAAAATG ACTGGGGAGT CTGAATGCCT TAACCCTTCA 3660

ACTCAGAGTC GCATCTCCAA ATTCTATCCA ATTCCTAGCC TGCACTCCAC TGGATCATAA 3720

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkv++a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv+

Q: 34    WEIIGELGDGAFGKVFKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E+qi+++++++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLEALNYLHENKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t eg++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLEGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaD+wslGIt+ie+a+ epP+++l+p+++llki+k+epp+l +++k+s++fk+f++kc

Q: 213   DYKADVWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLKKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+++s+ll+h+F+

Q: 273   LEKNVDARWNTSQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVFKAQN KETNVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHPNIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTESQIQ VVCKQTLEAL NYLHENKIIH 120

RDLKAGNILF TLEGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADVWSLGI TLIEMAQIEP PHHELNPMRV LLKIAKSEPP TLAQPSKWSS NFKDFLKKCL 240

EKNVDARWNT SQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013