EKS-SAH-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	507.5	1.1E-152	709	1014	306

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020508

UniProt Accession

G3WYK3;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017388	ENSSHAP00000020509	ENSSHAT00000020672
ENSSHAG00000017388	ENSSHAP00000020508	ENSSHAT00000020671

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1134

Protein Sequence
(FASTA)

MKRGEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LPKPSDAAKA EHSMSKMTTE 60

DPRQGRNPPK FVTYHKALQE IRNSLLPFAN EASSSTRSAS EVNRQMLQDM QIAGFDEDMV 120

IRALRQTNNK SIEAAIEFIS KMSYQDPRRE QMAAAAARPV NAGPKPPGNV QQSVNRKQSW 180

KGSKESLVPQ RHGPPLGESV VFRSESPNSQ TDVGRPLSGS GIAAFSQGHP VNGQRVNPPP 240

PPQVRSITPP PPPPRGQTPP PKGTPPSSWE PNSQTKRYSG NMDYMISRIS PVPPGTWQDN 300

YPPPSLNTSP LNPSSQGQRG INSVPVGRQP IIMQSSNNKF NFPSGRPGIQ NGSSQNDFMM 360

HQNVVPGGSV SRQPPPPYPL SPTNGQSPCT LQIQTGGPAN SSPYTNGNIP SSMMVPNRNS 420

HNMELYNITV PALQTSWPQS SSAPPQSSPS SGHEIPAWQP NIPVRSNSFN NPLGNRPSHS 480

ANSQPSATTV TAITPAPIQQ PVKSMRVLKP ELQTALAPTH PSWIPQPIQT TQSVPFSEGP 540

SSTMAVMPPV AEAPNYQGPP PPYPKHLLHQ NSSVPPYESV PKPSKEDQPC SPKEDEGEKN 600

YENTDSGDKE KKQITTSPVP VRKNKRDEER RESRIQSYSP QAFKFFMEQH VENILKSHHQ 660

RLHRKKQLEN EMMRVGLSQD AQDQMRKMLC QKESNYIRLK RAKMDKSMFV KIKTLGIGAF 720

GEVCLARKVD TNALYATKTL RKKDVLLRNQ VAHVKAERDI LAEADNEWVV RLYYSFQDKD 780

NLYFVMDYIP GGDMMSLLIR MGIFPENLAR FYIAELTCAV ESVHKMGFIH RDIKPDNILI 840

DRDGHIKLTD FGLCTGFRWT HDSKYYQSGD HPRQDSMDFS NEWGDPANCR CGDRLKPLER 900

RAARQHQRCL AHSLVGTPNY IAPEVLLRTG YTQLCDWWSV GVILFEMLVG QPPFLAQTPL 960

ETQMKVINWQ TALHIPQQAK LSPEASDLII KLCRGPEDRL GKNGADEIKA HPFFKAIDFS 1020

SDLRQQSASY IPKITHPTDT SNFDPVDPDK LWSEDNDEGN INDTLNGWYK NGKHPEHAFY 1080

EFTFRRFFDD NGYPYNYPKP IEYEYNNLQS SEQQSDEDDQ HTGTGVKNGD LVYV 1134

Nucleotide Sequence
(FASTA)

ATGAAGAGAG GGGAAAAGCC GGAAGGGTAT AGACAAATGA GGCCTAAGAC CTTTCCTGCC 60

AGTAACTACA CTGGCAGTAG CAGGCAAATG TTGCAAGAAA TACGGGAGTC TCTTAGAAAT 120

TTACCTAAAC CATCAGATGC TGCAAAAGCT GAGCACAGTA TGAGCAAAAT GACAACTGAA 180

GATCCTCGAC AAGGTCGGAA TCCACCCAAA TTTGTGACAT ATCATAAAGC TTTGCAAGAA 240

ATAAGAAACT CTCTACTCCC ATTTGCAAAT GAAGCCAGTT CATCCACCAG GAGTGCTTCA 300

GAAGTTAATC GACAAATGCT ACAAGATATG CAAATTGCTG GATTTGATGA GGATATGGTT 360

ATACGAGCAC TTCGGCAAAC TAATAATAAA AGTATAGAAG CAGCAATTGA ATTTATTAGT 420

AAAATGAGTT ACCAAGATCC TCGAAGAGAA CAAATGGCTG CAGCTGCTGC CAGACCTGTT 480

AATGCAGGCC CCAAACCACC AGGGAATGTA CAGCAATCAG TTAACCGGAA ACAAAGCTGG 540

AAAGGCTCTA AAGAATCTTT GGTCCCTCAA AGACATGGCC CACCACTGGG AGAAAGTGTA 600

GTTTTCCGCT CTGAAAGTCC TAACTCTCAG ACAGATGTAG GAAGACCTTT ATCAGGATCT 660

GGTATAGCAG CATTTTCTCA GGGTCATCCT GTCAATGGAC AGAGAGTGAA CCCCCCACCA 720

CCTCCACAAG TAAGGAGTAT TACCCCTCCT CCACCACCTC CAAGGGGCCA GACTCCCCCT 780

CCAAAAGGTA CACCTCCCTC ATCATGGGAA CCAAATTCTC AAACCAAACG TTATTCTGGG 840

AACATGGACT ATATGATTTC TCGTATTTCT CCAGTACCAC CTGGCACGTG GCAGGATAAC 900

TACCCTCCAC CATCTCTAAA CACTTCCCCA TTGAATCCTT CTAGTCAGGG ACAGAGAGGC 960

ATTAATTCTG TCCCTGTTGG CAGACAACCA ATCATCATGC AAAGCTCTAA CAACAAATTT 1020

AACTTTCCAT CGGGAAGACC TGGAATTCAA AATGGCAGTA GTCAGAATGA TTTTATGATG 1080

CACCAAAACG TTGTCCCTGG TGGCTCTGTA AGTCGTCAGC CTCCCCCTCC ATACCCTTTG 1140

TCTCCAACCA ATGGACAGAG TCCTTGTACT TTACAGATAC AAACTGGGGG ACCTGCTAAT 1200

TCTTCACCAT ACACAAATGG AAACATTCCT TCATCTATGA TGGTGCCAAA TAGAAACAGT 1260

CACAATATGG AACTTTATAA CATAACTGTA CCTGCATTAC AAACATCCTG GCCTCAGTCA 1320

TCATCTGCTC CACCCCAATC ATCACCTAGT AGTGGACATG AGATCCCTGC ATGGCAACCT 1380

AACATTCCAG TAAGATCAAA TTCTTTCAAT AATCCATTAG GAAATAGACC AAGCCACTCT 1440

GCTAATTCTC AGCCTTCAGC TACAACAGTA ACTGCTATTA CACCAGCCCC TATTCAGCAA 1500

CCAGTGAAAA GCATGCGTGT CTTAAAACCA GAACTCCAGA CTGCTTTAGC ACCTACCCAT 1560

CCTTCTTGGA TTCCACAACC AATTCAAACC ACACAGTCAG TCCCCTTTTC TGAGGGTCCA 1620

TCCTCAACTA TGGCAGTTAT GCCACCTGTT GCTGAGGCTC CAAATTATCA AGGCCCTCCA 1680

CCACCATATC CAAAACATTT ACTACACCAG AATTCCTCTG TTCCTCCTTA TGAATCAGTA 1740

CCCAAACCTA GCAAAGAGGA TCAACCTTGT TCACCGAAGG AAGATGAAGG GGAAAAGAAT 1800

TATGAAAATA CTGATAGTGG AGATAAAGAA AAGAAACAGA TTACAACTTC ACCTGTCCCT 1860

GTTAGGAAAA ATAAGAGAGA TGAAGAGAGA AGGGAATCTC GTATTCAGAG TTACTCTCCT 1920

CAGGCATTTA AATTCTTCAT GGAGCAGCAT GTGGAAAACA TACTCAAGTC TCATCACCAA 1980

CGTCTTCATC GTAAGAAACA ACTAGAAAAT GAAATGATGC GGGTTGGTTT ATCCCAAGAT 2040

GCTCAGGATC AAATGAGAAA GATGCTTTGC CAGAAGGAGT CTAATTACAT CCGTCTTAAA 2100

AGGGCTAAAA TGGACAAATC CATGTTTGTG AAGATAAAGA CACTAGGAAT AGGTGCATTT 2160

GGTGAAGTTT GCCTAGCAAG GAAAGTGGAT ACTAATGCTT TATATGCAAC AAAAACTCTG 2220

CGGAAGAAAG ATGTGCTGCT TCGAAATCAA GTTGCCCATG TCAAAGCTGA GCGAGATATC 2280

CTTGCAGAAG CTGACAATGA ATGGGTAGTT CGCCTGTACT ATTCATTCCA AGATAAGGAC 2340

AATTTGTACT TTGTAATGGA CTATATTCCT GGGGGTGATA TGATGAGCCT GCTAATTAGA 2400

ATGGGTATCT TTCCAGAAAA TTTGGCAAGG TTCTACATAG CAGAACTTAC CTGTGCTGTT 2460

GAAAGTGTTC ATAAAATGGG CTTCATTCAT AGGGATATTA AACCTGATAA CATTTTGATT 2520

GATCGTGATG GTCATATTAA ACTGACTGAT TTTGGCCTCT GTACAGGCTT TCGATGGACA 2580

CATGATTCTA AATATTATCA GAGTGGTGAC CATCCACGTC AAGATAGCAT GGACTTTAGT 2640

AATGAATGGG GTGATCCAGC CAATTGTCGC TGTGGTGACC GACTGAAACC TCTAGAGAGA 2700

AGAGCAGCAC GCCAGCATCA ACGTTGTCTG GCCCATTCGT TGGTTGGGAC TCCCAATTAT 2760

ATTGCTCCAG AAGTGTTGTT ACGAACAGGC TATACACAGT TGTGTGATTG GTGGAGTGTT 2820

GGTGTAATTC TTTTTGAAAT GTTGGTGGGG CAGCCTCCCT TCCTGGCACA GACACCATTG 2880

GAAACACAAA TGAAGGTTAT CAACTGGCAA ACAGCTCTTC ACATTCCACA ACAAGCTAAA 2940

CTGAGTCCAG AAGCCTCTGA CCTAATTATT AAACTTTGTC GAGGACCAGA AGACCGTTTA 3000

GGGAAGAATG GTGCCGATGA AATAAAAGCT CATCCATTTT TTAAAGCAAT TGATTTCTCT 3060

AGTGATCTGA GACAGCAGTC TGCTTCATAC ATTCCTAAAA TCACACACCC AACAGATACA 3120

TCAAATTTTG ACCCAGTTGA TCCAGATAAA TTATGGAGTG AGGATAATGA TGAAGGGAAT 3180

ATAAATGATA CTCTTAATGG ATGGTATAAG AATGGAAAGC ACCCTGAGCA TGCTTTCTAT 3240

GAATTTACTT TTCGAAGGTT TTTTGATGAT AATGGCTATC CATATAATTA TCCTAAGCCT 3300

ATTGAATATG AGTACAATAA TTTACAAAGC TCGGAGCAAC AGTCAGATGA AGATGATCAA 3360

CACACAGGCA CAGGGGTCAA AAATGGTGAT TTAGTTTATG TTTAG 3405

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k+k++g+GafGev+l+rk dt+++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 709   FVKIKTLGIGAFGEVCLARKVDTNALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  768

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf

Q: 769   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  828

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++ ++d++++s+

Q: 829   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNewgdpan  888

         ***************************************************999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml

Q: 889   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  948

         ************************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla+tp et++kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei

Q: 949   VGQPPFLAQTPLETQMKVINWQTALHIPQQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  1008

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 1009  KAHPFF  1014

         *****9

Domain Sequence
(FASTA)

FVKIKTLGIG AFGEVCLARK VDTNALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHPRQDSMD FSNEWGDPAN 180

CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240

VGQPPFLAQT PLETQMKVIN WQTALHIPQQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300

KAHPFF 306

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.
PF00627	; UBA; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013