EPS-SAH-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAH-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	178.7	1.9E-52	782	1028	247

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020534

UniProt Accession

G3WYM9;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017410	ENSSHAP00000020534	ENSSHAT00000020697

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1320

Protein Sequence
(FASTA)

MKRSGSRHCL HRRSRFSSRE RDWLKEDVKR GCVYLYGAET ATATTIASVA STVTSSSSDL 60

RLVLCTVETP ASEICAGEGK ESLYLQLHGD LVRRLDPAER PLQMVYEYLG SLGFEDPVRI 120

QEEATNPDLS CMIRFYGEKP CQMDHLDRIL LSGIYNVRKG KTQLHKWAER LVILCGTCLI 180

VSSVKDCQTG KMHILPLVGG KVEELKRRQH TLAFSSAGAQ APTYHVSFES LAECQRWHRQ 240

ASKVVSQRIS TVDLSCYSLE EVPEHLFYSQ DITYLNLRHN FMQLERPGGL DCLYRFSQLK 300

GLNLSHNKLG LFPILLCEIS TLTELNLSCN GFHELPVQIG NLLNLQTLCL DGNSLTGLPE 360

ELGNLQQLST LGLSFNNFSQ IPEACVKLTM LEKLSMAGNQ LEVLNLGILN RMKHIKHVDL 420

RLNSLKRTVI DNVEGNKHVT HMDLRDNQLT DLDLSSLGSL QQLHCERNQL RDLTLSGFTL 480

RVLCANANRL TTVNVYPVPS LLTSLELSRN QLEYVPDWVC ESKKLEVLDM SYNLLTEVPI 540

RILSSLSLRK LMVGYNHIQS LPDLLEHIPL EVLDLQHNLL TRLPETLFSK ALNLRYLNAS 600

ANSLESLPSA GSGEESLSML QLLYLTNNQL TDQCIPVLVG HPHLRILHLA NNQLQTFPAS 660

KLNKLEQLEE LNLSGNKLKT IPTTIANCKH LHTLVAHSNI ISIFPEILHL PQIQFVDLSC 720

NDLTEILIPE ALPPTLQDLD LTGNTNLVLE HKTLDVFSHI TTLKIDQKTL TADSAGASTF 780

WSHGLAEMAG QRNKLCVSAL AVDNFAEGVE AVYGMFDGDR NEELPRLLQC TMADVLSEEV 840

QQSAVDTVFM ANTFLVSHRK LGMAGQKLGS SALLCYIHHD TADPTSSFTL TVGNVGTCQA 900

VLCRNGQPLP LSKIFSLEHC PEEQQRVKEQ KAIITEDNKV NGVTCCTRML GCTYLYPWIL 960

PKPHICSLPL TVQDELLILG NKALWERLSY LEAVSTVRHV HDPLAAAKKL CTLAQSYGCQ 1020

DNVGAMVVCL NVGEDGCTCE VNGLSLPGPG GFAPTAVLKD APKPTTPSSS SGIASEFSSE 1080

MSTSEVSSEV GSTASDEHAA SGLDASLLPR PERRCSLHPV PTSGAFQRQP SCATFSSNQS 1140

DNGLDSDDDQ PVEGVIINGS RVEVEVDIHC CKGKGLEASP PALEETSLTQ GPEEDSGGLI 1200

FRFRRQNSVN CGTLLPLSRE LQKSPSTSCL YGKKLSNGSI VPLEDSLNLI EVATEAPKKK 1260

TGYFCAPTQL EPEDQLIIPH DLEEEVKEQL KQPQDTRGGT NSEPWEEDRV DHPEEFDTAL 1320

Nucleotide Sequence
(FASTA)

ATGAAGCGCA GTGGAAGCAG ACACTGTTTG CACAGGAGAA GTAGATTCAG CTCCCGTGAG 60

AGAGACTGGC TGAAAGAGGA TGTGAAGAGA GGATGTGTCT ACCTCTATGG AGCAGAAACA 120

GCTACGGCCA CTACCATTGC TTCTGTGGCC AGCACTGTTA CCTCTTCCTC TTCTGATTTG 180

CGCCTGGTCC TTTGCACAGT AGAGACACCA GCATCCGAGA TATGTGCTGG AGAGGGAAAG 240

GAAAGCCTTT ATTTACAGCT CCATGGAGAC CTTGTCAGGA GATTGGACCC TGCTGAACGA 300

CCCCTTCAGA TGGTATATGA ATATTTAGGC AGCCTGGGTT TTGAGGATCC TGTTCGTATT 360

CAGGAGGAGG CAACAAATCC TGACCTCAGC TGCATGATTC GCTTTTATGG AGAAAAACCA 420

TGCCAGATGG ATCATCTAGA CCGGATTCTT TTATCTGGTA TCTATAATGT ACGCAAGGGA 480

AAGACCCAGC TTCACAAGTG GGCTGAGCGC TTAGTTATTC TCTGTGGAAC TTGCCTTATC 540

GTGTCTTCGG TGAAAGACTG CCAGACTGGA AAGATGCACA TTTTGCCCCT TGTTGGGGGA 600

AAGGTAGAAG AATTGAAACG GCGACAACAC ACTCTCGCCT TCAGTTCTGC AGGAGCCCAG 660

GCTCCAACGT ACCATGTCAG CTTTGAGTCC TTGGCAGAGT GCCAGAGATG GCATCGGCAG 720

GCCTCCAAGG TGGTGTCGCA GAGAATAAGT ACAGTTGATC TCTCATGTTA TAGTCTTGAG 780

GAAGTTCCTG AGCATCTCTT CTATAGTCAA GACATCACCT ACCTCAACCT GCGACATAAC 840

TTTATGCAAC TAGAAAGACC AGGAGGCCTT GATTGTCTCT ACAGGTTTTC TCAACTGAAG 900

GGCTTGAATT TGTCTCACAA CAAGCTTGGG CTATTCCCCA TTTTACTTTG TGAGATTTCT 960

ACTCTAACAG AACTCAACCT TTCCTGTAAT GGATTTCACG AGTTGCCTGT TCAGATTGGC 1020

AATCTGCTTA ATCTACAGAC TCTCTGTCTT GATGGCAACT CCCTCACTGG TTTACCTGAA 1080

GAACTGGGAA ATTTGCAGCA GCTTTCCACT CTTGGACTCT CTTTCAATAA TTTTAGCCAA 1140

ATTCCTGAGG CTTGTGTGAA GCTCACCATG CTAGAGAAAC TGTCTATGGC AGGAAACCAG 1200

CTAGAAGTCT TGAATCTTGG AATTTTGAAC AGAATGAAAC ATATCAAACA TGTCGATTTA 1260

AGGTTGAATA GTTTGAAGAG AACTGTTATT GACAACGTGG AGGGAAATAA GCATGTTACC 1320

CACATGGATC TGCGGGATAA CCAGCTCACT GACCTGGATC TGAGTTCGCT GGGAAGCCTA 1380

CAGCAGTTGC ACTGTGAACG GAATCAGCTG AGGGACCTGA CCCTCAGTGG CTTCACTCTT 1440

CGGGTCCTCT GTGCCAATGC CAACAGGCTG ACCACTGTGA ATGTTTATCC AGTGCCTAGT 1500

CTGCTCACTT CCTTAGAACT CTCCAGGAAT CAATTAGAGT ATGTTCCTGA CTGGGTTTGT 1560

GAATCAAAGA AACTTGAGGT GTTGGATATG AGTTACAATC TTCTAACAGA GGTCCCCATT 1620

AGGATTCTGA GTAGTCTCAG TCTTAGGAAG CTGATGGTGG GATACAACCA TATACAAAGC 1680

CTTCCAGACC TTCTGGAACA CATTCCTCTT GAGGTCTTGG ATCTGCAGCA TAATTTACTC 1740

ACCAGGTTGC CAGAAACCCT CTTCTCCAAG GCCTTAAATC TCAGGTACCT GAATGCCTCT 1800

GCAAACAGCC TAGAGTCTCT GCCATCTGCT GGTTCTGGGG AAGAGAGTCT GAGTATGCTG 1860

CAGCTACTCT ATCTGACCAA TAATCAGCTG ACAGACCAAT GTATCCCTGT CCTGGTAGGA 1920

CACCCACATC TCCGAATCCT GCATCTTGCA AACAACCAAC TACAAACATT CCCAGCAAGC 1980

AAATTGAACA AGTTGGAGCA ACTTGAGGAG CTGAACCTGA GTGGCAACAA ACTAAAGACC 2040

ATTCCTACAA CCATTGCAAA TTGTAAACAC CTTCATACAC TTGTGGCACA TTCCAACATT 2100

ATCAGCATAT TTCCAGAGAT CCTGCATTTG CCTCAGATTC AGTTTGTAGA TTTAAGCTGT 2160

AATGACTTGA CAGAAATTCT GATTCCTGAG GCTTTGCCTC CTACCCTACA GGACCTTGAC 2220

CTAACTGGAA ATACAAATCT GGTTCTGGAA CATAAGACAC TGGATGTCTT CAGTCATATC 2280

ACCACCCTGA AAATTGATCA GAAAACCCTA ACAGCTGATT CTGCAGGTGC ATCGACCTTC 2340

TGGAGTCATG GTCTTGCCGA GATGGCTGGT CAGAGGAATA AACTCTGTGT GTCTGCTTTG 2400

GCTGTGGATA ACTTTGCTGA AGGTGTGGAA GCTGTATATG GCATGTTTGA TGGAGACCGG 2460

AATGAGGAGC TCCCCCGCCT CTTACAGTGT ACCATGGCTG ATGTGCTTTC GGAAGAGGTG 2520

CAGCAATCAG CAGTTGACAC AGTTTTTATG GCTAACACCT TTTTGGTATC TCACAGAAAG 2580

TTGGGAATGG CTGGCCAGAA ACTAGGCTCC TCTGCCCTCC TCTGTTACAT CCACCATGAT 2640

ACTGCTGATC CTACAAGTAG CTTCACTCTG ACAGTGGGCA ATGTGGGCAC GTGCCAGGCA 2700

GTCCTGTGCC GGAATGGACA ACCCTTGCCC CTCTCCAAAA TCTTCAGCCT AGAACATTGC 2760

CCAGAGGAGC AACAGCGGGT GAAAGAACAA AAAGCCATCA TAACTGAGGA CAACAAAGTG 2820

AATGGAGTAA CATGCTGTAC CCGGATGTTG GGCTGTACAT ACCTTTACCC TTGGATCCTT 2880

CCAAAGCCCC ATATATGCTC CCTTCCACTT ACAGTCCAAG ATGAGCTGCT GATCTTGGGA 2940

AACAAAGCAC TGTGGGAACG CCTGTCTTAC CTGGAAGCTG TTAGTACAGT ACGGCATGTC 3000

CACGATCCAT TAGCAGCTGC CAAGAAGTTG TGCACGTTGG CACAAAGCTA TGGTTGTCAG 3060

GACAACGTTG GCGCCATGGT GGTCTGTCTG AATGTGGGGG AGGATGGCTG TACTTGTGAG 3120

GTTAATGGCC TCAGTCTCCC AGGACCCGGG GGCTTTGCCC CAACTGCCGT CCTCAAAGAT 3180

GCCCCGAAGC CCACTACCCC TTCCTCAAGT AGCGGCATCG CTTCAGAGTT CAGCAGTGAG 3240

ATGTCCACGT CAGAAGTGAG CAGCGAAGTG GGCTCCACAG CTTCTGACGA ACACGCTGCC 3300

AGTGGCCTGG ACGCCAGCCT GCTGCCAAGG CCAGAACGAC GCTGCAGCCT CCATCCCGTG 3360

CCCACCTCAG GGGCATTTCA ACGCCAACCA TCTTGTGCCA CTTTTTCAAG TAACCAGTCC 3420

GATAATGGCC TGGACAGTGA TGATGACCAA CCAGTTGAAG GGGTCATAAT AAATGGCAGC 3480

AGAGTAGAGG TAGAAGTAGA TATCCACTGC TGTAAAGGGA AGGGTCTTGA GGCTTCTCCT 3540

CCTGCTCTTG AGGAGACTTC TCTGACTCAG GGTCCTGAGG AAGACTCTGG AGGATTGATC 3600

TTTAGGTTCC GGAGACAAAA CAGTGTGAAC TGTGGAACAC TTCTTCCATT AAGCAGGGAA 3660

TTACAGAAAT CTCCATCTAC TTCTTGCCTC TATGGGAAAA AACTCTCCAA TGGCTCTATC 3720

GTGCCCCTAG AAGACAGCTT AAATCTTATC GAGGTGGCAA CCGAAGCACC CAAGAAAAAA 3780

ACGGGGTACT TTTGTGCTCC CACTCAGCTG GAGCCAGAGG ATCAGCTTAT TATACCTCAT 3840

GACTTGGAAG AGGAAGTAAA AGAACAATTG AAACAGCCCC AGGATACCCG GGGTGGTACA 3900

AACTCAGAGC CCTGGGAGGA GGATCGAGTG GACCATCCAG AAGAATTTGA CACTGCTCTA 3960

TAA 3963

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ +++nf++  e+     ++g++DG++++e  + +++++ ++l

Q: 782   SHGLAEMAGQRNKLCVSALAVDNFAEGVEA-----VYGMFDGDRNEELPRLLQCTMADVL  836

         6899**********************9875.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    +++  + ++a++Fl  +++l       ++ +k Gs+a++++i ++

Q: 837   SEEVQ----QSAVDTVFMANTFLVSHRKL------GMAGQKLGSSALLCYIHHDtadpts  886

         ***99....56666678************......89***************99999***

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsr.edEleRieeaggsvilkdgaRvlGvL  172

           +l+v nvG ++avLcrng++++ls+ ++ ++ ++E +R++e+++ +++++  +v+Gv+

Q: 887   sfTLTVGNVGTCQAVLCRNGQPLPLSKIFSLEHcPEEQQRVKEQKAIITEDN--KVNGVT  944

         ******************************98637**********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R+lG++yl+p++ p+P++ s +lt +de liL+ + lw+ +s  eavs vr+v++

Q: 945   CCTRMLGCTYLYPWILPKPHICSLPLTVQDELLILGNKALWERLSYLEAVSTVRHVHD--  1002

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakkL++la+++g++dnv a+vv

Q: 1003  --PLAAAKKLCTLAQSYGCQDNVGAMVV  1028

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSALA VDNFAEGVEA VYGMFDGDRN EELPRLLQCT MADVLSEEVQ 60

QSAVDTVFMA NTFLVSHRKL GMAGQKLGSS ALLCYIHHDT ADPTSSFTLT VGNVGTCQAV 120

LCRNGQPLPL SKIFSLEHCP EEQQRVKEQK AIITEDNKVN GVTCCTRMLG CTYLYPWILP 180

KPHICSLPLT VQDELLILGN KALWERLSYL EAVSTVRHVH DPLAAAKKLC TLAQSYGCQD 240

NVGAMVV 247

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0003824	; F:catalytic activity
GO:0005543	; F:phospholipid binding
GO:0008152	; P:metabolic process

KEGG

InterPros

IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR001932	; PP2C-like.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF00481	; PP2C; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00233	; PH; 1.
SM00332	; PP2Cc; 1.

Prosites

PS51450

; LRR; 18.

Prints

Created Date

20-Feb-2013