EKS-SAH-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	447.4	2.2E-134	210	497	288

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020554

UniProt Accession

G3WYP9;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017429	ENSSHAP00000020554	ENSSHAT00000020718

Organism

Sarcophilus harrisii

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

MFDGVMILPV LMMITFPSPS VEDEEPKLNS NLYMCVCEGI SCGNQDHCEG QQCFASLSIN 60

DGIQVYQKGC FQVYEQGKMT CKTPPSPDQA VECCQGNWCN GNITAQLPTS KGKSFPGGYS 120

RFSLDYVAIF IGLSIAACLF VILLVVGIRK FKKRNQERLN PREVEYGTID GLITTNVGDS 180

TLADLMDHSC TSGSGSGLPF LVQRTVARQI TLLECVGKGR YGEVWRGHWQ GENVAVKIFS 240

SRDEKSWFRE TELYNTVLLR HENILGFIAS DMTSRHSSTQ LWLITHYHEM GSLYDYLQLT 300

TLDTVSCLRI VLSIASGLAH LHIEIFGTQG KPAISHRDLK SKNILVKKNG QCCIADLGLA 360

VIHSQTNNHL DVGNNPRVGT KRYMAPEVLD ETIQVNCFDS YKRVDIWAFG LVLWEVARRM 420

VSNGIVEDYK PPFYDVVPND PSFEDMRKVV CVDQQRPNIP NRWFSDPTLT SLAKLMKECW 480

YQNSSARLTA LRIKKTLTKI DNSLDKLKAD C 511

Nucleotide Sequence
(FASTA)

ATGTTTGATG GAGTTATGAT TTTACCTGTT CTCATGATGA TAACTTTCCC CTCTCCTAGT 60

GTGGAAGATG AGGAACCAAA GTTGAATTCA AATCTGTATA TGTGTGTGTG TGAAGGCATA 120

TCCTGTGGGA ATCAGGATCA TTGTGAGGGA CAACAGTGTT TTGCCTCATT GAGCATAAAT 180

GATGGTATTC AAGTGTACCA GAAAGGATGC TTCCAAGTGT ATGAGCAAGG GAAAATGACC 240

TGTAAGACTC CACCATCGCC GGACCAAGCT GTGGAGTGCT GTCAGGGAAA CTGGTGCAAT 300

GGAAACATCA CAGCCCAGCT ACCAACTTCA AAAGGAAAAT CCTTCCCAGG AGGATATTCA 360

CGATTCAGCC TGGATTATGT GGCCATCTTT ATAGGCCTCT CTATAGCAGC ATGCCTTTTT 420

GTTATTCTAC TGGTTGTGGG CATTCGGAAA TTTAAAAAAC GAAATCAGGA ACGGCTTAAC 480

CCTAGAGAAG TGGAATATGG CACCATTGAT GGACTCATCA CTACAAATGT TGGCGATAGT 540

ACCTTAGCAG ATTTAATGGA TCATTCTTGT ACATCAGGAA GTGGCTCTGG TCTTCCTTTT 600

CTCGTACAAA GAACCGTGGC TCGTCAAATT ACACTCTTGG AGTGTGTAGG AAAAGGCCGA 660

TATGGAGAGG TATGGCGAGG CCATTGGCAA GGAGAAAATG TTGCTGTGAA GATATTTTCC 720

TCTCGTGATG AGAAATCTTG GTTCAGAGAA ACAGAATTAT ATAACACTGT ATTGTTAAGA 780

CATGAAAATA TCTTAGGGTT CATTGCTTCA GATATGACAT CAAGACACTC CAGTACTCAG 840

TTGTGGTTAA TTACACATTA TCATGAAATG GGATCATTGT ATGACTACCT ACAGCTCACT 900

ACTCTGGACA CAGTTAGCTG TCTTCGAATT GTGCTGTCTA TTGCTAGTGG TCTGGCACAT 960

TTGCACATAG AGATATTTGG AACTCAAGGG AAGCCAGCTA TATCCCACCG GGATTTAAAG 1020

AGCAAAAATA TTCTTGTTAA GAAGAATGGA CAGTGCTGTA TAGCAGATTT GGGACTTGCA 1080

GTGATCCACT CCCAGACCAA CAATCACCTA GATGTTGGAA ACAACCCCCG TGTGGGTACC 1140

AAGCGCTACA TGGCCCCTGA AGTCTTAGAT GAAACTATCC AAGTGAACTG TTTTGACTCT 1200

TATAAAAGAG TTGACATTTG GGCCTTTGGA CTGGTCCTGT GGGAGGTGGC CAGGCGAATG 1260

GTGAGCAATG GTATTGTTGA AGATTATAAG CCACCCTTCT ATGATGTAGT TCCTAATGAT 1320

CCAAGTTTTG AAGATATGAG AAAGGTAGTC TGTGTGGATC AGCAGAGGCC AAACATTCCC 1380

AACAGATGGT TCTCAGATCC AACGTTAACC TCTCTGGCTA AACTTATGAA AGAGTGCTGG 1440

TATCAGAATT CATCTGCAAG ACTAACAGCT CTGCGTATCA AAAAGACTTT GACCAAAATT 1500

GATAATTCCT TAGATAAATT GAAAGCTGAC TGTTGA 1536

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tvllrhenil+fia

Q: 210   ITLLECVGKGRYGEVWRGHWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIA  269

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 270   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  329

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kpai+HRDlkskNilvkk+++cciaDlGLa+ +++++++ld+ +n +vGtkRYmaPE

Q: 330   G--KPAISHRDLKSKNILVKKNGQCCIADLGLAVIHSQTNNHLDVGNNPRVGTKRYMAPE  387

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 388   VLDETIQVNCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  446

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++++aRltalr+kk+l

Q: 447   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNSSARLTALRIKKTL  497

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGHW QGENVAVKIF SSRDEKSWFR ETELYNTVLL RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAISHRDL KSKNILVKKN GQCCIADLGL AVIHSQTNNH LDVGNNPRVG TKRYMAPEVL 180

DETIQVNCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNSSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013