EKS-SAH-00337

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00337

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	447.6	1.3E-134	267	516	250

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020669

UniProt Accession

G3WZ14;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017529	ENSSHAP00000020669	ENSSHAT00000020834

Organism

Sarcophilus harrisii

Functional Description

Protein Length

533

Protein Sequence
(FASTA)

MGSSKSKPKD PSQRRRSLEP TENVLHSGFP ASQTPSKASV PDAHRTPNPP FGTTAPETKL 60

FGGFNTSDTV TSPQRSGPLA GGVTTFVALY DYESRTETDL SFKKGERLQI VNNTEGDWWL 120

AHSLTTGQTG YIPSNYVAPS DSIQAEEWYF GKITRRESER LLLNSENPRG TFLVRESETT 180

KGAYCLSVSD FDNAKGLNVK HYKIRKLDSG GFYITSRTQF NSLQQLTAYY SKHADGLCHR 240

LTNVCPTSKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT RVAIKTLKPG 300

TMSPEAFLQE AQVMKKLRHE KLVQLYAVVS EEPIYIVTEY MNKGSLLDFL KGDMGKYLRL 360

PQLVDMAAQI ASGMAYVERM NYVHRDLRAA NILVGENLVC KVADFGLARL IEDNEYTARQ 420

GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LLTELTTKGR VPYPGMVNRE VLDQVERGYR 480

MPCPPECPES LHDLMCQCWR KDPEERPTFE YLQAFLEDYF TSTEPQYQPG ENL 533

Nucleotide Sequence
(FASTA)

ATGGGAAGTA GCAAAAGCAA ACCCAAAGAC CCCAGTCAGC GACGCCGAAG CCTGGAACCC 60

ACCGAGAATG TCCTCCACAG TGGCTTCCCT GCTTCTCAGA CCCCTAGCAA GGCATCTGTG 120

CCCGATGCCC ACCGCACTCC CAACCCACCC TTTGGGACCA CGGCACCTGA GACAAAGCTC 180

TTTGGCGGCT TCAACACATC AGACACAGTC ACCTCCCCCC AGCGCTCAGG GCCTTTGGCA 240

GGTGGAGTGA CCACTTTCGT GGCCCTATAT GACTATGAAT CCCGCACTGA GACAGATCTG 300

TCCTTCAAGA AAGGGGAACG CCTTCAGATA GTCAACAACA CAGAAGGAGA CTGGTGGCTG 360

GCCCACTCAC TCACCACTGG ACAGACTGGC TACATCCCCA GCAACTACGT AGCCCCATCT 420

GATTCTATCC AGGCCGAGGA GTGGTATTTT GGCAAGATCA CCCGTCGGGA GTCTGAGCGG 480

CTGCTGCTTA ATTCGGAGAA TCCCCGAGGC ACATTTCTGG TCCGGGAAAG TGAGACTACC 540

AAAGGTGCCT ATTGCCTTTC TGTCTCTGAC TTCGACAATG CCAAGGGCCT CAATGTGAAA 600

CATTATAAGA TCCGAAAACT GGACAGTGGA GGCTTCTACA TCACTTCCCG CACACAATTT 660

AACAGCCTGC AGCAGCTCAC GGCCTACTAC TCCAAACACG CTGATGGCTT GTGCCACAGA 720

CTCACCAACG TCTGTCCGAC GTCCAAGCCA CAGACCCAGG GCCTGGCGAA GGATGCCTGG 780

GAAATCCCCC GGGAGTCCCT GCGGTTGGAA GTGAAACTGG GTCAGGGCTG CTTTGGAGAA 840

GTGTGGATGG GGACCTGGAA TGGCACTACC AGAGTGGCGA TAAAGACCCT GAAGCCTGGC 900

ACCATGTCCC CAGAAGCCTT CTTGCAAGAA GCACAGGTCA TGAAGAAGCT TCGGCATGAG 960

AAGCTGGTAC AGCTGTATGC TGTGGTGTCT GAGGAGCCCA TCTACATTGT CACAGAATAT 1020

ATGAACAAGG GGAGCTTGCT GGACTTCCTT AAAGGTGACA TGGGCAAATA TCTTCGGCTG 1080

CCCCAGCTGG TGGACATGGC TGCTCAGATT GCATCAGGGA TGGCCTATGT GGAAAGGATG 1140

AACTATGTCC ACCGAGACCT CCGGGCTGCC AACATCCTGG TGGGAGAGAA TCTGGTGTGC 1200

AAGGTGGCAG ACTTTGGGCT GGCCCGGCTC ATTGAGGACA ATGAGTACAC TGCCAGACAA 1260

GGTGCCAAAT TTCCCATCAA ATGGACAGCC CCAGAAGCTG CCCTATATGG CCGGTTCACC 1320

ATCAAGTCTG ATGTGTGGTC CTTTGGAATC CTGCTGACTG AGCTGACAAC CAAGGGTCGA 1380

GTGCCATACC CAGGAATGGT GAACCGGGAG GTACTAGACC AGGTTGAGCG AGGATACCGG 1440

ATGCCCTGCC CACCAGAGTG CCCTGAATCC CTGCATGACC TCATGTGCCA GTGCTGGCGA 1500

AAGGACCCTG AAGAACGCCC CACATTTGAA TACCTGCAAG CATTTCTGGA GGACTACTTC 1560

ACATCCACAG AGCCCCAGTA TCAGCCTGGG GAGAACCTAT AG 1602

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 267   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  326

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk + gk+l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 327   AVVSE-EPIYIVTEYMNKGSLLDFLKGDMGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  385

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 386   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  445

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+kdpee

Q: 446   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEE  505

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 506   RPTFEYLQAFL  516

         *******9876

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMNKGSL LDFLKGDMGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKDPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013