EKS-SAH-00433
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00433
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK414.42.3E-12426321296
StatusUnreviewed
Ensembl ProteinENSSHAP00000020721
UniProt AccessionG3WZ65;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK8
Gene Synonyms/Alias MAPK8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000017573ENSSHAP00000020720ENSSHAT00000020886
ENSSHAG00000017573ENSSHAP00000020721ENSSHAT00000020887
OrganismSarcophilus harrisii
Functional Description
Protein Length384
Protein Sequence
(FASTA)
MSRSKRDSNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360
MDLEERTKNG VIRGQPAPLA QVQQ 384
Nucleotide Sequence
(FASTA)
ATGAGCAGGA GCAAGCGTGA CAGTAATTTC TATAGTGTAG AGATTGGAGA TTCGACATTT 60
ACTGTACTGA AACGGTATCA GAATTTAAAA CCTATAGGCT CAGGGGCCCA GGGAATAGTG 120
TGTGCAGCTT ATGATGCCAT TCTTGAAAGA AATGTTGCAA TTAAGAAGCT AAGCCGACCA 180
TTTCAGAATC AGACTCATGC CAAGCGTGCT TATAGAGAGC TTGTTCTTAT GAAATGTGTT 240
AATCACAAAA ATATAATTGG CCTCTTGAAT GTGTTCACAC CACAGAAATC CCTAGAAGAA 300
TTTCAGGATG TTTACATAGT CATGGAGCTC ATGGATGCAA ATCTTTGCCA AGTGATTCAA 360
ATGGAGCTAG ACCATGAACG AATGTCCTAC CTTCTCTATC AGATGCTGTG TGGAATCAAG 420
CACCTTCATT CTGCTGGAAT TATACATCGA GACTTAAAGC CCAGTAATAT AGTAGTAAAA 480
TCAGACTGCA CTTTGAAGAT TCTTGACTTT GGACTGGCCA GAACTGCAGG AACTAGTTTT 540
ATGATGACAC CTTATGTAGT GACTCGTTAC TACAGAGCAC CCGAGGTCAT CCTAGGGATG 600
GGCTACAAAG AAAACGTTGA CATTTGGTCA GTTGGGTGCA TCATGGGAGA AATGATCAAA 660
GGTGGTGTTT TGTTCCCAGG TACAGATCAT ATTGATCAAT GGAATAAAGT TATTGAGCAA 720
CTTGGAACAC CTTGTCCTGA GTTCATGAAG AAATTACAAC CAACAGTAAG AACTTATGTG 780
GAGAACAGAC CTAAATATGC TGGATATAGC TTTGAGAAGC TCTTCCCAGA TGTACTTTTC 840
CCAGCTGACT CGGAGCACAA CAAACTTAAA GCTAGTCAGG CAAGGGATTT GTTGTCAAAA 900
ATGCTGGTTA TAGATGCATC TAAAAGAATC TCTGTGGATG AAGCCCTCCA GCACCCTTAT 960
ATCAATGTCT GGTATGATCC TTCAGAAGCA GAAGCGCCTC CACCAAAGAT ACCTGACAAG 1020
CAGTTAGATG AAAGGGAGCA CACAATAGAA GAGTGGAAAG AATTGATATA CAAGGAAGTC 1080
ATGGACTTGG AGGAGAGAAC TAAGAATGGA GTTATACGGG GTCAACCAGC TCCTTTAGCA 1140
CAGGTGCAGC AGTGA 1155
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni
Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85
         899*********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs
Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144
         ************************************9.**********************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  + 
Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201
         **********************************976..*****************9.99
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+
Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260
         *****************************************************.5*****
S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288
         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY
Q: 261   ENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320
         *****************************99*****************************
S: 289   l  289
         +
Q: 321   I  321
         7
Domain Sequence
(FASTA)
YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60
IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120
GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180
VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240
YAGYSFEKLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>
EKS-BOT-00465
EKS-CAJ-00470
EKS-CAF-00466
EKS-CAP-00497
EKS-CIS-00222
EKS-DRM-00223
EKS-EQC-00453
EKS-GAM-00271
EKS-GOG-00455
EKS-HOS-00474
EKS-ICT-00440
EKS-LOA-00470
EKS-MAM-00462
EKS-MEG-00380
EKS-MOD-00457
EKS-MUM-00498
EKS-MUP-00455
EKS-NOL-00422
EKS-ORN-00587
EKS-ORC-00439
EKS-PES-00409
EKS-POA-00453
EKS-RAN-00483
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008351; MAPK_JNK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01772; JNKMAPKINASE.
Created Date20-Feb-2013