EKS-SAH-00143

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00143

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	554.4	4.0E-167	389	665	277

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020829

UniProt Accession

G3WZH5;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017666	ENSSHAP00000020829	ENSSHAT00000020997
ENSSHAG00000017666	ENSSHAP00000020830	ENSSHAT00000020998

Organism

Sarcophilus harrisii

Functional Description

Protein Length

733

Protein Sequence
(FASTA)

MWSWKGLLFW AVLVTATLCT ARPAPTLPEQ DALPSSEDDD DDDDSSSEEK ESDNTKPNRT 60

PVAPYWTSPE KMEKKLHAVP AAKTVKFKCP SNGTPNPTLR WLKNGKEFKP DHRIGGYKVR 120

YATWSIIMDS VVPSDKGNYT CIVENEYGSI NHTYQLDVVE RSPHRPILQA GLPANKTVAL 180

GSNVEFMCKV YSDPQPHIQW LKHIEVNGSK IGPDNLPYVQ ILKTAGVNTT DKEMEVLHLR 240

NVSFEDAGEY TCLAGNSIGL SHHSAWLTVL EALEERPAVM TSPLYLEIII YCTGAFLISC 300

MVGSVIIYKM KSGTKKSDFH SQMAVHKLAK SIPLRRQVTV SADSSASMNS GVLLVRPSRL 360

SSSGTPMLAG VSEYELPEDP RWELPRDRLV LGKPLGEGCF GQVVLAEAIG LDKDKPNRVT 420

KVAVKMLKSD ATEKDLSDLI SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL 480

REYLQARRPP GLEYCYNPSH APEEQLSSKD LVSCAYQVAR GMEYLASKKC IHRDLAARNV 540

LVTEDNVMKI ADFGLARDIH HIDYYKKTTN GRLPVKWMAP EALFDRIYTH QSDVWSFGVL 600

LWEIFTLGGS PYPGVPVEEL FKLLKEGHRM DKPSNCTNEL YMMMRDCWHA IPSQRPTFKQ 660

LVEDLDRIVA LTSNQEYLDL SVPLDQYSPS FPDTRSSTCS SGEDSVFSHD PLPEEPCLPR 720

HPAPLANGGL KRR 733

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGGGCCT CCTTTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACT 60

GCCAGACCAG CCCCAACCCT GCCTGAACAA GATGCTCTCC CTTCCTCAGA AGATGATGAT 120

GATGATGATG ATTCCTCATC AGAGGAGAAA GAGTCAGATA ACACTAAGCC AAACCGTACG 180

CCCGTGGCTC CATACTGGAC ATCACCAGAA AAGATGGAAA AGAAATTGCA TGCAGTACCG 240

GCGGCTAAAA CAGTGAAGTT CAAATGCCCT TCAAATGGCA CCCCTAACCC CACTCTGCGT 300

TGGCTGAAGA ATGGCAAAGA ATTCAAACCG GACCATCGGA TCGGGGGCTA CAAGGTCCGC 360

TATGCCACCT GGAGCATCAT AATGGACTCA GTGGTGCCAT CGGATAAAGG CAACTACACT 420

TGCATCGTAG AGAATGAATA TGGCAGCATT AACCACACCT ACCAACTGGA TGTTGTGGAG 480

CGGTCACCTC ATCGGCCCAT CCTGCAGGCT GGATTGCCTG CCAATAAAAC GGTGGCTTTG 540

GGCAGCAATG TGGAGTTTAT GTGCAAGGTG TACAGTGACC CACAGCCTCA CATCCAGTGG 600

TTAAAGCACA TCGAAGTGAA TGGGAGTAAG ATTGGCCCAG ACAACCTGCC GTATGTGCAA 660

ATTCTAAAGA CGGCCGGTGT TAATACCACT GACAAAGAGA TGGAAGTGCT TCACTTAAGG 720

AATGTCTCCT TTGAGGACGC GGGGGAGTAT ACATGCTTGG CGGGTAACTC TATCGGACTC 780

TCCCATCACT CTGCATGGCT GACCGTTCTG GAAGCCTTGG AGGAGAGACC AGCAGTGATG 840

ACTTCGCCTC TATATCTTGA GATCATCATC TATTGTACGG GGGCTTTCCT CATCTCCTGC 900

ATGGTGGGGT CCGTCATCAT CTACAAGATG AAGAGTGGTA CCAAAAAGAG TGACTTCCAC 960

AGCCAAATGG CTGTGCACAA GCTGGCCAAG AGCATCCCCC TGCGCAGACA GGTAACAGTG 1020

TCTGCTGATT CTAGTGCCTC CATGAATTCA GGGGTCCTGC TAGTTCGGCC TTCACGCCTT 1080

TCTTCTAGCG GGACCCCTAT GCTGGCAGGT GTCTCAGAGT ATGAACTTCC TGAGGATCCC 1140

CGCTGGGAAC TACCCCGGGA CAGGTTGGTT CTAGGCAAAC CACTGGGAGA GGGCTGCTTT 1200

GGACAAGTAG TATTGGCAGA AGCTATTGGG TTAGATAAGG ATAAACCCAA CCGGGTGACC 1260

AAGGTGGCAG TGAAGATGCT GAAATCGGAT GCAACAGAAA AGGACCTGTC AGATCTGATC 1320

TCAGAAATGG AGATGATGAA GATGATTGGG AAACACAAGA ACATTATCAA CCTGTTGGGG 1380

GCCTGCACAC AGGATGGCCC TCTTTATGTC ATTGTGGAAT ACGCCTCCAA GGGCAACCTT 1440

CGTGAGTACC TGCAGGCCAG GCGTCCCCCT GGGCTTGAAT ACTGCTACAA CCCCAGCCAT 1500

GCCCCAGAAG AGCAACTCTC CTCCAAGGAC CTAGTGTCGT GTGCCTATCA GGTGGCCAGG 1560

GGCATGGAAT ATCTTGCCTC AAAGAAGTGC ATCCACCGGG ATCTGGCAGC CCGGAATGTC 1620

TTGGTGACTG AAGACAATGT GATGAAAATT GCAGACTTTG GTCTTGCTCG GGACATCCAT 1680

CACATTGACT ACTACAAAAA GACAACCAAT GGTCGCCTGC CTGTGAAGTG GATGGCTCCT 1740

GAAGCACTGT TTGACCGGAT CTATACACAC CAGAGTGACG TGTGGTCATT TGGGGTGCTG 1800

CTTTGGGAAA TTTTCACCCT GGGAGGCTCC CCTTACCCTG GTGTGCCTGT AGAAGAGCTT 1860

TTCAAGCTGT TGAAAGAAGG TCATCGAATG GACAAGCCCA GCAATTGCAC CAATGAACTA 1920

TACATGATGA TGCGGGACTG CTGGCATGCG ATCCCTTCTC AAAGGCCTAC CTTCAAGCAG 1980

CTTGTAGAGG ACTTGGATCG AATTGTGGCC CTGACCTCTA ATCAGGAGTA CCTGGACCTA 2040

TCAGTACCCC TGGACCAGTA TTCACCCAGC TTTCCAGACA CCCGCAGTTC TACTTGCTCC 2100

TCCGGAGAGG ACTCCGTCTT CTCCCATGAC CCACTGCCTG AGGAGCCCTG CCTGCCCCGA 2160

CATCCAGCCC CACTGGCCAA TGGTGGACTC AAACGGCGCT GA 2202

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 389   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  448

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+a+eeql++

Q: 449   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHAPEEQLSS  508

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 509   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  568

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 569   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  628

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha +s+rptfkqlvedl

Q: 629   RMDKPSNCTNELYMMMRDCWHAIPSQRPTFKQLVEDL  665

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHAPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAIPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013