EKS-SAH-00001

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00001

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	520.3	6.7E-157	623	880	258

Status

Unreviewed

Ensembl Protein

ENSSHAP00000020967

UniProt Accession

G3WZW2;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA4

Gene Synonyms/Alias

EPHA4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000017781	ENSSHAP00000020967	ENSSHAT00000021137

Organism

Sarcophilus harrisii

Functional Description

Protein Length

988

Protein Sequence
(FASTA)

MAGIFYFILF SFLFGICNGV TGSRIYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 60

DEKNTPIRTY QVCNVMESSQ NNWLRTDWIP REGAQRVYIE IKFTLRDCNS LPGVMGTCKE 120

TFNLYYYESN NDKERFIRES QFAKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG 180

FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK 240

DVPKMYCGAD GEWLVPIGNC LCNAGHEERN GECQACKIGY YKALSTDNSC SKCPPHSYSV 300

WEGATSCTCD RGYFRAEDDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PENTGGRQDI 360

SYNVVCKKCG AGDSSRCRSC GSGVHYTPQQ NGLKSTKVSI TDLLAHTNYT FEIWAVNGVS 420

KYSPSHDQSV SVTVTTNQAA PSSIALIQAK EITRYSVALA WLEPDRPNGV ILEYEVKYYE 480

KDQNERSYRI VRTASRNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPFEV TTNTAVPSRI 540

IGDGTNSTVL LVSVSGSVVL VVILIAAFVI SRSRRSKYSK AKQEADEEKH LNQGVRTYVD 600

PFTYEDPNQA VREFAKEIDA SCIKIEKVIG VGEFGEVCSG RLKVPGKREI CVAIKTLKAG 660

YTDKQRRDFL SEASIMGQFD HPNIIHLEGV VTKCKPVMII TEYMENGSLD AFLRKNDGRF 720

TVIQLVGMLR GIGSGMKYLS DMSYVHRDLA ARNILVNSNL VCKVSDFGMS RVLEDDPEAA 780

YTTRGGKIPI RWTAPEAIAY RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVIKAIE 840

EGYRLPPPMD CPIALHQLML DCWQKERSDR PKFGQIVNML DKLIRNPNSL KRTGTESSRP 900

NTALLDPSSP EFSAVVSVGD WLQAIKMDRY KDNFTAAGYT TLEAVVHMNQ DDLARIGITA 960

PTHQNKILNS VQAMRTQMQQ MHGRMVPV 988

Nucleotide Sequence
(FASTA)

ATGGCTGGGA TTTTCTATTT CATCCTCTTT TCGTTTCTGT TTGGAATTTG CAATGGTGTC 60

ACCGGTTCTA GGATATATCC TGCCAACGAA GTTACCTTAT TGGATTCCAG ATCGGTTCAG 120

GGAGAGCTTG GGTGGATAGC CAGCCCTTTG GAAGGAGGGT GGGAAGAAGT GAGTATTATG 180

GATGAGAAAA ATACTCCAAT CCGTACTTAC CAAGTCTGCA ATGTCATGGA GTCCAGCCAA 240

AACAACTGGT TACGAACTGA TTGGATTCCT CGAGAAGGGG CTCAGAGGGT GTATATTGAG 300

ATTAAATTCA CACTGAGAGA CTGTAATAGC CTACCAGGAG TTATGGGAAC TTGCAAAGAG 360

ACTTTTAACT TGTACTACTA TGAATCCAAT AATGACAAAG AGCGCTTTAT CAGAGAAAGC 420

CAGTTTGCTA AGATCGACAC CATTGCTGCT GATGAGAGCT TCACCCAAGT GGACATTGGT 480

GATAGAATCA TGAAGTTGAA CACCGAGATA AGAGATGTGG GACCACTGAG CAAGAAAGGG 540

TTCTACTTGG CTTTTCAGGA TGTTGGAGCC TGTATTGCTC TAGTCTCTGT TCGGGTTTTC 600

TATAAGAAGT GTCCGTTGAC AGTTCGAAAT CTGGCCCAAT TTCCAGACAC CATCACTGGG 660

GCTGATACAT CCTCCCTAGT GGAAGTTCGA GGCTCTTGTG TCAACAACTC AGAAGAAAAG 720

GATGTGCCAA AAATGTATTG TGGGGCAGAT GGTGAATGGC TGGTACCCAT TGGCAACTGT 780

CTATGCAATG CTGGGCATGA AGAGAGAAAT GGAGAATGCC AAGCCTGCAA GATTGGATAC 840

TACAAGGCCC TTTCCACTGA CAATTCCTGT TCCAAGTGCC CTCCCCATAG CTATTCTGTC 900

TGGGAGGGAG CCACCTCCTG TACCTGTGAC CGTGGCTATT TTCGAGCAGA AGATGATGCA 960

GCTTCCATGC CCTGCACTCG TCCACCATCT GCTCCCCTCA ACTTGATTTC AAATGTCAAT 1020

GAAACATCAG TGAACCTGGA GTGGAGCAGT CCTGAGAACA CGGGGGGCCG CCAGGACATT 1080

TCCTACAATG TAGTGTGTAA GAAGTGCGGT GCTGGCGATT CCAGCCGGTG TCGGTCCTGT 1140

GGCAGTGGAG TCCACTACAC GCCCCAGCAG AATGGGCTCA AGAGCACCAA AGTCTCCATT 1200

ACAGACCTCC TGGCACATAC TAACTACACT TTTGAAATCT GGGCCGTAAA TGGAGTGTCC 1260

AAGTATAGCC CAAGTCACGA CCAGTCGGTT TCGGTTACTG TGACAACGAA CCAAGCAGCT 1320

CCATCTTCTA TAGCTTTGAT CCAAGCTAAA GAAATAACGA GATACAGCGT TGCATTGGCT 1380

TGGCTGGAAC CTGATCGGCC AAATGGAGTC ATCTTAGAGT ATGAAGTCAA ATATTATGAG 1440

AAGGATCAGA ATGAACGCAG TTATAGAATT GTTCGGACAG CCTCCAGGAA CACTGACATC 1500

AAAGGCCTGA ATCCCTTGAC TTCCTATGTA TTTCATGTGA GAGCCCGTAC AGCAGCTGGC 1560

TATGGAGACT TTAGTGAGCC CTTTGAGGTG ACAACTAACA CAGCAGTGCC TTCCCGAATC 1620

ATTGGAGATG GGACCAACTC CACTGTCCTG CTGGTGTCAG TTTCGGGCAG CGTGGTGCTG 1680

GTGGTCATTC TGATTGCAGC TTTTGTCATC AGCCGGAGCA GACGGAGTAA ATACAGTAAG 1740

GCAAAGCAAG AAGCAGATGA AGAGAAACAT TTGAATCAAG GTGTAAGAAC TTATGTTGAC 1800

CCTTTTACAT ATGAAGATCC TAACCAAGCT GTCCGAGAAT TTGCCAAAGA AATTGATGCG 1860

TCCTGCATTA AGATTGAAAA AGTCATAGGA GTGGGTGAAT TTGGCGAAGT GTGCAGTGGG 1920

CGTCTTAAAG TACCTGGGAA GAGAGAGATA TGTGTGGCTA TTAAAACTCT TAAAGCTGGA 1980

TATACAGACA AGCAGAGGAG GGATTTTCTG AGTGAGGCTA GCATCATGGG ACAGTTTGAC 2040

CACCCAAACA TCATCCACTT AGAAGGCGTA GTCACCAAAT GTAAACCTGT AATGATCATA 2100

ACCGAGTACA TGGAGAATGG CTCCTTGGAT GCATTCCTTA GGAAGAATGA TGGAAGATTT 2160

ACAGTGATTC AATTGGTTGG GATGCTTCGT GGCATTGGTT CTGGGATGAA ATATCTCTCT 2220

GATATGAGCT ATGTACATAG AGATCTAGCT GCCCGGAACA TCTTGGTCAA TAGCAACTTG 2280

GTCTGCAAAG TATCTGACTT TGGCATGTCT CGTGTTCTTG AAGATGATCC TGAAGCAGCT 2340

TACACAACCA GGGGTGGCAA GATTCCCATC CGGTGGACTG CACCAGAAGC AATCGCTTAT 2400

CGTAAATTCA CATCTGCAAG TGATGTATGG AGCTATGGAA TTGTGATGTG GGAAGTGATG 2460

TCTTATGGAG AGCGGCCCTA CTGGGATATG TCCAACCAGG ATGTTATAAA AGCTATCGAG 2520

GAAGGATACC GGCTACCTCC ACCAATGGAC TGCCCCATTG CTCTCCACCA GCTGATGCTA 2580

GACTGCTGGC AGAAGGAAAG AAGCGACAGG CCTAAATTTG GACAGATTGT CAACATGTTG 2640

GACAAACTCA TCCGCAACCC TAACAGCCTG AAGAGGACGG GTACTGAGAG CTCCAGGCCC 2700

AACACCGCCT TGTTGGATCC TAGCTCTCCT GAATTTTCTG CTGTGGTATC TGTAGGAGAT 2760

TGGCTGCAGG CCATTAAAAT GGACCGGTAT AAGGACAATT TCACAGCTGC CGGGTACACC 2820

ACCCTTGAGG CTGTGGTGCA CATGAACCAG GACGACCTGG CGAGAATCGG CATCACAGCC 2880

CCCACGCACC AGAACAAGAT CTTGAACAGC GTCCAGGCAA TGCGAACCCA AATGCAACAG 2940

ATGCATGGCA GGATGGTTCC TGTCTGA 2967

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp

Q: 623   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  682

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkylsdm

Q: 683   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM  742

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk

Q: 743   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  802

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc

Q: 803   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  862

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wqk+r++rpkf qiv++l

Q: 863   WQKERSDRPKFGQIVNML  880

         ***************985

Domain Sequence
(FASTA)

IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60

NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM 120

SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180

FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240

WQKERSDRPK FGQIVNML 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013