EKS-SAH-00374
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00374
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR553.03.4E-166414743330
StatusUnreviewed
Ensembl ProteinENSSHAP00000021110
UniProt AccessionG3X0A5;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000017900ENSSHAP00000021110ENSSHAT00000021280
OrganismSarcophilus harrisii
Functional Description
Protein Length800
Protein Sequence
(FASTA)
VICFFFNCSC KRGSQAVIRN KENILHELFG TDIWCCARND LGEKCTRLFT LDLNQSPETT 60
LPQLFIKEGE PLLIRCKAVY KNYEFRLAWK LENRTLKEGS HFQMSAYSAN RSMIRILFVF 120
MESVGRSDSG YYTCASSKHP SQSTLVTVLE KGFINASNLN EDYEIDEHEE FCFSIQLKAY 180
PQVICTWTFS QESIPCKQSN LKDGFSTSEF CDHKHQPGVY TFHAENGDAQ FTKTFTLYVK 240
RKPQVKMEIS INQTSCYSDG YPLPSWTWKK CKDKKQVVCT EITEGIWNKR ANRKVFGQWT 300
SSSTLNLSEQ FKGLLVECCA NNSLGSSCDS KLFNSPGSLP NTQDKISFYT TIGFCLPFIA 360
VLLTLIFHKY RKQYRYESQL QMVQVMGSSD NEYFYVDFRE FEYDLKWEFP RENLEFGQVL 420
GSGAFGKVMN ATAYGISETG VSIQVAVKML KEKSDRSEKD ALMSELKMMT HIGSHENIVN 480
LLGACTLSGP IYLIFEYCCY GDLLNYLRSK REKFHRTWTE VFKQHNFSFY PTFHSSSRMP 540
GLGGLHISQD FDLTSGFNGN SFYSEEEIEY ENQKRLVEEE DFNVLTFEDL LCFSYQVAKG 600
MEFLELKSCV HRDLAARNVL VTHGKMVKIC DFGLARDIMN DSNYVVRGNA RLPVKWMAPE 660
SLFEGIYTIK SDVWSFGILL WEIFSLGVNP YPGIPVDNNF YKLIQSGFKM DQPFYATEEI 720
YFIMQSCWSF DSRKRPSFPH LTSSLGCQLA NAEVAMYQNI EDGISKSMSS YQKRSSGSSH 780
ISPGQQPLPQ TQKDKNGEKK 800
Nucleotide Sequence
(FASTA)
GTTATTTGTT TTTTTTTTAA TTGCAGCTGC AAAAGAGGAA GTCAAGCTGT CATTAGAAAC 60
AAGGAAAATA TACTTCATGA ATTATTTGGA ACAGACATAT GGTGCTGTGC AAGAAATGAC 120
TTGGGCGAGA AATGTACAAG GCTTTTTACA CTAGATTTAA ATCAAAGCCC TGAAACAACT 180
CTACCACAAT TATTCATCAA AGAGGGAGAA CCCTTGTTGA TAAGATGCAA AGCTGTTTAT 240
AAAAATTATG AATTCAGGCT TGCTTGGAAA TTAGAAAACA GGACTTTAAA AGAGGGCAGC 300
CATTTTCAGA TGAGTGCCTA TTCAGCCAAC AGAAGTATGA TTCGGATTTT ATTTGTTTTT 360
ATGGAATCAG TAGGAAGAAG CGATTCTGGG TATTATACTT GTGCTTCATC AAAACATCCC 420
AGTCAATCAA CTTTGGTTAC TGTCTTAGAA AAGGGATTTA TAAATGCTTC CAACTTAAAT 480
GAAGATTATG AGATTGATGA ACATGAAGAA TTTTGCTTCT CAATACAGCT TAAAGCATAT 540
CCACAAGTCA TATGTACATG GACCTTTTCC CAAGAGTCAA TTCCTTGTAA ACAAAGTAAT 600
CTCAAGGATG GATTCAGTAC ATCAGAGTTT TGTGACCATA AGCACCAGCC AGGAGTGTAT 660
ACCTTCCATG CAGAAAATGG GGATGCTCAG TTCACAAAAA CATTTACACT TTATGTAAAA 720
AGGAAACCTC AAGTAAAAAT GGAAATATCA ATAAATCAGA CTTCTTGTTA CTCTGATGGC 780
TACCCTTTAC CATCTTGGAC CTGGAAGAAG TGCAAAGACA AAAAGCAGGT GGTTTGCACA 840
GAAATCACTG AAGGGATTTG GAATAAGAGA GCTAACAGGA AAGTGTTTGG ACAGTGGACA 900
TCGAGCAGCA CCCTGAATCT GAGTGAGCAG TTCAAAGGAC TCCTAGTTGA ATGTTGTGCC 960
AACAATTCAC TGGGCTCCTC CTGTGACTCA AAGCTTTTCA ACTCCCCAGG ATCTCTTCCT 1020
AATACCCAAG ACAAGATTTC CTTCTATACC ACCATTGGAT TTTGTCTGCC CTTCATTGCT 1080
GTTTTACTCA CACTCATTTT TCACAAGTAC AGAAAGCAAT ATAGGTATGA AAGTCAACTG 1140
CAGATGGTGC AAGTGATGGG CTCATCAGAT AATGAATACT TCTATGTTGA TTTCAGAGAA 1200
TTTGAATATG ACCTTAAGTG GGAGTTTCCA AGAGAAAACC TAGAATTTGG ACAAGTCCTA 1260
GGCTCAGGTG CCTTTGGAAA AGTGATGAAT GCTACAGCTT ATGGAATTAG TGAAACTGGA 1320
GTCTCAATCC AAGTTGCTGT CAAAATGCTG AAAGAAAAGT CTGACCGCTC AGAAAAAGAT 1380
GCTCTCATGT CAGAGCTCAA GATGATGACT CACATTGGAA GCCACGAGAA TATTGTGAAC 1440
TTATTAGGCG CTTGCACACT GTCAGGACCA ATTTATTTGA TATTTGAATA CTGTTGCTAT 1500
GGGGATCTTC TAAATTATCT AAGAAGTAAA AGAGAAAAAT TTCACAGGAC ATGGACAGAA 1560
GTCTTCAAAC AGCACAATTT CAGCTTTTAT CCCACTTTCC ATTCAAGTTC CAGAATGCCT 1620
GGTTTAGGAG GACTTCACAT AAGCCAAGAC TTTGATCTGA CCTCTGGATT CAATGGGAAT 1680
TCATTTTATT CTGAAGAAGA AATTGAATAT GAAAACCAAA AAAGACTTGT TGAAGAAGAG 1740
GACTTCAATG TGCTTACATT TGAGGATCTT CTCTGTTTCT CTTATCAAGT TGCCAAAGGA 1800
ATGGAATTTC TTGAATTAAA ATCGTGTGTT CATAGAGACC TTGCAGCCAG GAATGTACTT 1860
GTAACTCATG GAAAAATGGT GAAGATATGT GACTTTGGAT TGGCCAGAGA TATAATGAAT 1920
GACTCCAACT ATGTTGTCAG GGGCAATGCT CGGTTACCTG TGAAATGGAT GGCTCCTGAA 1980
AGCCTATTTG AAGGCATATA CACAATTAAG AGTGATGTCT GGTCCTTTGG AATATTACTT 2040
TGGGAAATAT TTTCTCTTGG TGTGAATCCT TACCCTGGCA TTCCAGTTGA CAATAATTTC 2100
TATAAACTCA TTCAAAGTGG ATTTAAAATG GACCAGCCAT TTTATGCTAC AGAAGAAATC 2160
TACTTTATAA TGCAATCCTG CTGGTCTTTT GACTCCAGGA AGAGACCATC CTTCCCACAT 2220
CTGACTTCTT CTCTGGGATG TCAACTGGCA AATGCAGAAG TTGCGATGTA TCAAAATATT 2280
GAAGATGGAA TCTCTAAATC TATGTCCAGT TACCAAAAGA GGTCATCTGG CAGCAGTCAC 2340
ATCAGTCCAG GCCAGCAGCC CCTTCCTCAA ACTCAGAAAG ACAAAAATGG AGAAAAGAAA 2400
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+G+vlGsGafGkv++atayG+s+++++++vavkmlk++++ sek+almselk+++h+G
Q: 414   LEFGQVLGSGAFGKVMNATAYGISETGVSIQVAVKMLKEKSDRSEKDALMSELKMMTHIG  473
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e +k+++++++ + 
Q: 474   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEVFKQHNFSFYPT-  532
         ********************************************************999.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               +  +ss+ +++ +  +++++d++  s ++ ++++se++ +++++++   +eeed
Q: 533   ------F--HSSSRMPGLGG-LHISQDFDLTSGFNGNSFYSEEEIEYENQKRL--VEEED  581
         ......4..55666778888.99************************999876..89999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+fsyqvakGmefl+ k+cvhrdlaarnvl+t+Gk+vkicdfGlardim+d
Q: 582   FNVLTFEDLLCFSYQVAKGMEFLELKSCVHRDLAARNVLVTHGKMVKICDFGLARDIMND  641
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvws+GillweifslG++pypg++vd++fy
Q: 642   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSFGILLWEIFSLGVNPYPGIPVDNNFY  701
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         kli++G++m+qp+yateeiy imq+cw ++++krpsf +l++
Q: 702   KLIQSGFKMDQPFYATEEIYFIMQSCWSFDSRKRPSFPHLTS  743
         ***************************************986
Domain Sequence
(FASTA)
LEFGQVLGSG AFGKVMNATA YGISETGVSI QVAVKMLKEK SDRSEKDALM SELKMMTHIG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEVFK QHNFSFYPTF 120
HSSSRMPGLG GLHISQDFDL TSGFNGNSFY SEEEIEYENQ KRLVEEEDFN VLTFEDLLCF 180
SYQVAKGMEF LELKSCVHRD LAARNVLVTH GKMVKICDFG LARDIMNDSN YVVRGNARLP 240
VKWMAPESLF EGIYTIKSDV WSFGILLWEI FSLGVNPYPG IPVDNNFYKL IQSGFKMDQP 300
FYATEEIYFI MQSCWSFDSR KRPSFPHLTS 330
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013