EKS-SAH-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	444.7	1.2E-133	983	1240	258

Status

Unreviewed

Ensembl Protein

ENSSHAP00000021281

UniProt Accession

G3X0S5;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000018037	ENSSHAP00000021281	ENSSHAT00000021453
ENSSHAG00000018037	ENSSHAP00000021280	ENSSHAT00000021452

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1263

Protein Sequence
(FASTA)

MLSADLELLQ SLVTGPAGHP GCQSCAACNW SESSLPGTGD TDNAVLVLDP DQPWLYSCGS 60

SLLGRCFVHE LDSQDRGPRL GRTSCLWDPS ANSPQHCPDC IASPLGTRVT VVPLGYSSYF 120

YVASTLNQTV ASRYSPHSVS IRRLKSNLRG FAPSSPALSV RPGYLATYPI EYVYTFHSGG 180

HVYFLTVQPE SLKVPTTFHT RLVRLSATEP DVGEYRELVL DCHFSNKRRR RRRQGVSLEK 240

ETYNVLQAAH VARVESSLAE GLGVPEGQKV LFGAFAVSRE GSRLPRPKSA VCAFSISKLD 300

ELIDNGMERC CGSPAQQERL ERGVEFFQPQ SYCPDPPQTI FLDPNVSCWN YPTMIPTNYP 360

REDLLNGHLD NVLLTAIHVI HQGNATVAHM GTADGRILQV KLFRSLNYLL YVSNFSLGSS 420

QPVHREVSCL GDHLFFSSGN KVFKVPIKGP GCRHFLTCKK CLQAEPFMGC GWCGNVCARQ 480

QECPGTWQQD SCPPIITEFH PKAGPTRGST KLTICGSNFH SHSQNLAPEG PQKVTVGQSP 540

CKVPPAATSY MPPSFKKNYV EQLECLLEAS SSQAPGPANV TLSIFGEPTK FHFQLNGSSV 600

LGGFSFVEPV VTSILPLFGP RAGGTELTIK GQNLNVGSSH LVLINGTECT LKQMEEQRLL 660

CVTPPGRDVA NVSISLSIGG SNISIPWLFQ YRDNPRIFSI SPNCSYPPSG SRITIQGQNL 720

DAVWQMTLAF EDGHRTKERL ECFNETLPTE RVCWAPAYAH LPDLEQAQGN LSISGDGSVL 780

YFHPDFPFYP KPQVHPQLGP LKIDHGTVEI KFPGLSAVAS CMEVNMTVGG QSCRANLKNN 840

PVICYVPPSL SIPRSGAPLQ ICLNGECWRL SNVIPSSSEL PQAFIIVFLI ITMLVVCFLS 900

LLLFKLWRKK NKRQDAYSLP KTTFSILNGT EPGPVQPISS TGSSSGCGVP LLRVKSICVA 960

KLSSELLAEV KDVLIPPERI LIHDDQVIGK GHFGIVYHGE YVDSSQNRIH CAVKSLNRIT 1020

ELEEVEAFLR EGLLMRSFCH PNVLSLTGIL LPSEGLPSVV LPYMKHGDLR HFIRSPERNP 1080

TVKDLIGFGI QVARGMAYLA EKKFVHRDLA ARNCMLDETF TVKVADFGLA RDIVDKEYYS 1140

IRKHSHARLP VKWMALESLQ TYKFTTKSDV WSFGVLLWEL LTRGASPYPN IDPFDIAHFL 1200

AQGRRLPQPE YCPDALYSVM LQCWDPVPTE RPAFGVLVRE VECVSASLRG EHYVNLHSGY 1260

VNL 1263

Nucleotide Sequence
(FASTA)

ATGCTGAGCG CCGACCTGGA GCTGCTCCAG AGCCTGGTCA CGGGCCCTGC CGGACACCCC 60

GGCTGCCAGT CCTGCGCAGC CTGTAATTGG TCAGAGTCCT CACTCCCCGG CACCGGAGAC 120

ACAGACAACG CCGTGTTGGT CCTGGATCCT GACCAGCCCT GGCTCTATAG CTGTGGCTCT 180

TCCCTGCTAG GCCGCTGCTT TGTTCACGAG CTGGACTCTC AGGACAGGGG CCCCCGCTTG 240

GGCCGCACCT CCTGCCTCTG GGACCCCTCG GCCAACAGTC CCCAGCATTG CCCCGACTGC 300

ATAGCCAGCC CGCTGGGCAC CCGGGTGACT GTGGTGCCGC TGGGCTACTC TTCATACTTC 360

TATGTGGCCT CCACCCTGAA CCAGACAGTG GCCTCCCGCT ACAGTCCCCA CTCGGTGTCC 420

ATCCGCAGGC TCAAGTCAAA CCTCCGAGGC TTTGCCCCCA GTTCTCCAGC TCTGTCCGTG 480

CGGCCCGGGT ATCTGGCCAC CTACCCCATC GAGTACGTCT ACACTTTCCA CTCTGGCGGC 540

CACGTCTACT TCCTGACGGT CCAGCCCGAG TCCCTGAAGG TTCCCACCAC TTTCCACACG 600

CGATTGGTGC GGCTGAGCGC GACCGAGCCG GACGTGGGGG AATACAGGGA GCTGGTCCTC 660

GATTGTCACT TTTCTAACAA GAGGCGGCGC CGGAGAAGAC AGGGGGTCAG CCTGGAGAAG 720

GAGACTTACA ATGTGCTGCA GGCAGCCCAC GTGGCCAGAG TGGAGTCTTC GCTGGCTGAG 780

GGTCTGGGAG TCCCTGAGGG CCAGAAAGTG CTGTTTGGGG CCTTTGCCGT GAGCCGGGAG 840

GGGAGCCGGC TCCCGCGCCC CAAATCGGCC GTCTGCGCCT TTTCCATAAG CAAACTGGAT 900

GAGCTCATTG ACAATGGCAT GGAGAGATGC TGTGGGTCTC CGGCCCAACA GGAGCGCCTG 960

GAGCGAGGAG TGGAGTTCTT TCAGCCCCAG AGCTACTGCC CAGATCCGCC TCAAACAATA 1020

TTCCTGGATC CCAATGTCAG CTGCTGGAAC TACCCCACAA TGATCCCCAC CAACTACCCC 1080

CGAGAGGACC TCCTCAATGG GCACCTGGAC AATGTTCTCC TTACAGCCAT CCACGTTATT 1140

CACCAGGGCA ATGCTACTGT GGCCCATATG GGCACTGCTG ATGGGCGCAT CCTGCAGGTG 1200

AAGTTGTTCA GGTCACTCAA CTATCTGCTC TACGTGTCCA ACTTTTCCCT GGGATCCTCC 1260

CAGCCTGTGC ATCGAGAGGT CAGCTGCCTT GGAGACCACC TGTTCTTCAG CTCTGGCAAT 1320

AAAGTCTTCA AGGTGCCAAT CAAGGGTCCC GGATGCCGTC ACTTCCTGAC CTGTAAAAAA 1380

TGCCTCCAAG CCGAGCCCTT CATGGGCTGT GGTTGGTGTG GGAATGTCTG TGCCCGGCAA 1440

CAGGAGTGTC CAGGTACTTG GCAGCAGGAC TCCTGCCCCC CCATTATTAC TGAGTTCCAC 1500

CCCAAAGCCG GACCCACAAG GGGCAGCACG AAGCTGACAA TATGCGGCTC TAACTTTCAC 1560

AGCCACTCCC AGAATCTGGC TCCAGAGGGT CCTCAGAAAG TCACGGTGGG CCAGAGCCCC 1620

TGCAAAGTGC CTCCTGCAGC TACCTCATAC ATGCCCCCAA GCTTTAAGAA GAACTATGTG 1680

GAACAGCTGG AGTGTTTGCT GGAGGCTTCG AGTTCCCAGG CTCCTGGTCC TGCCAACGTC 1740

ACCCTCAGCA TCTTTGGGGA ACCTACCAAA TTTCACTTTC AGCTGAATGG CTCTTCTGTC 1800

CTGGGCGGGT TCTCCTTTGT GGAGCCAGTG GTGACGTCCA TTTTGCCATT ATTTGGCCCT 1860

CGAGCTGGGG GCACTGAACT CACCATCAAA GGGCAAAATC TGAATGTGGG TTCCAGTCAC 1920

CTGGTGCTGA TTAATGGGAC TGAGTGCACC CTTAAACAGA TGGAAGAACA AAGGCTTCTG 1980

TGTGTCACGC CGCCGGGGAG GGACGTGGCC AATGTCTCCA TCAGCTTGTC CATTGGAGGT 2040

TCCAATATCT CTATCCCGTG GCTCTTCCAG TATCGGGACA ATCCCCGAAT CTTCAGCATC 2100

TCCCCCAATT GCAGCTATCC CCCCAGCGGC TCCCGCATTA CCATCCAAGG GCAGAATTTG 2160

GACGCCGTCT GGCAGATGAC TCTCGCCTTC GAGGATGGGC ACAGGACAAA GGAGCGCTTG 2220

GAGTGCTTCA ATGAGACTCT CCCCACTGAG CGCGTGTGCT GGGCTCCTGC CTACGCCCAC 2280

CTGCCGGACC TGGAGCAGGC GCAGGGCAAC CTGAGCATCA GTGGGGACGG CTCTGTTCTC 2340

TACTTCCACC CCGACTTCCC CTTCTACCCC AAGCCACAAG TCCACCCGCA GCTGGGCCCC 2400

CTGAAGATTG ACCACGGCAC TGTGGAAATA AAGTTTCCTG GGCTGAGTGC CGTGGCTTCC 2460

TGCATGGAGG TGAACATGAC CGTGGGTGGC CAGAGCTGCC GGGCCAACCT GAAGAATAAC 2520

CCCGTGATCT GCTATGTTCC TCCCTCCCTG TCCATCCCCC GCAGTGGAGC TCCCCTGCAG 2580

ATCTGCCTGA ATGGGGAATG TTGGCGCCTC AGTAACGTGA TACCAAGCTC CTCAGAGCTC 2640

CCCCAAGCCT TCATCATTGT GTTCTTAATC ATCACCATGC TGGTGGTCTG CTTCCTGTCC 2700

TTGCTGCTCT TCAAGCTGTG GAGGAAGAAG AATAAGAGGC AGGATGCTTA TTCCCTCCCA 2760

AAGACAACAT TCAGCATATT GAATGGCACT GAACCTGGCC CTGTTCAGCC GATATCATCC 2820

ACGGGCAGCA GCAGCGGTTG TGGGGTTCCC CTCCTTCGGG TCAAGTCCAT CTGTGTGGCC 2880

AAACTGAGTT CGGAGCTCCT GGCCGAGGTG AAGGATGTCC TCATCCCTCC TGAGAGGATA 2940

CTTATACACG ACGACCAAGT CATTGGCAAA GGACACTTTG GAATTGTCTA CCATGGGGAA 3000

TATGTGGATT CTTCTCAGAA TCGAATCCAT TGTGCCGTCA AATCACTGAA TCGGATCACA 3060

GAGCTGGAGG AGGTGGAGGC GTTCCTGAGG GAGGGCCTGC TCATGCGGAG CTTCTGTCAC 3120

CCGAACGTCC TGTCCCTCAC CGGCATCCTG CTGCCCTCCG AGGGGCTCCC CAGCGTGGTG 3180

CTGCCCTACA TGAAGCACGG GGATCTGCGG CACTTCATCC GCTCCCCCGA GAGGAATCCC 3240

ACAGTGAAGG ACCTCATTGG CTTCGGGATC CAGGTGGCCC GAGGGATGGC CTACCTGGCG 3300

GAGAAGAAAT TTGTTCACAG AGACCTTGCA GCTCGGAACT GCATGCTGGA TGAGACGTTT 3360

ACAGTAAAGG TGGCTGACTT TGGCCTAGCC CGGGACATTG TGGACAAGGA GTACTACAGC 3420

ATCAGGAAGC ACAGTCACGC CCGGCTACCG GTCAAGTGGA TGGCTCTGGA GAGTCTGCAG 3480

ACCTACAAGT TCACTACCAA GTCGGACGTG TGGTCCTTTG GGGTCCTCCT TTGGGAGCTG 3540

CTGACTCGAG GGGCATCCCC ATATCCCAAC ATCGATCCCT TTGACATTGC CCATTTCCTG 3600

GCACAAGGCC GACGTCTACC CCAGCCCGAG TACTGCCCTG ATGCCCTGTA TTCAGTGATG 3660

CTCCAGTGCT GGGATCCCGT CCCCACAGAG CGGCCAGCCT TCGGGGTGCT GGTGAGGGAG 3720

GTGGAGTGTG TCTCGGCCTC CCTCCGGGGG GAGCATTATG TCAACCTGCA CAGCGGCTAC 3780

GTGAACCTG 3789

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         + ++viGkGhfG+vy+ge++ds++++i++avksl+rit++e+ve+flregl+m+ + hpn

Q: 983   HDDQVIGKGHFGIVYHGEYVDSSQNRIHCAVKSLNRITELEEVEAFLREGLLMRSFCHPN  1042

         789*********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vlsl Gi l++eglp vvlpymk+Gdl++fir++ern+tvkdl++f++qva+gm yla+k

Q: 1043  VLSLTGILLPSEGLPSVVLPYMKHGDLRHFIRSPERNPTVKDLIGFGIQVARGMAYLAEK  1102

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlard++dke+y+ +++ +arlpvkw+aleslqt+

Q: 1103  KFVHRDLAARNCMLDETFTVKVADFGLARDIVDKEYYSIRKHSHARLPVKWMALESLQTY  1162

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         k fttksdvwsfGvllwelltrga+py+++++fd+ ++l++grrl++peycpd+ly vml

Q: 1163  K-FTTKSDVWSFGVLLWELLTRGASPYPNIDPFDIAHFLAQGRRLPQPEYCPDALYSVML  1221

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsi  260

         +cw + p erp f  lv

Q: 1222  QCWDPVPTERPAFGVLVRE  1240

         *************988865

Domain Sequence
(FASTA)

HDDQVIGKGH FGIVYHGEYV DSSQNRIHCA VKSLNRITEL EEVEAFLREG LLMRSFCHPN 60

VLSLTGILLP SEGLPSVVLP YMKHGDLRHF IRSPERNPTV KDLIGFGIQV ARGMAYLAEK 120

KFVHRDLAAR NCMLDETFTV KVADFGLARD IVDKEYYSIR KHSHARLPVK WMALESLQTY 180

KFTTKSDVWS FGVLLWELLT RGASPYPNID PFDIAHFLAQ GRRLPQPEYC PDALYSVMLQ 240

CWDPVPTERP AFGVLVRE 258

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013