EKS-SAH-00344

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00344

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	385.8	9.3E-116	253	502	250

Status

Unreviewed

Ensembl Protein

ENSSHAP00000021567

UniProt Accession

G3X1L2;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000018268	ENSSHAP00000021567	ENSSHAT00000021741

Organism

Sarcophilus harrisii

Functional Description

Protein Length

514

Protein Sequence
(FASTA)

MKQSWYPGGL SAAKMEPFLR KHLTFLSFFW NKLWPTSVPD DCIPRYPGPD PVTMDLDPDP 60

DPEPFSTKSS SPPPSVLFMV LYDFTARCAD ELSVSRGDKL FVIKEEGDYI FARRLSGRPS 120

TGLVPINYVA KATQDTFSNQ PWYFDGISRS EAQQLLLSSS NQHGAFLVRP SESSRGDYSL 180

SVRTQAKVCH YRISKAPEGG LYIQKGQVFS SLEELLTYYK ANWKIIQTPL LQPCVQERLL 240

ERDEWERPRS EFALRRKLGE GYFGEVWEGL WLNKIPVAIK IIKSADMKLD DFNKEIQNLK 300

NLKHEKLIRL HAVCSIGEPV YIVTELMRKG NLQSFLNSPE GKALSIIHLM SIACQVAEGM 360

TYLEERHIVH RDLAARNILV GEDLTCKIAD FGLARLLKDD IYSTKSSTKI PVKWTAPEAA 420

NYRIYSQKSD VWSYGILLYE VFTYGQCPYE GMTNQETIQQ ISRGYRLPRP LICSPEVYIL 480

MLECWKSNAE ERPAFSVLRE KLSSIYRRLH HSFT 514

Nucleotide Sequence
(FASTA)

ATGAAACAAT CTTGGTACCC TGGGGGTCTG TCAGCAGCCA AGATGGAGCC TTTCTTAAGA 60

AAACACTTGA CCTTCCTATC ATTCTTTTGG AACAAGCTCT GGCCCACCAG TGTTCCTGAT 120

GACTGCATCC CCAGATACCC AGGCCCTGAT CCTGTCACAA TGGATCTTGA TCCTGATCCT 180

GACCCAGAAC CCTTCTCTAC AAAATCAAGC AGCCCCCCTC CCTCGGTCCT TTTCATGGTT 240

CTGTATGACT TTACAGCCAG GTGTGCAGAT GAGCTGAGTG TGAGCAGAGG AGACAAGCTC 300

TTTGTGATCA AAGAAGAGGG TGACTACATC TTTGCCAGGA GGCTCTCTGG TCGGCCAAGC 360

ACTGGGCTTG TACCCATTAA TTATGTGGCC AAAGCCACCC AGGATACCTT CTCCAATCAA 420

CCATGGTATT TTGATGGGAT CAGCCGGAGC GAAGCTCAAC AACTTCTGCT GTCCTCCTCC 480

AACCAGCATG GAGCCTTTTT GGTTCGACCC AGTGAGAGTA GTCGAGGAGA CTACTCATTG 540

TCAGTTCGCA CACAGGCCAA GGTCTGCCAT TACCGAATTT CCAAGGCCCC AGAGGGTGGC 600

CTATATATTC AGAAAGGCCA GGTTTTCTCC AGCCTGGAGG AGCTCCTCAC TTACTACAAA 660

GCCAACTGGA AGATTATTCA GACACCCCTG CTGCAGCCCT GTGTACAAGA GCGGCTACTG 720

GAGAGGGATG AATGGGAACG GCCCCGGTCT GAGTTTGCCC TTCGAAGAAA GCTGGGAGAA 780

GGCTATTTTG GAGAGGTGTG GGAAGGCTTG TGGCTGAATA AGATTCCAGT GGCCATAAAG 840

ATCATAAAGT CTGCTGACAT GAAGCTTGAT GACTTCAACA AGGAGATTCA GAATCTAAAG 900

AATCTAAAGC ATGAGAAGCT GATCAGATTG CATGCAGTCT GTTCCATCGG GGAGCCTGTA 960

TACATTGTGA CTGAGCTCAT GAGAAAAGGG AACCTCCAGA GCTTTCTCAA CAGTCCAGAA 1020

GGGAAGGCTC TCAGCATCAT CCACCTCATG AGTATCGCCT GCCAGGTGGC TGAGGGTATG 1080

ACCTACCTGG AGGAGAGGCA CATTGTACAC CGGGATCTAG CTGCTCGAAA CATCCTGGTG 1140

GGAGAGGACC TCACCTGTAA GATCGCAGAC TTTGGCCTAG CCAGGCTGCT AAAGGATGAT 1200

ATTTATTCCA CAAAAAGCAG CACCAAAATT CCTGTAAAGT GGACAGCACC AGAAGCAGCC 1260

AATTATAGGA TCTATTCACA GAAGTCAGAT GTTTGGTCCT ATGGGATCCT GCTTTATGAA 1320

GTTTTCACAT ATGGACAGTG TCCCTATGAA GGAATGACCA ATCAGGAGAC CATTCAGCAG 1380

ATCTCCCGAG GTTACAGGCT TCCTCGCCCA CTCATTTGTT CCCCTGAAGT CTATATACTC 1440

ATGTTGGAGT GCTGGAAAAG CAATGCTGAG GAGAGACCTG CCTTCTCTGT GCTCAGAGAG 1500

AAGCTCAGCT CCATCTACAG ACGTCTCCAT CATTCTTTCA CATGA 1545

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l +klGeG+fGevw+g+w ++++va+k +k+++++ ++f +e+q lk+l+hekl++l+a

Q: 253   ALRRKLGEGYFGEVWEGLWLNKIPVAIKIIKSADMKLDDFNKEIQNLKNLKHEKLIRLHA  312

         688*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s +eP+yivtelm+kG+l++fl++ egk+l++ +l+ +a+qvaeGm+ylee++++hrd

Q: 313   VCSIGEPVYIVTELMRKGNLQSFLNSPEGKALSIIHLMSIACQVAEGMTYLEERHIVHRD  372

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarn+lvge+l++k+adfGlarl++dd+y++k+++k+P+kWtaPea++++ +++ksdvW

Q: 373   LAARNILVGEDLTCKIADFGLARLLKDDIYSTKSSTKIPVKWTAPEAANYRIYSQKSDVW  432

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         s+Gill+e++t+G++Py+Gmtn+e+++q++rgyrlprp  c  e+y l+lecwk+++eer

Q: 433   SYGILLYEVFTYGQCPYEGMTNQETIQQISRGYRLPRPLICSPEVYILMLECWKSNAEER  492

         ************************************************************

S: 242   Ptfetlqevl  251

         P+f +l+e+l

Q: 493   PAFSVLREKL  502

         ******9876

Domain Sequence
(FASTA)

ALRRKLGEGY FGEVWEGLWL NKIPVAIKII KSADMKLDDF NKEIQNLKNL KHEKLIRLHA 60

VCSIGEPVYI VTELMRKGNL QSFLNSPEGK ALSIIHLMSI ACQVAEGMTY LEERHIVHRD 120

LAARNILVGE DLTCKIADFG LARLLKDDIY STKSSTKIPV KWTAPEAANY RIYSQKSDVW 180

SYGILLYEVF TYGQCPYEGM TNQETIQQIS RGYRLPRPLI CSPEVYILML ECWKSNAEER 240

PAFSVLREKL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013