EKS-SAH-00345

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00345

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	365.2	1.8E-109	195	443	249

Status

Unreviewed

Ensembl Protein

ENSSHAP00000021633

UniProt Accession

G3X1S8;

Protein Name

Protein Synonyms/Alias

Gene Name

PTK6

Gene Synonyms/Alias

PTK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000018321	ENSSHAP00000021633	ENSSHAT00000021807

Organism

Sarcophilus harrisii

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

MDSRSLSHLG PKYLYVSLWD FEARTEDELS FQAGDHFYVT EKKEDWWKAT KLDAAGRSLG 60

EGYVPHNYLA EEETMETEPW FFGQISRSEA LHRLLAGENG TGTFLIRISE KTGADYVLSV 120

RDNQIVRHYK IWRNAEGRYH MNSAVSFPSL VGLVQYHKNK PLSHGLRLTT PCWKHEPKPL 180

PHWDDWERPR EEFILTRKLG SGYFGEVFEG YWKEKVKVAI KVIAKDDLMH QNTFYSEIEA 240

MKKLRHKHIL SLYAISSIGD PVYIITELMP KGNLLELLRD PKGAKLPTTE LVDIASQISE 300

GMCYLESQNY IHRDLAARNI LVGENNICKV GDFGLARLIK DDVYLSYAHN IPYKWTAPEA 360

LSYGYYSIKS DVWSFGILLY EIFSGGQIPY PGMSNNETHM KVLGGFRMLR PTKCPLSIYD 420

LMYKCWNLTP GERPCFKSLK EKLISFTNYE NPL 453

Nucleotide Sequence
(FASTA)

ATGGATTCAA GAAGTCTTTC CCATTTGGGT CCCAAATACC TCTATGTTAG TCTCTGGGAC 60

TTTGAAGCAA GGACAGAGGA TGAATTGAGC TTTCAGGCTG GGGATCATTT TTATGTAACA 120

GAGAAGAAGG AAGATTGGTG GAAAGCCACG AAGCTTGATG CTGCTGGAAG GAGCTTGGGA 180

GAAGGCTATG TCCCTCACAA TTATTTAGCT GAAGAAGAGA CAATGGAGAC TGAACCATGG 240

TTTTTTGGGC AGATCTCTCG TTCAGAAGCT CTGCATAGAC TCCTTGCAGG AGAAAATGGA 300

ACTGGTACCT TCCTTATAAG GATCAGTGAG AAGACAGGAG CAGACTATGT TCTCTCAGTT 360

CGGGACAACC AGATTGTAAG ACATTACAAG ATCTGGAGGA ATGCTGAGGG AAGATACCAC 420

ATGAACTCCG CTGTATCCTT CCCCAGTCTT GTTGGTCTAG TGCAGTATCA CAAAAATAAG 480

CCACTGTCCC ACGGCCTGAG GCTCACCACA CCCTGCTGGA AGCATGAGCC AAAACCATTG 540

CCTCATTGGG ATGACTGGGA AAGACCCAGG GAAGAGTTTA TCCTGACCAG GAAGCTGGGC 600

TCAGGATACT TTGGGGAAGT CTTTGAAGGA TACTGGAAAG AGAAAGTCAA AGTGGCCATT 660

AAGGTCATTG CCAAGGATGA CCTGATGCAT CAAAACACCT TCTACTCAGA GATTGAAGCC 720

ATGAAGAAGC TGCGCCACAA ACACATTCTC TCTCTCTATG CTATCTCTTC CATTGGGGAT 780

CCTGTCTATA TCATTACTGA ATTGATGCCC AAAGGAAACC TTCTGGAGCT CCTTAGAGAC 840

CCTAAAGGGG CAAAGCTACC CACCACAGAG CTTGTGGACA TAGCATCTCA AATATCAGAA 900

GGCATGTGCT ACCTTGAGTC ACAGAACTAT ATTCACCGAG ACCTGGCTGC CAGAAACATC 960

CTTGTGGGGG AAAATAACAT CTGCAAAGTG GGAGACTTTG GGCTGGCTCG GCTTATCAAG 1020

GATGATGTTT ATCTTTCCTA TGCACACAAC ATCCCCTACA AATGGACGGC ACCAGAAGCC 1080

CTCTCCTATG GATATTATTC AATCAAATCT GATGTCTGGT CCTTTGGAAT TCTTCTCTAT 1140

GAAATTTTCA GTGGTGGACA GATACCTTAT CCAGGGATGT CCAATAATGA GACTCACATG 1200

AAAGTCTTGG GTGGCTTTCG GATGCTCCGC CCCACAAAGT GCCCACTCTC CATCTATGAT 1260

CTCATGTATA AATGCTGGAA TCTGACTCCA GGAGAAAGAC CATGCTTCAA AAGCCTCAAA 1320

GAAAAACTCA TTAGCTTCAC TAATTATGAA AACCCACTCT GA 1362

Domain Profile

S: 3     lvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvklya  61

         l++klG+G+fGev++g+wk++vkva+k++ +++ +++++f +e++++kklrh+++++lya

Q: 195   LTRKLGSGYFGEVFEGYWKEKVKVAIKVIAKDDlMHQNTFYSEIEAMKKLRHKHILSLYA  254

         78***************************999879*************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         + s ++P+yi+telm kG+ll++l++ +g kl+ ++lvd+a+q++eGm+yle++n+ihrd

Q: 255   ISSIGDPVYIITELMPKGNLLELLRDPKGAKLPTTELVDIASQISEGMCYLESQNYIHRD  314

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarn+lvge++++kv+dfGlarli+dd y +   +++P+kWtaPea+++g ++iksdvW

Q: 315   LAARNILVGENNICKVGDFGLARLIKDDVYLSYA-HNIPYKWTAPEALSYGYYSIKSDVW  373

         ******************************9987.99***********************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfGill+ei++ G++PypGm+n+e+  +v  g+r+ rp++cp ++y+l+ +cw+ +p er

Q: 374   SFGILLYEIFSGGQIPYPGMSNNETHMKVLGGFRMLRPTKCPLSIYDLMYKCWNLTPGER  433

         ************************************************************

S: 242   Ptfetlqevl  251

         P+f+ l+e+l

Q: 434   PCFKSLKEKL  443

         ******9876

Domain Sequence
(FASTA)

LTRKLGSGYF GEVFEGYWKE KVKVAIKVIA KDDLMHQNTF YSEIEAMKKL RHKHILSLYA 60

ISSIGDPVYI ITELMPKGNL LELLRDPKGA KLPTTELVDI ASQISEGMCY LESQNYIHRD 120

LAARNILVGE NNICKVGDFG LARLIKDDVY LSYAHNIPYK WTAPEALSYG YYSIKSDVWS 180

FGILLYEIFS GGQIPYPGMS NNETHMKVLG GFRMLRPTKC PLSIYDLMYK CWNLTPGERP 240

CFKSLKEKL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013