EKS-SAH-00343

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00343

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	412.6	6.1E-124	243	494	252

Status

Unreviewed

Ensembl Protein

ENSSHAP00000021689

UniProt Accession

G3X1Y4;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000018366	ENSSHAP00000021689	ENSSHAT00000021863

Organism

Sarcophilus harrisii

Functional Description

Protein Length

516

Protein Sequence
(FASTA)

RKQLKQWAKK RIRNFFLAEI EVDKPVVIEN PHAVSPSTPP CQRQTPESER GHGRYFVALF 60

DYQARTAEDL SFRAGDKLQV LDSSHEGWWF ARHLEKRVDG PGQQLQGYIP SNYVAEDQSI 120

QAEPWFFGSI KRVDAEKQLL YPGNQNGAFL IRESETQKGD FSLSVLDNKI VKHYRVRRLD 180

EGGFFLTRRR TFDTLNAFVD HYTKTSDGLC IKLGKPCLKK EVPTTFDLSY KTVDQWEIDR 240

NSLQLLKILG SGQFGEVWEG LWNNTTPVAV KTLKPGSMDP KDFLREAQIM KNLRHPKLIQ 300

LYAVCTLEDP IYIITELMRH GSLQVYLQND AGSKIHLPQQ LDMAAQVASG MAYLESQNYI 360

HRDLAARNVL VGEHNVYKVA DFGLARVFKV ENEDIYESKP EIKLPVKWTA PEAIRSHKFS 420

IKSDVWSFGI LLYEIITYGK MPYPGMTGMQ VIQKLDQNYR LPQPDNCPLE LYNIMLQCWN 480

VDPKDRPTFE SLHLSLEDYY YELDSTSYLD TNNFVR 516

Nucleotide Sequence
(FASTA)

AGAAAACAAT TAAAGCAGTG GGCTAAAAAG AGAATCAGGA ATTTCTTCCT GGCAGAGATT 60

GAAGTGGATA AACCTGTTGT GATTGAAAAT CCACATGCCG TCTCCCCATC CACCCCTCCA 120

TGCCAGAGAC AGACCCCCGA GTCAGAAAGG GGTCATGGCC GCTATTTTGT GGCCTTGTTT 180

GATTATCAGG CCCGGACGGC AGAAGATCTG AGCTTCCGAG CTGGAGACAA ACTTCAGGTC 240

CTGGATTCTT CTCATGAGGG CTGGTGGTTT GCCAGGCATT TGGAGAAGAG GGTAGATGGC 300

CCTGGGCAGC AACTCCAAGG TTATATTCCT TCCAATTATG TGGCTGAGGA TCAGAGCATC 360

CAGGCTGAGC CGTGGTTCTT TGGTTCAATC AAGCGAGTGG ATGCAGAAAA ACAACTCCTG 420

TACCCAGGAA ACCAGAATGG TGCCTTCCTA ATTAGAGAAA GTGAAACTCA GAAAGGAGAC 480

TTCTCTCTTT CAGTTTTAGA TAACAAAATT GTGAAGCATT ACCGAGTGAG AAGACTTGAT 540

GAGGGAGGCT TTTTCCTTAC ACGGAGAAGA ACTTTTGATA CCTTGAATGC TTTTGTGGAC 600

CACTACACCA AGACGAGTGA TGGCCTCTGT ATCAAACTTG GAAAACCATG CTTAAAGAAA 660

GAAGTCCCAA CTACTTTTGA TTTGTCATAT AAGACTGTGG ACCAATGGGA AATAGATCGA 720

AACTCTCTGC AACTTCTGAA AATATTAGGA TCTGGCCAGT TTGGTGAGGT GTGGGAAGGT 780

TTATGGAATA ATACCACTCC TGTAGCAGTC AAAACATTAA AACCAGGTTC AATGGATCCA 840

AAGGACTTCC TAAGGGAGGC ACAGATAATG AAGAACTTGA GACATCCCAA GCTTATCCAG 900

CTTTATGCTG TTTGCACTTT AGAGGATCCA ATTTATATTA TTACAGAACT GATGAGACAT 960

GGAAGTCTGC AAGTCTATCT CCAAAATGAT GCTGGGTCCA AAATCCATCT GCCTCAACAG 1020

CTAGACATGG CAGCTCAAGT TGCCTCAGGA ATGGCTTATC TAGAATCGCA GAATTACATC 1080

CACAGAGATC TGGCTGCCAG AAATGTCCTT GTTGGTGAAC ATAATGTTTA CAAAGTTGCA 1140

GACTTTGGAC TTGCAAGAGT TTTTAAGGTA GAAAATGAAG ACATCTATGA ATCAAAACCA 1200

GAAATCAAAC TTCCAGTGAA ATGGACAGCA CCTGAAGCCA TTCGATCCCA CAAATTCAGC 1260

ATTAAGTCTG ATGTATGGTC TTTTGGGATA CTTCTTTATG AAATTATTAC TTATGGCAAG 1320

ATGCCTTATC CAGGTATGAC TGGGATGCAG GTAATCCAGA AGTTGGATCA AAACTATAGA 1380

CTTCCTCAAC CAGATAACTG TCCATTGGAA CTCTACAACA TCATGTTGCA ATGCTGGAAT 1440

GTGGATCCCA AAGATCGGCC AACGTTTGAA TCACTGCACT TGAGTCTTGA GGATTATTAT 1500

TATGAATTAG ATTCTACCTC TTACTTGGAT ACAAATAATT TTGTTAGATG A 1551

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 243   LQLLKILGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPKDFLREAQIMKNLRHPKLIQLY  302

         689999******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+ +l+++ g+k++lp+++d+aaqva+Gmayle++n+ihr

Q: 303   AVCTLEDPIYIITELMRHGSLQVYLQNDAGSKIHLPQQLDMAAQVASGMAYLESQNYIHR  362

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++v+kvadfGlar+++   +d+y++k + klP+kWtaPeai+ +kf+ik

Q: 363   DLAARNVLVGEHNVYKVADFGLARVFKvenEDIYESKPEIKLPVKWTAPEAIRSHKFSIK  422

         ************************99887899****************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+PypGmt  +v+++++++yrlp+p++cp ely+++l+cw+ d

Q: 423   SDVWSFGILLYEIITYGKMPYPGMTGMQVIQKLDQNYRLPQPDNCPLELYNIMLQCWNVD  482

         ************************************************************

S: 238   peerPtfetlqe  249

         p++rPtfe l+

Q: 483   PKDRPTFESLHL  494

         ********9975

Domain Sequence
(FASTA)

LQLLKILGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPKD FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQVYLQNDAG SKIHLPQQLD MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNVYKVADF GLARVFKVEN EDIYESKPEI KLPVKWTAPE AIRSHKFSIK 180

SDVWSFGILL YEIITYGKMP YPGMTGMQVI QKLDQNYRLP QPDNCPLELY NIMLQCWNVD 240

PKDRPTFESL HL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013