EPS-SAH-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAH-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	152.5	7.5E-45	133	278	146

Status

Unreviewed

Ensembl Protein

ENSSHAP00000021754

UniProt Accession

G3X249;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000018419	ENSSHAP00000021754	ENSSHAT00000021928

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1160

Protein Sequence
(FASTA)

MATSNDPEEE QVVPDTEDGA DVKAVQAHYL RSPSPSQYSM VSDAETESIF MDPIHLSSAV 60

AAKKIINEEL KPREIKADTV CPGMLESAEQ LLVEDLYNRV KEKIDDTSLY NTPCVMDLQR 120

ALVQDRQEAP WNEVDEVWPN VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYN 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK ILVSSEMGIS RSAVLVVAYL 240

MIFHHMTILE ALMTVRKKRA ICPNDGFLKQ LRELNEKLME ERDQDYGREE GDYEDERDSS 300

SVLGGEGDTG SVFGARVHSI IVEEEEDTAS TLSGSSVRST RRTSKPGTLV DGEEEEKLYK 360

DWRKKQGLPQ ARNGQSLDQE GGEESEEDLE RVIQEWQSRN EKYRAERSRR WSREEEEEEE 420

GERDGESLSG RSRRRTFSEC STSESTLSHD IRVLKQQLEL SSRRRTQRKH SDSESSESTW 480

DMWNQRLLEI EKEASQRYHS RSRREEAESD SETGRRERED DEESVASDAS SFYNFCKRNK 540

DKLTALERWK IKRIQFGFHK RDSEAGEGTS EQGEGATEGE KNLSDVNLTA YQAWKLKHQK 600

KIGNENKDEV VELSKGEDSV LTKKKQRRLE LLERTRQTLE DSQSMDSWDA ESTATSRSIP 660

LSALWSSATS ANADGDSGSV LSMQSNRSRL SQAPSNVSAS LPNIPLPNLP VGPGDTISVA 720

SIQNWIANVV TETLAQKQNE MLLLSRPPST ASMKPTPLGN GVGDDQMSCL SGQSARSLGA 780

SLLTRPQDRP GADAQSVLSC STTSSRTEGI GGKGKGTSKP FYSLFADDVN LQELRQKEKD 840

MQSGIREKMS EYKMEKLASD NKRSQLFKKK KAKEEEEEEG EDGGEEDTDS AIGSFRYSSR 900

SESHKPETTL SSSSSLAISD RRGNAHVANL EVDRSINKWL SGLKPEGEVP PQRDGSRSSG 960

ERYSRSSTLR EVESEAATYR MSKSRSEERD SSSHHQSDGS SVRSTSRFSS SSTREDRETY 1020

KFSRSKFRET SSSREESPEP YFFQRSPEPS QGQESPEPLR RPSWSRPHDW EDVEESSKSD 1080

FTEFGAKRKF TQSFMKSDEE GERERTENTE EGKFASGRRF QYRRSTDKED EEEMDDEAII 1140

AAWRRRQEET KTKLQRRREE 1160

Nucleotide Sequence
(FASTA)

ATGGCGACCA GCAATGATCC AGAGGAGGAG CAGGTTGTTC CGGATACAGA AGATGGAGCT 60

GACGTGAAGG CTGTGCAGGC CCACTATCTC CGAAGCCCTT CTCCCAGCCA GTACTCCATG 120

GTCTCAGATG CTGAAACAGA GAGTATTTTC ATGGATCCCA TTCACCTGTC ATCAGCTGTT 180

GCTGCCAAGA AGATCATTAA TGAAGAGCTC AAACCAAGGG AAATCAAAGC AGACACTGTG 240

TGCCCAGGGA TGCTGGAGTC TGCAGAGCAA CTGCTGGTGG AAGATCTCTA CAACAGAGTC 300

AAAGAGAAGA TTGATGATAC CAGCCTGTAT AACACCCCCT GTGTCATGGA CCTCCAGAGG 360

GCTTTGGTTC AGGACCGCCA GGAGGCCCCC TGGAATGAAG TGGATGAAGT CTGGCCCAAC 420

GTCTTCATCG CAGAGAAGAG TGTGGCTGTA AATAAGGGGC GGCTGAAGAG GCTAGGGATC 480

ACACATATCC TCAATGCGGC TCATGGCACG GGTGTTTACA CCGGACCAGA GTTCTACAAT 540

GGCCTGGAGA TTCAGTATCT GGGTGTAGAG GTGGATGATT TCCCTGAGGT AGACATATCC 600

CAACATTTTC GGAAGGCTGC GGAGTTCCTT GATGAAGCTC TGCTGACATA CAGAGGGAAA 660

ATCCTGGTCA GTAGTGAAAT GGGAATCAGC CGATCAGCTG TGCTGGTGGT TGCTTACCTG 720

ATGATCTTCC ACCATATGAC CATCCTAGAA GCTCTAATGA CTGTGAGGAA GAAACGTGCC 780

ATCTGTCCCA ATGATGGCTT CCTGAAGCAA TTGAGGGAGC TGAATGAGAA GCTGATGGAG 840

GAGCGAGACC AGGACTATGG GAGGGAGGAA GGGGATTACG AGGATGAAAG AGACAGCAGT 900

TCTGTACTAG GGGGTGAAGG AGACACAGGG AGTGTGTTTG GGGCCAGAGT TCACTCAATC 960

ATAGTAGAGG AAGAGGAAGA TACAGCCAGC ACCCTGAGTG GTTCTTCTGT GAGGAGCACT 1020

CGTAGGACCT CCAAGCCTGG CACCCTCGTT GACGGTGAAG AGGAAGAGAA GCTGTATAAG 1080

GACTGGAGGA AGAAGCAAGG TCTCCCCCAG GCTAGGAATG GACAGTCCTT GGATCAGGAA 1140

GGAGGAGAAG AATCTGAGGA GGATCTAGAG AGAGTCATTC AGGAGTGGCA AAGCCGAAAT 1200

GAGAAGTACC GAGCAGAAAG GTCCCGTAGA TGGTCTAGAG AGGAGGAAGA GGAAGAAGAA 1260

GGGGAGAGAG ATGGAGAGTC CCTCTCGGGG AGGAGCAGGA GGCGCACATT CAGTGAGTGC 1320

AGCACCTCGG AGAGTACCCT AAGTCACGAC ATCCGGGTCT TGAAGCAGCA GTTGGAGCTC 1380

AGCAGCCGAA GGCGGACCCA GAGAAAGCAT TCCGATTCAG AGTCCTCGGA GAGCACCTGG 1440

GACATGTGGA ACCAAAGGCT GCTGGAGATT GAGAAGGAAG CATCTCAGAG ATATCACTCT 1500

AGGAGCAGAC GGGAGGAGGC TGAATCAGAT TCAGAGACGG GGAGGAGAGA GAGGGAGGAT 1560

GATGAGGAAA GCGTAGCCTC CGATGCTAGC TCCTTCTATA ACTTCTGCAA AAGGAACAAG 1620

GACAAGCTGA CGGCCTTAGA ACGGTGGAAG ATTAAAAGAA TCCAGTTTGG ATTTCACAAG 1680

AGGGACTCGG AGGCAGGAGA GGGCACGAGT GAACAAGGCG AAGGAGCCAC CGAAGGGGAG 1740

AAGAACCTCT CAGATGTCAA TCTGACAGCC TACCAGGCCT GGAAGTTAAA ACACCAGAAG 1800

AAGATAGGGA ATGAAAACAA AGACGAGGTG GTGGAACTCA GTAAAGGGGA GGACTCGGTT 1860

TTGACCAAGA AAAAGCAAAG GAGGCTGGAG CTGTTAGAAA GGACCAGGCA GACCCTGGAG 1920

GACAGCCAGT CCATGGATAG CTGGGACGCT GAGAGCACAG CCACCAGCAG AAGCATCCCC 1980

CTGTCTGCTT TGTGGTCTTC TGCTACCTCG GCCAACGCTG ATGGGGACTC GGGCTCCGTG 2040

CTGAGCATGC AAAGCAACAG GTCCCGCCTG TCTCAGGCCC CAAGCAATGT CTCAGCTTCC 2100

TTGCCAAACA TACCTCTGCC CAACCTGCCG GTGGGACCTG GAGACACCAT CTCTGTGGCC 2160

AGCATTCAGA ACTGGATCGC CAACGTGGTC ACCGAGACCC TCGCTCAAAA ACAAAATGAG 2220

ATGTTGTTGC TGTCTCGCCC TCCTTCTACC GCGAGCATGA AGCCCACCCC CCTAGGCAAT 2280

GGCGTGGGAG ATGATCAAAT GTCCTGCCTC AGTGGGCAGA GTGCCCGATC CTTGGGTGCC 2340

TCCTTGCTGA CTCGTCCCCA GGACAGGCCC GGCGCCGACG CTCAGTCTGT GTTGTCCTGT 2400

AGCACGACGA GCTCAAGAAC CGAAGGAATC GGGGGGAAGG GGAAAGGAAC GAGTAAGCCT 2460

TTCTATAGCC TCTTTGCAGA TGACGTTAAC CTACAGGAGC TGAGACAGAA AGAAAAGGAC 2520

ATGCAAAGTG GGATCAGGGA GAAGATGTCC GAGTACAAAA TGGAGAAACT CGCTTCGGAC 2580

AATAAACGCA GCCAGCTGTT CAAGAAGAAG AAGGCCAAGG AAGAAGAGGA GGAGGAGGGG 2640

GAAGATGGCG GCGAAGAAGA CACCGATAGT GCCATAGGGA GCTTCAGATA TTCTTCTCGG 2700

AGTGAGTCTC ATAAGCCCGA GACAACTCTT TCCTCTTCCT CCTCCTTGGC TATCTCCGAT 2760

CGCCGTGGAA ACGCCCACGT GGCCAACTTA GAAGTGGACA GAAGTATTAA TAAGTGGCTC 2820

AGTGGCCTCA AGCCGGAAGG AGAGGTTCCC CCGCAACGAG ACGGGTCTAG GAGCTCCGGG 2880

GAAAGGTACT CCAGGTCGAG CACTCTCCGG GAGGTGGAGT CCGAAGCGGC CACTTACAGG 2940

ATGTCCAAGT CCCGGTCAGA GGAGCGAGAT AGCTCCTCCC ACCATCAGTC CGACGGCAGC 3000

TCGGTGAGGA GTACCTCGCG ATTCTCCTCT TCCTCCACTA GGGAGGACAG GGAGACGTAC 3060

AAGTTCTCCA GATCCAAATT CAGGGAGACC TCGAGCTCTA GGGAAGAAAG TCCCGAGCCT 3120

TACTTCTTCC AAAGGAGCCC GGAACCTTCC CAGGGACAGG AGTCCCCCGA GCCGCTGCGA 3180

AGACCGAGCT GGTCTAGACC CCACGACTGG GAAGACGTCG AAGAGTCATC CAAGTCCGAT 3240

TTTACTGAAT TTGGAGCCAA GAGGAAATTC ACCCAGAGTT TCATGAAGTC TGATGAGGAA 3300

GGGGAGAGGG AAAGAACGGA AAACACCGAA GAAGGAAAAT TTGCGTCAGG GAGGAGGTTC 3360

CAGTATCGGA GAAGCACGGA CAAGGAGGAT GAGGAAGAGA TGGATGATGA AGCCATCATT 3420

GCTGCCTGGA GACGTCGGCA AGAAGAAACT AAAACGAAGC TACAGAGAAG ACGGGAAGAA 3480

TAA 3483

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe++   +i+y++++v

Q: 133   EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYNGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gk+lv +++G+sRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKILVSSEMGISRSAVLVVAYLMIFHHMTILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL+el++kl

Q: 252   LMTVRKKR-AICPNDGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYNGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKIL VSSEMGISRS AVLVVAYLMI FHHMTILEAL 120

MTVRKKRAIC PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013