EPS-SAH-00020

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SAH-00020

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	290.1	2.0E-86	23	293	271

Status

Unreviewed

Ensembl Protein

ENSSHAP00000021891

UniProt Accession

G3X2I6;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000018530	ENSSHAP00000021891	ENSSHAT00000022066

Organism

Sarcophilus harrisii

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL DNWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT NNEDFRAAEK PGSALEPSVE NVKSGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PEHVYFINCG DSRAVLFRSG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEK VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 300

VSDEAVKKDS DLDKHLESRV EEIMEKSGEE GMPDLAHIMR ILSAENIPNL PPGGGLAGKR 360

YIIEAVYNRL NPHRENDGAP DDAEESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL 420

AKVQGEESAA ESAAGATSSN NDAGDPVTML EPHTETKSDL DELEHSNEDS GTQMSDSRI 479

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACT GAGAAACACA ATGCTCACGG TGCTGGGAAT 60

GGTTTGCGTT ACGGCCTAAG CAGCATGCAA GGATGGAGAG TAGAAATGGA AGATGCTCAC 120

ACAGCGGTTG TAGGTATTCC TCATGGCTTG GACAACTGGT CATTTTTTGC TGTTTATGAT 180

GGTCATGCTG GATCTCGAGT GGCAAATTAT TGCTCAACAC ACTTATTAGA ACATATTACT 240

AATAATGAAG ATTTTAGGGC AGCAGAAAAA CCTGGATCTG CTCTTGAACC TTCAGTGGAA 300

AATGTTAAGA GCGGAATCAG AACTGGCTTC TTGAAAATTG ATGAATACAT GCGTAACTTT 360

TCAGATCTCA GAAATGGAAT GGACAGGAGT GGCTCAACTG CAGTAGGAGT TATGATTTCA 420

CCTGAACATG TCTACTTTAT CAACTGTGGA GATTCACGTG CTGTCCTTTT TAGGAGTGGA 480

CAAGTCTGCT TTTCAACCCA GGATCACAAA CCTTGCAATC CAAGGGAGAA GGAGAGAATC 540

CAAAATGCAG GAGGCAGTGT AATGATACAG CGTGTTAATG GTTCATTAGC AGTTTCTCGA 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTG GATGGCAAGG GCCCTACAGA ACAACTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAAATTTTA AGAGCAGAAG AGGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGC AATGAGGAGC TCTGTGAATT TGTTAAATCT 780

AGGCTTGAGG TATCTGATGA CCTGGAAAAA GTGTGCAATT GGGTTGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTATT GTGCTAGTTT GTTTTTCAAA TGCTCCTAAG 900

GTCTCAGATG AGGCAGTGAA AAAAGATTCA GACTTGGATA AGCACTTGGA ATCACGGGTT 960

GAAGAAATTA TGGAGAAGTC TGGTGAGGAA GGAATGCCTG ATCTTGCCCA TATCATGCGC 1020

ATATTGTCTG CAGAAAATAT CCCTAATTTA CCTCCAGGGG GAGGTCTTGC TGGCAAGCGC 1080

TATATTATTG AGGCTGTTTA TAATAGACTA AATCCACATA GAGAGAATGA TGGGGCCCCC 1140

GATGATGCTG AGGAAAGTGG ATCACAGGGA AAATTGGTGG AAGCTCTCAG GCAAATGAGA 1200

ATTAATCATA GGGGAAACTA CCGACAACTT CTGGAAGAGA TGCTGACTAG TTACAGGCTA 1260

GCTAAAGTAC AGGGAGAAGA AAGCGCTGCT GAATCAGCTG CTGGAGCTAC TTCTTCGAAC 1320

AATGATGCTG GAGACCCAGT GACAATGCTG GAACCCCATA CTGAAACAAA AAGTGATCTT 1380

GATGAATTAG AACATTCTAA TGAAGATTCA GGGACACAGA TGAGCGATTC ACGCATATGA 1440

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++       d+++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPHG---LDNWSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************985555544...455***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TNNEDfraaekpgsALEPSVENVKSGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99*********99********************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL+r+g+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPEHVYFINCGDSRAVLFRSGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLEKVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLDN WSFFAVYDGH AGSRVANYCS THLLEHITNN 60

EDFRAAEKPG SALEPSVENV KSGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPE 120

HVYFINCGDS RAVLFRSGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLEKVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013