EKS-SUS-00247
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00247
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR433.06.3E-130204490287
StatusUnreviewed
Ensembl ProteinENSSSCP00000000247
UniProt AccessionF1SGK0;
Protein Name
Protein Synonyms/Alias
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000000232ENSSSCP00000028472ENSSSCT00000033395
ENSSSCG00000000232ENSSSCP00000000247ENSSSCT00000000251
OrganismSus scrofa
Functional Description
Protein Length504
Protein Sequence
(FASTA)
MTLDPPKRGF LMLLMALSLT QGNPVKPSRD LLVTCTCENP YCKGPTCQGA WCTVVLVREE 60
GGHPQEHRGC GNLHQELCRG HPTEFVNHYC CYSSLCNHNV SLALEATQTP PEQPQADSQL 120
PLILGPVLAF LVLVALGALG LWHVRRRQEK QRGLNSELGE SSLILKASEQ GDSMLGDLMD 180
SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG LWHGESVAVK IFSSRDEQSW 240
FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300
LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQGS 360
DYLDIGNNPR VGTKRYMAPE VLEEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIVNGIVE 420
DYRPPFYDVV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR 480
LTALRIKKTL QKLSNGLQKP KGIH 504
Nucleotide Sequence
(FASTA)
ATGACCTTGG ACCCTCCCAA GAGAGGCTTT CTGATGCTAC TGATGGCCTT GAGCCTGACC 60
CAGGGCAACC CCGTGAAGCC CTCTCGGGAT CTGCTGGTGA CCTGCACGTG TGAGAACCCA 120
TACTGCAAGG GGCCCACCTG CCAGGGGGCC TGGTGCACAG TAGTGCTGGT GCGGGAGGAG 180
GGCGGCCACC CCCAGGAACA TCGGGGCTGT GGGAACCTGC ACCAGGAGCT CTGCAGGGGG 240
CACCCCACTG AGTTCGTCAA CCACTACTGC TGCTACAGCT CCCTCTGCAA CCACAACGTG 300
TCCCTGGCAC TGGAGGCCAC CCAGACTCCT CCGGAGCAGC CACAAGCAGA CAGCCAGCTG 360
CCTCTGATCC TGGGCCCTGT GCTGGCCTTC CTGGTCCTGG TGGCCCTGGG TGCCCTGGGC 420
CTGTGGCATG TCCGGCGGAG GCAGGAGAAG CAGCGGGGCC TAAACAGCGA GCTGGGCGAG 480
TCCAGCCTCA TCCTGAAGGC ATCTGAGCAG GGGGACAGCA TGTTGGGGGA CCTCATGGAC 540
AGTGACTGCA CCACGGGCAG TGGCTCAGGG CTCCCCTTCC TGGTACAGAG GACAGTGGCA 600
CGGCAGGTTG CCCTGGTGGA GTGTGTGGGA AAGGGCCGCT ATGGCGAGGT GTGGCGGGGC 660
CTGTGGCATG GCGAGAGTGT GGCGGTCAAG ATCTTCTCCT CCAGGGATGA ACAGTCCTGG 720
TTCCGGGAGA CTGAGATCTA CAACACGGTG TTGCTCAGAC ACGACAACAT CCTAGGCTTT 780
ATCGCCTCGG ACATGACGTC CCGCAACTCG AGCACGCAGC TGTGGCTCAT CACGCACTAC 840
CACGAGCATG GCTCGCTCTA CGACTTTCTG CAGAGGCAGA CGCTGGAGCC GCAGCTGGCC 900
CTGAGGCTAG CCGTGTCGGC GGCCTGCGGC CTGGCGCACC TGCACGTGGA GATCTTCGGC 960
ACGCAGGGCA AGCCGGCCAT CGCCCACCGC GACCTCAAGA GCCGCAACGT GCTGGTCAAG 1020
AGCAACCTGC AGTGCTGCAT CGCAGACCTG GGCCTGGCTG TGATGCACTC CCAGGGTAGC 1080
GATTACCTGG ACATCGGCAA CAACCCGCGA GTGGGCACCA AGCGGTACAT GGCCCCCGAG 1140
GTGCTGGAAG AGCAGATCCG CACTGACTGC TTTGAGTCCT ACAAGTGGAC GGACATCTGG 1200
GCCTTTGGCC TGGTGCTGTG GGAGATCGCC AGGCGGACCA TTGTCAACGG CATTGTCGAG 1260
GACTACAGGC CCCCCTTCTA TGATGTGGTG CCTAATGATC CCAGCTTTGA GGACATGAAG 1320
AAGGTGGTGT GTGTTGACCA GCAGACACCC ACCATCCCCA ACCGACTGGC TGCAGACCCG 1380
GTCCTCTCAG GCCTGGCTCA GATGATGCGG GAGTGCTGGT ACCCCAACCC CTCTGCCCGC 1440
CTCACTGCGC TGCGGATCAA GAAGACGCTA CAGAAACTCA GCAACGGTCT CCAGAAGCCC 1500
AAAGGGATTC ACTAG 1515
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+
Q: 204   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  263
         689*********************************************************
S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121
         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH ei+gt+g
Q: 264   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQG  323
         ************************************************************
S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181
           KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPEv
Q: 324   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV  381
         ..**********************************************************
S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241
         lee++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf++vv++dPs+e+mk
Q: 382   LEEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFYDVVPNDPSFEDMK  440
         ********************************99.*************************
S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l
Q: 441   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  490
         ************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60
DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALRL AVSAACGLAH LHVEIFGTQG 120
KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQGSDYL DIGNNPRVGT KRYMAPEVLE 180
EQIRTDCFES YKWTDIWAFG LVLWEIARRT IVNGIVEDYR PPFYDVVPND PSFEDMKKVV 240
CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPNPSARLTA LRIKKTL 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00263
EKS-BOT-00281
EKS-CAJ-00287
EKS-CAF-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-EQC-00273
EKS-FEC-00267
EKS-GOG-00280
EKS-HOS-00287
EKS-ICT-00265
EKS-LOA-00291
EKS-MAM-00283
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PAT-00265
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-TUT-00043
EKS-VIP-00020
EKS-XET-00353
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0001525; P:angiogenesis
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217; P:regulation of blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
ssc:100153279;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013