EKS-SUS-00243

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00243

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.4	4.7E-137	207	494	288

Status

Unreviewed

Ensembl Protein

ENSSSCP00000000248

UniProt Accession

D3K5N5; F1SGJ9;

Protein Name

Protein Synonyms/Alias

Activin A receptor, type IB;

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000000233	ENSSSCP00000000248	ENSSSCT00000000252

Organism

Sus scrofa

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QANYTCETDG ACMVSIFNLD 60

GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDF CNKIDLRVPS GHLKEPEHPS 120

MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 180

DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 240

ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 300

IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 360

DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 420

GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN 480

GAARLTALRI KKTLSQLSVQ EDVKI 505

Nucleotide Sequence
(FASTA)

ATGGCGGAGT CGGCTGGAGC CTCCTCCTTC TTCCCCCTTG TTGTCCTCCT GCTCGCCGGC 60

AGCGGCGGGT CCGGGCCCCG GGGGATCCAG GCTCTGCTCT GTGCCTGCAC CAGCTGCCTC 120

CAGGCCAACT ACACGTGTGA GACGGATGGG GCCTGCATGG TTTCCATTTT CAACCTGGAC 180

GGGATGGAGC ACCATGTGCG CACCTGCATC CCCAAGGTGG AGCTGGTCCC CGCTGGGAAG 240

CCCTTCTACT GCCTGAGCTC CGAGGACCTG CGCAACACGC ACTGCTGCTA CACCGACTTC 300

TGCAACAAGA TCGACCTGAG GGTGCCCAGC GGTCACCTCA AGGAGCCTGA GCACCCCTCC 360

ATGTGGGGCC CCGTGGAGCT GGTGGGCATT ATTGCCGGCC CAGTGTTCCT CCTGTTTCTC 420

ATCATCATCA TCGTCTTCCT TGTCATTAAC TACCATCAGC GCGTCTATCA CAACCGCCAG 480

AGGCTGGACA TGGAGGACCC CTCGTGTGAG ATGTGTCTCT CCAAGGACAA GACGCTCCAG 540

GACCTCGTCT ACGACCTCTC CACGTCGGGG TCGGGCTCAG GGTTACCCCT TTTTGTTCAG 600

CGCACAGTGG CCCGAACCAT CGTTTTGCAG GAGATTATTG GCAAGGGCCG CTTTGGAGAA 660

GTGTGGCGTG GCCGCTGGAG AGGTGGCGAC GTGGCTGTGA AAATATTCTC CTCTCGCGAA 720

GAGCGGTCTT GGTTCCGGGA AGCAGAGATA TACCAGACGG TCATGCTGCG CCATGAAAAC 780

ATCCTTGGCT TCATTGCTGC CGACAACAAA GATAACGGCA CGTGGACACA GCTGTGGCTC 840

GTCTCGGACT ACCACGAGCA CGGCTCCCTG TTTGACTACC TTAACCGCTA CACGGTGACC 900

ATCGAGGGGA TGATCAAGTT GGCCTTGTCT GCCGCGAGCG GGTTGGCACA CCTGCACATG 960

GAGATCGTGG GCACCCAAGG GAAGCCTGGA ATTGCTCATC GAGACTTAAA GTCAAAGAAC 1020

ATCCTGGTGA AGAAGAATGG CATGTGCGCC ATCGCAGACC TGGGCCTGGC CGTCCGTCAC 1080

GATGCCGTCA CTGACACCAT TGACATTGCC CCTAACCAAA GGGTGGGAAC CAAACGATAC 1140

ATGGCCCCCG AGGTACTTGA TGAAACCATC AACATGAAGC ACTTCGACTC CTTCAAGTGT 1200

GCGGACATCT ATGCCCTCGG GCTCGTGTAT TGGGAGATTG CCCGAAGATG CAACTCTGGA 1260

GGAGTCCATG AAGAATATCA GCTGCCATAT TATGACCTAG TGCCCTCTGA TCCTTCCATC 1320

GAGGAGATGC GGAAGGTCGT ATGTGACCAG AAGCTGCGTC CCAACATCCC CAACTGGTGG 1380

CAGAGTTATG AGGCGCTGCG GGTGATGGGG AAGATGATGC GGGAGTGCTG GTATGCCAAC 1440

GGCGCGGCCC GCCTCACCGC ACTGCGCATC AAGAAGACCC TGTCCCAGCT CAGCGTGCAG 1500

GAGGACGTGA AGATCTAG 1518

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 207   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  266

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 267   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  326

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 327   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  384

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 385   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  443

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 444   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  494

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001942	; P:hair follicle development
GO:0001701	; P:in utero embryonic development
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

ssc:100152462

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013