EKS-SUS-00361

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00361

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	374.4	4.7E-112	189	454	266

Status

Unreviewed

Ensembl Protein

ENSSSCP00000000849

UniProt Accession

A9QT42;

Protein Name

Protein Synonyms/Alias

Interleukin-1 receptor-associated kinase 4;

Gene Name

IRAK4

Gene Synonyms/Alias

IRAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000000799	ENSSSCP00000029325	ENSSSCT00000035861
ENSSSCG00000000799	ENSSSCP00000000849	ENSSSCT00000000866

Organism

Sus scrofa

Functional Description

Protein Length

460

Protein Sequence
(FASTA)

MNKPITASTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL 60

QTGKSPTCEL LFDWGTTNCT VGDLVDLLVQ NEFFAPASLL LPDAVPKPIN TLPSKVTVTV 120

EQKQMPLYGS NRTSVMPCQN PEHNSMPPDS SSPESKSLEV SDTRFHSFAF CELKDVTNNF 180

DERPVSIGGN KMGEGGFGVV YKGYVNNRAV AVKKLAAVVD ISTEELKQQF DQEIKVLAKC 240

QHENLVELLG FSSDGDDLCL VYVYMSNGSL LDRLSCLDDT PPLSWYMRCK IAQGAANGLS 300

FLHENHHIHR DIKSANILLD EDFTAKISDF GLARASEKFA QTVMTSRIVG TTAYMAPEAL 360

RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK EEIEDEEKTI EDYIDKKMND 420

TDSTSIETMY SVASQCLHEK KNKRPDIKKV QQLLQEMTAS 460

Nucleotide Sequence
(FASTA)

ATGAACAAAC CCATAACAGC TTCAACATAT GTGCGCTGCC TCAATGTTGG ACTAATTAGG 60

AAGTTGTCAG ATTTTATTGA TCCTCAAGAA GGATGGAAGA AGTTAGCAGT AGCTATTAAA 120

AAACCATCTG GTGATGACAG ATACAACCAG TTTCATATAA GGAGATTCGA AGCATTACTT 180

CAAACTGGAA AAAGTCCCAC TTGTGAATTA CTGTTTGACT GGGGCACCAC AAATTGCACA 240

GTTGGTGATC TCGTGGATCT CTTGGTCCAA AATGAGTTTT TTGCCCCTGC AAGTCTTTTG 300

CTTCCAGATG CTGTTCCCAA ACCCATTAAC ACACTGCCTT CTAAAGTCAC TGTAACAGTT 360

GAGCAGAAAC AGATGCCTCT CTACGGTTCA AACAGGACAT CTGTGATGCC CTGTCAGAAT 420

CCTGAACACA ACTCTATGCC ACCAGACTCT TCAAGTCCAG AAAGTAAAAG TTTAGAAGTT 480

AGTGATACAC GTTTTCACAG TTTTGCGTTC TGTGAATTGA AGGATGTTAC AAATAACTTT 540

GATGAGCGAC CCGTTTCTAT TGGTGGTAAC AAGATGGGAG AGGGAGGATT TGGAGTTGTG 600

TATAAAGGCT ACGTGAACAA CAGGGCTGTT GCAGTGAAGA AGCTTGCAGC AGTGGTTGAC 660

ATTAGTACTG AAGAACTGAA ACAACAGTTT GATCAAGAAA TAAAAGTACT GGCAAAGTGT 720

CAGCATGAAA ACTTAGTAGA ACTACTTGGT TTCTCAAGTG ATGGAGATGA CCTCTGCTTA 780

GTATATGTTT ACATGTCCAA TGGTTCACTG CTAGACCGAC TGTCTTGCTT GGATGATACT 840

CCACCACTCT CTTGGTACAT GAGATGCAAG ATTGCTCAGG GTGCAGCTAA TGGCCTCAGT 900

TTTTTACATG AAAACCATCA TATTCATAGA GATATTAAAA GTGCAAATAT CTTATTAGAT 960

GAAGACTTTA CAGCCAAGAT ATCTGACTTT GGGCTTGCAC GGGCTTCTGA GAAGTTTGCC 1020

CAGACAGTCA TGACTAGCAG AATTGTGGGA ACAACAGCTT ATATGGCACC TGAAGCTTTG 1080

CGAGGAGAAA TAACACCCAA ATCTGACATC TACAGCTTTG GTGTGGTTCT ATTAGAAATA 1140

ATAACTGGAC TTCCAGCTGT GGATGAACAC CGTGAACCTC AGTTATTGCT AGATATTAAA 1200

GAAGAAATTG AAGATGAGGA AAAAACAATT GAAGATTATA TTGATAAGAA GATGAATGAC 1260

ACTGATTCCA CTTCCATTGA AACTATGTAC TCTGTTGCCA GTCAGTGTCT GCATGAAAAG 1320

AAAAATAAGA GACCAGACAT TAAGAAGGTT CAACAGCTGC TGCAAGAAAT GACAGCTTCT 1380

TAA 1383

Domain Profile

S: 4     dnrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnilel  63

         +n++geGgfg+vy+g ++n avavkkl++ +d+s++elkq+f++E+kvla+++H+n++el

Q: 189   GNKMGEGGFGVVYKGYVNNRAVAVKKLAAVVDISTEELKQQFDQEIKVLAKCQHENLVEL  248

         69**********************************************************

S: 64    lgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasps  123

         lg+s+++++lcLvY ym+nGsL drL+c ++++pLsW +R++i++G+a++++fLHe+  +

Q: 249   LGFSSDGDDLCLVYVYMSNGSLLDRLSCLDDTPPLSWYMRCKIAQGAANGLSFLHEN--H  306

         *********************************************************..*

S: 124   lihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefirv  183

         +ih+diksaNiLLDe++t+K++Dfglar   +sek ++tv+ ts+++gt+aY+++e++r

Q: 307   HIHRDIKSANILLDEDFTAKISDFGLAR---ASEKFAQTVM-TSRIVGTTAYMAPEALR-  361

         ****************************...9********9.*****************.

S: 184   gqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfldkkag  243

         g++t k+D+ySfG+VllE++tGl+avde+r+++ L+d+ keeie+e+ +++e+++dkk++

Q: 362   GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDI-KEEIEDEE-KTIEDYIDKKMN  419

         *************************************9.********.9***********

S: 244   kleeellealielalaclaekakkrPtmsqvlell  278

         + ++++ e+++++a++cl+ek++krP++++v++ll

Q: 420   DTDSTSIETMYSVASQCLHEKKNKRPDIKKVQQLL  454

         ********************************986

Domain Sequence
(FASTA)

GNKMGEGGFG VVYKGYVNNR AVAVKKLAAV VDISTEELKQ QFDQEIKVLA KCQHENLVEL 60

LGFSSDGDDL CLVYVYMSNG SLLDRLSCLD DTPPLSWYMR CKIAQGAANG LSFLHENHHI 120

HRDIKSANIL LDEDFTAKIS DFGLARASEK FAQTVMTSRI VGTTAYMAPE ALRGEITPKS 180

DIYSFGVVLL EIITGLPAVD EHREPQLLLD IKEEIEDEEK TIEDYIDKKM NDTDSTSIET 240

MYSVASQCLH EKKNKRPDIK KVQQLL 266

Keyword

Complete proteome; Kinase; Receptor; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0001816	; P:cytokine production
GO:0019221	; P:cytokine-mediated signaling pathway

KEGG

ssc:100127166

;

InterPros

IPR011029	; DEATH-like.
IPR017428	; Interleukin-1_rcpt-assoc_kin4.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013