EKS-SUS-00230

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00230

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	468.8	1.1E-140	155	468	314

Status

Unreviewed

Ensembl Protein

ENSSSCP00000001025

UniProt Accession

F1RYI2;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000000958	ENSSSCP00000001025	ENSSSCT00000001047

Organism

Sus scrofa

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

GGSKHTMNDH LHVGSHSHGQ IQVQQLFEDN SNKRTVLTTQ PNGLTTVGKT GLPVVPERQL 60

ESIHRRQGSS TSLKSLEGMG KVKATPMTPE QAMKQYMQKL TSFEHHEIFS YPEIYFLGPN 120

AKKRQGMTGG PNNGGYDDDQ GSYVQVPHDH VAYRYEVLKV IEKGSFGQVV KAYDHKVHQH 180

VALKMVRNEK RFHRQAAEEI RILEHLRKQD KDNTMNVIHM LENFTFRNHI CMTFELLSMN 240

LYELIKKNKF QGFSLPLVRK FAHSILQCLD ALHKNRIIHC DLKPENILLK QQGRSGIKVI 300

DFGSSCYEHQ RVYTYIQSRF YRAPEVILGA RYGMPIDMWS LGCILAELLT GYPLLPGEDE 360

GDQLACMIEL LGMPSQKLLD ASKRAKNFVS SKGYPRYCTV TTLSDGSVVL NGGRSRRGKL 420

RGPPESREWG NALKGCDDPL FLDFLKQCLE WDPAVRMTPG QALRHPWLRR RLPKPPTGEK 480

TSVKRITEST GAITSISKLP PPSSSASKLR TNLAQMTDAN GNIQQRTVLP KLVS 534

Nucleotide Sequence
(FASTA)

GGCGGCAGTA AGCACACAAT GAATGATCAC CTACACGTCG GCAGCCACAG CCACGGACAG 60

ATCCAGGTTC AGCAGCTGTT TGAGGATAAC AGCAACAAGC GGACAGTGCT CACGACACAA 120

CCAAATGGGC TTACAACAGT GGGCAAAACG GGGTTGCCCG TGGTGCCGGA GCGGCAGCTG 180

GAGAGCATCC ACAGACGGCA GGGGAGCTCC ACCTCTCTGA AGTCTCTGGA AGGCATGGGG 240

AAGGTGAAAG CCACTCCCAT GACACCCGAG CAAGCAATGA AGCAATACAT GCAAAAACTA 300

ACCAGCTTTG AACACCATGA GATTTTCAGC TACCCTGAGA TATATTTCTT GGGTCCAAAT 360

GCAAAGAAGC GCCAGGGCAT GACAGGCGGG CCCAACAACG GTGGCTACGA TGATGACCAG 420

GGATCCTACG TGCAGGTGCC CCACGATCAC GTGGCCTACA GGTACGAGGT CCTCAAGGTC 480

ATTGAGAAGG GGAGCTTCGG GCAGGTGGTC AAGGCCTACG ACCACAAAGT CCACCAGCAC 540

GTGGCTCTGA AGATGGTGCG GAACGAGAAG CGCTTCCACC GGCAGGCGGC CGAGGAGATC 600

CGCATCCTGG AGCACCTGCG CAAGCAGGAC AAGGACAACA CCATGAACGT CATCCACATG 660

CTGGAGAACT TCACCTTCCG CAACCACATC TGCATGACGT TCGAGCTGCT GAGCATGAAC 720

CTCTACGAGC TCATCAAGAA GAACAAGTTC CAGGGCTTCA GCCTGCCTTT GGTTCGCAAG 780

TTTGCCCACT CCATCCTGCA GTGCCTGGAC GCTCTGCACA AAAACAGGAT CATTCACTGT 840

GACCTGAAGC CTGAGAACAT TTTATTGAAG CAGCAGGGTA GAAGTGGGAT TAAAGTGATT 900

GATTTCGGCT CCAGTTGTTA CGAGCATCAG CGGGTCTACA CGTACATCCA GTCCCGTTTT 960

TACCGGGCCC CGGAAGTGAT CCTGGGCGCC AGGTACGGCA TGCCCATTGA CATGTGGAGC 1020

CTGGGCTGCA TCCTCGCGGA GCTCCTCACT GGTTACCCCC TCTTGCCTGG GGAGGACGAA 1080

GGGGACCAGC TGGCCTGTAT GATTGAACTG CTGGGCATGC CCTCCCAGAA ACTGCTGGAT 1140

GCCTCCAAAC GAGCCAAAAA TTTTGTGAGC TCCAAGGGTT ATCCCCGTTA CTGCACTGTC 1200

ACGACTCTCT CGGACGGCTC CGTGGTTCTC AACGGAGGCC GTTCCCGGAG GGGGAAACTG 1260

CGGGGCCCAC CAGAGAGCAG AGAGTGGGGG AATGCACTGA AGGGGTGTGA CGACCCCCTT 1320

TTCCTTGACT TCTTAAAACA GTGTTTAGAG TGGGATCCTG CGGTTCGCAT GACCCCTGGC 1380

CAGGCTTTGC GGCACCCTTG GCTGAGGAGG CGGCTGCCAA AGCCTCCGAC GGGGGAGAAG 1440

ACGTCAGTGA AAAGGATCAC CGAGAGCACT GGTGCTATCA CATCCATTTC CAAGTTACCT 1500

CCACCTTCCA GCTCAGCTTC CAAACTGAGG ACTAATTTGG CACAGATGAC AGATGCCAAC 1560

GGGAATATTC AGCAGAGGAC AGTGTTGCCA AAACTTGTTA GCTGA 1605

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vi kGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 155   YEVLKVIEKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT  214

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 215   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  274

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 275   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  333

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+

Q: 334   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKG  393

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp

Q: 394   YPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  453

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp +al+hp++

Q: 454   AVRMTPGQALRHPWL  468

         **************6

Domain Sequence
(FASTA)

YEVLKVIEKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNT 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDASKR AKNFVSSKGY 240

PRYCTVTTLS DGSVVLNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPA 300

VRMTPGQALR HPWL 314

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0030529	; C:ribonucleoprotein complex
GO:0000151	; C:ubiquitin ligase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0042771	; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725	; P:positive regulation of glycogen biosynthetic process
GO:0007224	; P:smoothened signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013