EKS-SUS-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	859.4	1.1E-258	80	653	574

Status

Unreviewed

Ensembl Protein

ENSSSCP00000001688

UniProt Accession

B7UCT2;

Protein Name

Protein Synonyms/Alias

SFRS protein kinase 1; Serine/arginine-rich protein specific kinase 1;

Gene Name

SRPK1

Gene Synonyms/Alias

SRPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000001554	ENSSSCP00000001688	ENSSSCT00000001732

Organism

Sus scrofa

Functional Description

Protein Length

655

Protein Sequence
(FASTA)

MERKVLALQA RKKRTKAKKD KAQRKSETQH RGSAPHSESD LPEQEEEILG SDDDEQEDPN 60

DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET 120

ALDEIRLLKS VRNSDPNDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN 180

YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR 240

SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ 300

KRPNKQEESE SPVERPLKEN PPNKMTQEKL EESSTIHQDQ TLTERGVEGG AAEINCNGVI 360

EIVNYTENSN KETLRLKEDL RNANDCDVQN LKQEPSLLNS QNGDSSTSQE TDSCTPVTSE 420

VSDTMICQSS SNVDQSFSEQ DISQLQESIR AEIPCEDEQE QEHNGPLDSK GKSTAGNFLI 480

NPLEPKNAEK LQVKIADLGN ACWVHKHFTE DIQTRQYRSL EVLIGSGYNT PADIWSTACM 540

AFELATGDYL FEPHSGEEYT RDEDHIALII ELLGKVPRKL IVAGKYSKEF FTKKGDLKHI 600

TKLKPWGLFE VLVEKYEWSQ EEAAGFTDFL LPMLELIPEK RATAADCLRH PWLNS 655

Nucleotide Sequence
(FASTA)

ATGGAGCGGA AAGTGCTTGC GCTCCAGGCC CGAAAGAAAA GGACCAAGGC CAAGAAGGAC 60

AAAGCCCAAA GGAAATCTGA AACTCAGCAC CGAGGCTCTG CTCCCCACTC TGAAAGTGAT 120

CTACCAGAGC AGGAAGAGGA GATTCTGGGA TCTGATGATG ATGAGCAGGA AGATCCCAAT 180

GATTACTGTA AAGGAGGCTA CCATCTTGTG AAAATCGGAG ATCTATTCAA TGGGAGATAT 240

CATGTGATCC GAAAATTGGG CTGGGGACAC TTTTCAACAG TATGGTTATC ATGGGATATT 300

CAGGGGAAGA AATTTGTGGC AATGAAAGTC GTTAAAAGTG CTGAACATTA TACTGAAACA 360

GCACTCGATG AAATCCGGTT GCTAAAATCC GTTCGCAATT CAGATCCTAA TGATCCAAAT 420

AGAGAAATGG TTGTTCAACT ACTAGATGAT TTTAAAATAT CAGGAGTTAA TGGAACACAT 480

ATCTGCATGG TGTTTGAAGT TTTGGGCCAT CATCTGCTCA AGTGGATCAT CAAGTCCAAT 540

TATCAAGGGC TTCCTCTGCC TTGTGTCAAA AAAATTATTC AGCAAGTGTT ACAGGGTCTG 600

GATTATTTAC ACACCAAGTG CCGTATCATC CACACTGACA TTAAACCAGA AAACATCTTA 660

TTGTCAGTGA ATGAGCAGTA CATCCGGAGG CTGGCCGCAG AAGCAACAGA ATGGCAGCGA 720

TCTGGAGCAC CTCCACCTTC TGGATCTGCA GTGAGTACTG CGCCCCAGCC TAAACCAGCT 780

GACAAAATGT CAAAGAATAA GAAGAAGAAA TTGAAGAAGA AGCAGAAGCG CCAGGCAGAA 840

TTACTAGAGA AGCGAATGCA GGAAATTGAG GAAATGGAGA AAGAGTCGGG CCCTGGGCAA 900

AAAAGACCAA ACAAGCAAGA AGAATCAGAG AGTCCTGTTG AAAGACCCTT GAAAGAGAAC 960

CCACCTAATA AAATGACCCA AGAAAAACTT GAAGAGTCAA GTACCATTCA CCAGGATCAG 1020

ACACTTACGG AACGTGGTGT AGAGGGTGGT GCAGCAGAAA TTAATTGCAA TGGAGTAATT 1080

GAAATTGTTA ATTATACTGA GAACAGTAAT AAAGAGACAT TGAGACTTAA AGAGGATCTA 1140

CGTAATGCTA ATGACTGTGA TGTCCAAAAT TTGAAGCAGG AACCTAGTTT ACTAAATTCC 1200

CAAAATGGAG ATAGCAGCAC ATCTCAAGAA ACAGACTCTT GTACACCTGT AACCTCTGAG 1260

GTGTCAGATA CCATGATATG CCAGTCTTCA TCAAATGTAG ACCAGTCGTT CAGTGAACAG 1320

GACATCAGCC AACTTCAAGA AAGCATTCGG GCCGAGATAC CCTGTGAAGA TGAGCAAGAG 1380

CAAGAACATA ATGGACCACT AGACAGCAAA GGAAAATCCA CTGCTGGAAA TTTTCTTATT 1440

AATCCCCTTG AGCCAAAAAA CGCAGAAAAG CTCCAAGTGA AGATTGCTGA TCTTGGAAAT 1500

GCCTGTTGGG TGCACAAACA TTTCACTGAA GATATTCAAA CAAGGCAGTA TCGCTCCTTG 1560

GAAGTACTGA TAGGATCTGG TTATAATACC CCTGCTGACA TTTGGAGCAC AGCATGCATG 1620

GCCTTTGAAC TGGCCACAGG CGACTATTTA TTTGAACCTC ATTCAGGGGA AGAGTACACT 1680

CGAGATGAAG ATCACATTGC ATTGATCATA GAACTTCTGG GGAAGGTGCC TCGCAAGCTC 1740

ATTGTGGCAG GAAAATATTC CAAGGAATTT TTCACCAAAA AAGGTGACCT GAAACATATC 1800

ACGAAGCTGA AACCTTGGGG CCTTTTTGAG GTTCTAGTGG AGAAGTATGA GTGGTCTCAG 1860

GAAGAGGCAG CTGGTTTCAC AGATTTCTTA TTGCCCATGT TGGAGCTGAT CCCCGAGAAG 1920

AGAGCCACTG CCGCCGACTG TCTCCGGCAC CCTTGGCTCA ACTCGTAA 1968

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWL+wd+q+k+fva+kvvksaehytetaldei+llksvr+sdp+dp

Q: 80    YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDP  139

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         +re+vvqllddfkisGvnG+h+c+vfevLG++Llk+iiksny+Glpl++vkkii+qvL+g

Q: 140   NREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQG  199

         ************************************************************

S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180

         Ldylh+kC+iihtdikPen+Ll+v+++yirrlaaeatewq++ga+ppsgsavstapq+k+

Q: 200   LDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKP  259

         ************************************************************

S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214

         ++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 260   ADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkesgpgqkrpnkqeesespverplke  319

         ************************************************************

S: 215   ..........aaeanseaedqelkedaekgeleeieadveeevanedeaseeee......  258

                   ++e++++ +dq+l+e+  +g+++ei+++ ++e++n++e+s++e+

Q: 320   nppnkmtqekLEESSTIHQDQTLTERGVEGGAAEINCNGVIEIVNYTENSNKETlrlked  379

         *********99999***********************************99999999999

S: 259   ..............essltsssdaesksgelseastellsesleqlacgsvls.......  297

                       e sl++s++ +s+++++++++t+++se+++++ c+s+++

Q: 380   lrnandcdvqnlkqEPSLLNSQNGDSSTSQETDSCTPVTSEVSDTMICQSSSNvdqsfse  439

         99999999**9999*************************************999******

S: 298   ........................................vnplepknadkikvkiadLG  317

                                                 +nplepkna+k++vkiadLG

Q: 440   qdisqlqesiraeipcedeqeqehngpldskgkstagnflINPLEPKNAEKLQVKIADLG  499

         ************************************************************

S: 318   naCwvhkhftediqtrqyrslevliGagygtpadiWstaClafeLatGdyLfephsgedy  377

         naCwvhkhftediqtrqyrslevliG+gy+tpadiWstaC+afeLatGdyLfephsge+y

Q: 500   NACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEY  559

         ************************************************************

S: 378   srdedhiakiiellGkiPrklilkGkysreffnkkgeLrhitkLkpwsLlevLvekyews  437

         +rdedhia iiellGk+Prkli++Gkys+eff+kkg+L+hitkLkpw+L+evLvekyews

Q: 560   TRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWS  619

         ************************************************************

S: 438   keeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         +eeaa f+dfLlPmlel+pekra+aa+cl+hpwL

Q: 620   QEEAAGFTDFLLPMLELIPEKRATAADCLRHPWL  653

         *********************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLSWD IQGKKFVAMK VVKSAEHYTE TALDEIRLLK SVRNSDPNDP 60

NREMVVQLLD DFKISGVNGT HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIQQVLQG 120

LDYLHTKCRI IHTDIKPENI LLSVNEQYIR RLAAEATEWQ RSGAPPPSGS AVSTAPQPKP 180

ADKMSKNKKK KLKKKQKRQA ELLEKRMQEI EEMEKESGPG QKRPNKQEES ESPVERPLKE 240

NPPNKMTQEK LEESSTIHQD QTLTERGVEG GAAEINCNGV IEIVNYTENS NKETLRLKED 300

LRNANDCDVQ NLKQEPSLLN SQNGDSSTSQ ETDSCTPVTS EVSDTMICQS SSNVDQSFSE 360

QDISQLQESI RAEIPCEDEQ EQEHNGPLDS KGKSTAGNFL INPLEPKNAE KLQVKIADLG 420

NACWVHKHFT EDIQTRQYRS LEVLIGSGYN TPADIWSTAC MAFELATGDY LFEPHSGEEY 480

TRDEDHIALI IELLGKVPRK LIVAGKYSKE FFTKKGDLKH ITKLKPWGLF EVLVEKYEWS 540

QEEAAGFTDF LLPMLELIPE KRATAADCLR HPWL 574

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

ssc:100155422

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013