EKS-SUS-00388

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00388

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	487.9	9.4E-147	18	286	269

Status

Unreviewed

Ensembl Protein

ENSSSCP00000002731

UniProt Accession

F1SAM8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000002523	ENSSSCP00000002731	ENSSSCT00000002802

Organism

Sus scrofa

Functional Description

Protein Length

1657

Protein Sequence
(FASTA)

AKPFTQLVKE MQLHREDFEI IKVIGRGAFG EVAVVRMKST ERIYAMKILN KWEMLKRAET 60

ACFREERDVL VNGDSQWLTT LHYAFQDENY LYLVMDYYVG GDLLTLLSKF EDRLPEDMAR 120

FYIGEMVLAI DSIHQLHYVH SNRDIKPDNV LLDVNGHIRL ADFGSCLKMN DDGTVQSSVA 180

VGTPDYISPE ILQAMEDGMG RYGPECDWWS LGVCMYEMLY GETPFYAESL VETYGKIMNH 240

EERFQFPSHV TDVSEEAKDL IQRLICSRER RLGQNGVEDF KKHAFFQGLN WETIRNLEAP 300

YIPDVSSPSD TSNFDVDDDV LRNVEILPPA SHTGFSGLHL PFIGFTFTTE SCFSDRGSLK 360

SIMQSSTLTK DEGLQRDLEN SLQVEAYERR IRRLEQERLE LSRKLQEATQ TVQSFHGAAR 420

TLGSAARDKE IKKLNEEIER LKNKIAESNK LERQLEDTVT LRQEQEDSTH RLKGLEKQYR 480

AVRQEKEDFH KQLIEASERL KSQARELKDA HQQRKLALQE FSELNERMAE LRSQKQKVSR 540

QLRDREEEVE AALQKIDALR QEVRRADKCR KELEAQLEDA VAEASKERKL REHSENFSKQ 600

IESELEALKM KQGGRGPGAA LEHQQEISRI KSELEKKVLF YEEELVRREA SHVLELKTVK 660

KEVHDSEGHQ LALQKEVLVL KDKLEKSKRE RHSELEEAVG TVKDKYERER AVLSEENKKL 720

TAENEKLCAF VDKLTAQNRQ LEDELQDLAA KKESVAHWEA QIAEIIQWVS DEKDARGYLQ 780

ALASKMTEEL EALRSSSLGS RTLDPLWKVR RSQKLDMSAR LELQSALEAE IRAKQLVQEE 840

LRKVKDMNLS FESKLKDSEA KNRELLEEME ILKKKMEEKF RTDAGLKLPD FQDSIFEYFN 900

TAPLAHDLTF RASSASEQET QAAKPEAMPP SSVAASTEQQ EDVARAPQRP PTVPLPSTQA 960

LALAGPKPKA HQFSIKSFSS PTQCSHCTSL MVGLIRQGYA CDVCSFACHV SCRDSAPQVC 1020

PIPPEQSKRP LGVDVQRGIG TAYKGYVKVP KPTGVKKGWQ RAYAVVCDCK LFLYDLPEGK 1080

STQPGVVASQ VLDLRDEEFS VSSVLASDVI HASRRDIPCI FRVTASLLGT PSKTSSLLIL 1140

TENENEKRKW VGILEGLQSI LQKNRLRSQV VHSPQEAYDS SLPLIKAVLA AAILDADRIA 1200

VGLEEGLYVV EVTRDVIVRV ADYKKVYQIE LAPKEKVAAL LCGRNHHVHL CPWSSFDGAE 1260

GTVDIKLPET KGCQLIATGA PKKSSPTCLF VAVKRLVLCY EMQRTKPFHR KLSELAAPGP 1320

VQWMAVLKDK LCVGYPSGFS LLSPQGEGQA LNLVNPNDPS LTFLSQQSFD ALCAVELQSE 1380

EYLLCFSHMG LYVDPQGRRS RMQELMWPAA PVACSCSPSH VTVYSDYGVD VFDARSMEWV 1440

QTIGLRRIRP LNSEGSLNLL NCEPPRLIYF KSKFAGPALN VPDTSDNSKK QMLRTRSKRR 1500

FVFKVPEEER LQQRRREMLR DPELRSRMIS NPTNFNHVAH MGPGDGMQVL MDLPLSAVPP 1560

SQEERPGPAP ASLSRQPPPR NKPYVSWPSS GGSEPGVAVP LRSMSDPDQD FDKEPDSDST 1620

KHSTPSNSSN PSGPPSPNSP HRSQLPLEGL EQPSYDA 1657

Nucleotide Sequence
(FASTA)

GCTAAACCAT TTACACAGCT GGTGAAGGAA ATGCAACTTC ATCGAGAAGA CTTCGAAATA 60

ATTAAAGTAA TTGGAAGAGG TGCTTTCGGC GAGGTCGCTG TGGTCAGGAT GAAGAGCACC 120

GAGCGCATCT ACGCCATGAA GATTCTCAAC AAGTGGGAGA TGCTGAAGCG AGCAGAGACG 180

GCTTGTTTCC GGGAGGAGCG GGACGTGCTG GTGAACGGCG ACTCTCAGTG GCTCACCACG 240

CTGCACTACG CCTTTCAGGA TGAAAACTAT CTGTACCTGG TCATGGACTA CTACGTGGGC 300

GGCGACCTGC TGACCCTGCT CAGCAAGTTC GAAGACCGGC TCCCGGAGGA CATGGCGCGG 360

TTCTACATCG GGGAGATGGT GCTGGCCATC GACTCCATCC ATCAGCTCCA CTACGTGCAC 420

AGTAACAGAG ACATTAAACC TGACAATGTC CTTTTGGATG TGAATGGTCA TATCCGCCTG 480

GCCGACTTTG GATCATGTTT GAAGATGAAT GATGATGGAA CTGTCCAGTC CTCCGTGGCC 540

GTCGGCACCC CGGACTACAT CTCCCCGGAG ATCCTGCAGG CGATGGAGGA CGGCATGGGC 600

AGGTACGGCC CCGAGTGCGA CTGGTGGTCG CTGGGCGTCT GCATGTACGA GATGCTCTAC 660

GGAGAGACGC CGTTTTACGC CGAGTCGCTG GTGGAGACCT ACGGCAAGAT CATGAACCAC 720

GAGGAGCGAT TTCAGTTCCC TTCCCACGTC ACGGATGTGT CTGAGGAAGC GAAAGATCTC 780

ATCCAGAGGC TGATCTGCAG CCGGGAGCGC CGGCTGGGCC AGAACGGGGT TGAGGACTTC 840

AAGAAGCACG CGTTTTTCCA AGGCCTGAAT TGGGAAACTA TACGGAACCT CGAGGCACCG 900

TACATTCCGG ACGTGAGCAG CCCTTCGGAC ACGTCCAACT TCGACGTGGA CGACGACGTG 960

CTGAGAAACG TCGAAATACT ACCTCCCGCG TCTCACACAG GCTTTTCGGG GCTGCACCTG 1020

CCCTTCATCG GCTTCACGTT CACAACAGAA AGCTGTTTTT CTGACCGAGG CTCTCTGAAG 1080

AGCATAATGC AGTCCAGCAC GCTGACCAAA GACGAGGGCC TGCAGCGGGA CTTGGAGAAC 1140

AGCCTGCAGG TTGAAGCCTA CGAGAGGCGG ATCCGGAGGC TGGAGCAGGA GAGACTGGAG 1200

CTGAGCAGGA AGCTCCAAGA GGCCACCCAG ACCGTGCAGT CCTTCCACGG CGCAGCCCGG 1260

ACCCTGGGCA GTGCCGCCCG TGACAAAGAA ATCAAAAAGC TCAACGAAGA AATTGAACGT 1320

TTGAAGAATA AAATAGCAGA GTCAAATAAG CTGGAGCGAC AGCTTGAGGA CACGGTGACT 1380

CTTCGCCAAG AGCAGGAGGA CTCCACGCAC CGGCTGAAAG GCCTGGAAAA GCAGTACCGC 1440

GCGGTGCGGC AGGAAAAGGA GGACTTCCAC AAGCAATTGA TTGAAGCTTC CGAGCGGCTG 1500

AAGTCCCAGG CCAGGGAACT GAAGGACGCC CACCAGCAGC GGAAGCTGGC CCTGCAGGAG 1560

TTCTCGGAGC TCAACGAGCG CATGGCCGAG CTCCGCTCCC AGAAGCAGAA GGTGTCTCGG 1620

CAGCTGCGGG ACCGAGAGGA GGAGGTGGAG GCGGCCTTGC AGAAGATCGA CGCCCTGCGG 1680

CAGGAGGTCC GCAGGGCCGA CAAGTGCCGG AAGGAGCTGG AAGCCCAGCT CGAGGACGCC 1740

GTTGCTGAGG CCTCCAAGGA GCGCAAGCTG CGAGAGCACA GCGAGAACTT CTCCAAGCAA 1800

ATAGAGAGTG AGCTTGAGGC CCTCAAGATG AAGCAAGGAG GCCGGGGGCC AGGCGCCGCC 1860

TTGGAGCACC AGCAGGAGAT TTCCAGGATA AAGTCTGAGC TCGAGAAGAA AGTCCTGTTT 1920

TACGAGGAGG AGTTGGTCAG GCGGGAGGCC TCCCATGTGC TGGAGCTGAA GACCGTGAAG 1980

AAGGAGGTGC ACGACTCCGA GGGCCACCAG CTGGCCCTGC AGAAGGAGGT GCTGGTGCTG 2040

AAGGACAAGC TGGAGAAGTC CAAGCGGGAG CGGCACAGTG AGCTGGAGGA GGCCGTGGGC 2100

ACAGTCAAGG ACAAATACGA ACGCGAGAGG GCCGTGCTGT CCGAGGAGAA CAAGAAGTTA 2160

ACTGCTGAGA ACGAGAAGCT TTGTGCCTTT GTGGATAAGC TCACAGCTCA AAATAGGCAG 2220

TTGGAGGACG AGCTGCAGGA TCTGGCGGCC AAGAAGGAGT CGGTTGCCCA CTGGGAAGCC 2280

CAGATCGCAG AGATCATTCA GTGGGTCAGC GACGAGAAGG ATGCCCGGGG CTACCTTCAG 2340

GCCCTCGCTT CTAAGATGAC TGAGGAGCTG GAGGCGCTGA GGAGCTCCAG CCTGGGGTCG 2400

AGGACACTGG ATCCCCTTTG GAAAGTTCGC CGTAGTCAGA AGCTAGACAT GTCTGCGCGG 2460

CTGGAGCTGC AGTCTGCTCT CGAGGCGGAG ATCCGGGCCA AGCAGCTCGT CCAGGAGGAG 2520

CTGAGGAAGG TCAAGGACAT GAATCTCTCC TTCGAAAGCA AACTAAAGGA TTCTGAAGCC 2580

AAAAATAGAG AATTATTAGA AGAAATGGAA ATTTTGAAGA AGAAGATGGA AGAAAAATTT 2640

AGAACAGATG CTGGACTCAA ACTTCCAGAT TTCCAGGATT CCATTTTTGA ATATTTCAAC 2700

ACTGCACCTC TTGCACATGA TCTGACGTTT AGAGCCAGCT CAGCTAGTGA GCAGGAAACA 2760

CAAGCCGCAA AGCCAGAGGC GATGCCCCCA AGCTCTGTGG CCGCGAGCAC AGAACAGCAG 2820

GAGGACGTGG CTCGGGCCCC TCAGAGGCCA CCCACCGTGC CGCTGCCCAG CACTCAGGCC 2880

CTCGCTCTGG CTGGACCAAA GCCGAAAGCA CACCAGTTCA GCATCAAGTC CTTCTCCAGC 2940

CCCACTCAGT GCAGCCACTG CACCTCCCTG ATGGTGGGGC TGATCCGCCA GGGCTACGCC 3000

TGTGACGTGT GCTCGTTCGC CTGCCACGTG TCCTGCAGAG ACAGCGCTCC CCAGGTGTGC 3060

CCCATCCCCC CCGAGCAGTC CAAGCGGCCC CTGGGCGTGG ACGTGCAGAG GGGCATAGGG 3120

ACGGCCTACA AGGGCTACGT GAAGGTCCCC AAGCCGACCG GGGTGAAGAA GGGCTGGCAG 3180

CGGGCCTACG CGGTGGTCTG TGACTGCAAG CTGTTTCTCT ACGACCTGCC CGAGGGAAAG 3240

TCCACACAGC CTGGCGTCGT GGCCAGTCAG GTCTTGGATC TCAGAGATGA AGAGTTCTCT 3300

GTGAGCTCAG TCCTGGCCTC AGACGTCATA CACGCGTCGC GCCGAGATAT TCCGTGTATA 3360

TTCAGGGTGA CGGCCTCTCT CTTAGGTACA CCTTCTAAGA CCAGCTCACT GCTCATTCTG 3420

ACAGAAAATG AGAACGAGAA GAGGAAGTGG GTTGGGATTC TGGAAGGCCT GCAGTCCATC 3480

CTGCAGAAGA ACCGCCTGAG GAGCCAGGTG GTGCACTCCC CCCAGGAGGC CTACGACAGC 3540

TCCCTGCCCC TCATCAAGGC CGTCCTCGCC GCCGCCATCC TGGACGCGGA CAGGATTGCC 3600

GTTGGCCTGG AAGAAGGGCT CTACGTCGTG GAGGTGACCC GCGATGTGAT CGTCCGAGTG 3660

GCTGACTACA AGAAGGTGTA CCAGATCGAG CTTGCTCCCA AAGAGAAGGT CGCCGCCCTC 3720

CTCTGCGGCC GGAACCACCA CGTCCACCTC TGTCCGTGGT CCTCCTTTGA CGGGGCGGAA 3780

GGCACCGTTG ACATCAAGCT CCCGGAGACC AAAGGCTGCC AGCTCATCGC GACCGGGGCG 3840

CCCAAGAAGA GCTCCCCCAC CTGCCTGTTT GTGGCAGTGA AGCGGCTGGT CCTTTGCTAT 3900

GAGATGCAGA GAACTAAGCC TTTCCACAGG AAGCTCAGCG AGCTTGCGGC CCCCGGCCCT 3960

GTGCAGTGGA TGGCCGTGCT CAAGGACAAG CTCTGTGTTG GCTACCCTTC TGGGTTCTCC 4020

CTGTTGAGCC CCCAGGGAGA GGGGCAGGCT CTAAACCTGG TAAATCCCAA TGACCCCTCG 4080

CTTACGTTCC TCTCACAGCA GTCTTTTGAT GCCCTCTGTG CTGTGGAGCT CCAAAGTGAG 4140

GAGTACCTGC TTTGCTTCAG CCACATGGGA CTGTACGTGG ACCCACAAGG TCGGAGGTCA 4200

CGCATGCAGG AGCTCATGTG GCCTGCGGCA CCTGTCGCCT GTAGTTGCAG CCCCTCGCAC 4260

GTGACGGTGT ACAGCGACTA CGGCGTGGAC GTCTTCGATG CGCGCTCCAT GGAGTGGGTG 4320

CAGACCATCG GCCTGCGCAG GATCCGGCCG CTGAACTCGG AGGGCAGCCT CAACCTCCTC 4380

AACTGCGAGC CTCCCCGCCT CATCTACTTC AAGAGCAAGT TCGCGGGGCC GGCCCTCAAC 4440

GTGCCCGACA CCTCTGACAA CAGCAAGAAG CAGATGCTTC GCACCAGGAG CAAGAGGCGG 4500

TTTGTCTTCA AGGTGCCGGA GGAGGAGCGG CTGCAGCAGC GGCGCAGAGA GATGCTCAGA 4560

GACCCGGAGC TGAGGTCGCG GATGATCTCC AACCCCACCA ACTTCAATCA CGTGGCCCAC 4620

ATGGGCCCCG GCGACGGCAT GCAGGTGCTC ATGGACCTGC CTCTGAGCGC TGTGCCCCCT 4680

TCCCAGGAGG AAAGGCCCGG CCCTGCTCCT GCCAGCCTGT CGCGTCAGCC TCCGCCCAGG 4740

AACAAGCCCT ACGTTTCCTG GCCCTCATCG GGTGGCTCTG AGCCCGGGGT GGCTGTGCCT 4800

CTGAGAAGCA TGTCTGATCC CGACCAGGAC TTTGACAAGG AGCCCGATTC GGACTCCACC 4860

AAACACTCGA CTCCATCCAA CAGCTCCAAC CCCAGCGGCC CGCCGAGCCC CAACTCTCCC 4920

CACAGGAGCC AGCTCCCGCT CGAAGGCCTG GAGCAGCCGT CCTATGACGC CTGA 4974

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavvr+k+te++yamkil+k+e+lkrae+a+freerdvlv++ds+w

Q: 18    FEIIKVIGRGAFGEVAVVRMKSTERIYAMKILNKWEMLKRAETACFREERDVLVNGDSQW  77

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +++l+yafqde+ylylvm+y+vGGdlltllsk+ed+lpe++arfy+ e+vla+ds+h+l+

Q: 78    LTTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYIGEMVLAIDSIHQLH  137

         ************************************************************

S: 121   yvh..rdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkalee  178

         yvh  rdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+

Q: 138   YVHsnRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED  197

         ***999******************************************************

S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseea  237

         g+g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseea

Q: 198   GMGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEA  257

         ****************************************************99******

S: 238   kdlikklltsreerlgregiedlkkhpff  266

         kdli++l++sre+rlg++g+ed+kkh+ff

Q: 258   KDLIQRLICSRERRLGQNGVEDFKKHAFF  286

         ****************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVRM KSTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDSQW 60

LTTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDRLPED MARFYIGEMV LAIDSIHQLH 120

YVHSNRDIKP DNVLLDVNGH IRLADFGSCL KMNDDGTVQS SVAVGTPDYI SPEILQAMED 180

GMGRYGPECD WWSLGVCMYE MLYGETPFYA ESLVETYGKI MNHEERFQFP SHVTDVSEEA 240

KDLIQRLICS RERRLGQNGV EDFKKHAFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013