EKS-SUS-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	324.8	5.1E-97	17	273	257

Status

Unreviewed

Ensembl Protein

ENSSSCP00000003204

UniProt Accession

F1RI42;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K1

Gene Synonyms/Alias

MAP4K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000002962	ENSSSCP00000003204	ENSSSCT00000003286

Organism

Sus scrofa

Functional Description

Protein Length

829

Protein Sequence
(FASTA)

MDLVDPDIFN RDPRDHYDLL QRLGGGTYGE VFKARDKVTG DLVALKMVKM EPDDDVSTLQ 60

KEILILKTCR HANIVAYHGS YLWWLQKLWI CMEFCGAGSL QDIYQVTGPL SELQISYVCR 120

EVLQGLAYLH SQKKIHRDIK GANILINDAG EVRLADFGIS AQIGATLARR LSFIGTPYWM 180

APEVAAVALK GGYNELCDIW SLGITAIELA ELQPPFFDVH PLRVLFLMTK SGYQPPRLKE 240

KGKWSAAFHN FVKVTLTKNP KKRPGATKML SHQLVSQPGL NRGLILDLLD KLRNPGKGAP 300

GGEIEDEEPE LPPAIPRRIR STHRSSSLGT PDADCCRRHM EFRRLRGMES RPTANTAHLQ 360

PPGDLRSSSP RRHQSESDDD YDDVDIPTPA EDTPPPLPPK PKFRSPSDEG PGGTGDEGQL 420

SPGVLVRCAS GPPPRTPHLG PPPATRSPHL TAHSEPSLWN PAPREPDQPP LLPPKKEKMK 480

RKLKGGSTEP GCALLVKLFN GCPLRIHSTA AWTHPSTKDQ HLLLGAEEGI FILNRNDQEA 540

TLEMLFSSRT TWVYSINNVL MSLSGKTPYL YSHSILGLLE RKEARAGNPI AHISPHRLLA 600

RKNMVSTKIQ DTKGCRACCV AEGASSGGPF LCGALETSVV LLQWYQPMNK FLLVRQVLFP 660

LPTPLPVFAL LTGPGSELPA VCIGVSPGRP AKSVLFHTVR FGALSCWLGE MSTEHKGPVQ 720

VTQVEEDKVM VLMDGSLKLV TPDGAPVRGL RTPEIPMTEA VEAVAVVGGR LQAFWKHGVQ 780

VWALGSDQLL QELRDPSLTF RLLGSPRPVV VETRPADDPT APSNLYIQE 829

Nucleotide Sequence
(FASTA)

ATGGACCTCG TGGACCCCGA CATTTTTAAT AGGGATCCCC GGGACCACTA CGACCTGCTG 60

CAGCGGCTGG GTGGCGGCAC CTATGGGGAA GTCTTCAAGG CTCGAGACAA GGTGACGGGG 120

GACCTGGTGG CATTGAAGAT GGTGAAGATG GAGCCTGACG ATGATGTGTC CACACTTCAG 180

AAGGAAATCC TCATCTTGAA AACCTGTCGG CACGCCAACA TCGTGGCCTA CCACGGCAGT 240

TATCTCTGGT GGCTGCAGAA GCTCTGGATC TGCATGGAAT TCTGTGGGGC TGGTTCTCTC 300

CAGGACATCT ACCAAGTGAC AGGCCCCCTG TCAGAGCTGC AGATCAGCTA CGTCTGCCGG 360

GAAGTGCTCC AGGGACTGGC CTATCTGCAC TCACAGAAGA AGATACACCG GGACATCAAG 420

GGAGCCAACA TCCTCATCAA TGATGCTGGG GAGGTCAGAC TGGCTGACTT TGGTATCTCG 480

GCTCAGATTG GGGCCACTCT GGCTCGACGC CTCTCTTTCA TCGGGACACC TTACTGGATG 540

GCTCCGGAAG TGGCAGCTGT GGCCCTGAAG GGGGGATACA ATGAGCTGTG TGACATCTGG 600

TCCCTGGGCA TCACTGCCAT CGAATTAGCT GAGCTACAGC CACCATTCTT TGATGTGCAC 660

CCTCTCAGAG TTCTCTTCCT CATGACCAAG AGTGGCTACC AGCCCCCGAG GCTAAAGGAA 720

AAAGGCAAAT GGTCGGCTGC CTTCCACAAC TTTGTCAAAG TCACCCTCAC CAAGAACCCC 780

AAGAAACGAC CTGGCGCCAC CAAGATGCTC AGTCATCAGC TGGTGTCCCA GCCTGGGCTA 840

AACAGAGGCC TGATCCTAGA TCTTCTCGAC AAGCTGAGGA ACCCCGGGAA GGGGGCCCCT 900

GGGGGCGAGA TTGAAGACGA GGAGCCTGAG CTGCCCCCCG CCATCCCGCG GCGGATCAGA 960

TCCACCCACC GATCCAGCTC CCTGGGGACT CCAGACGCGG ACTGCTGTCG GCGGCACATG 1020

GAGTTCAGGA GGCTCAGAGG AATGGAGTCC AGACCCACGG CCAACACGGC TCACTTACAG 1080

CCCCCTGGAG ACTTGAGGAG CAGCAGTCCT AGGAGGCACC AGTCTGAGTC CGACGATGAC 1140

TACGACGATG TGGACATCCC CACCCCTGCA GAAGACACGC CCCCTCCACT GCCCCCCAAG 1200

CCCAAGTTCC GTTCTCCATC CGATGAGGGT CCTGGGGGCA CTGGAGATGA GGGGCAGCTG 1260

AGCCCTGGGG TGCTGGTCCG GTGTGCCAGT GGGCCTCCCC CACGCACCCC CCATCTTGGA 1320

CCTCCCCCAG CTACCCGCAG CCCCCACCTC ACTGCCCACT CAGAACCTTC ACTCTGGAAC 1380

CCAGCCCCCC GGGAGCCAGA CCAGCCCCCC CTGTTGCCCC CCAAGAAGGA AAAGATGAAG 1440

AGAAAGCTAA AAGGAGGTAG CACAGAGCCA GGATGTGCCC TCCTCGTGAA GTTGTTCAAT 1500

GGCTGCCCCC TCCGGATCCA CAGCACAGCC GCCTGGACAC ACCCCTCCAC CAAAGACCAG 1560

CACCTGCTCC TGGGGGCCGA GGAAGGCATT TTCATCCTGA ACCGAAATGA CCAGGAGGCC 1620

ACGCTGGAGA TGCTCTTTTC TAGCCGGACG ACCTGGGTGT ACTCCATCAA CAATGTCCTC 1680

ATGTCTCTCT CAGGGAAGAC CCCCTACTTG TATTCGCACA GCATCCTGGG CCTGCTGGAA 1740

CGGAAAGAGG CCAGAGCAGG CAACCCCATC GCTCACATTA GTCCTCACCG GCTACTGGCA 1800

AGGAAGAACA TGGTCTCCAC TAAGATTCAG GACACCAAAG GCTGCCGGGC ATGCTGTGTG 1860

GCGGAGGGCG CGAGCTCCGG GGGCCCGTTC CTGTGTGGGG CATTGGAGAC ATCCGTGGTC 1920

TTGCTTCAGT GGTATCAGCC CATGAACAAG TTCCTGCTGG TCCGGCAGGT GCTGTTCCCC 1980

CTACCCACGC CTCTGCCGGT GTTCGCACTG CTGACCGGGC CAGGCTCCGA GCTGCCCGCT 2040

GTGTGCATCG GCGTGAGCCC CGGGCGGCCG GCCAAGTCGG TGCTCTTCCA CACCGTGCGC 2100

TTCGGCGCGC TTTCCTGCTG GCTGGGCGAG ATGAGCACAG AACACAAGGG ACCAGTACAG 2160

GTGACTCAGG TTGAGGAAGA CAAAGTGATG GTGTTGATGG ATGGGTCTCT GAAGCTGGTG 2220

ACCCCAGACG GGGCCCCGGT CCGGGGGCTT CGAACTCCAG AGATCCCTAT GACTGAAGCA 2280

GTGGAGGCCG TGGCTGTGGT CGGGGGGCGG CTGCAAGCCT TCTGGAAGCA TGGCGTGCAG 2340

GTGTGGGCTC TAGGCTCAGA CCAGCTGCTG CAGGAGCTGA GAGACCCCTC CCTCACCTTC 2400

CGTCTGCTTG GATCCCCCAG GCCTGTGGTG GTAGAGACAC GTCCAGCAGA TGATCCTACT 2460

GCCCCCAGCA ACCTCTACAT CCAGGAATGA 2490

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ll+++g G++g+v++ar+k tg+lva+k++++e  +++++lqkei +lk+++h niv+

Q: 17    YDLLQRLGGGTYGEVFKARDKVTGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVA  76

         899*********************************************************

S: 61    ylesflk.eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119

         y++s+l   ++lw++me++ +Gsl+d+++  ++ +l+E qi+y++revl++L+ylHs+k+

Q: 77    YHGSYLWwLQKLWICMEFCGAGSLQDIYQ--VTGPLSELQISYVCREVLQGLAYLHSQKK  134

         ******989********************..*****************************

S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYd  178

         iHrdik++niL+++ geV+L+dfg++aq+ +t ++r +++gtpywmAPEv a+  + gY+

Q: 135   IHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVAlKGGYN  194

         ****************************************************998999**

S: 179   ekaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvek  236

         e +DiwslGItaielae +pPf+d++pl++l++++k+   pp+lk+k k+s +f++fv+

Q: 195   ELCDIWSLGITAIELAELQPPFFDVHPLRVLFLMTKSGyqPPRLKEKGKWSAAFHNFVKV  254

         ***********************************998889*******************

S: 237   clqknpekRpsasellkhk  255

          l+knp+kRp a+++l+h+

Q: 255   TLTKNPKKRPGATKMLSHQ  273

         ******************8

Domain Sequence
(FASTA)

YDLLQRLGGG TYGEVFKARD KVTGDLVALK MVKMEPDDDV STLQKEILIL KTCRHANIVA 60

YHGSYLWWLQ KLWICMEFCG AGSLQDIYQV TGPLSELQIS YVCREVLQGL AYLHSQKKIH 120

RDIKGANILI NDAGEVRLAD FGISAQIGAT LARRLSFIGT PYWMAPEVAA VALKGGYNEL 180

CDIWSLGITA IELAELQPPF FDVHPLRVLF LMTKSGYQPP RLKEKGKWSA AFHNFVKVTL 240

TKNPKKRPGA TKMLSHQ 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008349	; F:MAP kinase kinase kinase kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013