EPS-SUS-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SUS-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	613.8	6.0E-185	185	496	312

Status

Unreviewed

Ensembl Protein

ENSSSCP00000003354

UniProt Accession

F1RM25;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000003098	ENSSSCP00000003354	ENSSSCT00000003437

Organism

Sus scrofa

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

HAMAEAKRTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 60

NAIYYGNRSL AYLRTECYGY ALADATRAIE MDKKYIKGYY RRAASNMALG KFRAALRDYQ 120

TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK 180

LEDGRVTATF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RSRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENHL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAA YIHLRGSDLR PQFHQFTAVP 480

HPDVKPMAYA STLLQLGMM 499

Nucleotide Sequence
(FASTA)

CATGCGATGG CGGAGGCGAA GCGGACTGAG TGTGCTGAGC CCCCCCGGGA CGAGCCCCCG 60

GCTGATGGCG CGCTGAAGCG GGCAGAGGAG CTCAAGACGC AGGCCAACGA CTACTTCAAA 120

GCCAAGGACT ACGAGAACGC CATCAAGTTC TACAGTCAGG CCATAGAGCT GAACCCAAGC 180

AATGCCATCT ACTATGGCAA CCGCAGCCTG GCCTACCTGC GCACCGAGTG CTACGGCTAC 240

GCGCTGGCCG ACGCCACACG GGCCATCGAG ATGGACAAGA AGTACATCAA GGGTTACTAC 300

CGCCGCGCAG CCAGCAACAT GGCCCTGGGC AAGTTCCGGG CCGCCCTGCG CGACTACCAG 360

ACGGTGGTGA AGGTGAAGCC CCACGACAAG GACGCCAAGA TGAAGTACCA GGAATGCAAC 420

AAGATCGTGA AGCAGAAAGC CTTCGAGCGG GCCATTGCAG GTGATGAGCA CAAGCGCTCC 480

GTCGTGGACT CACTCGACAT CGAGAGCATG ACCATCGAGG ATGAGTACAG CGGGCCCAAG 540

CTGGAGGACG GCCGAGTGAC AGCCACCTTC ATGAAGGAGC TCATGCAGTG GTACAAGGAC 600

CAGAAGAAAC TGCACCGGAA GTGCGCCTAC CAGATCCTGG TACAGGTCAA AGAGGTCCTC 660

TCTAAGCTGA GCACGCTGGT GGAGACCACA CTCAAAGAGA CAGAGAAGAT TACAGTGTGC 720

GGGGACACCC ACGGCCAGTT CTATGATCTC CTCAACATAT TTGAGCTCAA CGGTTTACCC 780

TCGGAGACCA ACCCCTATAT ATTTAATGGT GACTTCGTGG ACCGTGGCTC CTTTTCCGTA 840

GAAGTGATCC TCACCCTTTT TGGTTTTAAG CTCCTCTACC CAGATCACTT TCACCTACTT 900

CGAGGCAACC ATGAGACGGA CAACATGAAC CAGATCTATG GCTTCGAGGG CGAGGTGAAG 960

GCCAAGTACA CAGCCCAGAT GTACGAGCTC TTCAGTGAGG TGTTCGAGTG GCTCCCGCTG 1020

GCCCAGTGCA TCAATGGCAA AGTGCTGATC ATGCACGGGG GCTTGTTCAG TGAAGACGGC 1080

GTCACGCTGG ATGACATCAG GAAGATCGAG CGGAGTCGGC AGCCTCCAGA TTCAGGTCCC 1140

ATGTGTGACC TGCTCTGGTC GGACCCACAG CCACAGAACG GGCGCTCGGT CAGCAAGCGG 1200

GGCGTGAGCT GCCAGTTCGG GCCTGACGTC ACCAAGGCCT TCCTGGAGGA GAACCACCTG 1260

GACTACATCA TCCGCAGCCA CGAGGTCAAG GCCGAGGGCT ATGAGGTGGC CCACGGTGGC 1320

CGCTGTGTCA CCGTCTTCTC TGCCCCCAAC TACTGCGACC AGATGGGGAA CAAAGCCGCC 1380

TACATCCACC TCCGGGGCTC TGACCTGCGG CCCCAGTTCC ACCAGTTCAC AGCAGTGCCT 1440

CATCCCGACG TCAAGCCCAT GGCCTACGCC AGCACGCTGC TGCAGTTAGG GATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         +v+  f+k+l++++k++kkl+rk+a++ilv+v++vl+kl++++e+++ke++kitvcGdth

Q: 185   RVTATFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTH  244

         68999*******************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkier +qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 365   DIRKIERSRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENHLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+a++ih+r++dlr+++++f+av+hpdv

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKAAYIHLRGSDLRPQFHQFTAVPHPDV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+ +ll+l

Q: 485   KPMAYASTLLQL  496

         ********9987

Domain Sequence
(FASTA)

RVTATFMKEL MQWYKDQKKL HRKCAYQILV QVKEVLSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERSRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENHLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKAAYIHL RGSDLRPQFH QFTAVPHPDV 300

KPMAYASTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013